Natarajan Raghunand, PhD

Natarajan Raghunand, PhD

Academic Rank: Associate Member

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    • Cancer Imaging and Metabolism
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • Texas A&M University, PhD - Chemical Engineering
    • Colorado State University, MS - Chemical Engineering

Dr. Raghunand's research focus is in developing non-invasive imaging biomarkers that enable the individualized selection of therpeutic regimens.


  • Raghunand N, Scicinski J, Guntle GP, Jagadish B, Mash EA, Bruckheimer E, Oronsky B, Korn RL. Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors. Oncotarget. 2017 Jun. Pubmedid: 28620142.
  • Ramanathan RK, Korn R, Raghunand N, Sachdev JC, Newbold RG, Jameson G, Fetterly GJ, Prey J, Klinz SG, Kim J, Cain J, Hendriks BS, Drummond DC, Bayever E, Fitzgerald JB. Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study. Clin Cancer Res. 2017 Jul;23(14):3638-3648. Pubmedid: 28159813.
  • Hingorani SR, Harris WP, Beck JT, Berdov BA, Wagner SA, Pshevlotsky EM, Tjulandin S, Gladkov O, Holcombe RF, Korn R, Raghunand N, Dychter S, Jiang P, Shepard HM, Devoe CE. Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer. Clin Cancer Res. 2016 Jun;22(12):2848-2854. Pubmedid: 26813359.
  • Landowski TH, Guntle GP, Zhao D, Jagadish B, Mash EA, Dorr RT, Raghunand N. Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model. Transl Oncol. 2016 Jun;9(3):228-235. Pubmedid: 27267841. Pmcid: PMC4907896.
  • Jagadish B, Ozumerzifon TJ, Roberts SA, Hall GB, Mash EA, Raghunand N. IMPROVED SYNTHESIS OF 10-(2-ALKYLAMINO-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID DERIVATIVES BEARING ACID-SENSITIVE LINKERS. Synthetic Commun. 2014 Jan;44(3). Pubmedid: 24363464. Pmcid: PMC3866964.
  • Rajaraman S, Rodriguez JJ, Raghunand N. Response to Andrew Melbourne, "comment on: automated registration of sequential breath-hold dynamic contrast-enhanced MR images: a comparison of three techniques". Magn Reson Imaging. 2013 Feb;31(2):326-328. Pubmedid: 22925607.
  • Guntle GP, Jagadish B, Mash EA, Powis G, Dorr RT, Raghunand N. Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium. Transl Oncol. 2012 Jun;5(3):190-199. Pubmedid: 22741038. Pmcid: PMC3384273.
  • Jagadish B, Guntle GP, Zhao D, Gokhale V, Ozumerzifon TJ, Ahad AM, Mash EA, Raghunand N. Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives. J Med Chem. 2012 Dec;55(23):10378-10386. Pubmedid: 23148501. Pmcid: PMC3607631.
  • Rajaraman S, Rodriguez JJ, Graff C, Altbach MI, Dragovich T, Sirlin CB, Korn RL, Raghunand N. Automated registration of sequential breath-hold dynamic contrast-enhanced MR images: a comparison of three techniques. Magn Reson Imaging. 2011 Jun;29(5):668-682. Pubmedid: 21531108. Pmcid: PMC3100446.
  • Jagadish B, Brickert-Albrecht GL, Nichol GS, Mash EA, Raghunand N. On the Synthesis of 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane. Tetrahedron Lett. 2011 Apr;52(17):2058-2061. Pubmedid: 21516221. Pmcid: PMC3079211.
  • Raghunand N, Guntle GP, Gokhale V, Nichol GS, Mash EA, Jagadish B. Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging. J Med Chem. 2010 Sep;53(18):6747-6757. Pubmedid: 20722424. Pmcid: PMC2941433.
  • Raghunand N. Tissue pH measurement by magnetic resonance spectroscopy and imaging. Methods Mol Med. 2006;124:347-364. Pubmedid: 16506429.
  • Raghunand N, Gatenby R, Gillies R. Microenvironmenalamd cellular consequences of altered blood flow in tumours. Br J Radiol. 2003;76:S11-S22. Pubmedid: 15456710.
  • Raghunand N, Gillies R. pH and chemotherapy. Novartis Found Symp. 2001;240:199-211. Pubmedid: 11727930.
  • Gillies RJ, Scherer PG, Raghunand N, Okerlund LS, Martinez-Zaguilan R, Hesterberg L, Dale BE. Iteration of hybridoma growth and productivity in hollow fiber bioreactors using 31P NMR. Magn Reson Med. 1991 Mar;18(1):181-192. Pubmedid: 2062229.
  • Gillies R, Raghunand N, Garcia-Martin M, Gatenby R. pH imaging. A review of pH measurement methods and applications in cancers. Ieee Eng Med Biol Mag. 23(5):57-64. Pubmedid: 15565800.