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Clinical Trials for Astrocytomas and Gliomas

clinical trials

A type of neurological tumor (glioma) that can affect people of all ages, astrocytoma, develops from precursors to the star-shaped brain cells known as astrocytes. Astrocytes normally assist with many critical functions, such as maintaining the blood-brain barrier, delivering essential nutrients to nerve tissues and aiding in the repair of brain trauma. When they form tumors, astrocytomas can be challenging to treat.

At Moffitt Cancer Center, the scientists and clinicians in our Neuro-Oncology Program are continually investigating new and better ways to treat astrocytoma and other forms of brain cancer, and we are making great strides. Our research breakthroughs have received national acclaim, including a Comprehensive Cancer Center designation by the National Cancer Institute.

The focus of our studies

Through our robust portfolio of clinical trials, Moffitt’s research team is able to assess the effectiveness of novel therapies for brain and nervous system tumors as compared to the current standard of care. These important medical research studies also offer our patients opportunities to be among the first to benefit from promising new treatment options that are not yet widely available, such as:

  • Surgical techniques for brain tumor removal
  • Radiation therapy delivery methods for the microscopic portions of these tumors that cannot be surgically removed safely and spare normal brain
  • Chemotherapy medications and combinations of existing medications
  • Immunotherapies and vaccines
  • Supportive therapies to manage the side effects of existing treatments and enhance quality of life

Moffitt is a leading destination for astrocytoma and glioma clinical trials, which are especially important given the limitations of the currently available treatment options. In addition to our renowned scientific researchers, our Neuro-Oncology Program includes experienced surgeons, medical oncologists, radiation oncologists, neurologists, geneticists, personalized medicine doctors, and neuropsycologists all of whom specialize in treating cancers of the brain and spinal cord. Working together, we provide our patients with highly individualized care, which we believe is key to achieving the best possible outcome and quality of life.

Medical Reviewed by Dr. Peter Forsyth, Chair, Department of Neuro-Oncology  

If you have questions or would like to find astrocytoma clinical trials that are currently accepting new patients, please call 1-888-663-3488 or complete our new patient registration form online to request an appointment at Moffitt.

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Open Clinical Trials:

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CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 19327

A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients with Metastatic Melanoma or Non-small Cell Lung Cancer with Untreated Brain Metastases

Disease Site: Non small cell lung cancer, Brain and Nervous System, Lung, Melanoma, skin, Gliomas

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CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20145

A Pilot Study of Intratumorally and Intraparenchymally Administered OS2966 using Convection-enhanced Delivery in Patients with Recurrent/Progressive High-grade Glioma Undergoing a Clinically-indicated Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast, Leptomeningeal (LMD)

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CLINICAL TRIAL 20637

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease

Disease Site: Brain and Nervous System, Brain metastasis

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CLINICAL TRIAL 20899

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20956

A Two-Part, Phase 1a/B, Open-Label, Multicenter Trial Evaluating Pharmacokinetics, Safety and Efficacy Of PF-07284890 (ARRY-461) In Participants With BRAF V600-Mutant Solid Tumors With And Without Brain Involvement

Disease Site: Any Site, Brain and Nervous System, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Other Skin, Brain metastasis, Gliomas

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CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21022

A Phase 1b/2, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 (pINN sotorasib) in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation

Disease Site: Any Site, Brain and Nervous System, Lung, Pancreas, Rectum, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21039

A Pivotal Randomized, Open-Label Study Of OPTUNE(R)(TTFIELDS, 200KHZ) Concomitant With Radiation Therapy And Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 21193

Pre-operative Hypofractionated Stereotactic Radiosurgery for Resectable Brain Metastases

Disease Site: Brain and Nervous System, Brain metastasis

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CLINICAL TRIAL 21681

A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain metastasis, Gliomas, Leptomeningeal (LMD), Meningiomas

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CLINICAL TRIAL 21737

A Pilot Study of Advanced Multi-parametric MRI to Evaluate De Novo Glioblastoma Tumors Prior to Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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