Image Place holder

Naomi Brownstein, PhD

Program: Biostatistics and Bioinformatics

Google Scholar Profile



    • Biostatistics and Bioinformatics
    • Radiation Oncology
    • Health Outcomes & Behavior Program
    • Health Outcomes & Behavior Program

Education & Training


Dr. Brownstein develops and applies statistical methodology for cancer related translational research with specialties in survival analysis, clustering, and proper application of expert judgment. Her primary collaborative areas include health outcomes and behavior, and radiation oncology.


  • Brownstein NC, Bunn V, Castro LM, Sinha D. Bayesian analysis of survival data with missing censoring indicators. Biometrics. 2021 Mar.77(1):305-315. Pubmedid: 32282929. Pmcid: PMC7733523.
  • Brownstein NC, Chen YA. Predictive values, uncertainty, and interpretation of serology tests for the novel coronavirus. Sci Rep. 2021 Mar.11(1):5491. Pubmedid: 33750810. Pmcid: PMC7943825.
  • Bulls HW, Chang PH, Brownstein NC, Zhou JM, Hoogland AI, Gonzalez BD, Johnstone P, Jim HSL. Patient-reported symptom burden in routine oncology care: Examining racial and ethnic disparities. Cancer Rep (Hoboken). 2021 Jun.e1478. Pubmedid: 34165256.
  • Dhahri A, Kaplan J, Naqvi SMH, Brownstein NC, Ntiri SO, Imanirad I, Felder SI, Dineen SP, Sanchez J, Dessureault S, Carballido E, Powers BD. The impact of socioeconomic status on survival in stage III colon cancer patients: A retrospective cohort study using the SEER census-tract dataset. Cancer Med. 2021 Aug.10(16):5643-5652. Pubmedid: 34197047. Pmcid: PMC8366079.
  • Jim HSL, Hoogland AI, Brownstein NC, Barata A, Dicker AP, Knoop H, Gonzalez BD, Perkins R, Rollison D, Gilbert SM, Nanda R, Berglund A, Mitchell R, Johnstone PAS. Innovations in research and clinical care using patient-generated health data. CA-Cancer J Clin. 2020 May.70(3):182-199. Pubmedid: 32311776. Pmcid: PMC7488179.
  • Brownstein NC, Chen YA. Predictive values, uncertainty, and interpretation of serology tests for the novel coronavirus. medRxiv. 2020 Jun. Pubmedid: 32577683. Pmcid: PMC7302289.
  • Middlemiss W, Brownstein NC, Nelson SP, Manchiraju S, Leddy M, Steliotes N, Grzywacz JG. Crafting effective messages to enhance safe infant sleep. J Am Assoc Nurse Pract. 2020 Feb.33(6):441-450. Pubmedid: 32039958.
  • Middlemiss W, Brownstein NC, Leddy M, Nelson S, Manchiraju S, Grzywacz JG. Baby Box Distributions: Public Health Benefit or Concern?. Public Health Rep. 2019 May.134(4):328-331. Pubmedid: 31067412. Pmcid: PMC6598133.
  • Brownstein NC, Adolfsson A, Ackerman M. Descriptive statistics and visualization of data from the R datasets package with implications for clusterability. Data Brief. 2019 May.25:104004. Pubmedid: 31317060. Pmcid: PMC6612012.
  • Brownstein NC, Louis TA, O'Hagan A, Pendergast J. The Role of Expert Judgment in Statistical Inference and Evidence-Based Decision-Making. Am Stat. 2019 Mar.73(1):56-68. Pubmedid: 31057338. Pmcid: PMC6474725.
  • Brownstein NC, Cai J. Tests of trend between disease outcomes and ordinal covariates discretized from underlying continuous variables: simulation studies and applications to NHANES 2007-2008. BMC Med Res Methodol. 2019 Jan.19(1):2. Pubmedid: 30611216. Pmcid: PMC6321711.
  • Rappazzo KM, Warren JL, Davalos AD, Meyer RE, Sanders AP, Brownstein NC, Luben TJ. Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort. Birth Defects Res. 2019 Apr.111(6):312-323. Pubmedid: 30592382. Pmcid: PMC6445756.
