Philipp <span>M.</span> Altrock, PhD
Researcher

Philipp M. Altrock, PhD

Academic Rank: Assistant Member

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Overview

Darwinian selection is a universal feature of life on all sales. We unravel how Darwinian evolution works in cancer, which helps to understand and improve cancer therapy and cancer patients’ lives.

Discipline

    • Integrated Mathematical Oncology
    • Malignant Hematology
    • Blood and Marrow Transplant and Cellular Immunotherapy
    • Cancer Biology and Evolution Program

Education & Training

    • University of Kiel, PhD - Natural Sciences
    • University of Leipzig, MSc - Physics
Research

We apply theoretical evolutionary biology models, together with computational, bioinformatics and statistical approaches to cancer cell biology. Of particular interest to us is how the tumor microenvironment shapes selective pressures that play a fundamental role in the evolution of tumor progression and resistance to therapy.  

Publications

  • Gerlee P, Altrock PM. Extinction rates in tumour public goods games. J R Soc Interface. 2017 Sep;14(134). Pubmedid: 28954847. Pmcid: PMC5636271.
  • Altrock PM, Traulsen A, Nowak MA. Evolutionary games on cycles with strong selection. Phys Rev E. 2017 Feb;95(2-1):022407. Pubmedid: 28297871.
  • Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. Am J Hematol. 2016 Sep;91(9):931-937. Pubmedid: 27299299. Pmcid: PMC5093908.
  • Werner B, Scott JG, Sottoriva A, Anderson AR, Traulsen A, Altrock PM. The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Res. 2016 Apr;76(7):1705-1713. Pubmedid: 26833122. Pmcid: PMC4900896.
  • Gerlee P, Altrock PM. Complexity and stability in growing cancer cell populations. Proc Natl Acad Sci U S A. 2015 May;112(21):E2742-E2743. Pubmedid: 25941414. Pmcid: PMC4450388.
  • Li XY, Pietschke C, Fraune S, Altrock PM, Bosch TC, Traulsen A. Which games are growing bacterial populations playing?. J R Soc Interface. 2015 Jul;12(108):20150121. Pubmedid: 26236827. Pmcid: PMC4528578.
  • Altrock PM, Liu LL, Michor F. The mathematics of cancer: integrating quantitative models. Nat Rev Cancer. 2015 Dec;15(12):730-745. Pubmedid: 26597528.
  • Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014 Oct;514(7520):54-58. Pubmedid: 25079331. Pmcid: PMC4184961.
  • Ashcroft P, Altrock PM, Galla T. Fixation in finite populations evolving in fluctuating environments. J R Soc Interface. 2014 Nov;11(100):20140663. Pubmedid: 25165604. Pmcid: PMC4191092.
  • Du J, Wu B, Altrock PM, Wang L. Aspiration dynamics of multi-player games in finite populations. J R Soc Interface. 2014 May;11(94):20140077. Pubmedid: 24598208. Pmcid: PMC3973373.
  • Reeves RG, Bryk J, Altrock PM, Denton JA, Reed FA. First steps towards underdominant genetic transformation of insect populations. PLoS One. 2014 May;9(5):e97557. Pubmedid: 24844466. Pmcid: PMC4028297.
  • Hilbe C, Abou Chakra M, Altrock PM, Traulsen A. The evolution of strategic timing in collective-risk dilemmas. PLoS One. 2014 Jan;8(6):e66490. Pubmedid: 23799109. Pmcid: PMC3682992.
  • Franzenburg S, Fraune S, Altrock PM, Künzel S, Baines JF, Traulsen A, Bosch TC. Bacterial colonization of Hydra hatchlings follows a robust temporal pattern. ISME J. 2013 Apr;7(4):781-790. Pubmedid: 23344242. Pmcid: PMC3603398.
  • Altrock PM, Traulsen A, Galla T. The mechanics of stochastic slowdown in evolutionary games. J Theor Biol. 2012 Oct;311:94-106. Pubmedid: 22814474.
  • Altrock PM, Traulsen A, Reed FA. Stability properties of underdominance in finite subdivided populations. PLoS Comput Biol. 2011 Nov;7(11):e1002260. Pubmedid: 22072956. Pmcid: PMC3207953.
  • Wu B, Altrock PM, Wang L, Traulsen A. Universality of weak selection. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct;82(4 Pt 2):046106. Pubmedid: 21230344.
  • Altrock PM, Traulsen A, Reeves RG, Reed FA. Using underdominance to bi-stably transform local populations. J Theor Biol. 2010 Nov;267(1):62-75. Pubmedid: 20691703.
  • Altrock PM, Gokhale CS, Traulsen A. Stochastic slowdown in evolutionary processes. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jul;82(1 Pt 1):011925. Pubmedid: 20866666.
  • Altrock PM, Traulsen A. Deterministic evolutionary game dynamics in finite populations. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jul;80(1 Pt 1):011909. Pubmedid: 19658731.