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Seth Felder, MD

★★★★★
★★★★★
4.8 (90 ratings)
Specialty: Surgery
Program: Gastrointestinal Oncology

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Overview

Cancer Focus: Anal Cancer, Appendiceal (Appendix) Cancer, Colon Cancer, Colorectal Cancer, Gastrointestinal Carcinoid Tumor, Neuroendocrine Tumor, Small Intestine Cancer

Dr. Seth Felder is a board-certified colon and rectal surgical oncologist in the Department of Gastrointestinal Oncology at Moffitt Cancer Center and is an Associate Member who treats diseases of the small intestine, colon, rectum, and anus.    Following his colon and rectal surgery training at the University of Minnesota with international leaders within the field, he pursued additional training at Memorial Sloan Kettering Cancer Center in Advanced Colorectal Surgical Oncology to gain further expertise to best care for patients diagnosed with cancers of  the intestine. He understands the fears patients face with his/her diagnosis, specifically regarding the impact it may have on bowel function.  He focuses on these important aspects of a patient’s quality of life, and whenever possible, he uses nerve-sparing surgical techniques that can help to preserve anal, bladder, and sexual function. Dr. Felder has significant experience in complex Robotic minimally invasive surgery, providing optimal surgical outcomes and shortened recovery times.  He also has expertise in transanal minimally invasive procedures.  He works closely with specialists in medical oncology, radiation oncology, radiology, pathology to discuss individual cases at Moffitt’s weekly tumor board conferences, with the goals of providing the most comprehensive care possible for each patient.  Dr. Felder has additional expertise in rectal cancer, personalizing each patient’s treatment to maximize both cancer and quality of life outcomes.  His research is largely focused on enhancing the degree of rectal tumor response to treatments, allowing some patients to avoid resection of the rectum, and follow a “watch-and-wait” strategy.  Dr. Felder’s research has been presented at national meetings and published in medical journals as well as textbook chapters.  He is member of the Clinical Guidelines Committee for the American Society of Colon and Rectal Surgery, the National Comprehensive Cancer Network (NCCN) guidelines for Hereditary (Familial/Genetic) Colorectal Cancer, and on the  Scientific Advisory Board for FORCE, a resource empowering patients and families facing hereditary cancer.


Education & Training

Fellowship:

  • University of Minnesota - Colon and Rectal Surgery
  • Memorial Sloan Kettering - Advanced Colorectal Surgical Oncology

Residency:

  • Cedars-Sinai Medical Center - General Surgery

Medical School:

  • University of South Florida - MD
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

