Christine <span>M.</span> Pierce, PhD, MPH
Researcher

Christine M. Pierce, PhD, MPH

Academic Rank: Assistant Member

Overview

Integrating molecular epidemiology and microbiome science to better understand how cancer patients respond to therapy.

Discipline

    • Cancer Epidemiology
    • Thoracic Oncology
    • Center for Infection Research in Cancer
    • Cancer Epidemiology Program

Education & Training

    • University of Michigan School of Public Health, PhD - Epidemiological Science
    • University of Michigan School of Public Health, MPH - Epidemiology
    • Moffitt Cancer Center & Research Institute, Fellow - Epidemiology
Research

Dr. Pierce Campbell’s research is focused on understanding the complex interactions between the human microbiome (bacterial, fungal, and viral communities that exist throughout the human body) and immune system within the context of cancer development, tumor progression, and the response to cancer therapy. Through the use of integrative molecular epidemiological techniques, Dr. Pierce Campbell’s research aims to assist in the development of molecular biomarkers for cancer diagnosis, prognosis, and therapeutic outcomes. The human body harbors several diverse and complex microbial communities, each occupying a unique ecological niche. An estimated 500-1,000 bacterial species live in the gut and over 600 live in the oral cavity. These commensal microbes (i.e., microbiota) have co-evolved with human hosts and play a critical role in maintaining our physiology and metabolism, and modulating our immune and inflammatory responses. Microbiota also influence the host’s ability to mount a successful anti-tumor immune response. Dr. Pierce Campbell’s research aims to understand how a patient’s microbiota may influence the effectiveness of cancer therapies, particularly immunotherapy. Her studies have largely concentrated on cancers of the head and neck, lung, breast, and colon. These studies will improve our understanding of the role of the microbiome in cancer treatment and may aid in the development of personalized microbiota-based interventions to optimize anticancer therapies (e.g., prebiotics, probiotics, and fecal microbiome transplants).  

