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Robert J. Keenan, MD, FACS, MMM


Specialty: Thoracic Surgery
Program: Thoracic Oncology

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Overview

Dr. Keenan was born in Ontario, Canada and lived in many places in the province and country. As an undergraduate, he was balancing passions for medicine and wildlife ecology until medicine won out. He received his medical degree from the University of Alberta then moved to Toronto to complete a residency in general surgery and a fellowship in thoracic surgery. In between, Dr. Keenan spent two years at the University of Pittsburgh where he conducted research on lung transplantation. He returned to Pittsburgh, in 1992, for a faculty position after completing his thoracic surgical fellowship. During his time at the University of Pittsburgh, Dr. Keenan became Director of Thoracic Surgery and then Vice-Chair of the Division of Cardiothoracic Surgery. He was also the Director of the Lung Transplant and Lung Volume Reduction programs. In 2000, Dr. Keenan moved to the West Penn Allegheny Health System (now Allegheny Health Network) where he was System Director of Thoracic Surgery and Chief Quality Officer for two of the major hospitals. In 2015, he was recruited to join Moffitt Cancer Center as the Chief Medical Officer and Vice-President of Quality. He is a Senior Member in the Department of Thoracic Oncology and a Professor of Oncologic Sciences at the University of South Florida. He is a Fellow of the American College of Surgeons and of the Royal College of Surgeons of Canada. Dr. Keenan’s clinical research activities include being a Principal Investigator for the National Emphysema Treatment Trial, a site Principal Investigator for numerous thoracic oncology cooperative group trials through ACOSOG, CALGB and ECOG and a national Co-Investigator for a randomized trial for early stage lung cancers. He is the author or co-author of over 230 scientific articles and book chapters. In the area of quality, Dr. Keenan has been an Examiner for the Malcolm Baldrige National Quality Award and holds a Healthcare Lean Certificate from the University of Michigan.

Education & Training

Board Certification:

  • General Surgery

Fellowship:

  • University of Pittsburgh - Lung Transplant Research
  • University of Toronto - Thoracic Surgery

Residency:

  • University of Toronto - General Surgery

Medical School:

  • The University of Alberta - MD
Participating Trials

If you believe you are eligible for one of these trials or studies, please call
1-888-MOFFITT (1-888-663-3488).