Publications

  • Liu J, Wang X, Sahin IH, Imanirad I, Felder SI, Kim RD, Xie H. Tumor Response-speed Heterogeneity as a Novel Prognostic Factor in Patients With Metastatic Colorectal Cancer. Am J Clin Oncol. 2023 Feb.46(2):50-57. Pubmedid: 36606664.
  • Read M, Powers BD, Pimiento JM, Laskowitz D, Mihelic E, Imanirad I, Dessureault S, Felder S, Dineen SP. Management of Malignant Small Bowel Obstruction: Is Intestinal Bypass Effective Palliation?. Ann Surg Oncol. 2022 Oct.29(11):6980-6987. Pubmedid: 35864366.
  • Read M, Powers BD, Pimiento JM, Laskowitz D, Mihelic E, Imanirad I, Dessureault S, Felder S, Dineen SP. ASO Visual Abstract: Management of Malignant Small Bowel Obstruction-Is Intestinal Bypass Effective Palliation?. Ann Surg Oncol. 2022 Oct.29(11):6990. Pubmedid: 35913671.
  • Tan E, Whiting J, Xie H, Imanirad I, Carballido E, Felder S, Frakes J, Mo Q, Walko C, Permuth JB, Sommerer K, Kim R, Anaya DA, Fleming JB, Sahin IH. BRAF Mutations Are Associated with Poor Survival Outcomes in Advanced-stage Mismatch Repair-deficient/Microsatellite High Colorectal Cancer. Oncologist. 2022 Mar.27(3):191-197. Pubmedid: 35274712. Pmcid: PMC8914499.
  • Vogel JD, Felder SI, Bhama AR, Hawkins AT, Langenfeld SJ, Shaffer VO, Thorsen AJ, Weiser MR, Chang GJ, Lightner AL, Feingold DL, Paquette IM. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer. Dis Colon Rectum. 2022 Feb.65(2):148-177. Pubmedid: 34775402.
  • Naffouje SA, Lauwers G, Klapman J, Dam A, Pena L, Friedman M, Sanchez J, Dessureault S, Felder S. Malignant colon polyps: predicting lymph node metastasis following endoscopic excision. Int J Colorectal Dis. 2022 Feb.37(2):393-402. Pubmedid: 35001147.
  • Naffouje SA, Manguso N, Imanirad I, Sahin IH, Xie H, Hoffe S, Frakes J, Sanchez J, Dessureault S, Felder S. Neoadjuvant rectal score is prognostic for survival: A population-based propensity-matched analysis. J Surg Oncol. 2022 Dec.126(7):1219-1231. Pubmedid: 35916542.
  • Mills MN, Naz A, Sanchez J, Dessureault S, Imanirad I, Lauwers G, Moore M, Hoffe S, Frakes J, Felder S. Rectal tumor fragmentation as a response pattern following chemoradiation. J Gastrointest Oncol. 2022 Dec.13(6):2951-2962. Pubmedid: 36636056. Pmcid: PMC9830359.
  • Mehta R, Frakes J, Kim J, Nixon A, Liu Y, Howard L, Martinez Jimenez ME, Carballido E, Imanirad I, Sanchez J, Dessureault S, Xie H, Felder S, Sahin I, Hoffe S, Malafa M, Kim R. Phase I Study of Lenvatinib and Capecitabine with External Radiation Therapy in Locally Advanced Rectal Adenocarcinoma. Oncologist. 2022 Aug.27(8):621-e617. Pubmedid: 35325225. Pmcid: PMC9355805.
  • Karan C, Tan E, Sarfraz H, Knepper TC, Walko CM, Felder S, Kim R, Sahin IH. Human Epidermal Growth Factor Receptor 2-Targeting Approaches for Colorectal Cancer: Clinical Implications of Novel Treatments and Future Therapeutic Avenues. JCO Oncol Pract. 2022 Aug.18(8):545-554. Pubmedid: 35613416.
  • Tan E, Whiting J, Knepper T, Xie H, Imanirad I, Carballido E, Felder S, Frakes J, Mo Q, Permuth JB, Somerer K, Kim R, Anaya DA, Fleming JB, Walko C, Sahin IH. Core Homologous Recombination Mutations and Improved Survival in Nonpancreatic GI Cancers. Am J Clin Oncol. 2022 Apr.45(4):137-141. Pubmedid: 35320814.
  • Naffouje S, Sabesan A, Powers BD, Dessureault S, Sanchez J, Schell M, Imanirad I, Sahin I, Xie H, Felder S. Patient Risk Subgroups Predict Benefit of Adjuvant Chemotherapy in Stage II Rectal Cancer Patients Following Neoadjuvant Chemoradiation and Total Mesorectal Excision. Clin Colorectal Cancer. 2021 Sep.20(3):e155-e164. Pubmedid: 33775560.
  • Felder SI, Garcia-Aguilar J. ASO Author Reflections: Endoscopic Rectal Cancer Response to Neoadjuvant Therapy: Qualitative or Quantitative Interpretation?. Ann Surg Oncol. 2021 Sep.28(9):5224-5225. Pubmedid: 33796996.
  • Felder SI, Patil S, Kennedy E, Garcia-Aguilar J. Endoscopic Feature and Response Reproducibility in Tumor Assessment after Neoadjuvant Therapy for Rectal Adenocarcinoma. Ann Surg Oncol. 2021 Sep.28(9):5205-5223. Pubmedid: 33796995. Pmcid: PMC8355052.
