Anders <span>E.</span> Berglund, PhD
Researcher

Anders E. Berglund, PhD

Academic Rank: Assistant Member

Overview

Discipline

    • Biostatistics and Bioinformatics
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • Umea University Umea Sweden, PhD - Chemometrics/Organic Chemistry
    • Washington University St. Louis, Fellow - Molecular Design
Research

Dr. Berglund's research is focused on applying existing strategies and deriving new methods to analyze high dimensional, complex data from various types of cancer related experiments.

Publications

  • Teer JK, Zhang Y, Chen L, Welsh EA, Cress WD, Eschrich SA, Berglund AE. Evaluating somatic tumor mutation detection without matched normal samples. Hum Genomics. 2017 Sep;11(1):22. Pubmedid: 28870239. Pmcid: PMC5584341.
  • Strom T, Harrison LB, Giuliano AR, Schell MJ, Eschrich SA, Berglund A, Fulp W, Thapa R, Coppola D, Kim S, Frakes J, Foekens J, Mulé JJ, Torres-Roca JF. Tumour radiosensitivity is associated with immune activation in solid tumours. Eur J Cancer. 2017 Oct;84:304-314. Pubmedid: 28863385.
  • Li B, Eschrich SA, Berglund A, Mitchell M, Fenstermacher D, Danaee H, Dai H, Sullivan D, Trepicchio WL, Dalton WS. Use of the Total Cancer Care System to Enrich Screening for CD30-Positive Solid Tumors for Patient Enrollment Into a Brentuximab Vedotin Clinical Trial: A Pilot Study to Evaluate Feasibility. JMIR Res Protoc. 2017 Mar;6(3):e45. Pubmedid: 28320689. Pmcid: PMC5379017.
  • Berglund AE, Welsh EA, Eschrich SA. Characteristics and Validation Techniques for PCA-Based Gene-Expression Signatures. Int J Genomics. 2017 Mar;2017:2354564. Pubmedid: 28265563. Pmcid: PMC5317117.
  • Luu HN, Lin HY, Sørensen KD, Ogunwobi OO, Kumar N, Chornokur G, Phelan C, Jones D, Kidd L, Batra J, Yamoah K, Berglund A, Rounbehler RJ, Yang M, Lee SH, Kang N, Kim SJ, Park JY, Di Pietro G. miRNAs associated with prostate cancer risk and progression. BMC Urol. 2017 Mar;17(1):18. Pubmedid: 28320379. Pmcid: PMC5359825.
  • Prabhakaran S, Rizk VT, Ma Z, Cheng CH, Berglund AE, Coppola D, Khalil F, Mulé JJ, Soliman HH. Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes. Breast Cancer Res. 2017 Jun;19(1):71. Pubmedid: 28629479. Pmcid: PMC5477261.
  • Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF. A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study. Lancet Oncol. 2017 Feb;18(2):202-211. Pubmedid: 27993569.
  • Ahmed KA, Berglund AE, Welsh EA, Naghavi AO, Kim Y, Yu M, Robinson TJ, Eschrich SA, Johnstone PA, Torres-Roca JF. The radiosensitivity of brain metastases based upon primary histology utilizing a multigene index of tumor radiosensitivity. Neurooncol. 2017 Aug;19(8):1145-1146. Pubmedid: 28379582. Pmcid: PMC5570253.
  • Wang D, Berglund AE, Kenchappa RS, MacAulay RJ, Mulé JJ, Etame AB. BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats. Sci Rep. 2017 Aug;7(1):9350. Pubmedid: 28839258. Pmcid: PMC5570925.
  • Scott JG, Torres-Roca JF, Harrison LB, Berglund AE, Schell M, Mihaylov IB, Fulp WJ, Yue B, Welsh EA, Caudell JJ, Ahmed KA, Strom T, Mellon EA, Venkat PS, Johnstone PA, Moros EG, Lee J, Foekens J, Dalton WS, Eschrich SA, McLeod HL. A Genomic Framework for Precision Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):S215-S216. Pubmedid: 27675815.