Publications

  • Srivistava R, Zalisko BE, Keenan RJ, Howell SH. The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes. Plant Physiol. 2017 Feb;173(2):1137-1145. Pubmedid: 27923985. Pmcid: PMC5291014.
  • Nguyen DT, Fontaine JP, Robinson LA, Keenan RJ, Toloza EM. P1.17: Improved Survival for Stage-2 (N1) Pulmonary Adenocarcinoma and Squamous Cell Carcinoma After Pulmonary Lobectomy: Track: Early Stage NSCLC (Stage I - III). J Thorac Oncol. 2016 Oct;11(10S):S191-S192. Pubmedid: 27676503.
  • Nguyen DT, Fontaine JP, Robinson LA, Keenan RJ, Toloza EM. P1.22: Temporal Survival Improvement for Stage-II (T3N0M0) Lung Adenocarcinoma After Pulmonary Lobectomy: Track: Early Stage NSCLC (Stage I - III). J Thorac Oncol. 2016 Oct;11(10S):S195. Pubmedid: 27676508.
  • Sharma P, Keenan RJ, Sexton WJ. Mass in Solitary Intrathoracic Kidney Within Bochdalek Hernia. Urology. 2016 Nov;97:e15-e16. Pubmedid: 27554626.
  • Bang D, Xu J, Keenan R, Pike V, Lehmann R, Tenner C, Crittenden D, Pillinger M, Krasnokutsky S. Cardiovascular Disease Prevalence in Patients with Osteoarthritis, Gout, or Both. Bull Hosp Jt Dis (2013). 2016 Jun;74(2):113-118. Pubmedid: 27281314.
  • Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA. Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs. Structure. 2016 Feb;24(2):300-309. Pubmedid: 26749445. Pmcid: PMC4740257.
  • Borowska MT, Dominik PK, Anghel SA, Kossiakoff AA, Keenan RJ. A YidC-like Protein in the Archaeal Plasma Membrane. Structure. 2015 Sep;23(9):1715-1724. Pubmedid: 26256539. Pmcid: PMC4558205.
  • Svensson E, Culig MH, Keenan RJ, Song T, Biederman R. Left ventricular aneurysm with herniation through the chest wall. Ann Thorac Surg. 2012 Sep;94(3):e63-e64. Pubmedid: 22916781.
  • Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ. A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic. 2011 Sep;12(9):1119-1123. Pubmedid: 21658170. Pmcid: PMC3155638.
  • Hegde RS, Keenan RJ. Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol. 2011 Nov;12(12):787-798. Pubmedid: 22086371. Pmcid: PMC3760496.
  • Mariappan M, Mateja A, Dobosz M, Bove E, Hegde RS, Keenan RJ. The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature. 2011 Aug;477(7362):61-66. Pubmedid: 21866104. Pmcid: PMC3760497.
  • Mariappan M, Li X, Stefanovic S, Sharma A, Mateja A, Keenan RJ, Hegde RS. A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature. 2010 Aug;466(7310):1120-1124. Pubmedid: 20676083. Pmcid: PMC2928861.
  • Meyers BF, Downey RJ, Decker PA, Keenan RJ, Siegel BA, Cerfolio RJ, Landreneau RJ, Reed CE, Balfe DM, Dehdashti F, Ballman KV, Rusch VW, Putnam JB. The utility of positron emission tomography in staging of potentially operable carcinoma of the thoracic esophagus: results of the American College of Surgeons Oncology Group Z0060 trial. J Thorac Cardiovasc Surg. 2007 Mar;133(3):738-745. Pubmedid: 17320575.
  • Hartman MS, Epstein DM, Geyer SJ, Keenan RJ. Alveolar adenoma. Ann Thorac Surg. 2004 Nov;78(5):1842-1843. Pubmedid: 15511494.
  • Andujar JJ, Papasavas PK, Birdas T, Robke J, Raftopoulos Y, Gagné DJ, Caushaj PF, Landreneau RJ, Keenan RJ. Laparoscopic repair of large paraesophageal hernia is associated with a low incidence of recurrence and reoperation. Surg Endosc. 2004 Mar;18(3):444-447. Pubmedid: 14752653.
  • Santos RS, Raftopoulos Y, Keenan RJ, Halal A, Maley RH, Landreneau RJ. Bronchoscopic palliation of primary lung cancer: single or multimodality therapy?. Surg Endosc. 2004 Jun;18(6):931-936. Pubmedid: 15108108.
