Lung Cancer Metabolism P01: Publications

All Lung Cancer Metabolism Working Group investigators are underlined.

2024

• Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB, Das S, Rocha-Munguba L, Pham VM, Li R, Tarhini AA, Furqan M, Dalton W, Churchman M, Moran-Segura CM, Nguyen J, Perez B, Kojetin DJ, Obermayer A, Yu X (BB), Chen A, Shaw TI, Conejo-Garcia JR, Rodriguez PC (Immunology). Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages. Immunity 2024 May; 57: (5) 1124-1140.e9 PMID: 38636522. PMCID: PMC11096038. IF: 32.400
• Liao Y, Remsing Rix LL, Li X, Fang B, Izumi V, Welsh EA, Monastyrskyi A, Haura EB (Thoracic), Koomen JM (Molec Onc), Doebele RC, Rix U. Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2. Cell Chem Biol 2024 Feb; 31: (2) 284-297.e10 PMID: 37848034. PMCID: PMC10922442. IF: 8.600

2023

• DeBlasi JM, Falzone A, Caldwell S, Prieto-Farigua N, Prigge JR, Schmidt EE, Chio IIC, Karreth FA (Molec Onc), DeNicola GM (MP). Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression. Cancer Res 2023 Jun; 83: (12) 1953-1967 PMID: 37062029. PMCID: PMC10267679. IF: 11.200
• Zheng H, Yu X (BB), Ibrahim ML, Foresman D, Xie M, Johnson JO, Boyle TA (Path), Ruffell B, Perez BA, Antonia SJ, Ready N, Saltos AN, Cantwell MJ, Beg AA. Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity. Cancer Immunol Res 2023 Apr; 11: (4) 466-485 PMID: 36757308. PMCID: PMC10165690. IF: 10.100
• Soupir AC, Tian Y, Stewart PA (BB), Nunez-Lopez YO, Manley BJ, Pellini B, Bloomer AM, Zhang J, Mo Q, Marchion DC, Liu M, Koomen JM (Molec Onc), Siegel EM, Wang L. Detectable Lipidomes and Metabolomes by Different Plasma Exosome Isolation Methods in Healthy Controls and Patients with Advanced Prostate and Lung Cancer. Int J Mol Sci 2023 Jan; 24: (3) PMID: 36768152. PMCID: PMC9916336. IF: 5.600
• Saltos AN, Creelan BC, Tanvetyanon T, Chiappori AA, Antonia SJ, Shafique MR, Ugrenovic-Petrovic M, Sansil S, Neuger A, Ozakinci H, Boyle TA (Path), Kim J, Haura EB (Thoracic), Gray JE. A phase I/IB trial of binimetinib in combination with erlotinib in NSCLC harboring activating KRAS or EGFR mutations. Lung Cancer 2023 Sep; 183: 107313- PMID: 37499521. IF: 5.300
• Ross KE, Zhang G, Akcora C, Lin Y, Fang B, Koomen J (Molec Onc), Haura EB (Thoracic), Grimes M. Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer. PLoS Comput Biol 2023 Mar; 19: (3) e1010690- PMID: 36996232. PMCID: PMC10089347. IF: 4.300
• Liao Y, Chin Chan S, Welsh EA, Fang B, Sun L, Schönbrunn E, Koomen JM (Molec Onc), Duckett DR, Haura EB (Thoracic), Monastyrskyi A, Rix U. Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. Acs Chem Biol 2023 Feb; 18: (2) 251-264 PMID: 36630201. IF: 4.000
• Hu Q, Liao Y, Cao J, Fang B, Yun S, Kinose F, Haura E (Thoracic), Lawrence H, Doebele R, Koomen J (Molec Onc), Rix U. Differential Chemoproteomics Reveals MARK2/3 as Cell Migration-Relevant Targets of the ALK Inhibitor Brigatinib. Chembiochem 2023 Jun; 24: (11) e202200766- PMID: 36922348. PMCID: PMC10413441. IF: 3.200