Publications

  • Robinson LA, Jaing CJ, Campbell CP, Magliocco A, Xiong Y, Magliocco G, Thissen JB, Antonia S. Reply to: Comment on 'Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung'. Brit J Cancer. 2017 Jan;116(3):e6. Pubmedid: 27764846. Pmcid: PMC5294469.
  • Pierce Campbell CM, Gheit T, Tommasino M, Lin HY, Torres BN, Messina JL, Stoler MH, Rollison DE, Sirak BA, Abrahamsen M, Carvalho da Silva RJ, Sichero L, Villa LL, Lazcano-Ponce E, Giuliano AR. Cutaneous beta human papillomaviruses and the development of male external genital lesions: A case-control study nested within the HIM Study. Virology. 2016 Oct;497:314-322. Pubmedid: 27518539.
  • Rahman S, Pierce Campbell CM, Torres BN, O'Keefe MT, Ingles DJ, Villa LL, Carvalho da Silva RJ, Cintra RC, Lazcano-Ponce E, Salmeron J, Quiterio M, Giuliano AR. Distribution and factors associated with salivary secretory leukocyte protease inhibitor concentrations. Oral Dis. 2016 Nov;22(8):781-790. Pubmedid: 27470907. Pmcid: PMC5056814.
  • Pierce Campbell CM, Viscidi RP, Torres BN, Lin HY, Fulp W, Abrahamsen M, Lazcano-Ponce E, Villa LL, Kreimer AR, Giuliano AR. Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study. J Infect Dis. 2016 Jul;214(1):45-48. Pubmedid: 26931445. Pmcid: PMC4907411.
  • Sudenga SL, Ingles DJ, Pierce Campbell CM, Lin HY, Fulp WJ, Messina JL, Stoler MH, Abrahamsen M, Villa LL, Lazcano-Ponce E, Giuliano AR. Genital Human Papillomavirus Infection Progression to External Genital Lesions: The HIM Study. Eur Urol. 2016 Jan;69(1):166-173. Pubmedid: 26051441. Pmcid: PMC4670812.
  • Rahman S, Pierce Campbell CM, Waterboer T, Rollison DE, Ingles DJ, Torres BN, Michel A, Sudenga SL, Pawlita M, Villa LL, Lazcano Ponce E, Borenstein AR, Wang W, Giuliano AR. Seroprevalence of cutaneous human papillomaviruses (HPVs) among men in the multinational HPV Infection in Men study. J Gen Virol. 2016 Dec;97(12):3291-3301. Pubmedid: 27902363.
  • Nunes EM, Sudenga SL, Gheit T, Tommasino M, Baggio ML, Ferreira S, Galan L, Silva RC, Pierce Campbell CM, Lazcano-Ponce E, Giuliano AR, Villa LL, Sichero L. Diversity of beta-papillomavirus at anogenital and oral anatomic sites of men: The HIM Study. Virology. 2016 Aug;495:33-41. Pubmedid: 27161202. Pmcid: PMC4949595.
  • Robinson LA, Jaing CJ, Pierce Campbell C, Magliocco A, Xiong Y, Magliocco G, Thissen JB, Antonia S. Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung. Brit J Cancer. 2016 Aug;115(4):497-504. Pubmedid: 27415011. Pmcid: PMC4985355.
  • Pierce Campbell CM, Giuliano AR, Torres BN, O'Keefe MT, Ingles DJ, Anderson RL, Teras LR, Gapstur SM. Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort. Oral Oncol. 2016 Apr;55:1-5. Pubmedid: 27016010. Pmcid: PMC4808568.
  • Rahman S, Rollison DE, Pierce Campbell CM, Waterboer T, Michel A, Pawlita M, Villa LL, Lazcano Ponce E, Wang W, Borenstein AR, Giuliano AR. Seroprevalence of Cutaneous Human Papillomaviruses and the Risk of External Genital Lesions in Men: A Nested Case-Control Study. PLoS One. 2016;11(11):e0167174. Pubmedid: 27893841. Pmcid: PMC5125700.
  • Rahman S, Pierce Campbell CM, Rollison DE, Wang W, Waterboer T, Michel A, Pawlita M, Villa LL, Lazcano Ponce E, Borenstein AR, Giuliano AR. Seroprevalence and Associated Factors of 9-Valent Human Papillomavirus (HPV) Types among Men in the Multinational HIM Study. PLoS One. 2016;11(11):e0167173. Pubmedid: 27902759. Pmcid: PMC5130234.
  • Vyas NS, Pierce Campbell CM, Mathew R, Abrahamsen M, Van der Kooi K, Jukic DM, Stoler MH, Villa LL, da Silva RC, Lazcano-Ponce E, Quiterio M, Salmeron J, Sirak BA, Ingles DJ, Giuliano AR, Messina JL. Role of histological findings and pathologic diagnosis for detection of human papillomavirus infection in men. J Med Virol. 2015 Oct;87(10):1777-1787. Pubmedid: 25945468. Pmcid: PMC4780420.
