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Frederick Locke, MD
Vice Chair, Department of Blood and Marrow Transplant and Cellular ImmunotherapyProgram Co-Leader, Immuno-Oncology
Sub Specialty: Medical Oncology
Program: Blood and Marrow Transplant and Cellular Immunotherapy
Dr. Locke is a medical oncologist and translational researcher in the Department of Blood and Marrow Transplant and Cellular Immunotherapy. He leads the Immune Cell Therapy (ICE-T) initiative at Moffitt, an integrated cross-departmental translational team. Dr. Locke is a clinical research leader in the field of Chimeric Antigen Receptor (CAR) T cell therapy, acting as a national P.I. for several pivotal trials of anti-CD19 CARs for lymphoma. In addition, Dr. Locke is translating findings from his laboratory into new cellular immunotherapies such as the Moffitt created whole protein survivin tumor vaccine for multiple myeloma. Dr. Locke graduated with a B.S. in Physiology from Michigan State University, and with an M.D. from Wayne State University. He stayed at Wayne State and the Detroit Medical Center for Internal Medicine residency training and then served as Chief Medical Resident at Detroit Receiving. Dr. Locke received Medical Oncology, clinical research, and laboratory research training at the University of Chicago. Dr. Locke provides care for multiple myeloma, lymphoma, and leukemia patients. He oversees both autologous and allogeneic hematopoietic stem cell transplants as well as cellular immunotherapy treatments such as CAR T cell Therapy.
Education & Training
Start Year: 2012 End Year: Internal Research Grant Award, Sponsor: American Cancer Society
Start Year: 2015 End Year: Miles for Moffitt Scientist Award, Sponsor:
Start Year: 2015 End Year: Mentored Patient-Oriented Research Career Development Award, Sponsor: National Cancer Institute
Start Year: 2016 End Year: Cancer Clinical Investigator Team Leadership Award, Sponsor: National Cancer Institute
CLINICAL TRIAL 19724
CLINICAL TRIAL 20578
CLINICAL TRIAL 19960
CLINICAL TRIAL 20571
Title: Severe ER stress limits the efficacy of promising CAR-T cell treatments
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