Types of Uterine Cancer

The most common type of uterine cancer is endometrial cancer, which develops in the cells of the inner lining of the uterus – the endometrium. Endometrial cancer, which is often simply referred to as “uterine cancer” interchangeably, can be subcategorized into different types, known as “histologic types,” which are named for the appearance of the cancer cells.

Common types of uterine cancer

Some common types of endometrial cancer include:

  • Adenocarcinoma – The majority of uterine cancers are adenocarcinomas, which form in mucus-producing glands of organs.
  • Sarcoma – Uterine sarcoma develops in the connective tissues of the uterus or in the myometrium, which is the muscle of the organ.
  • Uterine carcinosarcoma – These cancers feature characteristics of both endometrial carcinoma (forms in the endometrium, or inner lining of the uterus) and sarcoma (forms in the muscle cells of the uterus).

Endometrioid cancer

Endometrioid cancer is the most common type of endometrial adenocarcinoma. These cancers develop in the glandular cells of the endometrium, and under a microscope, the cells look very similar to normal, healthy endometrial cells. Sometimes these tumors contain squamous cells along with the glandular cells.

Types of endometrioid cancer include:

  • Adenocarcinoma (the squamous cells are what differentiate this from other endometrial adenocarcinomas)
  • Adenoacanthoma
  • Adenosquamous (or mixed cell)
  • Secretory carcinoma
  • Ciliated carcinoma
  • Villoglandular adenocarcinoma

Less-common types of uterine cancer

The following endometrial cancers are less common:

  • Small cell carcinoma
  • Squamous cell carcinoma
  • Serous carcinoma
  • Transitional carcinoma

Some other rare types of uterine cancer tend to grow and spread faster than others. These include clear-cell carcinoma, undifferentiated carcinoma, mucinous adenocarcinoma, serous adenocarcinoma and dedifferentiated carcinoma.

Treatment at Moffitt Cancer Center

Moffitt’s gynecologic clinic is home to a renowned multispecialty team of physicians who focus on the treatment of all types of uterine cancer. Our talented team collaborates to develop individualized treatment plans for all patients, which can include innovative therapies through our robust clinical trials program.

To learn more about the various types of uterine cancer and Moffitt’s approach to treatment, call 1-888-663-3488 or complete our new patient registration form online. Referrals are never needed to visit Moffitt.