Dorina Avram, PhD

Avram lab investigates transcriptional and epigenetic regulators that dictate the programs of tumor infiltrating T lymphocytes (TILs). Through complex manipulations of these decision factors, the goal is to reach a state in which the stemness, residency and effector programs of TILs are maintained, while the exhaustion is blocked. Such a state will make the TILs resistant to the immunosuppressive tumor microenvironment. We use patient derived samples, genetically engineered mouse models, along with state of the art molecular methodologies, including transcriptomics (bulk and scRNAseq, as well as scMULTIOME), epigenomics, CRISPR-genome editing, multiplex immunofluorescence and spatial transcriptomics. We hope that our studies will lead to technologies that improve adoptive cell therapies with TILs, as well as CAR-T cell behavior in solid tumors. Additional research interests in Avram Lab include ubiquitination in inflammation and cancer, with the goal of harnessing the immune responses for cancer therapies. Team: Dorina Avram, PhD (PI and Mentor), Shamima Islam, PhD (Postdoc), Khanjada Shahnewaj Mannan, PhD (Postdoc), Leonardo Silvane, PhD (Postdoc), Tomas Zelenka, PhD (Postdoc), Sayan Chakraborty (Postdoc). Recent Publications: https://pubmed.ncbi.nlm.nih.gov/37115913/; https://pubmed.ncbi.nlm.nih.gov/37127708/.  

Associations

• Immunology
• Gastrointestinal Oncology
• Immuno-Oncology Program

Education & Training

Graduate:

• Oregon State University, Corvallis, PhD - Genetics

Fellowship:

• Oregon State University - Molecular Pharmacology

Avram lab investigates transcriptional and epigenetic regulators that dictate the programs of tumor infiltrating T lymphocytes (TILs). Through complex manipulations of these decision factors, the goal is to reach a state in which the stemness, residency and effector programs of TILs are maintained, while the exhaustion is blocked. Such a state will make the TILs resistant to the immunosuppressive tumor microenvironment. We use patient derived samples, genetically engineered mouse models, along with state of the art molecular methodologies, including transcriptomics (bulk and scRNAseq, as well as scMULTIOME), epigenomics, CRISPR-genome editing, multiplex immunofluorescence and spatial transcriptomics. We hope that our studies will lead to technologies that improve adoptive cell therapies with TILs, as well as CAR-T cell behavior in solid tumors. Additional research interests in Avram Lab include ubiquitination in inflammation and cancer, with the goal of harnessing the immune responses for cancer therapies. Team: Dorina Avram, PhD (PI and Mentor), Shamima Islam, PhD (Postdoc), Khanjada Shahnewaj Mannan, PhD (Postdoc), Leonardo Silvane, PhD (Postdoc), Tomas Zelenka, PhD (Postdoc), Sayan Chakraborty (Postdoc). Recent Publications: https://pubmed.ncbi.nlm.nih.gov/37115913/; https://pubmed.ncbi.nlm.nih.gov/37127708/.  