2022

• Chiappori AA, Creelan B, Tanvetyanon T, Gray JE, Haura EB (Thoracic), Thapa R, Barlow ML, Chen Z, Chen DT, Beg AA, Boyle TA (Path), Castro J, Morgan L, Morris E, Aregay M, Hurtado FK, Manenti L, Antonia S. Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer. Clin Cancer Res 2022 Jun; 28: (11) 2313-2320 PMID: 35254415. PMCID: PMC9167697. IF: 11.500
• Remsing Rix LL, Sumi NJ, Hu Q, Desai B, Bryant AT, Li X, Welsh EA, Fang B, Kinose F, Kuenzi BM, Chen YA, Antonia SJ, Lovly CM, Koomen JM (Molec Onc), Haura EB (Thoracic), Marusyk A, Rix U. IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells. Sci Signal 2022 Aug; 15: (747) eabj5879- PMID: 35973030. PMCID: PMC9528501. IF: 7.300
• Majumder A, Hosseinian S, Stroud M, Adhikari E, Saller JJ, Smith MA, Zhang G, Agarwal S, Creixell M, Meyer BS, Kinose F, Bowers K, Fang B, Stewart PA (BB), Welsh EA, Boyle TA (Path), Meyer AS, Koomen JM (Molec Onc), Haura EB (Thoracic). Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration. Mol Cancer Res 2022 Apr; 20: (4) 542-555 PMID: 35022314. PMCID: PMC8983558. IF: 5.200
• Madanayake TW, Welsh EA, Darville LNF, Koomen JM (Molec Onc), Chalfant CE, Haura EB (Thoracic), Robinson TJ. Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition. Nucleic Acid Ther 2022 Oct; 32: (5) 391-400 PMID: 35861718. PMCID: PMC9595651. IF: 4.000
• Mahajan S, Majumder A, Stewart PA (BB), Chen YA, Adhikari E, Fang B, Yang Y, Lawrence H, Kinose F, Koomen JM (Molec Onc), Haura EB (Thoracic). Deubiquitinase Vulnerabilities Identified through Activity-Based Protein Profiling in Non-Small Cell Lung Cancer. Acs Chem Biol 2022 Apr; 17: (4) 776-784 PMID: 35311290. IF: 4.000

2021

• Creelan BC, Wang C, Teer JK, Toloza EM, Yao J, Kim S, Landin AM, Mullinax JE, Saller JJ, Saltos AN, Noyes DR, Montoya LB, Curry W, Pilon-Thomas SA, Chiappori AA, Tanvetyanon T, Kaye FJ, Thompson ZJ, Yoder SJ, Fang B, Koomen JM (Molec Onc), Sarnaik AA, Chen DT, Conejo-Garcia JR, Haura EB (Thoracic), Antonia SJ. Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial. Nat Med 2021 Aug; 27: (8) 1410-1418 PMID: 34385708. PMCID: PMC8509078. IF: 82.900
• Park K, Haura EB (Thoracic), Leighl NB, Mitchell P, Shu CA, Girard N, Viteri S, Han JY, Kim SW, Lee CK, Sabari JK, Spira AI, Yang TY, Kim DW, Lee KH, Sanborn RE, Trigo J, Goto K, Lee JS, Yang JC, Govindan R, Bauml JM, Garrido P, Krebs MG, Reckamp KL, Xie J, Curtin JC, Haddish-Berhane N, Roshak A, Millington D, Lorenzini P, Thayu M, Knoblauch RE, Cho BC. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study. J Clin Oncol 2021 Oct; 39: (30) 3391-3402 PMID: 34339292. PMCID: PMC8791812. IF: 45.400
• Shields MD, Hicks JK, Boyle TA (Path), Haura EB (Thoracic), Creelan BC. Selpercatinib Overcomes CCDC6-RET-Mediated Resistance to Osimertinib. J Thorac Oncol 2021 Mar; 16: (3) e15-e17 PMID: 33641722. IF: 20.400
• Bertino EM, Gentzler RD, Clifford SE, Kolesar JM, Muzikansky A, Haura EB (Thoracic), Piotrowska Z, Camidge DR, Stinchcombe TE, Hann CL, Malhotra J, Villaruz LC, Paweletz CP, Lau CJ, Sholl LM, Takebe N, Moscow JA, Shapiro GI, Janne PA, Oxnard GR. Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903). Clin Cancer Res 2021 Mar; 27: (6) 1604-1611 PMID: 33376097. PMCID: PMC7976451. IF: 11.500
• Lin S, Li Y, Wang D, Huang C, Marino D, Bollt O, Wu C, Taylor MD, Li W, DeNicola GM (MP), Hao J, Singh PK, Yang S. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett 2021 Oct; 518: 230-242 PMID: 34303764. PMCID: PMC8355190. IF: 9.700
• Perez BA, Kim S, Wang M, Karimi AM, Powell C, Li J, Dilling TJ, Chiappori A, Latifi K, Rose T, Lannon A, MacMillan G, Saller J, Grass GD, Rosenberg S, Gray J, Haura E (Thoracic), Creelan B, Tanvetyanon T, Saltos A, Shafique M, Boyle TA (Path), Schell MJ, Conejo-Garcia JR, Antonia SJ. Prospective Single-Arm Phase 1 and 2 Study: Ipilimumab and Nivolumab With Thoracic Radiation Therapy After Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2021 Feb; 109: (2) 425-435 PMID: 33002543. PMCID: PMC8465780. IF: 7.000
• DeNicola GM (MP), Shackelford DB. Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer. Cold Spring Harb Perspect Med 2021 Nov; 11: (11) PMID: 34127512. PMCID: PMC8559540. IF: 5.400
• Alfonso JCL, Grass GD, Welsh E, Ahmed KA, Teer JK, Pilon-Thomas S, Harrison LB, Cleveland JL (Tumor Biol), Mulé JJ, Eschrich SA, Torres-Roca JF, Enderling H. Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability. Neoplasia 2021 Nov; 23: (11) 1110-1122 PMID: 34619428. PMCID: PMC8502777. IF: 4.800