  • Ahmed KA, Berglund AE, Welsh EA, Naghavi AO, Perez BA, Dilling TJ, Eschrich SA, Torres-Roca JF. Differences in the Radiosensitivity Index (RSI) Between Lung Metastases Based Upon Primary Histology. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):S68. Pubmedid: 27675988.
  • Bush SH, Tollin S, Marchion DC, Xiong Y, Abbasi F, Ramirez IJ, Zgheib NB, Boac B, Judson PL, Chon HS, Wenham RM, Apte SM, Cubitt CL, Berglund AE, Havrilesky LJ, Lancaster JM. Sensitivity of ovarian cancer cells to acetaminophen reveals biological pathways that affect patient survival. Mol Clin Oncol. 2016 Mar;4(3):399-404. Pubmedid: 26998291. Pmcid: PMC4774474.
  • Schabath MB, Welsh EA, Fulp WJ, Chen L, Teer JK, Thompson ZJ, Engel BE, Xie M, Berglund AE, Creelan BC, Antonia SJ, Gray JE, Eschrich SA, Chen DT, Cress WD, Haura EB, Beg AA. Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma. Oncogene. 2016 Jun;35(24):3209-3216. Pubmedid: 26477306. Pmcid: PMC4837098.
  • Mårell L, Lindgren M, Nyhlin KT, Ahlgren C, Berglund A. "Struggle to obtain redress": Women's experiences of living with symptoms attributed to dental restorative materials and/or electromagnetic fields. Int J Qual Stud Health Well-being. 2016 Jan;11(1):32820. Pubmedid: 28169761.
  • Wang D, Berglund A, Kenchappa RS, Forsyth PA, Mulé JJ, Etame AB. BIRC3 is a novel driver of therapeutic resistance in Glioblastoma. Sci Rep. 2016 Feb;6:21710. Pubmedid: 26888114. Pmcid: PMC4757860.
  • Boac BM, Xiong Y, Marchion DC, Abbasi F, Bush SH, Ramirez IJ, Khulpateea BR, Clair McClung E, Berry AL, Zgheib NB, Chon HS, Shahzad MM, Judson PL, Wenham RM, Apte SM, Berglund AE, Magliocco AM, Lancaster JM. Micro-RNAs associated with the evolution of ovarian cancer cisplatin resistance. Gynecol Oncol. 2016 Feb;140(2):259-263. Pubmedid: 26731723. Pmcid: PMC4724442.
  • Berglund AE, Scott KE, Li W, Yang C, Fernandez MR, Schaub FX, Cleveland JL, Rounbehler RJ. Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function. Oncotarget. 2016 Dec;7(50):83462-83475. Pubmedid: 27825143. Pmcid: PMC5341258.
  • Zargar-Shoshtari K, Spiess PE, Berglund AE, Sharma P, Powsang JM, Giuliano A, Magliocco AM, Dhillon J. Clinical Significance of p53 and p16(ink4a) Status in a Contemporary North American Penile Carcinoma Cohort. Clin Genitourin Cancer. 2016 Aug;14(4):346-351. Pubmedid: 26794389.
  • Ahmed KA, Caudell JJ, El-Haddad G, Berglund AE, Welsh EA, Yue B, Hoffe SE, Naghavi AO, Abuodeh YA, Frakes JM, Eschrich SA, Torres-Roca JF. Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Aug;95(5):1399-1404. Pubmedid: 27319288.
  • Wang H, Schabath MB, Liu Y, Berglund AE, Bloom GC, Kim J, Stringfield O, Eikman EA, Klippenstein DL, Heine JJ, Eschrich SA, Ye Z, Gillies RJ. Semiquantitative Computed Tomography Characteristics for Lung Adenocarcinoma and Their Association With Lung Cancer Survival. Clin Lung Cancer. 2015 Nov;16(6):e141-e163. Pubmedid: 26077095. Pmcid: PMC4609593.
  • Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA, Eschrich S, Gillies RJ. Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma. PLoS One. 2015 Mar;10(3):e0118261. Pubmedid: 25739030. Pmcid: PMC4349806.
  • Ahmed KA, Fulp WJ, Berglund AE, Hoffe SE, Dilling TJ, Eschrich SA, Shridhar R, Torres-Roca JF. Differences Between Colon Cancer Primaries and Metastases Using a Molecular Assay for Tumor Radiation Sensitivity Suggest Implications for Potential Oligometastatic SBRT Patient Selection. Int J Radiat Oncol Biol Phys. 2015 Jul;92(4):837-842. Pubmedid: 25838188. Pmcid: PMC4481172.
