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Margaret M. Byrne
My research efforts are dedicated to developing, evaluating, and implementing tools that help clinicians and patients make informed decisions about complicated medical decisions in full consideration of the ethical, psychosocial, and economic factors impacting the decision.
- Health Outcomes and Behavior
- Health Outcomes & Behavior Program
Education & Training
- University of Florida, PhD - Economics
- University of Florida, MS - Zoology
- National Science Foundation, Fellow - Ethics
My research efforts are dedicated to developing, evaluating, and implementing tools that help clinicians and patients make informed decisions about complicated medical decisions in full consideration of the ethical, psychosocial, and economic factors impacting the decisionResearch Interests: The three main areas of my current research arise from my graduate training in Economics (PhD), and a post-graduate NSF fellowship in ethics. Each of these areas will be briefly described below. Medical Decision MakingAt its core, economics concerns itself with decision making: how people make decisions about activities and allocate resources to yield the greatest utility for themselves and others. My own research interests in the area of decision making current focus on how we can help patients and providers make decisions in preference sensitive situations. That is, when there is no “one right” decision for all patients, and so patients’ preferences and values should be central or at least considered in the decision. The two areas that I am currently most focused on in this type of research are: 1) decisions about participation in a cancer clinical trial; and 2) decisions about screening for lung cancer. In both of these areas, decision making is often compromised by lack of information, non-consideration of patient values, or both. I and colleagues have developed interactive decision aids which aim to help individuals and patients make more informed decisions that align with the patient’s preferences. Other topic areas in my decision making research have included: 1) decisions about eating shell fish and going to the beach during a Florida Red Tide; 2) decisions about pregnancy in HIV infected women; 3) decisions about screening for colorectal cancer; and 4) decisions about medical versus surgical interventions for knee osteoarthritis. Evaluation of Health Care InterventionsAs a health economist, I am interested in the overall issue about where it is most important and useful for us to put resources to improve health care (by whatever measure we chose to use to evaluate improvements in health care). Specifically, in this area I have collaborated on a wide range of health care projects and interventions with the goal of determining the resource utilization (costs) and cost-effectiveness of these interventions. Such information is basic and essential in determining optimal resource all location and improving health care. Examples of specific interventions where I have assessed costs and cost-effectiveness include: 1) provision of diabetic retinopathy screening in a community setting; 2) provision of different forms of cervical and colorectal cancer screening in the community; 3) costs of secondary conditions in women with severe disabilities; 4) provision of diabetic outpatient treatment; and 5) costs and output of Institutional Review Boards in health research, among others. Ethical Issues in ResearchMy background in ethical issues in health research was born from my interest in the use of financial incentives in health care situations. Early on in my career, I and a colleague published a number of economic modeling papers looking at the effect of financial incentives in: 1) End of life treatment; 2) Organ donation; 3) Participation in medical research; and 4) Promotion of prevention health care use. From the specific focus on the use of financial incentives in trials, I completed a 1 year NSF funded fellowship in which I studied ethical foundations broadly, and ethical issues specifically related to health care and use of financial incentives (for example, the possible roles of coercion and exploitation for example). I have been involved with bioethics research directly or indirectly for all of my career after that, with empirical studies including: 1) the effective of financial incentives in substance abuse treatment research; 2) the potential use of financial incentives to reduce the therapeutic misconception in research studies; and a variety of genomic studies which included both ethical concerns and patient decision making aspects.
- Asfar T, Arheart KL, Koru-Sengul T, Byrne MM, Dietz NA, Chen CJ, Lee DJ. National estimates and correlates of secondhand smoke exposure in US cancer survivors. J Cancer Surviv. 2017 Aug;11(4):469-476. Pubmedid: 28224453.
- Shneyderman Y, Rutten LJ, Arheart KL, Byrne MM, Kornfeld J, Schwartz SJ. Health Information Seeking and Cancer Screening Adherence Rates. J Cancer Educ. 2016 Mar;31(1):75-83. Pubmedid: 25619195.
- Bacon S, Kyithar MP, Rizvi SR, Donnelly E, McCarthy A, Burke M, Colclough K, Ellard S, Byrne MM. Successful maintenance on sulphonylurea therapy and low diabetes complication rates in a HNF1A-MODY cohort. Diabet Med. 2016 Jul;33(7):976-984. Pubmedid: 26479152.
- Politi MC, Kuzemchak MD, Kaphingst KA, Perkins H, Liu J, Byrne MM. Decision Aids Can Support Cancer Clinical Trials Decisions: Results of a Randomized Trial. Oncologist. 2016 Dec;21(12):1461-1470. Pubmedid: 27511904. Pmcid: PMC5153351.