  • Alavi K, Poylin V, Davids JS, Patel SV, Felder S, Valente MA, Paquette IM, Feingold DL. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colonic Volvulus and Acute Colonic Pseudo-Obstruction. Dis Colon Rectum. 2021 Sep.64(9):1046-1057. Pubmedid: 34016826.
  • Weiss JM, Gupta S, Burke CA, Axell L, Chen LM, Chung DC, Clayback KM, Dallas S, Felder S, Gbolahan O, Giardiello FM, Grady W, Hall MJ, Hampel H, Hodan R, Idos G, Kanth P, Katona B, Lamps L, Llor X, Lynch PM, Markowitz AJ, Pirzadeh-Miller S, Samadder NJ, Shibata D, Swanson BJ, Szymaniak BM, Wiesner GL, Wolf A, Yurgelun MB, Zakhour M, Darlow SD, Dwyer MA, Campbell M. NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 1.2021. J Natl Compr Canc Ne. 2021 Oct.19(10):1122-1132. Pubmedid: 34666312.
  • Felder SI, Feuerlein S, Parsee A, Imanirad I, Sanchez J, Dessureault S, Kim R, Hoffe S, Frakes J, Costello J. Endoscopic and MRI response evaluation following neoadjuvant treatment for rectal cancer: a pictorial review with matched MRI, endoscopic, and pathologic examples. Abdom Radiol (NY). 2021 May.46(5):1783-1804. Pubmedid: 33111189.
  • Bigness A, Imanirad I, Sahin IH, Xie H, Frakes J, Hoffe S, Laskowitz D, Felder S. Locally advanced rectal adenocarcinoma: Treatment sequences, intensification, and rectal organ preservation. CA-Cancer J Clin. 2021 May.71(3):198-208. Pubmedid: 33592118.
  • Hardiman KM, Felder SI, Friedman G, Migaly J, Paquette IM, Feingold DL. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer. Dis Colon Rectum. 2021 May.64(5):517-533. Pubmedid: 33591043.
  • McDonald J, Chuang CY, Hicks JK, Berry DK, Imanirad I, Rishi A, Frakes JM, Hoffe SE, Felder S. FANCD2 Mutation in a Patient With Early Rectal Cancer Receiving Definitive Chemoradiation. Adv Radiat Oncol. 2021 May.6(5):100717. Pubmedid: 34258475. Pmcid: PMC8260782.
  • Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL. Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse. Oncoimmunology. 2021 Mar.10(1):1862529. Pubmedid: 33763292. Pmcid: PMC7951964.
  • Powers BD, Felder SI, Imanirad I, Dessureault S, Dineen SP. The Impact of Histologic Subtype on Receipt of Adjuvant Chemotherapy and Overall Survival in Stage III Colon Cancer: a Retrospective Cohort Analysis. J Gastrointest Cancer. 2021 Jun.52(2):719-727. Pubmedid: 32743731.
  • Van Vliet A, Girardot A, Bouchez J, Bigness A, Wang K, Moino D, Theodotou A, Pothuraju T, Felder S, Smith P, Kumar A, Dayicioglu D. How Big Is Too Big?: The Effect of Defect Size on Postoperative Complications of Vertical Rectus Abdominis Flap Reconstruction. Ann Plast Surg. 2021 Jun.86(6S Suppl 5):S571-S574. Pubmedid: 34100815.
  • Felder SI, Fleming JB, Gatenby RA. Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma. Adv Cancer Res. 2021 Jun.151:39-67. Pubmedid: 34148619.
  • Himbert C, Figueiredo JC, Shibata D, Ose J, Lin T, Huang LC, Peoples AR, Scaife CL, Pickron B, Lambert L, Cohan JN, Bronner M, Felder S, Sanchez J, Dessureault S, Coppola D, Hoffman DM, Nasseri YF, Decker RW, Zaghiyan K, Murrell ZA, Hendifar A, Gong J, Firoozmand E, Gangi A, Moore BA, Cologne KG, El-Masry MS, Hinkle N, Monroe J, Mutch M, Bernadt C, Chatterjee D, Sinanan M, Cohen SA, Wallin U, Grady WM, Lampe PD, Reddi D, Krane M, Fichera A, Moonka R, Herpel E, Schirmacher P, Kloor M, von Knebel-Doeberitz M, Nattenmueller J, Kauczor HU, Swanson E, Jedrzkiewicz J, Schmit SL, Gigic B, Ulrich AB, Toriola AT, Siegel EM, Li CI, Ulrich CM, Hardikar S. Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset. Cancers (Basel). 2021 Jul.13(15). Pubmedid: 34359718. Pmcid: PMC8345133.
  • Yuan Z, Frazer M, Rishi A, Latifi K, Tomaszewski MR, Moros EG, Feygelman V, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Harrison LB, Hoffe SE, Zhang GG, Frakes JM. Pretreatment CT and PET radiomics predicting rectal cancer patients in response to neoadjuvant chemoradiotherapy. Rep Pract Oncol Radiother. 2021 Feb.26(1):29-34. Pubmedid: 33948299. Pmcid: PMC8086711.