  • Stickles XB, Marchion DC, Bicaku E, Al Sawah E, Abbasi F, Xiong Y, Bou Zgheib N, Boac BM, Orr BC, Judson PL, Berry A, Hakam A, Wenham RM, Apte SM, Berglund AE, Lancaster JM. BAD-mediated apoptotic pathway is associated with human cancer development. Int J Mol Med. 2015 Apr;35(4):1081-1087. Pubmedid: 25653146. Pmcid: PMC4356438.
  • Ohmann EL, Loeb S, Robinson D, Bill-Axelson A, Berglund A, Stattin P. Nationwide, population-based study of prostate cancer stage migration between and within clinical risk categories. Scand J Urol. 2014 Oct;48(5):426-435. Pubmedid: 24611795.
  • Berglund A, Ekelund M, Fletcher MA, Nyman L. All-cause pneumonia hospitalizations in children <2 years old in sweden, 1998 to 2012: impact of pneumococcal conjugate vaccine introduction. PLoS One. 2014 Nov;9(11):e112211. Pubmedid: 25379659. Pmcid: PMC4224441.
  • Siegel EM, Berglund AE, Riggs BM, Eschrich SA, Putney RM, Ajidahun AO, Coppola D, Shibata D. Expanding epigenomics to archived FFPE tissues: an evaluation of DNA repair methodologies. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2622-2631. Pubmedid: 25472669. Pmcid: PMC4256717.
  • Siegel EM, Eschrich S, Winter K, Riggs B, Berglund A, Ajidahun A, Simko J, Moughan J, Ajani J, Magliocco A, Elahi A, Hoffe S, Shibata D. Epigenomic characterization of locally advanced anal cancer: a radiation therapy oncology group 98-11 specimen study. Dis Colon Rectum. 2014 Aug;57(8):941-957. Pubmedid: 25003289. Pmcid: PMC4100249.
  • Enlund M, Berglund A, Andreasson K, Cicek C, Enlund A, Bergkvist L. The choice of anaesthetic--sevoflurane or propofol--and outcome from cancer surgery: a retrospective analysis. Ups J Med Sci. 2014 Aug;119(3):251-261. Pubmedid: 24857018. Pmcid: PMC4116765.
  • Lundh MH, Lampic C, Nordin K, Ahlgren J, Bergkvist L, Lambe M, Berglund A, Johansson B. Changes in health-related quality of life by occupational status among women diagnosed with breast cancer--a population-based cohort study. Psychooncology. 2013 Oct;22(10):2321-2331. Pubmedid: 23585294.
  • Siegel E, Eschrich S, Winter K, Riggs B, Berglund A, Ajidahun A, Simko J, Ajani J, Magliocco A, Elahi A, Coppola D, Shibata D. Epigenomic profiling of anal cancer: does size matter? An RTOG 98-11 specimen study. Sex Health. 2013 Nov;10(6):590. Pubmedid: 24262262.
  • Welsh EA, Eschrich SA, Berglund AE, Fenstermacher DA. Iterative rank-order normalization of gene expression microarray data. BMC Bioinformatics. 2013 May;14:153. Pubmedid: 23647742. Pmcid: PMC3651355.
  • Marchion DC, Bicaku E, Xiong Y, Zgheib NB, Al Sawah E, Stickles XB, Judson PL, Lopez AS, Cubitt CL, Gonzalez-Bosquet J, Wenham RM, Apte SM, Berglund A, Lancaster JM. A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-2018. Pubmedid: 23467907. Pmcid: PMC4536335.
  • Hernandez JM, Siegel EM, Riggs B, Eschrich S, Elahi A, Qu X, Ajidahun A, Berglund A, Coppola D, Grady WM, Giuliano AR, Shibata D. DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia. PLoS One. 2013 May;7(11):e50533. Pubmedid: 23226306. Pmcid: PMC3511539.