2020

• Boyle TA, Quinn GP Pentz RD, Schabath MB, Muñoz-Antonia T, Saller JJ, Duarte LF, Hair LS, Teer JK, DY, Leary R, Wong CC, Savchenko A, Singh AP, Charette L, Mendell K, Gorgun G, Antonia SJ, Chiappori AA, Creelan BC, Gray JE, Haura EB. A Community Based Lung Cancer Rapid Tissue Donation Protocol Provides High Quality Drug Resistant Specimens for Proteogenomic Analyses. Cancer Med. January 2020.
• Davis AJ, Tsinkevich M, Rodencal J, Abbas HA, Su XH, Gi YJ, Fang B, Rajapakshe K, Coarfa C, Gunaratne PH, Koomen JM, Tsai KY, Flores ER. TAp63-regulated microRNAs suppress cutaneous squamous cell carcinoma through inhibition of a network of cell cycle genes. Cancer Research. 2020 Mar 10. PMID: 32156775.
• Fang B, Izumi V, Rix LLR, Welsh E, Pike I, Reuther GW, Haura EB, Rix U, Koomen JM. Lowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach. Proteomics. 2020 Aug 31:e2000116.
• Hesterberg RS, Beatty MS, Han Y, Fernandez MR, Akuffo AA, Goodheart WE, Yang C, Chang S, Colin CM, Alontaga AY, McDaniel JM, Mailloux AW, Billington JMR, Yue L, Russell S, Gillies RJ, Yun SY, Ayaz M, Lawrence NJ, Lawrence HR, Yu XZ, Fu J, Darville LN, Koomen JM, Ren X, Messina J, Jiang K, Garrett TJ, Rajadhyaksha AM, Cleveland JL, Epling-Burnette PK. Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes. Blood. 2020 Aug 13;136(7):857-870.
• Haura EB, Hicks K, Boyle TA. Erdafitinib Overcomes Acquired Resistance to Osimertinib through FGFR3-TACC3 Fusion. Letter to the Editor. J Thorac Oncol. 2020 Sep;15(9):e154-e156.
• Kang YP, Falzone A, Liu M, González-Sánchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Cancer Metab. 2020 Jun 15;8:6.
• Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 Apr 14;52(4):668-682.e7.
• Torrente L, Prieto-Farigua N, Falzone A, Elkins CM, Boothman DA, Haura EB, DeNicola GM. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. Redox Biology.2020 Feb; 30:101440.
• Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. The Journal of Experimental Medicine. 2020 Jun 1;217(6).
• Yurdagul A Jr, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, Tabas I. Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Cell Metabolism. 2020 Mar 3;31(3):518-533.e10.

