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Seth Felder, MD
Cancer Focus: Anal Cancer, Appendiceal (Appendix) Cancer, Colon Cancer, Colorectal Cancer , Gastrointestinal Carcinoid Tumor , GIST (Gastrointestinal Stromal Tumor) , Neuroendocrine Tumor , Small Intestine Cancer
Dr. Seth Felder is a colon and rectal surgical oncologist in the Department of Gastrointestinal Oncology at Moffitt Cancer Center. He is an Assistant Professor of Surgery and Assistant Professor of Oncologic Sciences at the University of South Florida Morsani College of Medicine. Following his colon and rectal surgery training at the University of Minnesota with highly esteemed international leaders in the field, he pursued additional training at Memorial Sloan Kettering Cancer Center in Advanced Colorectal Surgical Oncology. While there, Dr. Felder gained surgical expertise in managing complex colorectal cancers, training in the newest minimally invasive Robotic surgical techniques for the treatment of colon, rectal and anal cancers. He also gained further experience in transanal endoscopic microsurgery, peritoneal tumor debulking, and exenterative resections for recurrent disease in the pelvis, with incorporation of intraoperative radiation therapy. Dr. Felder utilizes minimally invasive Robotic techniques, when possible, that allows him to provide patients with optimal surgical outcomes and shortened recovery times. He focuses on important aspects of a patient’s quality of life, and whenever possible, he uses nerve-sparing surgical techniques that preserve anal, bladder, and sexual function. Dr. Felder works closely with specialists in medical oncology, radiation oncology, radiology, pathology, and gastroenterology to discuss individual cases at Moffitt’s weekly conferences, with the goals of providing the most comprehensive care possible for each patient. Dr. Felder emphasizes personalized patient care with an emphasis on a team approach, closely working with multi-disciplinary specialists to treat each patient’s particular needs. Dr. Felder’s main interest is in rectal preservation treatment protocols for rectal cancer, or the so-called “watch-and-wait strategy.” In this non-operative management strategy, some patients may be treated with neoadjuvant therapy and throughout the course of treatment intermittently examined with a flexible sigmoidoscopy, digital rectal exam, and rectal MRI to assess the degree of tumor response. Once neoadjuvant treatment is completed, a decision on the degree of tumor response, which can be complete in up to 40%, is made regarding whether close observation without surgery is appropriate. A portion of patients with rectal cancer can potentially forego or delay a rectal resection without an apparent negative effect on cancer outcomes, and be spared the side-effects of a major rectal surgery. Dr. Felder has studied the reproducibility of clinical tools in assessing rectal cancer response to neoadjuvant therapy. More specifically, he has contributed to the investigation of the endoscopic treatment response of rectal cancer to neoadjuvant chemoradiation and chemotherapy. He has also studied the endoscopic diagnostic concordance between expert surgeons actively managing these patients under a “watch-and-wait” strategy. In addition, Dr. Felder collaborates with radiologists in correlating treatment response of MRI findings with the endoscopic response to determine whether a patient may be a candidate for a rectal preservation strategy.
Education & Training
- Colon & Rectal Surgery
- University of Minnesota - Colon and Rectal Surgery
- Memorial Sloan Kettering - Advanced Colorectal Surgical Oncology
- Cedars-Sinai Medical Center - General Surgery
- University of South Florida - MD
- Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL. Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse. Oncoimmunology. 2021 Mar.10(1):1862529. Pubmedid: 33763292. Pmcid: PMC7951964.
- Bigness A, Imanirad I, Sahin IH, Xie H, Frakes J, Hoffe S, Laskowitz D, Felder S. Locally advanced rectal adenocarcinoma: Treatment sequences, intensification, and rectal organ preservation. CA-Cancer J Clin. 2021 Feb. Pubmedid: 33592118.
- Hardiman KM, Felder SI, Friedman G, Migaly J, Paquette IM, Feingold DL. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer. Dis Colon Rectum. 2021 Feb. Pubmedid: 33591043.
- Naffouje S, Sabesan A, Powers BD, Dessureault S, Sanchez J, Schell M, Imanirad I, Sahin I, Xie H, Felder S. Patient Risk Subgroups Predict Benefit of Adjuvant Chemotherapy in Stage II Rectal Cancer Patients Following Neoadjuvant Chemoradiation and Total Mesorectal Excision. Clin Colorectal Cancer. 2021 Feb. Pubmedid: 33775560.
- Yuan Z, Frazer M, Ahmed KA, Naqvi SMH, Schell MJ, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Torres-Roca JF, Hoffe SE, Frakes JM. Modeling precision genomic-based radiation dose response in rectal cancer. Future Oncol. 2020 Oct.16(30):2411-2420. Pubmedid: 32686956.