• Bracho-Sanchez E, Rocha FG, Bedingfield SK, Partain BD, Macias SL, Brusko MA, Colazo JM, Fettis MM, Farhadi SA, Helm EY, Koenders K, Kwiatkowski AJ, Restuccia A, Morales BS, Wanchoo A, Avram D, Allen KD, Duvall CL, Wallet SM, Hudalla GA, Keselowsky BG. Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase. Nat Biomed Eng. 2023 Sep.7(9):1156-1169. Pubmedid: 37127708. Pmcid: PMC10504068.
• Feng Y, Yuan Q, Newsome RC, Robinson T, Bowman RL, Zuniga AN, Hall KN, Bernsten CM, Shabashvili DE, Krajcik KI, Gunaratne C, Zaroogian ZJ, Venugopal K, Casellas Roman HL, Levine RL, Chatila WK, Yaeger R, Riva A, Jobin C, Kopinke D, Avram D, Guryanova OA. Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer. J Exp Med. 2023 Nov.220(11). Pubmedid: 37615936. Pmcid: PMC10450614.
• Kwiatkowski AJ, Helm EY, Stewart J, Leon J, Drashansky T, Avram D, Keselowsky B. Design principles of microparticle size and immunomodulatory factor formulation dictate antigen-specific amelioration of multiple sclerosis in a mouse model. Biomaterials. 2023 Mar.294:122001. Pubmedid: 36716589.
• Dean JW, Helm EY, Fu Z, Xiong L, Sun N, Oliff KN, Muehlbauer M, Avram D, Zhou L. The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8+ T cell differentiation and function. Cell Rep. 2023 Jan.42(1):111963. Pubmedid: 36640340. Pmcid: PMC9940759.
• Helm EY, Zelenka T, Cismasiu VB, Islam S, Silvane L, Zitti B, Holmes TD, Drashansky TT, Kwiatkowski AJ, Tao C, Dean J, Obermayer AN, Chen X, Keselowsky BG, Zhang W, Huo Z, Zhou L, Sheridan BS, Conejo-Garcia JR, Shaw TI, Bryceson YT, Avram D. Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8+ T cells. Sci Immunol. 2023 Apr.8(82):eabn0484. Pubmedid: 37115913. Pmcid: PMC10231135.
• Kwiatkowski AJ, Helm EY, Stewart JM, Drashansky TT, Cho JJ, Avram D, Keselowsky BG. Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice. Proc Natl Acad Sci U S A. 2022 Oct.119(43):e2205417119. Pubmedid: 36256820. Pmcid: PMC9618088.
• Kim MC, Borcherding N, Ahmed KK, Voigt AP, Vishwakarma A, Kolb R, Kluz PN, Pandey G, De U, Drashansky T, Helm EY, Zhang X, Gibson-Corley KN, Klesney-Tait J, Zhu Y, Lu J, Lu J, Huang X, Xiang H, Cheng J, Wang D, Wang Z, Tang J, Hu J, Wang Z, Liu H, Li M, Zhuang H, Avram D, Zhou D, Bacher R, Zheng SG, Wu X, Zakharia Y, Zhang W. CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells. Nat Commun. 2021 Oct.12(1):5764. Pubmedid: 34599187. Pmcid: PMC8486774.
• Holmes TD, Pandey RV, Helm EY, Schlums H, Han H, Campbell TM, Drashansky TT, Chiang S, Wu CY, Tao C, Shoukier M, Tolosa E, Von Hardenberg S, Sun M, Klemann C, Marsh RA, Lau CM, Lin Y, Sun JC, Månsson R, Cichocki F, Avram D, Bryceson YT. The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation. Sci Immunol. 2021 Mar.6(57). Pubmedid: 33712472. Pmcid: PMC8274449.
• Valisno JAC, May J, Singh K, Helm EY, Venegas L, Budbazar E, Goodman JB, Nicholson CJ, Avram D, Cohen RA, Mitchell GF, Morgan KG, Seta F. BCL11B Regulates Arterial Stiffness and Related Target Organ Damage. Circ Res. 2021 Mar.128(6):755-768. Pubmedid: 33530702. Pmcid: PMC7969164.
• Kolb R, De U, Khan S, Luo Y, Kim MC, Yu H, Wu C, Mo J, Zhang X, Zhang P, Zhang X, Borcherding N, Koppel D, Fu YX, Zheng SG, Avram D, Zheng G, Zhou D, Zhang W. Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells. Nat Commun. 2021 Feb.12(1):1281. Pubmedid: 33627663. Pmcid: PMC7904819.
• Drashansky TT, Helm EY, Curkovic N, Cooper J, Cheng P, Chen X, Gautam N, Meng L, Kwiatkowski AJ, Collins WO, Keselowsky BG, Sant'Angelo D, Huo Z, Zhang W, Zhou L, Avram D. BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program. iScience. 2021 Apr.24(4):102307. Pubmedid: 33870128. Pmcid: PMC8042176.