- Bacon S, Kyithar MP, Condron EM, Vizzard N, Burke M, Byrne MM. Prolonged episodes of hypoglycaemia in HNF4A-MODY mutation carriers with IGT. Evidence of persistent hyperinsulinism into early adulthood. Acta Diabetol. 2016 Dec;53(6):965-972. Pubmedid: 27552834.
- Dalmaris E, Ramalho CE, Poot P, Veneklaas EJ, Byrne M. A climate change context for the decline of a foundation tree species in south-western Australia: insights from phylogeography and species distribution modelling. Ann Bot (Lond). 2015 Nov;116(6):941-952. Pubmedid: 25851142. Pmcid: PMC4640123.
- Bacon S, Engelbrecht B, Schmid J, Pfeiffer S, Gallagher R, McCarthy A, Burke M, Concannon C, Prehn JH, Byrne MM. MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise. Genes (Basel). 2015 Jun;6(2):399-416. Pubmedid: 26110317. Pmcid: PMC4488671.
- Messiah A, Dietz NA, Byrne MM, Hooper MW, Fernandez CA, Baker EA, Stevens M, Ocasio M, Sherman RL, Parker DF, Lee DJ. Combining Community-Based Participatory Research (CBPR) with a Random-Sample Survey to Assess Smoking Prevalence in an Under-Served Community. J Natl Med Assoc. 2015 Jun;107(2):97-101. Pubmedid: 27269496.
- Yakoub D, Avisar E, Koru-Sengul T, Miao F, Tannenbaum SL, Byrne MM, Moffat F, Livingstone A, Franceschi D. Factors associated with contralateral preventive mastectomy. Breast Cancer (Dove Med Press). 2015 Jan;7:1-8. Pubmedid: 25609997. Pmcid: PMC4293214.
- Al-Azhri J, Koru-Sengul T, Miao F, Saclarides C, Byrne MM, Avisar E. Predictors of Surgery Types after Neoadjuvant Therapy for Advanced Stage Breast Cancer: Analysis from Florida Population-Based Cancer Registry (1996-2009). Breast Cancer (Auckl). 2015 Dec;9:99-108. Pubmedid: 26691964. Pmcid: PMC4677798.
- Gahan JM, Byrne MM, Hill M, Quinn EM, Murphy RT, Anney RJ, Ryan AW. Detecting Allelic Expression Imbalance at Candidate Genes Using 5' Exonuclease Genotyping Technology. Methods Mol Biol. 2015 Aug;1326:93-103. Pubmedid: 26498616.
- Carrasquillo O, McCann S, Amofah A, Pierre L, Rodriguez B, Alonzo Y, Ilangovan K, Gonzalez M, Trevil D, Byrne MM, Koru-Sengul T, Kobetz E. Rationale and design of the research project of the South Florida Center for the Reduction of Cancer Health Disparities (SUCCESS): study protocol for a randomized controlled trial. Trials. 2014 Jul;15:299. Pubmedid: 25056208. Pmcid: PMC4127186.
- Byrne MM, Tannenbaum SL, Glück S, Hurley J, Antoni M. Participation in cancer clinical trials: why are patients not participating?. Med Decis Making. 2014 Jan;34(1):116-126. Pubmedid: 23897588.
- Kirkpatrick B, Kohler K, Byrne MM, Studts J. Florida Red Tide Knowledge and Risk Perception: Is there a need for tailored messaging?. Harmful Algae. 2014 Feb;32:27-32. Pubmedid: 24563634. Pmcid: PMC3927915.
- Tannenbaum SL, Koru-Sengul T, Miao F, Byrne MM. Disparities in survival after female breast cancer diagnosis: a population-based study. Cancer Causes Control. 2013 Sep;24(9):1705-1715. Pubmedid: 23775026.
- Tannenbaum SL, Zhao W, Koru-Sengul T, Miao F, Lee D, Byrne MM. Marital status and its effect on lung cancer survival. Springerplus. 2013 Oct;2:504. Pubmedid: 25674396. Pmcid: PMC4320128.
- Kornfeld J, Byrne MM, Vanderpool R, Shin S, Kobetz E. HPV knowledge and vaccine acceptability among Hispanic fathers. J Prim Prev. 2013 Apr;34(1-2):59-69. Pubmedid: 23377881. Pmcid: PMC3801294.