- Felder SI, Feuerlein S, Parsee A, Imanirad I, Sanchez J, Dessureault S, Kim R, Hoffe S, Frakes J, Costello J. Endoscopic and MRI response evaluation following neoadjuvant treatment for rectal cancer: a pictorial review with matched MRI, endoscopic, and pathologic examples. Abdom Radiol (NY). 2020 Oct. Pubmedid: 33111189.
- Frazer ML, Yang G, Felder S, McDonald J, Sanchez J, Dessureault S, Imanirad I, Carballido E, Kim RD, Hoffe SE, Frakes JM. Determining Optimal Follow-up for Patients With Anal Cancer Following Chemoradiation. Am J Clin Oncol. 2020 May.43(5):319-324. Pubmedid: 32028341.
- Saller J, Qin D, Felder S, Coppola D. Microsatellite Stable Colorectal Cancer With an Immunogenic Phenotype: Challenges in Diagnosis and Treatment. Clin Colorectal Cancer. 2020 Jun.19(2):123-131. Pubmedid: 32171644.
- Yuan Z, Frazer M, Zhang GG, Latifi K, Moros EG, Feygelman V, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Harrison LB, Hoffe SE, Frakes JM. CT-based radiomic features to predict pathological response in rectal cancer: A retrospective cohort study. J Med Imaging Radiat Oncol. 2020 Jun.64(3):444-449. Pubmedid: 32386109.
- Leiting JL, Cloyd JM, Ahmed A, Fournier K, Lee AJ, Dessureault S, Felder S, Veerapong J, Baumgartner JM, Clarke C, Mogal H, Staley CA, Zaidi MY, Patel SH, Ahmad SA, Hendrix RJ, Lambert L, Abbott DE, Pokrzywa C, Raoof M, LaRocca CJ, Johnston FM, Greer J, Grotz TE. Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative. World J Gastrointest Oncol. 2020 Jul.12(7):756-767. Pubmedid: 32864043. Pmcid: PMC7428797.
- Sabesan A, Felder S, Feuerlein S, Lam C, McGettigan M, Powers BD, Dessureault S, Dineen SP. Preoperative Radiographic Assessment Predicts Incomplete Cytoreduction in Patients with Low Grade Mucinous Adenocarcinoma of the Appendix. Ann Surg Oncol. 2020 Jan.27(1):165-170. Pubmedid: 31388776.
- Tchelebi LT, Romesser PB, Feuerlein S, Hoffe S, Latifi K, Felder S, Chuong MD. Magnetic Resonance Guided Radiotherapy for Rectal Cancer: Expanding Opportunities for Non-Operative Management. Cancer Control. 2020 Jan.27(1). Pubmedid: 33118384. Pmcid: PMC7791447.
- Powers BD, Felder S, Veerapong J, Baumgartner JM, Clarke C, Mogal H, Staley CA, Maithel SK, Patel S, Dhar V, Lambert L, Hendrix RJ, Abbott DE, Pokrzywa C, Raoof M, Lee B, Johnston FM, Greer J, Cloyd JM, Kimbrough C, Grotz T, Leiting J, Fournier K, Lee AJ, Imanirad I, Dessureault S, Dineen SP. Repeat Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Not Associated with Prohibitive Complications: Results of a Multiinstitutional Retrospective Study. Ann Surg Oncol. 2020 Dec.27(13):4883-4891. Pubmedid: 32318945.
- Powers BD, Felder SI, Imanirad I, Dessureault S, Dineen SP. The Impact of Histologic Subtype on Receipt of Adjuvant Chemotherapy and Overall Survival in Stage III Colon Cancer: a Retrospective Cohort Analysis. J Gastrointest Cancer. 2020 Aug. Pubmedid: 32743731.
- Gollub MJ, Blazic I, Felder S, Knezevic A, Gonen M, Garcia-Aguilar J, Paty PP, Smith JJ. Value of adding dynamic contrast-enhanced MRI visual assessment to conventional MRI and clinical assessment in the diagnosis of complete tumour response to chemoradiotherapy for rectal cancer. Eur Radiol. 2019 Mar.29(3):1104-1113. Pubmedid: 30242504. Pmcid: PMC6358522.
- Felder SI, Hoffe SE. Redefining Rectal Cancer Priorities Through a Watch-and-Wait Paradigm: Balancing Cancer Cure and Quality of Life. J Oncol Pract. 2019 Mar.15(3):135-136. Pubmedid: 30861366.
- Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2019 Mar.3:CD004318. Pubmedid: 30916777. Pmcid: PMC6450215.
- Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2019 Aug.8:CD004318. Pubmedid: 31449321. Pmcid: PMC6709764.
- Patel DN, Felder SI, Luu M, Daskivich TJ, N Zaghiyan K, Fleshner P. Early Urinary Catheter Removal Following Pelvic Colorectal Surgery: A Prospective, Randomized, Noninferiority Trial. Dis Colon Rectum. 2018 Oct.61(10):1180-1186. Pubmedid: 30192326.
- Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2018 Nov.11:CD004318. Pubmedid: 30481366. Pmcid: PMC6517131.
- Felder SI, Ramanathan R, Russo AE, Jimenez-Rodriguez RM, Hogg ME, Zureikat AH, Strong VE, Zeh HJ, Weiser MR. Robotic gastrointestinal surgery. Curr Probl Surg. 2018 Jun.55(6):198-246. Pubmedid: 30470267. Pmcid: PMC6377083.
- Felder SI, Kwaan MR. Palliative Care in Advanced Colorectal Cancer - Balancing Treatment With Comfort. Dis Colon Rectum. 2016 Nov.59(11):1102-1104. Pubmedid: 27749487.
- Felder SI. Trauma sternotomy for presumed haemopericardium with incidental coccidioidal pericarditis. Trauma Case Rep. 2015 Feb.1(1-2):4-8. Pubmedid: 30101167. Pmcid: PMC6082434.
- Barrett AM, Harrison DJ, Phillips EH, Felder SI, Burch MA. Superior mesenteric artery syndrome following sleeve gastrectomy: case report, review of the literature, and video on technique for surgical correction. Surg Endosc. 2015 Apr.29(4):992-994. Pubmedid: 25115864.
- Felder S, Margel D, Murrell Z, Fleshner P. Usefulness of bowel sound auscultation: a prospective evaluation. J Surg Educ. 2014 Sep.71(5):768-773. Pubmedid: 24776861.
- Felder SI, Larson B, Balzer B, Wachsman A, Haker K, Fleshner P, Annamalai A, Margulies DR. Fulminant clostridium difficile colitis: comparing computed tomography with histopathology: are they concordant?. Am Surg. 2014 Oct.80(10):1064-1068. Pubmedid: 25264661.
- Felder SI, Barmparas G, Murrell Z, Fleshner P. Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak. Am J Surg. 2014 Jul.208(1):58-64. Pubmedid: 24476970.
- Felder SI, Barmparas G, Lynn J, Murrell Z, Margulies DR, Fleshner P. Can the need for colectomy after computed tomography-guided percutaneous drainage for diverticular abscess be predicted?. Am Surg. 2013 Oct.79(10):1013-1016. Pubmedid: 24160790.
- Zaghiyan K, Felder S, Ovsepyan G, Murrell Z, Sokol T, Moore B, Fleshner P. A prospective randomized controlled trial of sugared chewing gum on gastrointestinal recovery after major colorectal surgery in patients managed with early enteral feeding. Dis Colon Rectum. 2013 Mar.56(3):328-335. Pubmedid: 23392147.
- Felder SI, Menon VG, Nissen NN, Margulies DR, Lo S, Colquhoun SD. Hepaticojejunostomy using short-limb Roux-en-Y reconstruction. JAMA Surg. 2013 Mar.148(3):253-257. Pubmedid: 23553273.
- Granström A, Felder S, Frykman P. Laparoscopic repyloromyotomy following open pyloromyotomy for recurrent pyloric stenosis: a case report and review of the literature. Eur J Pediatr Surg. 2013 Dec.23(6):499-501. Pubmedid: 23165509.
- Bukur M, Felder SI, Singer MB, Ley EJ, Malinoski DJ, Margulies DR, Salim A. Trauma center level impacts survival for cirrhotic trauma patients. J Trauma Acute Care Surg. 2013 Apr.74(4):1133-1137. Pubmedid: 23511156.
- Edwards M, Felder S, Ley E, Srour M, Mirocha J, Margulies DR, Salim A. Venous thromboembolism in coagulopathic surgical intensive care unit patients: is there a benefit from chemical prophylaxis?. J Trauma. 2011 Jun.70(6):1398-1400. Pubmedid: 21817976.
- Felder S, Rabinovitz H, Oliviero M, Kopf A. Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ. Dermatol Surg. 2006 Mar.32(3):423-425. Pubmedid: 16640692.
- Felder S, Rabinovitz H, Oliviero M, Kopf A. Dermoscopic pattern of pigmented basal cell carcinoma, blue-white variant. Dermatol Surg. 2006 Apr.32(4):569-570. Pubmedid: 16681668.
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