  • Tang J, Wong G, Naffouje S, Felder S, Sanchez J, Dineen S, Powers BD, Dessureault S, Gurd E, Castillo D, Hodul P. A Novel Nomogram for Early Identification and Intervention in Colorectal Cancer Patients at Risk for Malnutrition. Am Surg. 2021 Dec. Pubmedid: 34920671.
  • Dhahri A, Kaplan J, Naqvi SMH, Brownstein NC, Ntiri SO, Imanirad I, Felder SI, Dineen SP, Sanchez J, Dessureault S, Carballido E, Powers BD. The impact of socioeconomic status on survival in stage III colon cancer patients: A retrospective cohort study using the SEER census-tract dataset. Cancer Med. 2021 Aug.10(16):5643-5652. Pubmedid: 34197047. Pmcid: PMC8366079.
  • Yuan Z, Frazer M, Ahmed KA, Naqvi SMH, Schell MJ, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Torres-Roca JF, Hoffe SE, Frakes JM. Modeling precision genomic-based radiation dose response in rectal cancer. Future Oncol. 2020 Oct.16(30):2411-2420. Pubmedid: 32686956.
  • Frazer ML, Yang G, Felder S, McDonald J, Sanchez J, Dessureault S, Imanirad I, Carballido E, Kim RD, Hoffe SE, Frakes JM. Determining Optimal Follow-up for Patients With Anal Cancer Following Chemoradiation. Am J Clin Oncol. 2020 May.43(5):319-324. Pubmedid: 32028341.
  • Saller J, Qin D, Felder S, Coppola D. Microsatellite Stable Colorectal Cancer With an Immunogenic Phenotype: Challenges in Diagnosis and Treatment. Clin Colorectal Cancer. 2020 Jun.19(2):123-131. Pubmedid: 32171644.
  • Yuan Z, Frazer M, Zhang GG, Latifi K, Moros EG, Feygelman V, Felder S, Sanchez J, Dessureault S, Imanirad I, Kim RD, Harrison LB, Hoffe SE, Frakes JM. CT-based radiomic features to predict pathological response in rectal cancer: A retrospective cohort study. J Med Imaging Radiat Oncol. 2020 Jun.64(3):444-449. Pubmedid: 32386109.
  • Leiting JL, Cloyd JM, Ahmed A, Fournier K, Lee AJ, Dessureault S, Felder S, Veerapong J, Baumgartner JM, Clarke C, Mogal H, Staley CA, Zaidi MY, Patel SH, Ahmad SA, Hendrix RJ, Lambert L, Abbott DE, Pokrzywa C, Raoof M, LaRocca CJ, Johnston FM, Greer J, Grotz TE. Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative. World J Gastrointest Oncol. 2020 Jul.12(7):756-767. Pubmedid: 32864043. Pmcid: PMC7428797.
  • Sabesan A, Felder S, Feuerlein S, Lam C, McGettigan M, Powers BD, Dessureault S, Dineen SP. Preoperative Radiographic Assessment Predicts Incomplete Cytoreduction in Patients with Low Grade Mucinous Adenocarcinoma of the Appendix. Ann Surg Oncol. 2020 Jan.27(1):165-170. Pubmedid: 31388776.
  • Tchelebi LT, Romesser PB, Feuerlein S, Hoffe S, Latifi K, Felder S, Chuong MD. Magnetic Resonance Guided Radiotherapy for Rectal Cancer: Expanding Opportunities for Non-Operative Management. Cancer Control. 2020 Jan.27(1). Pubmedid: 33118384. Pmcid: PMC7791447.
  • Powers BD, Felder S, Veerapong J, Baumgartner JM, Clarke C, Mogal H, Staley CA, Maithel SK, Patel S, Dhar V, Lambert L, Hendrix RJ, Abbott DE, Pokrzywa C, Raoof M, Lee B, Johnston FM, Greer J, Cloyd JM, Kimbrough C, Grotz T, Leiting J, Fournier K, Lee AJ, Imanirad I, Dessureault S, Dineen SP. Repeat Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Is Not Associated with Prohibitive Complications: Results of a Multiinstitutional Retrospective Study. Ann Surg Oncol. 2020 Dec.27(13):4883-4891. Pubmedid: 32318945.
  • Gollub MJ, Blazic I, Felder S, Knezevic A, Gonen M, Garcia-Aguilar J, Paty PP, Smith JJ. Value of adding dynamic contrast-enhanced MRI visual assessment to conventional MRI and clinical assessment in the diagnosis of complete tumour response to chemoradiotherapy for rectal cancer. Eur Radiol. 2019 Mar.29(3):1104-1113. Pubmedid: 30242504. Pmcid: PMC6358522.
  • Felder SI, Hoffe SE. Redefining Rectal Cancer Priorities Through a Watch-and-Wait Paradigm: Balancing Cancer Cure and Quality of Life. J Oncol Pract. 2019 Mar.15(3):135-136. Pubmedid: 30861366.
  • Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2019 Mar.3:CD004318. Pubmedid: 30916777. Pmcid: PMC6450215.
  • Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2019 Aug.8:CD004318. Pubmedid: 31449321. Pmcid: PMC6709764.
  • Patel DN, Felder SI, Luu M, Daskivich TJ, N Zaghiyan K, Fleshner P. Early Urinary Catheter Removal Following Pelvic Colorectal Surgery: A Prospective, Randomized, Noninferiority Trial. Dis Colon Rectum. 2018 Oct.61(10):1180-1186. Pubmedid: 30192326.
  • Felder S, Rasmussen MS, King R, Sklow B, Kwaan M, Madoff R, Jensen C. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2018 Nov.11:CD004318. Pubmedid: 30481366. Pmcid: PMC6517131.
  • Felder SI, Ramanathan R, Russo AE, Jimenez-Rodriguez RM, Hogg ME, Zureikat AH, Strong VE, Zeh HJ, Weiser MR. Robotic gastrointestinal surgery. Curr Probl Surg. 2018 Jun.55(6):198-246. Pubmedid: 30470267. Pmcid: PMC6377083.
  • Felder SI, Kwaan MR. Palliative Care in Advanced Colorectal Cancer - Balancing Treatment With Comfort. Dis Colon Rectum. 2016 Nov.59(11):1102-1104. Pubmedid: 27749487.
  • Felder SI. Trauma sternotomy for presumed haemopericardium with incidental coccidioidal pericarditis. Trauma Case Rep. 2015 Feb.1(1-2):4-8. Pubmedid: 30101167. Pmcid: PMC6082434.
  • Barrett AM, Harrison DJ, Phillips EH, Felder SI, Burch MA. Superior mesenteric artery syndrome following sleeve gastrectomy: case report, review of the literature, and video on technique for surgical correction. Surg Endosc. 2015 Apr.29(4):992-994. Pubmedid: 25115864.
  • Felder S, Margel D, Murrell Z, Fleshner P. Usefulness of bowel sound auscultation: a prospective evaluation. J Surg Educ. 2014 Sep.71(5):768-773. Pubmedid: 24776861.
  • Felder SI, Larson B, Balzer B, Wachsman A, Haker K, Fleshner P, Annamalai A, Margulies DR. Fulminant clostridium difficile colitis: comparing computed tomography with histopathology: are they concordant?. Am Surg. 2014 Oct.80(10):1064-1068. Pubmedid: 25264661.
  • Felder SI, Barmparas G, Murrell Z, Fleshner P. Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak. Am J Surg. 2014 Jul.208(1):58-64. Pubmedid: 24476970.
  • Felder SI, Barmparas G, Lynn J, Murrell Z, Margulies DR, Fleshner P. Can the need for colectomy after computed tomography-guided percutaneous drainage for diverticular abscess be predicted?. Am Surg. 2013 Oct.79(10):1013-1016. Pubmedid: 24160790.
  • Zaghiyan K, Felder S, Ovsepyan G, Murrell Z, Sokol T, Moore B, Fleshner P. A prospective randomized controlled trial of sugared chewing gum on gastrointestinal recovery after major colorectal surgery in patients managed with early enteral feeding. Dis Colon Rectum. 2013 Mar.56(3):328-335. Pubmedid: 23392147.
  • Felder SI, Menon VG, Nissen NN, Margulies DR, Lo S, Colquhoun SD. Hepaticojejunostomy using short-limb Roux-en-Y reconstruction. JAMA Surg. 2013 Mar.148(3):253-257. Pubmedid: 23553273.
  • Granström A, Felder S, Frykman P. Laparoscopic repyloromyotomy following open pyloromyotomy for recurrent pyloric stenosis: a case report and review of the literature. Eur J Pediatr Surg. 2013 Dec.23(6):499-501. Pubmedid: 23165509.
  • Bukur M, Felder SI, Singer MB, Ley EJ, Malinoski DJ, Margulies DR, Salim A. Trauma center level impacts survival for cirrhotic trauma patients. J Trauma Acute Care Surg. 2013 Apr.74(4):1133-1137. Pubmedid: 23511156.
  • Edwards M, Felder S, Ley E, Srour M, Mirocha J, Margulies DR, Salim A. Venous thromboembolism in coagulopathic surgical intensive care unit patients: is there a benefit from chemical prophylaxis?. J Trauma. 2011 Jun.70(6):1398-1400. Pubmedid: 21817976.
  • Felder S, Rabinovitz H, Oliviero M, Kopf A. Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ. Dermatol Surg. 2006 Mar.32(3):423-425. Pubmedid: 16640692.
  • Felder S, Rabinovitz H, Oliviero M, Kopf A. Dermoscopic pattern of pigmented basal cell carcinoma, blue-white variant. Dermatol Surg. 2006 Apr.32(4):569-570. Pubmedid: 16681668.

Patient Comments
Overall Satisfaction
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★★★★★
★★★★★

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