  • Szwerc MF, Landreneau RJ, Santos RS, Keenan RJ, Murray GF. Minithoracotomy combined with mechanically stapled bronchial and vascular ligation for anatomical lung resection. Ann Thorac Surg. 2004 Jun;77(6):1904-1909. Pubmedid: 15172234.
  • Raftopoulos Y, Papasavas P, Landreneau R, Hayetian F, Santucci T, Gagné D, Caushaj P, Keenan R. Clinical outcome of laparoscopic antireflux surgery for patients with irritable bowel syndrome. Surg Endosc. 2004 Apr;18(4):655-659. Pubmedid: 15026924.
  • Santos R, Colonias A, Parda D, Trombetta M, Maley RH, Macherey R, Bartley S, Santucci T, Keenan RJ, Landreneau RJ. Comparison between sublobar resection and 125Iodine brachytherapy after sublobar resection in high-risk patients with Stage I non-small-cell lung cancer. Surgery. 2003 Oct;134(4):691-697. Pubmedid: 14605631.
  • Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagné DJ, Landreneau RJ. Prediction of postoperative gas bloating after laparoscopic antireflux procedures based on 24-h pH acid reflux pattern. Surg Endosc. 2003 Mar;17(3):381-385. Pubmedid: 12457222.
  • Coxson HO, Whittall KP, Nakano Y, Rogers RM, Sciurba FC, Keenan RJ, Hogg JC. Selection of patients for lung volume reduction surgery using a power law analysis of the computed tomographic scan. Thorax. 2003 Jun;58(6):510-514. Pubmedid: 12775863. Pmcid: PMC1746695.
  • Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagné DJ, Landreneau RJ. Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy. Surg Endosc. 2003 Aug;17(8):1200-1205. Pubmedid: 12739117.
  • Scheidler MG, Keenan RJ, Maley RH, Wiechmann RJ, Fowler D, Landreneau RJ. "True" parahiatal hernia: a rare entity radiologic presentation and clinical management. Ann Thorac Surg. 2002 Feb;73(2):416-419. Pubmedid: 11845852.
  • Luketich JD, Fernando HC, Christie NA, Buenaventura PO, Keenan RJ, Ikramuddin S, Schauer PR. Outcomes after minimally invasive esophagomyotomy. Ann Thorac Surg. 2001 Dec;72(6):1909-1912. Pubmedid: 11789770.
  • Nakano Y, Coxson HO, Bosan S, Rogers RM, Sciurba FC, Keenan RJ, Walley KR, Paré PD, Hogg JC. Core to rind distribution of severe emphysema predicts outcome of lung volume reduction surgery. Am J Respir Crit Care Med. 2001 Dec;164(12):2195-2199. Pubmedid: 11751187.
  • Rogers RM, Coxson HO, Sciurba FC, Keenan RJ, Whittall KP, Hogg JC. Preoperative severity of emphysema predictive of improvement after lung volume reduction surgery: use of CT morphometry. Chest. 2000 Nov;118(5):1240-1247. Pubmedid: 11083670.
  • Coxson HO, Whittall KP, Rogers RM, Sciurba FC, Keenan RJ, Hogg JC. A cluster analysis of CT scans predicts patients who respond to lung volume reduction surgery. Chest. 2000 May;117(5 Suppl 1):247S-248S. Pubmedid: 10843932.
  • Naunheim KS, Hazelrigg SR, Kaiser LR, Keenan RJ, Bavaria JE, Landreneau RJ, Osterloh J, Keller CA. Risk analysis for thoracoscopic lung volume reduction: a multi-institutional experience. Eur J Cardiothorac Surg. 2000 Jun;17(6):673-679. Pubmedid: 10856858.
  • Orons PD, Amesur NB, Dauber JH, Zajko AB, Keenan RJ, Iacono AT. Balloon dilation and endobronchial stent placement for bronchial strictures after lung transplantation. J Vasc Interv Radiol. 2000 Jan;11(1):89-99. Pubmedid: 10693719.
  • Pham SM, Rao AS, Zeevi A, McCurry KR, Keenan RJ, Vega JD, Kormos RL, Hattler BG, Fung JJ, Starzl TE, Griffith BP. Effects of donor bone marrow infusion in clinical lung transplantation. Ann Thorac Surg. 2000 Feb;69(2):345-350. Pubmedid: 10735661. Pmcid: PMC2981807.
  • Luketich JD, Meehan M, Nguyen NT, Christie N, Weigel T, Yousem S, Keenan RJ, Schauer PR. Minimally invasive surgical staging for esophageal cancer. Surg Endosc. 2000 Aug;14(8):700-702. Pubmedid: 10954812.