• Kwiatkowski AJ, Stewart JM, Cho JJ, Avram D, Keselowsky BG. Nano and Microparticle Emerging Strategies for Treatment of Autoimmune Diseases: Multiple Sclerosis and Type 1 Diabetes. Adv Healthc Mater. 2020 Jun.9(11):e2000164. Pubmedid: 32519501. Pmcid: PMC7588284.
• Fu Z, Ye J, Dean JW, Bostick JW, Weinberg SE, Xiong L, Oliff KN, Chen ZE, Avram D, Chandel NS, Zhou L. Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function. Cell Rep. 2019 Jul.28(1):159-171.e4. Pubmedid: 31269437. Pmcid: PMC6679941.
• Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019 Feb.10(1):701. Pubmedid: 30741923. Pmcid: PMC6370850.
• Drashansky TT, Helm E, Huo Z, Curkovic N, Kumar P, Luo X, Parthasarathy U, Zuniga A, Cho JJ, Lorentsen KJ, Xu Z, Uddin M, Moshkani S, Zhou L, Avram D. Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells. Sci Adv. 2019 Aug.5(8):eaaw0480. Pubmedid: 31457080. Pmcid: PMC6685710.
• Sun X, Winglee K, Gharaibeh RZ, Gauthier J, He Z, Tripathi P, Avram D, Bruner S, Fodor A, Jobin C. Microbiota-Derived Metabolic Factors Reduce Campylobacteriosis in Mice. Gastroenterology. 2018 May.154(6):1751-1763.e2. Pubmedid: 29408609. Pmcid: PMC5927838.
• Califano D, Furuya Y, Roberts S, Avram D, McKenzie ANJ, Metzger DW. IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells. Mucosal Immunol. 2018 Jan.11(1):209-219. Pubmedid: 28513592. Pmcid: PMC5693789.
• Bryant AJ, Shenoy V, Fu C, Marek G, Lorentsen KJ, Herzog EL, Brantly ML, Avram D, Scott EW. Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 Feb.58(2):170-180. Pubmedid: 28862882. Pmcid: PMC5805999.
• Lorentsen KJ, Cho JJ, Luo X, Zuniga AN, Urban JF, Zhou L, Gharaibeh R, Jobin C, Kladde MP, Avram D. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018 Apr.9(1):1679. Pubmedid: 29700302. Pmcid: PMC5920086.
• Li S, Bostick JW, Ye J, Qiu J, Zhang B, Urban JF, Avram D, Zhou L. Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function. Immunity. 2018 11.49(5):915-928.e5. Pubmedid: 30446384. Pmcid: PMC6249058.
• Lorentsen KJ, Cho JJ, Luo X, Zuniga AN, Urban JF, Zhou L, Gharaibeh R, Jobin C, Kladde MP, Avram D. Publisher Correction: Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nat Commun. 2018 07.9(1):2901. Pubmedid: 30026604. Pmcid: PMC6053379.
• Cho JJ, Stewart JM, Drashansky TT, Brusko MA, Zuniga AN, Lorentsen KJ, Keselowsky BG, Avram D. An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis. Biomaterials. 2017 Oct.143:79-92. Pubmedid: 28772190. Pmcid: PMC5870833.
• Sharp SP, Avram D, Stain SC, Lee EC. Local and systemic Th17 immune response associated with advanced stage colon cancer. J Surg Res. 2017 Feb.208:180-186. Pubmedid: 27993206. Pmcid: PMC6086724.
• Abboud G, Stanfield J, Tahiliani V, Desai P, Hutchinson TE, Lorentsen KJ, Cho JJ, Avram D, Salek-Ardakani S. Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function during Poxvirus Infection. Front Immunol. 2016 Oct.7:425. Pubmedid: 27790219. Pmcid: PMC5061747.
• Periasamy S, Avram D, McCabe A, MacNamara KC, Sellati TJ, Harton JA. An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. PLoS Pathog. 2016 Mar.12(3):e1005517. Pubmedid: 27015566. Pmcid: PMC4807818.
• Uddin MN, Sultana DA, Lorentsen KJ, Cho JJ, Kirst ME, Brantly ML, Califano D, Sant'Angelo DB, Avram D. Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival. Proc Natl Acad Sci U S A. 2016 Jul.113(27):7608-7613. Pubmedid: 27330109. Pmcid: PMC4941433.