  • Naar S, Ellis D, Cunningham P, Pennar AL, Lam P, Brownstein NC, Bruzzese JM. Comprehensive Community-Based Intervention and Asthma Outcomes in African American Adolescents. Pediatrics. 2018 Oct.142(4). Pubmedid: 30185428. Pmcid: PMC6317763.
  • Campbell KM, Brownstein NC, Livingston H, Rodríguez JE. Improving Underrepresented Minority in Medicine Representation in Medical School. South Med J. 2018 Apr.111(4):203-208. Pubmedid: 29719030.
  • Guan X, Brownstein NC, Young NL, Marshall AG. Ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo amino acid sequencing for a seven-protein mixture by paired single-residue transposed Lys-N and Lys-C digestion. Rapid Commun Mass Spectrom. 2017 Jan.31(2):207-217. Pubmedid: 27813191.
  • Wright KN, Strong CE, Addonizio MN, Brownstein NC, Kabbaj M. Reinforcing properties of an intermittent, low dose of ketamine in rats: effects of sex and cycle. Psychopharmacology (Berl). 2017 Feb.234(3):393-401. Pubmedid: 27837330. Pmcid: PMC5384643.
  • Campbell KM, Rodríguez JE, Brownstein NC, Fisher ZE. Status of Tenure Among Black and Latino Faculty in Academic Medicine. J Racial Ethn Health Disparities. 2017 Apr.4(2):134-139. Pubmedid: 26931546.
  • Geletko KW, Myers K, Brownstein N, Jameson B, Lopez D, Sharpe A, Bellamy GR. Medical Residents' and Practicing Physicians' e-Cigarette Knowledge and Patient Screening Activities: Do They Differ?. Health Serv Res Manag Epidemiol. 2016 Nov.3. Pubmedid: 28462285. Pmcid: PMC5266463.
  • Cope EC, Morris DR, Gower-Winter SD, Brownstein NC, Levenson CW. Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. Exp Neurol. 2016 May.279:96-103. Pubmedid: 26902472.
  • Hurwitz SN, Conlon MM, Rider MA, Brownstein NC, Meckes DG. Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis. J Extracell Vesicles. 2016 Jul.5:31295. Pubmedid: 27421995. Pmcid: PMC4947197.
  • Rappazzo KM, Warren JL, Meyer RE, Herring AH, Sanders AP, Brownstein NC, Luben TJ. Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Res A Clin Mol Teratol. 2016 Apr.106(4):240-249. Pubmedid: 26970546. Pmcid: PMC4833532.
  • Warren JL, Luben TJ, Sanders AP, Brownstein NC, Herring AH, Meyer RE. An evaluation of metrics for assessing maternal exposure to agricultural pesticides. J Expo Sci Environ Epidemiol. 2015 May.24(5):497-503. Pubmedid: 24149974. Pmcid: PMC3997755.
  • Brownstein NC, Cai J, Slade GD, Bair E. Parameter estimation in Cox models with missing failure indicators and the OPPERA study. Stat Med. 2015 Dec.34(30):3984-3996. Pubmedid: 26242613. Pmcid: PMC4715503.
  • Brownstein NC, Guan X, Mao Y, Zhang Q, DiMaggio PA, Xia Q, Zhang L, Marshall AG, Young NL. Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometr. Rapid Commun Mass Spectrom. 2015 Apr.29(7):659-666. Pubmedid: 26212284.
  • Slade GD, Sanders AE, Bair E, Brownstein N, Dampier D, Knott C, Fillingim R, Maixner WO, Smith S, Greenspan J, Dubner R, Ohrbach R. Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study. Pain. 2013 May.154(5):750-760. Pubmedid: 23531476. Pmcid: PMC3652580.
  • Bair E, Brownstein NC, Ohrbach R, Greenspan JD, Dubner R, Fillingim RB, Maixner W, Smith SB, Diatchenko L, Gonzalez Y, Gordon SM, Lim PF, Ribeiro-Dasilva M, Dampier D, Knott C, Slade GD. Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study. J Pain. 2013 Dec.14(12 Suppl):T2-19. Pubmedid: 24275220. Pmcid: PMC3855654.
  • Brownstein NC. Statistical considerations are necessary in assessing associations between micronutrient intake and times to clinical events. J Nutr. 2012 Oct.142(10):1917. Pubmedid: 22996166. Pmcid: PMC3442797.


Title: Barriers to Screening Breast MRI Utilization among Patients at Elevated Risk (B-SUPER)
Sponsor: Breast Cancer Research Fdtn
PI: Brownstein, N.