Kujtim Latifi, PhD
Researcher

Kujtim Latifi, PhD

Academic Rank: Assistant Member

Overview

Dr. Latifi is an Assistant Member of the Department of Radiation Oncology and Department of Cancer Imaging and Metabolism at Moffitt Cancer Center.  He specializes in imaging applications for radiation oncology. Dr. Latifi’s clinical focus is the application of advanced imaging techniques and software solutions to improve patient care and clinical workflow in radiation therapy. 

Discipline

    • Radiation Oncology
    • Cancer Imaging and Metabolism
    • Cancer Imaging and Technology

Education & Training

    • University of South Florida, PhD - Applied Physics with concentration in Applied Physics
    • Northern Illinois University, MS - Physics
    • Moffitt Cancer Center, Fellow - Radiation Oncology
Research

His research has been on the development and evaluation of algorithms for calculating lung ventilation using 4D CT, thus taking into account the challenges afforded by respiratory motion in precise targeting of radiation. The goal is to develop robust and practical methods to segregate functional from non-functional lung areas in the patients with thoracic malignancies, and to deliver radiation therapy that preferentially spares functional lung. Recently, his focus has been on the investigation and development of quantitative imaging biomarkers (radiomics) from CT and PET/CT to predict treatment outcomes for patients treated with radiation.