• Califano D, Cho JJ, Uddin MN, Lorentsen KJ, Yang Q, Bhandoola A, Li H, Avram D. Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells. Immunity. 2015 Aug.43(2):354-368. Pubmedid: 26231117. Pmcid: PMC4657441.
• Avram D, Califano D. The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases. J Immunol. 2014 Sep.193(5):2059-2065. Pubmedid: 25128552. Pmcid: PMC4135393.
• Califano D, Sweeney KJ, Le H, VanValkenburgh J, Yager E, O'Connor W, Kennedy JS, Jones DM, Avram D. Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis. J Clin Invest. 2014 Jan.124(1):174-187. Pubmedid: 24316973. Pmcid: PMC3871236.
• Uddin MN, Zhang Y, Harton JA, MacNamara KC, Avram D. TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014 Feb.192(4):1946-1953. Pubmedid: 24446520. Pmcid: PMC3946214.
• Harmon EY, Fronhofer V, Keller RS, Feustel PJ, Zhu X, Xu H, Avram D, Jones DM, Nagarajan S, Lennartz MR. Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques. J Am Heart Assoc. 2014 Dec.3(6):e001232. Pubmedid: 25516435. Pmcid: PMC4338708.
• Zhang Y, Jones M, McCabe A, Winslow GM, Avram D, MacNamara KC. MyD88 signaling in CD4 T cells promotes IFN-γ production and hematopoietic progenitor cell expansion in response to intracellular bacterial infection. J Immunol. 2013 May.190(9):4725-4735. Pubmedid: 23526822. Pmcid: PMC3633622.
• Bucur O, Almasan A, Nikolajczyk BS, Nicolson GL, Lawler J, Velculescu VE, Draghici S, Leabu M, Avram D, Bucur I, Calautti E, Calin GA, Chauhan SC, Ciubotaru M, Constantinescu SN, Datta D, Duda DG, Friedman MT, Galardy PJ, Harris BT, Huarte M, Khalil AM, Marchetti D, Movileanu L, Nat R, Nucera C, Popa-Wagner A, Stancu AL, Zhu S, Liehn EA. Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry. Discoveries (Craiova). 2013 Dec.1(1):e1. Pubmedid: 32309535. Pmcid: PMC6919543.
• Vanvalkenburgh J, Albu DI, Bapanpally C, Casanova S, Califano D, Jones DM, Ignatowicz L, Kawamoto S, Fagarasan S, Jenkins NA, Copeland NG, Liu P, Avram D. Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease. J Exp Med. 2011 Sep.208(10):2069-2081. Pubmedid: 21875956. Pmcid: PMC3182057.
• Albu DI, VanValkenburgh J, Morin N, Califano D, Jenkins NA, Copeland NG, Liu P, Avram D. Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes. Proc Natl Acad Sci U S A. 2011 Apr.108(15):6211-6216. Pubmedid: 21444811. Pmcid: PMC3076841.
• Albu DI, Califano D, Avram D. Flow cytometry analysis of transcription factors in T lymphocytes. Methods Mol Biol. 2010 May.647:377-390. Pubmedid: 20694680. Pmcid: PMC3788577.
• Zhang S, Rozell M, Verma RK, Albu DI, Califano D, VanValkenburgh J, Merchant A, Rangel-Moreno J, Randall TD, Jenkins NA, Copeland NG, Liu P, Avram D. Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b. J Exp Med. 2010 Aug.207(8):1687-1699. Pubmedid: 20660613. Pmcid: PMC2916134.
• Cismasiu VB, Duque J, Paskaleva E, Califano D, Ghanta S, Young HA, Avram D. BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes. Biochem J. 2009 Jan.417(2):457-466. Pubmedid: 18831712. Pmcid: PMC2639648.
• Cismasiu VB, Paskaleva E, Suman Daya S, Canki M, Duus K, Avram D. BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex. Virology. 2008 Oct.380(2):173-181. Pubmedid: 18768194. Pmcid: PMC2637995.
• Albu DI, Feng D, Bhattacharya D, Jenkins NA, Copeland NG, Liu P, Avram D. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med. 2007 Nov.204(12):3003-3015. Pubmedid: 17998389. Pmcid: PMC2118514.
• Cismasiu VB, Ghanta S, Duque J, Albu DI, Chen HM, Kasturi R, Avram D. BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood. 2006 Oct.108(8):2695-2702. Pubmedid: 16809611. Pmcid: PMC1895584.
• Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D. BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. Oncogene. 2005 Oct.24(45):6753-6764. Pubmedid: 16091750.
• Amparan D, Avram D, Thomas CG, Lindahl MG, Yang J, Bajaj G, Ishmael JE. Direct interaction of myosin regulatory light chain with the NMDA receptor. J Neurochem. 2005 Jan.92(2):349-361. Pubmedid: 15663482.
• Leid M, Ishmael JE, Avram D, Shepherd D, Fraulob V, Dollé P. CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis. Gene Expr Patterns. 2004 Oct.4(6):733-739. Pubmedid: 15465497. Pmcid: PMC2819357.
• Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem. 2003 Oct.278(44):43041-43050. Pubmedid: 12930829. Pmcid: PMC2819354.
• Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E. Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. J Virol. 2003 May.77(9):5415-5427. Pubmedid: 12692243. Pmcid: PMC153947.
• Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M. COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. Biochem J. 2002 Dec.368(Pt 2):555-563. Pubmedid: 12196208. Pmcid: PMC1223006.
• Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem. 2000 Jun.275(22):16827-16836. Pubmedid: 10828067.
• Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000 Apr.275(14):10315-10322. Pubmedid: 10744719. Pmcid: PMC2819356.
• Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. J Biol Chem. 1999 May.274(20):14331-14336. Pubmedid: 10318855. Pmcid: PMC2823254.
• Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M. Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. J Biol Chem. 1999 May.274(22):15901-15907. Pubmedid: 10336495.
• Avram D, Leid M, Bakalinsky AT. Fzf1p of Saccharomyces cerevisiae is a positive regulator of SSU1 transcription and its first zinc finger region is required for DNA binding. Yeast. 1999 Apr.15(6):473-480. Pubmedid: 10234785.
• Bouvier C, Avram D, Peterson VJ, Hettinger B, Soderstrom K, Murray TF, Leid M. Catecholaminergic CATH.a cells express predominantly delta-opioid receptors. Eur J Pharmacol. 1998 May.348(1):85-93. Pubmedid: 9650835.
• Avram D, Bakalinsky AT. SSU1 encodes a plasma membrane protein with a central role in a network of proteins conferring sulfite tolerance in Saccharomyces cerevisiae. J Bacteriol. 1997 Sep.179(18):5971-5974. Pubmedid: 9294463. Pmcid: PMC179495.
• Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M. p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J Biol Chem. 1997 Dec.272(52):33435-33443. Pubmedid: 9407140.
• Avram D, Bakalinsky AT. Multicopy FZF1 (SUL1) suppresses the sulfite sensitivity but not the glucose derepression or aberrant cell morphology of a grr1 mutant of Saccharomyces cerevisiae. Genetics. 1996 Oct.144(2):511-521. Pubmedid: 8889516. Pmcid: PMC1207546.
• Xu X, Wightman JD, Geller BL, Avram D, Bakalinsky AT. Isolation and characterization of sulfite mutants of Saccharomyces cerevisiae. Curr Genet. 1994 Jun.25(6):488-496. Pubmedid: 8082198.

• Title: Tissue-Anchored vs. Circulating Constructs for Immunometabolic Resolution of Psoriasis
  Sponsor: Nat Institutes of Health
  PI (MPI): Avram, D.
• Title: Platinum-induced lipid reprogramming and tumor immune microenvironment in SCLC
  Sponsor: Nat Institutes of Health
  PI: Avram, D.
• Title: Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury
  Sponsor: Nat Institutes of Health
  PI: Avram, D.
• Title: High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase implicated in multiple sclerosis
  Sponsor: Nat Institutes of Health
  PI (MPI): Avram, D.
• Title: Role of Bcl11b in CD4+ T Cells and Innate Lymphoid Cells
  Sponsor: Nat Institutes of Health
  PI: Avram, D.