2019

• Boyle TA, Khalil FK, Mino-Kenudson M, Sica GL, Moreira AL, Sholl LM, Knight MZ, Saller JJ, Zhang L, Varella-Garcia M, Berry LD, Chen H, Ellison KE, Rivard CJ, Kuglar K, Wistuba II, Fujimoto J, Kwiatkowski DJ, Bunn PA, Kris MG, Haura EB, Hirsch FR. Round robin evaluation of MET protein expression in lung adenocarcinomas improves inter-observer concordance. Appl Immunohistochem Mol Morphol. November 2019.
• Gordian E, Welsh EA, Gimbrone N, Siegel EM, Shibata D, Creelan BC, Cress WD, Eschrich SA, Haura EB, Munoz-Antonia T. Transforming growth factor beta-induced epithelial-to-mesenchymal signature predicts metastasis-free survival in non-small cell lung cancer. Oncotarget. 2019;10(8):810-24. PubMed: 30783512
• Gray JE, Saltos A, Tanvetyanon T, Haura EB, Creelan B, Antonia SJ, Shafique M, Zheng H, Dai W, Saller JJ, Tchekmedyian N, Goas K, Thapa R, Boyle TA, Chen D-T, Beg AA. Phase 1/1b study of pembrolizumab plus vorinostat in advanced/metastatic non-small cell lung cancer. Clin Cancer Res. November 2019.
• Li Q, Fisher K, Meng W, Fang B, Welsh EA, Haura EB, Koomen JM, Eschrich SA, Fridley BL, Chen YA. GMSimpute: a generalized two-step Lasso approach to impute missing values in label-free mass spectrum analysis. Bioinformatics, 2019 Jun 14; https://doi.org/10.1093/bioinformatics/btz488
• Ramello MC, Benzaïd I, Kuenzi BM, Lienlaf-Moreno M, Kandell WM, Santiago DN, Pabón-Saldaña M, Darville L, Fang B, Rix U, Yoder S, Berglund A, Koomen JM, Haura EB, Abate-Daga D. An immunoproteomic approach to characterize the CAR interactome and signalosome. Sci Signal. 2019 Feb 12;12(568).
• Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, Francis JM, Saller JJ, Mesa T, Zhang C, Yoder S, DeNicola GM, Beg AA, Boyle TA, Teer JK, Ann Chen Y, Koomen JM, Eschrich SA, Haura EB. Proteogenomic landscape of squamous cell lung cancer.Nat Commun. 2019 Aug 8;10(1):3578. 
• Stewart PA, Welsh EA, Slebos RJC, Fang B, Izumi V, Chambers M, Zhang G, Cen L, Pettersson F, Zhang Y, Chen Z, Cheng CH, Thapa R, Thompson Z, Fellows KM, Francis JM, Saller JJ, Mesa T, Zhang C, Yoder S, DeNicola GM, Beg AA, Boyle TA, Teer JK, Chen A, Koomen JM, Eschrich SA, Haura EB. Proteogenomic Landscape of Squamous Cell Lung Cancer. Nature Communications. 2019 Aug 8;10(1):3578.
• Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, deMingo-Pulido A, Gilvary D, Anadon CA, Costich TL, Wei1 S, Ruffel B, Flores ER, Conejo-Garcia J, Rodriguez PC. AMPKa1 intrinsically regulates the function and differentiation of tumor-related MDSC. Cancer Res. 2019 Aug 13. pii: canres.0880.2019. doi: 10.1158/0008-5472.CAN-19-0880. [Epub ahead of print] PMID:31409640
• Xie M, Zheng H, Madan-Lala R, Dai W, Gimbrone NT, Chen Z, Kinose F, Blackstone SA, Smalley KSM, Cress WD, Haura EB, Rix U, Beg AA. MEK inhibition modulates cytokine response to mediate therapeutic efficacy in lung cancer. Cancer Res. 2019. PubMed: 31362929
• Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J. BCL2 amplicon loss and transcriptional remodeling drives ABT-199 resistance in B cell lymphoma models. Cancer Cell 35, 752-766, 2019. PMID: 31085176.