  • Messina JL, Fenstermacher DA, Eschrich S, Qu X, Berglund AE, Lloyd MC, Schell MJ, Sondak VK, Weber JS, Mulé JJ. 12-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy?. Sci Rep. 2013 Mar;2:765. Pubmedid: 23097687. Pmcid: PMC3479449.
  • Botling J, Edlund K, Lohr M, Hellwig B, Holmberg L, Lambe M, Berglund A, Ekman S, Bergqvist M, Pontén F, König A, Fernandes O, Karlsson M, Helenius G, Karlsson C, Rahnenführer J, Hengstler JG, Micke P. Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation. Clin Cancer Res. 2013 Jan;19(1):194-204. Pubmedid: 23032747.
  • Marchion DC, Xiong Y, Chon HS, Sawah EA, Zgheib NB, Ramirez IJ, Abbasi F, Stickles XB, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Berglund AE, Lancaster JM. Gene expression data reveal common pathways that characterize the unifocal nature of ovarian cancer. Am J Obstet Gynecol. 2013 Dec;209(6):576.e1-576.e16. Pubmedid: 23933223. Pmcid: PMC3840156.
  • Källestedt ML, Berglund A, Herlitz J, Leppert J, Enlund M. The impact of CPR and AED training on healthcare professionals' self-perceived attitudes to performing resuscitation. Scand J Trauma Resusc Emerg Med. 2012 Sep;20:26. Pubmedid: 22480164. Pmcid: PMC3352321.
  • Berglund A, Lambe M, Lüchtenborg M, Linklater K, Peake MD, Holmberg L, Møller H. Social differences in lung cancer management and survival in South East England: a cohort study. BMJ Open. 2012 Oct;2(3). Pubmedid: 22637374. Pmcid: PMC3367157.
  • Edlund K, Lindskog C, Saito A, Berglund A, Pontén F, Göransson-Kultima H, Isaksson A, Jirström K, Planck M, Johansson L, Lambe M, Holmberg L, Nyberg F, Ekman S, Bergqvist M, Landelius P, Lamberg K, Botling J, Ostman A, Micke P. CD99 is a novel prognostic stromal marker in non-small cell lung cancer. Int J Cancer. 2012 Nov;131(10):2264-2273. Pubmedid: 22392539.
  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
  • Schmidt M, Hellwig B, Hammad S, Othman A, Lohr M, Chen Z, Boehm D, Gebhard S, Petry I, Lebrecht A, Cadenas C, Marchan R, Stewart JD, Solbach C, Holmberg L, Edlund K, Kultima HG, Rody A, Berglund A, Lambe M, Isaksson A, Botling J, Karn T, Müller V, Gerhold-Ay A, Cotarelo C, Sebastian M, Kronenwett R, Bojar H, Lehr HA, Sahin U, Koelbl H, Gehrmann M, Micke P, Rahnenführer J, Hengstler JG. A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin κ C as a compatible prognostic marker in human solid tumors. Clin Cancer Res. 2012 May;18(9):2695-2703. Pubmedid: 22351685.
  • Stenberg P, Pettersson F, Saura AO, Berglund A, Larsson J. Sequence signature analysis of chromosome identity in three Drosophila species. BMC Bioinformatics. 2005 Jun;6:158. Pubmedid: 15975141. Pmcid: PMC1181806.
  • Schrader J, Nilsson J, Mellerowicz E, Berglund A, Nilsson P, Hertzberg M, Sandberg G. A high-resolution transcript profile across the wood-forming meristem of poplar identifies potential regulators of cambial stem cell identity. Plant Cell. 2004 Sep;16(9):2278-2292. Pubmedid: 15316113. Pmcid: PMC520933.
  • van Noort R, Gjerdet NR, Schedle A, Björkman L, Berglund A. An overview of the current status of national reporting systems for adverse reactions to dental materials. J Dent. 2004 Jul;32(5):351-358. Pubmedid: 15193782.
  • Wissel K, Pettersson F, Berglund A, Jansson S. What affects mRNA levels in leaves of field-grown aspen? A study of developmental and environmental influences. Plant Physiol. 2003 Nov;133(3):1190-1197. Pubmedid: 14563929. Pmcid: PMC281614.