  • Luketich JD, Friedman DM, Weigel TL, Meehan MA, Keenan RJ, Townsend DW, Meltzer CC. Evaluation of distant metastases in esophageal cancer: 100 consecutive positron emission tomography scans. Ann Thorac Surg. 1999 Oct;68(4):1133-1136. Pubmedid: 10543468.
  • Stilley CS, Miller DJ, Manzetti JD, Marino IR, Keenan RJ. Optimism and coping styles: A comparison of candidates for liver transplantation with candidates for lung transplantation. Psychother Psychosom. 1999 Nov;68(6):299-303. Pubmedid: 10559709.
  • Nunley DR, Hattler B, Keenan RJ, Iacono AT, Yousem S, Ohori NP, Dauber JH. Lung transplantation for end-stage pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):93-100. Pubmedid: 10207947.
  • Thaete FL, Peterson MS, Plunkett MB, Ferson PF, Keenan RJ, Landreneau RJ. Computed tomography-guided wire localization of pulmonary lesions before thoracoscopic resection: results in 101 cases. J Thorac Imaging. 1999 Apr;14(2):90-98. Pubmedid: 10210479.
  • Landreneau RJ, Wiechmann RJ, Hazelrigg SR, Mack MJ, Keenan RJ, Ferson PF. Effect of minimally invasive thoracic surgical approaches on acute and chronic postoperative pain. Chest Surg Clin N Am. 1998 Nov;8(4):891-906. Pubmedid: 9917931.
  • Kapucu LO, Meltzer CC, Townsend DW, Keenan RJ, Luketich JD. Fluorine-18-fluorodeoxyglucose uptake in pneumonia. J Nucl Med. 1998 Jul;39(7):1267-1269. Pubmedid: 9669408.
  • Luketich JD, Schauer PR, Meltzer CC, Landreneau RJ, Urso GK, Townsend DW, Ferson PF, Keenan RJ, Belani CP. Role of positron emission tomography in staging esophageal cancer. Ann Thorac Surg. 1997 Sep;64(3):765-769. Pubmedid: 9307471.
  • Belani CP, Luketich JD, Landreaneau RJ, Kim R, Ramanathan RK, Day R, Ferson PF, Keenan RJ, Posner M, Seeger J, Lembersky B. Efficacy of cisplatin, 5-fluorouracil, and paclitaxel regimen for carcinoma of the esophagus. Semin Oncol. 1997 Dec;24(6 Suppl 19):S19-S89. Pubmedid: 9427275.
  • Luketich JD, Schauer P, Urso K, Townsend DW, Belani CP, Cidis Meltzer C, Ferson PF, Keenan RJ. Minimally invasive surgical biopsy confirms PET findings in esophageal cancer. Surg Endosc. 1997 Dec;11(12):1213-1215. Pubmedid: 9373297.
  • Lee KH, Martich GD, Boujoukos AJ, Keenan RJ, Griffith BP. Predicting ICU length of stay following single lung transplantation. Chest. 1996 Oct;110(4):1014-1017. Pubmedid: 8874262.
  • Holbert JM, Brown ML, Sciurba FC, Keenan RJ, Landreneau RJ, Holzer AD. Changes in lung volume and volume of emphysema after unilateral lung reduction surgery: analysis with CT lung densitometry. Radiology. 1996 Dec;201(3):793-797. Pubmedid: 8939233.
  • Landreneau FE, Landreneau RJ, Keenan RJ, Ferson PF. Diagnosis and management of spinal metastases from breast cancer. J Neurooncol. 1995 Sep;23(2):121-134. Pubmedid: 7643148.
  • Pham SM, Keenan RJ, Rao AS, Fontes PA, Kormos RL, Abu-Elmagd K, Zeevi A, Kawai A, Hattler BG, Hardesty RL. Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients. Ann Thorac Surg. 1995 Oct;60(4):1015-1020. Pubmedid: 7574940. Pmcid: PMC2967193.
  • Mitruka S, Landreneau RJ, Mack MJ, Fetterman LS, Gammie J, Bartley S, Sutherland SR, Bowers CM, Keenan RJ, Ferson PF. Diagnosing the indeterminate pulmonary nodule: percutaneous biopsy versus thoracoscopy. Surgery. 1995 Oct;118(4):676-684. Pubmedid: 7570322.
  • Zenati M, Keenan RJ, Landreneau RJ, Paradis IL, Ferson PF, Griffith BP. Lung reduction as bridge to lung transplantation in pulmonary emphysema. Ann Thorac Surg. 1995 Jun;59(6):1581-1583. Pubmedid: 7771852.