- Byrne MM, Croft JR, French MT, Dugosh KL, Festinger DS. Development and preliminary results of the Financial Incentive Coercion Assessment questionnaire. J Subst Abuse Treat. 2012 Jul;43(1):86-93. Pubmedid: 22116011. Pmcid: PMC3701294.
- Finney Rutten LJ, Hesse BW, Moser RP, Ortiz Martinez AP, Kornfeld J, Vanderpool RC, Byrne M, Tortolero Luna G. Socioeconomic and geographic disparities in health information seeking and Internet use in Puerto Rico. J Med Internet Res. 2012 Jul;14(4):e104. Pubmedid: 22849971. Pmcid: PMC3409614.
- Byrne MM, Kornfeld J, Vanderpool R, Belanger M. Discussions of cancer clinical trials with the National Cancer Institute's Cancer Information Service. J Health Commun. 2012 Jul;17(3):319-337. Pubmedid: 22150169. Pmcid: PMC4753796.
- Yang R, Cheung MC, Pedroso FE, Byrne MM, Koniaris LG, Zimmers TA. Obesity and weight loss at presentation of lung cancer are associated with opposite effects on survival. J Surg Res. 2011 Sep;170(1):e75-e83. Pubmedid: 21704331. Pmcid: PMC3154461.
- Koniaris LG, Levi DM, Pedroso FE, Franceschi D, Tzakis AG, Santamaria-Barria JA, Tang J, Anderson M, Misra S, Solomon NL, Jin X, DiPasco PJ, Byrne MM, Zimmers TA. Is surgical resection superior to transplantation in the treatment of hepatocellular carcinoma?. Ann Surg. 2011 Sep;254(3):527-537. Pubmedid: 21865950. Pmcid: PMC4425302.
- Vanderpool RC, Kornfeld J, Mills L, Byrne MM. Rural-urban differences in discussions of cancer treatment clinical trials. Patient Educ Couns. 2011 Nov;85(2):e69-e74. Pubmedid: 21458194. Pmcid: PMC3162073.
- Caban-Martinez AJ, Davila EP, Zhao W, Arheart K, Hooper MW, Byrne M, Messiah A, Dietz N, Huang Y, Fleming LE, Lee DJ. Disparities in hypertension control advice according to smoking status. Prev Med. 2011 Jan;51(3-4):302-306. Pubmedid: 20600258. Pmcid: PMC2939289.
- Fleming LE, Kirkpatrick B, Backer LC, Walsh CJ, Nierenberg K, Clark J, Reich A, Hollenbeck J, Benson J, Cheng YS, Naar J, Pierce R, Bourdelais AJ, Abraham WM, Kirkpatrick G, Zaias J, Wanner A, Mendes E, Shalat S, Hoagland P, Stephan W, Bean J, Watkins S, Clarke T, Byrne M, Baden DG. Review of Florida Red Tide and Human Health Effects. Harmful Algae. 2011 Jan;10(2):224-233. Pubmedid: 21218152. Pmcid: PMC3014608.
- Nierenberg K, Byrne M, Fleming LE, Stephan W, Reich A, Backer LC, Tanga E, Dalpra DR, Kirkpatrick B. Florida Red Tide Perception: Residents versus Tourists. Harmful Algae. 2010 Sep;9(6):600-606. Pubmedid: 20824108. Pmcid: PMC2932630.
- Byrne MM, Koru-Sengul T, Zhao W, Weissfeld JL, Roberts MS. Healthcare use after screening for lung cancer. Cancer. 2010 Oct;116(20):4793-4799. Pubmedid: 20597136. Pmcid: PMC3062436.
- Petersen LA, Byrne MM, Daw CN, Hasche J, Reis B, Pietz K. Relationship between clinical conditions and use of Veterans Affairs health care among Medicare-enrolled veterans. Health Serv Res. 2010 Jun;45(3):762-791. Pubmedid: 20403056. Pmcid: PMC2875759.
- Davila EP, Zhao W, Byrne M, Webb M, Huang Y, Arheart K, Dietz N, Caban-Martinez A, Parker D, Lee DJ. Correlates of smoking quit attempts: Florida Tobacco Callback Survey, 2007. Tob Induc Dis. 2009 Jun;5(1):10. Pubmedid: 19563642. Pmcid: PMC2717923.
- Byrne MM, Daw CN, Nelson HA, Urech TH, Pietz K, Petersen LA. Method to develop health care peer groups for quality and financial comparisons across hospitals. Health Serv Res. 2009 Apr;44(2 Pt 1):577-592. Pubmedid: 19178585. Pmcid: PMC2677055.