Philipp <span>M.</span> Altrock, PhD
Researcher

Philipp M. Altrock, PhD

Academic Rank: Assistant Member

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Email
Overview

Discipline

    • Integrated Mathematical Oncology
    • Malignant Hematology
    • Blood and Marrow Transplant and Cellular Immunotherapy
    • Cancer Biology and Evolution Program

Education & Training

    • University of Kiel, PhD - Natural Sciences
    • University of Leipzig, MSc - Physics
Research

Dr. Altrock's research focus is in the somatic evolution of cancer, dynamics of the hematopoietic system, epidemiology, population dynamics, evolutionary game theory, and population genetics. One of our current focus  areas is the dynamics of healthy tissues and cancers with differentiation structure (stem cell, progenitors and differentiated cells). In particuar we attempt to describe somatic evolution and Darwinian seleciton in the hematopoietic system, as well as in leukemias and lymphomas (e.g. during CAR-T cell therapy).

Publications

  • Gerlee P, Altrock PM. Extinction rates in tumour public goods games. J R Soc Interface. 2017 Sep;14(134). Pubmedid: 28954847. Pmcid: PMC5636271.
  • Altrock PM, Traulsen A, Nowak MA. Evolutionary games on cycles with strong selection. Phys Rev E. 2017 Feb;95(2-1):022407. Pubmedid: 28297871.
  • Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016 Sep;91(9):931-937. Pubmedid: 27299299. Pmcid: PMC5093908.
  • Werner B, Scott JG, Sottoriva A, Anderson AR, Traulsen A, Altrock PM. The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Res. 2016 Apr;76(7):1705-1713. Pubmedid: 26833122. Pmcid: PMC4900896.
  • Gerlee P, Altrock PM. Complexity and stability in growing cancer cell populations. Proc Natl Acad Sci U S A. 2015 May;112(21):E2742-E2743. Pubmedid: 25941414. Pmcid: PMC4450388.
  • Li XY, Pietschke C, Fraune S, Altrock PM, Bosch TC, Traulsen A. Which games are growing bacterial populations playing?. J R Soc Interface. 2015 Jul;12(108):20150121. Pubmedid: 26236827. Pmcid: PMC4528578.
  • Altrock PM, Liu LL, Michor F. The mathematics of cancer: integrating quantitative models. Nat Rev Cancer. 2015 Dec;15(12):730-745. Pubmedid: 26597528.
  • Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014 Oct;514(7520):54-58. Pubmedid: 25079331. Pmcid: PMC4184961.
  • Ashcroft P, Altrock PM, Galla T. Fixation in finite populations evolving in fluctuating environments. J R Soc Interface. 2014 Nov;11(100):20140663. Pubmedid: 25165604. Pmcid: PMC4191092.
  • Du J, Wu B, Altrock PM, Wang L. Aspiration dynamics of multi-player games in finite populations. J R Soc Interface. 2014 May;11(94):20140077. Pubmedid: 24598208. Pmcid: PMC3973373.
  • Reeves RG, Bryk J, Altrock PM, Denton JA, Reed FA. First steps towards underdominant genetic transformation of insect populations. PLoS One. 2014 May;9(5):e97557. Pubmedid: 24844466. Pmcid: PMC4028297.
  • Hilbe C, Abou Chakra M, Altrock PM, Traulsen A. The evolution of strategic timing in collective-risk dilemmas. PLoS One. 2014 Jan;8(6):e66490. Pubmedid: 23799109. Pmcid: PMC3682992.
  • Franzenburg S, Fraune S, Altrock PM, Künzel S, Baines JF, Traulsen A, Bosch TC. Bacterial colonization of Hydra hatchlings follows a robust temporal pattern. ISME J. 2013 Apr;7(4):781-790. Pubmedid: 23344242. Pmcid: PMC3603398.
  • Altrock PM, Traulsen A, Galla T. The mechanics of stochastic slowdown in evolutionary games. J Theor Biol. 2012 Oct;311:94-106. Pubmedid: 22814474.
  • Altrock PM, Traulsen A, Reed FA. Stability properties of underdominance in finite subdivided populations. PLoS Comput Biol. 2011 Nov;7(11):e1002260. Pubmedid: 22072956. Pmcid: PMC3207953.
  • Wu B, Altrock PM, Wang L, Traulsen A. Universality of weak selection. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct;82(4 Pt 2):046106. Pubmedid: 21230344.
  • Altrock PM, Traulsen A, Reeves RG, Reed FA. Using underdominance to bi-stably transform local populations. J Theor Biol. 2010 Nov;267(1):62-75. Pubmedid: 20691703.
  • Altrock PM, Gokhale CS, Traulsen A. Stochastic slowdown in evolutionary processes. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jul;82(1 Pt 1):011925. Pubmedid: 20866666.
  • Altrock PM, Traulsen A. Deterministic evolutionary game dynamics in finite populations. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jul;80(1 Pt 1):011909. Pubmedid: 19658731.