  • Schwarz RE, Posner MC, Plunkett MB, Ferson PF, Keenan RJ, Landreneau RJ. Needle-localized thoracoscopic resection of indeterminate pulmonary nodules: impact on management of patients with malignant disease. Ann Surg Oncol. 1995 Jan;2(1):49-55. Pubmedid: 7834454.
  • O'Riordan TG, Iacono A, Keenan RJ, Duncan SR, Burckart GJ, Griffith BP, Smaldone GC. Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):516-521. Pubmedid: 7842214.
  • Pigula FA, Keenan RJ, Naunheim KS, Ferson PF, Landreneau RJ. Diagnosis of postpneumonectomy bronchopleural fistula using ventilation scintigraphy. Ann Thorac Surg. 1995 Dec;60(6):1812-1814. Pubmedid: 8787494.
  • Siegfried JM, Davis AL, Testa JR, Hunt JD, Keenan RJ, Yousem SA, Ritter PS, Ferson PF, Landreneau RJ. Ability to culture resectable non-small cell lung carcinomas is correlated with recurrence. Ann Thorac Surg. 1994 Sep;58(3):662-666. Pubmedid: 7944686.
  • Bando K, Keenan RJ, Paradis IL, Konishi H, Komatsu K, Hardesty RL, Griffith BP. Impact of pulmonary hypertension on outcome after single-lung transplantation. Ann Thorac Surg. 1994 Nov;58(5):1336-1342. Pubmedid: 7979655.
  • Griffith BP, Bando K, Hardesty RL, Armitage JM, Keenan RJ, Pham SM, Paradis IL, Yousem SA, Komatsu K, Konishi H. A prospective randomized trial of FK506 versus cyclosporine after human pulmonary transplantation. Transplantation. 1994 Mar;57(6):848-851. Pubmedid: 7512292. Pmcid: PMC2975521.
  • Magee MJ, Klain M, Ferson PF, Keenan RJ, Landreneau RJ. Nasotracheal jet ventilation for rigid endoscopy. Ann Thorac Surg. 1994 Apr;57(4):1031-1032. Pubmedid: 8166507.
  • Landreneau RJ, Mack MJ, Hazelrigg SR, Naunheim K, Dowling RD, Ritter P, Magee MJ, Nunchuck S, Keenan RJ, Ferson PF. Prevalence of chronic pain after pulmonary resection by thoracotomy or video-assisted thoracic surgery. J Thorac Cardiovasc Surg. 1994 Apr;107(4):1079-1085. Pubmedid: 8159030.
  • Landreneau RJ, Mack MJ, Keenan RJ, Hazelrigg SR, Dowling RD, Ferson PF. Strategic planning for video-assisted thoracic surgery. Ann Thorac Surg. 1993 Sep;56(3):615-619. Pubmedid: 8379753.
  • Landreneau RJ, Keenan RJ, Hazelrigg SR, Dowling RD, Mack MJ, Ferson PF. VATS wedge resection of the lung using the neodymium:yttrium-aluminum garnet laser. Ann Thorac Surg. 1993 Sep;56(3):758-761. Pubmedid: 8379789.
  • Dowling RD, Keenan RJ, Ferson PF, Landreneau RJ. Video-assisted thoracoscopic resection of pulmonary metastases. Ann Thorac Surg. 1993 Sep;56(3):772-775. Pubmedid: 8379792.
  • Aeba R, Killinger WA, Keenan RJ, Yousem SA, Hamamoto I, Hardesty RL, Griffith BP. Lazaroid U74500A as an additive to University of Wisconsin solution for pulmonary grafts in the rat transplant model. J Thorac Cardiovasc Surg. 1992 Nov;104(5):1333-1339. Pubmedid: 1434715.
  • Keenan RJ, Eiras G, Burckart GJ, Stuart RS, Hardesty RL, Vogelsang G, Griffith BP, Zeevi A. Immunosuppressive properties of thalidomide. Inhibition of in vitro lymphocyte proliferation alone and in combination with cyclosporine or FK506. Transplantation. 1991 Nov;52(5):908-910. Pubmedid: 1719668.
  • Raftopoulos Y, Landreneau RJ, Hayetian F, Papasavas P, Naunheim KS, Hazelrigg SR, Santos R, Gagné D, Caushaj P, Keenan RJ. Factors affecting quality of life after minimally invasive Heller myotomy for achalasia. J Gastrointest Surg. 8(3):233-239. Pubmedid: 15019914.
  • Gammie JS, Banks MC, Fuhrman CR, Pham SM, Griffith BP, Keenan RJ, Luketich JD. The pigtail catheter for pleural drainage: a less invasive alternative to tube thoracostomy. JSLS. 3(1):57-61. Pubmedid: 10323171. Pmcid: PMC3015347.