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Michael Jain, MD, PhD


Specialty: Hematology
Program: Blood and Marrow Transplant and Cellular Immunotherapy

Call 1-888-MOFFITT
(1-888-663-3488)

Call 1-888-MOFFITT
(1-888-663-3488)


Locations: Moffitt Cancer Center
Overview

Dr. Jain’s clinical interests focus on treatment modalities for relapsed lymphoma, particularly stem cell transplantation and cellular and immunotherapies.

Education & Training

Board Certification:

  • Internal Medicine

Fellowship:

  • Princess Margaret Cancer Center - Lymphoma and Autologous Stem Cell Transplantation

Residency:

  • University of Toronto - Internal Medicine
  • University of Toronto - Hematology

Medical School:

  • McGill University - MD/PhD
Participating Trials

CLINICAL TRIAL 19511
Immune Mechanisms of Resistance to CD19 CAR T cells in Lymphoma
Condition: Malignant Hematology
Intervention:
Open

CLINICAL TRIAL 19696
Dynamics of Gut Microbiota in Patients Treated with CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy
Condition: Immunotherapy
Intervention:
Open

CLINICAL TRIAL 19725
A Phase 1/2 Multicenter Study Evaluating the Safety And Efficacy Of Axicabtagene Ciloleucel in Combination with Utomilumab in Subjects with Refractory Large B-Cell Lymphoma (Zuma-11)
Condition: Malignant Hematology
Intervention:
Open

CLINICAL TRIAL 19072
A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects with Relapsed/Refractory Indolent Non-Hodgkin Lymphoma (iNHL)
Condition: Malignant Hematology
Intervention: Axicabtagene Ciloleucel (KTE-C19); cyclophosphamide; cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate)
Open

CLINICAL TRIAL 19341
A Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel versus Standard of Care Therapy in Subjects with Relapsed/Refractory Diffuse Large B Cell Lymphoma (ZUMA-7)
Condition: Immunotherapy
Intervention: Axicabtagene Ciloleucel (KTE-C19); KTE-C19; MESNA; cyclophosphamide; cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate)
Open

CLINICAL TRIAL 19204
A Phase III Randomized Open-Label Multi-Center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid-Refractory Chronic Graft vs Host Disease after Allogeneic Stem Cell Transplantation (REACH 3)
Condition: Malignant Hematology
Intervention: Cellcept (Mycophenolate Mofetil); Gleevac (Imatinib Mesylate); Imatinib Mesylate; Infliximab (Remicade); Jakafi (Ruxolitinib); Mycophenolate Mofetil; Pentostatin; Rapamune (Sirolimus); Rapamycin (Sirolimus); Rituxan (rituximab); Ruxolitinib; STI571 (Imatinib Mesylate); Sirolimus; everolimus (RAD001); methotrexate; rituximab
Open

CLINICAL TRIAL 19595
Optimizing ctDNA based MRD assessment in DLBCL patients undergoing CAR Therapy
Condition: Malignant Hematology
Intervention:
Open

CLINICAL TRIAL 19158
A Pilot Study of Atezolizumab (MPDL3280A) Following Adoptive Cell Transfer in Active Hematologic or Solid Tumor Malignancies
Condition: Malignant Hematology
Intervention: Atezolizumab (Tecentriq)
Open

CLINICAL TRIAL 19627
A Randomized Phase III Trial of Consolidation with Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients with Mantle Cell Lymphoma In Minimal Residual Disease-Negative First Complete Remission
Condition: Malignant Hematology
Intervention: Rituxan (rituximab); Rituxan Hycela; rituximab
Open

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

Publications

  • Jain MD, Bachmeier CA, Phuoc VH, Chavez JC. Axicabtagene ciloleucel (KTE-C19), an anti-CD19 CAR T therapy for the treatment of relapsed/refractory aggressive B-cell non-Hodgkin's lymphoma. Ther Clin Risk Manag. 2018 May;14:1007-1017. Pubmedid: 29910620. Pmcid: PMC5987753.
  • Jain MD, Davila ML. Concise Review: Emerging Principles from the Clinical Application of Chimeric Antigen Receptor T Cell Therapies for B Cell Malignancies. Stem Cells. 2018 Jan;36(1):36-44. Pubmedid: 29024301.
  • Locke FL, Jain MD. Advances in aggressive lymphoma from the 2018 American Society of Clinical Oncology annual meeting: commentary. Clin Adv Hematol Oncol. 2018 Aug;16 Suppl 14(8):20-23. Pubmedid: 30300338.
  • Jain MD, Tomlinson GA, Lam D, Liu J, Damaraju D, Detsky AS, Devine LA. Workplace-Based Assessment of Internal Medicine Resident Diagnostic Accuracy. J Grad Med Educ. 2014 Sep;6(3):532-535. Pubmedid: 26279781. Pmcid: PMC4535220.
  • Jain MD, Nikonova A. Methemoglobinemia from curing salt. CMAJ. 2013 Nov;185(16):E771. Pubmedid: 23670150. Pmcid: PMC3826356.
  • Smirle J, Au CE, Jain M, Dejgaard K, Nilsson T, Bergeron J. Cell biology of the endoplasmic reticulum and the Golgi apparatus through proteomics. Cold Spring Harb Perspect Biol. 2013 Jan;5(1):a015073. Pubmedid: 23284051. Pmcid: PMC3579394.
  • Jain MD, Cabrerizo-Sanchez R, Karkouti K, Yau T, Pendergrast JM, Cserti-Gazdewich CM. Seek and you shall find--but then what do you do? Cold agglutinins in cardiopulmonary bypass and a single-center experience with cold agglutinin screening before cardiac surgery. Transfus Med Rev. 2013 Apr;27(2):65-73. Pubmedid: 23375735.