  • Pierce Campbell CM, Kreimer AR, Lin HY, Fulp W, O'Keefe MT, Ingles DJ, Abrahamsen M, Villa LL, Lazcano-Ponce E, Giuliano AR. Long-term persistence of oral human papillomavirus type 16: the HPV Infection in Men (HIM) study. Cancer Prev Res (Phila). 2015 Mar;8(3):190-196. Pubmedid: 25575501. Pmcid: PMC4355174.
  • Giuliano AR, Nyitray AG, Kreimer AR, Pierce Campbell CM, Goodman MT, Sudenga SL, Monsonego J, Franceschi S. EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection. Int J Cancer. 2015 Jun;136(12):2752-2760. Pubmedid: 25043222. Pmcid: PMC4297584.
  • Ingles DJ, Pierce Campbell CM, Messina JA, Stoler MH, Lin HY, Fulp WJ, Abrahamsen M, Sirak BA, O'Keefe MT, Papenfuss M, Gage C, da Silva RC, Sosa RG, Juarez OR, Villa LL, Ponce EL, Giuliano AR. Human papillomavirus virus (HPV) genotype- and age-specific analyses of external genital lesions among men in the HPV Infection in Men (HIM) Study. J Infect Dis. 2015 Apr;211(7):1060-1067. Pubmedid: 25344518. Pmcid: PMC4432433.
  • Sichero L, Pierce Campbell CM, Fulp W, Ferreira S, Sobrinho JS, Baggio M, Galan L, Silva RC, Lazcano-Ponce E, Giuliano AR, Villa LL. High genital prevalence of cutaneous human papillomavirus DNA on male genital skin: the HPV Infection in Men Study. BMC Infect Dis. 2014 Dec;14:677. Pubmedid: 25857319. Pmcid: PMC4265346.
  • Sichero L, Pierce Campbell CM, Ferreira S, Sobrinho JS, Luiza Baggio M, Galan L, Silva RC, Lazcano-Ponce E, Giuliano AR, Villa LL. Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study. Virology. 2013 Sep;443(2):214-217. Pubmedid: 23722104. Pmcid: PMC3782990.
  • Kreimer AR, Pierce Campbell CM, Lin HY, Fulp W, Papenfuss MR, Abrahamsen M, Hildesheim A, Villa LL, Salmerón JJ, Lazcano-Ponce E, Giuliano AR. Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. Lancet. 2013 Sep;382(9895):877-887. Pubmedid: 23827089. Pmcid: PMC3904652.
  • Pierce Campbell CM, Guan W, Sprung R, Koomen JM, O'Keefe MT, Ingles DJ, Abrahamsen M, Giuliano AR. Quantification of secretory leukocyte protease inhibitor (SLPI) in oral gargle specimens collected using mouthwash. J Immunol Methods. 2013 Dec;400-401:117-121. Pubmedid: 24140751. Pmcid: PMC3990009.
  • Pierce Campbell CM, Messina JL, Stoler MH, Jukic DM, Tommasino M, Gheit T, Rollison DE, Sichero L, Sirak BA, Ingles DJ, Abrahamsen M, Lu B, Villa LL, Lazcano-Ponce E, Giuliano AR. Cutaneous human papillomavirus types detected on the surface of male external genital lesions: a case series within the HPV Infection in Men Study. J Clin Virol. 2013 Dec;58(4):652-659. Pubmedid: 24210970. Pmcid: PMC3866698.
  • Pierce Campbell CM, Darwish-Yassine M, Harlow SD, Johnston CM, Curado MP, Cho KR, Soliman AS. Cervical cancer screening among Michigan women: 'The Special Cancer Behavioral Risk Factor Survey', 2004-2008. J Obstet Gynaecol. 2013 Aug;33(6):617-621. Pubmedid: 23919863.
  • Pierce Campbell CM, Lin HY, Fulp W, Papenfuss MR, Salmerón JJ, Quiterio MM, Lazcano-Ponce E, Villa LL, Giuliano AR. Consistent condom use reduces the genital human papillomavirus burden among high-risk men: the HPV infection in men study. J Infect Dis. 2013 Aug;208(3):373-384. Pubmedid: 23644283. Pmcid: PMC3699010.
  • Pierce Campbell CM, Menezes LJ, Paskett ED, Giuliano AR. Prevention of invasive cervical cancer in the United States: past, present, and future. Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1402-1408. Pubmedid: 22556273. Pmcid: PMC3556792.
  • Pierce Campbell CM, Curado MP, Harlow SD, Soliman AS. Variation of cervical cancer incidence in Latin America and the Caribbean. Rev Panam Salud Publica. 2012 Jun;31(6):492-498. Pubmedid: 22858816. Pmcid: PMC3629916.
  • Pierce Campbell CM, Curado MP, Harlow SD, Soliman AS. Regional variation in histopathology-specific incidence of invasive cervical cancer among Peruvian women. Int J Gynaecol Obstet. 2012 Jan;116(1):47-51. Pubmedid: 22036058. Pmcid: PMC3641528.
  • Aiello AE, Haan MN, Pierce CM, Simanek AM, Liang J. Persistent infection, inflammation, and functional impairment in older Latinos. J Gerontol A-Biol. 2008 Jun;63(6):610-618. Pubmedid: 18559636. Pmcid: PMC3178457.