Publications

  • Li Q, Kim J, Balagurunathan Y, Qi J, Liu Y, Latifi K, Moros EG, Schabath MB, Ye Z, Gillies RJ, Dilling TJ. CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy. Radiat Oncol. 2017 Sep;12(1):158. Pubmedid: 28946909. Pmcid: PMC5613447.
  • Zhang GG, Latifi K, Feygelman V, Chou KT, Huang TC, Dilling TJ, Perez BA, Moros EG. Ventilation Series Similarity: A Study for Ventilation Calculation Using Deformable Image Registration and 4DCT to Avoid Motion Artifacts. Contrast Media Mol Imaging. 2017 Sep;2017:9730380. Pubmedid: 29097945. Pmcid: PMC5623778.
  • Oliver JA, Budzevich M, Hunt D, Moros EG, Latifi K, Dilling TJ, Feygelman V, Zhang G. Sensitivity of Image Features to Noise in Conventional and Respiratory-Gated PET/CT Images of Lung Cancer: Uncorrelated Noise Effects. Technol Cancer Res Treat. 2017 Oct;16(5):595-608. Pubmedid: 27502957. Pmcid: PMC5665151.
  • Shafiq-Ul-Hassan M, Zhang GG, Latifi K, Ullah G, Hunt DC, Balagurunathan Y, Abdalah MA, Schabath MB, Goldgof DG, Mackin D, Court LE, Gillies RJ, Moros EG. Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels. Med Phys. 2017 Mar;44(3):1050-1062. Pubmedid: 28112418. Pmcid: PMC5462462.
  • Oliver JA, Venkat P, Frakes JM, Klapman J, Harris C, Montilla-Soler J, Dhadham GC, Altazi BA, Zhang GG, Moros EG, Shridhar R, Hoffe SE, Latifi K. Fiducial markers coupled with 3D PET/CT offer more accurate radiation treatment delivery for locally advanced esophageal cancer. Endosc Int Open. 2017 Jun;5(6):E496-E504. Pubmedid: 28573183. Pmcid: PMC5451282.
  • Poleszczuk J, Walker R, Moros EG, Latifi K, Caudell JJ, Enderling H. Predicting Patient-Specific Radiotherapy Protocols Based on Mathematical Model Choice for Proliferation Saturation Index. Bull Math Biol. 2017 Jul. Pubmedid: 28681150.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Hoffe S, Frakes J, Zhang GG. Superficial and peripheral dose in compensator-based FFF beam IMRT. J Appl Clin Med Phys. 2017 Jan;18(1):151-156. Pubmedid: 28291940.
  • Chung H, Polf J, Badiyan S, Biagioli M, Fernandez D, Latifi K, Wilder R, Mehta M, Chuong M. Rectal dose to prostate cancer patients treated with proton therapy with or without rectal spacer. J Appl Clin Med Phys. 2017 Jan;18(1):32-39. Pubmedid: 28291917.
  • Li Q, Kim J, Balagurunathan Y, Liu Y, Latifi K, Stringfield O, Garcia A, Moros EG, Dilling TJ, Schabath MB, Ye Z, Gillies RJ. Imaging features from pretreatment CT scans are associated with clinical outcomes in nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy. Med Phys. 2017 Aug;44(8):4341-4349. Pubmedid: 28464316. Pmcid: PMC5553698.
  • Ryckman JM, Shelton JW, Waller AF, Schreibmann E, Latifi K, Diaz R. Anatomic structure-based deformable image registration of brachytherapy implants in the treatment of locally advanced cervix cancer. Brachytherapy. 2016 Sep;15(5):584-592. Pubmedid: 27263057.
  • Jin W, Mellon EA, Hoffe SE, Frakes JM, Springett GM, Centeno BA, Kim R, Mahipal A, Pimiento JM, Malafa MP, Latifi K. Does Metabolic Tumor Volume Predict Tumor Regression Grade After Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer?. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E195. Pubmedid: 27674030.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 May;17(3):331-346. Pubmedid: 28297346.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 Mar;17(2):550-560. Pubmedid: 28297411.
  • Permuth JB, Choi J, Balarunathan Y, Kim J, Chen DT, Chen L, Orcutt S, Doepker MP, Gage K, Zhang G, Latifi K, Hoffe S, Jiang K, Coppola D, Centeno BA, Magliocco A, Li Q, Trevino J, Merchant N, Gillies R, Malafa M, On Behalf Of The Florida Pancreas Collaborative . Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms. Oncotarget. 2016 Dec;7(52):85785-85797. Pubmedid: 27589689. Pmcid: PMC5349874.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 05;17(3):331-346. Pubmedid: 27167292.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 03;17(2):550-560. Pubmedid: 27074479.
  • Frakes JM, Figura ND, Ahmed KA, Juan TH, Patel N, Latifi K, Sarangkasiri S, Strom TJ, Chinnaiyan P, Rao NG, Etame AB. Potential role for LINAC-based stereotactic radiosurgery for the treatment of 5 or more radioresistant melanoma brain metastases. J Neurosurg. 2015 Nov;123(5):1261-1267. Pubmedid: 26140482.
  • Prokopiou S, Moros EG, Poleszczuk J, Caudell J, Torres-Roca JF, Latifi K, Lee JK, Myerson R, Harrison LB, Enderling H. A proliferation saturation index to predict radiation response and personalize radiotherapy fractionation. Radiat Oncol. 2015 Jul;10:159. Pubmedid: 26227259. Pmcid: PMC4521490.
  • Oliver JA, Budzevich M, Zhang GG, Dilling TJ, Latifi K, Moros EG. Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of Lung Cancer. Transl Oncol. 2015 Dec;8(6):524-534. Pubmedid: 26692535. Pmcid: PMC4700295.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Zhang GG. Monte carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy. PLoS One. 2014 Oct;9(10):e109389. Pubmedid: 25275550. Pmcid: PMC4183586.
  • Zhang GG, Latifi K, Huang T, Feygelman V, Stevens CW, Dilling TJ, Moros EG, Elmpt Wv, Dekker A. Effects of Noise in 4D CT on Deformable Image Registration and Derived Ventilation Data. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S7-S8. Pubmedid: 24674566.
  • Kuykendall CC, Budzevich MM, Latifi K, Moros EG, Hoffe SE, Dilling TJ, Zhang GG, Montilla-Soler JL, Eikman EA. 4D PET/CT: Radiology Imaging to Radiation Therapy. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S28. Pubmedid: 24674534.
  • Figura N, Latifi K, Dilling TJ, Kuykendall CC, Eikman EA, Moros EG, Zhang GG, Leuthold S, Mehra C, Hoffe SE. Dosimetric Implications of Treating 4D PET/CT-Defined Maximum Inhale Versus Exhale Target Volumes in Esophageal Cancer. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S34-S35. Pubmedid: 24674556.
  • Budzevich MM, Kuykendall CC, Latifi K, Oliver J, Dilling TJ, Hoffe SE, Eikman EA, Montilla-Soler JI, Zhang GG, Moros EG. A Method to Determine the Optimal Number of Bins in 4D PET. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S25. Pubmedid: 24674527.
  • Oliver JA, Budzevich M, Zhang G, Moros EG, Latifi K, Kuykendall C, Hoffe S, Montilla-Soler J, Eikman E, Dilling T. Positron emission tomography texture analysis of necrosis in primary adenocarcinomas of the lung. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S29-S30. Pubmedid: 24674537.
  • Latifi K, Dilling TJ, Hoffe SE, Stevens CW, Moros EG, Zhang GG. Evaluating Effects of Radiation Therapy Treatment on 4DCT-Calculated Lung Ventilation. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S6-S7. Pubmedid: 24674563.
  • Saeed N, Latifi K, Hoffe SE, Cruz A, Opp DW, Moros EG, Zhang GG, Budzevich MM, Shridhar R, Dilling TJ. Optimizing Options for Re-irradiation With Deformable Image Registration of Prior Plans. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S16-S17. Pubmedid: 24674497.
  • Latifi K, Oliver J, Baker R, Dilling TJ, Stevens CW, Kim J, Yue B, Demarco M, Zhang GG, Moros EG, Feygelman V. Study of 201 non-small cell lung cancer patients given stereotactic ablative radiation therapy shows local control dependence on dose calculation algorithm. Int J Radiat Oncol Biol Phys. 2014 Apr;88(5):1108-1113. Pubmedid: 24529716.
  • Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep;40(9):091710. Pubmedid: 24007143.
  • Latifi K, Huang TC, Feygelman V, Budzevich MM, Moros EG, Dilling TJ, Stevens CW, van Elmpt W, Dekker A, Zhang GG. Effects of quantum noise in 4D-CT on deformable image registration and derived ventilation data. Phys Med Biol. 2013 Nov;58(21):7661-7672. Pubmedid: 24113375.
  • Latifi K, Forster KM, Hoffe SE, Dilling TJ, Dekker A, Van Elmpt W, Zhang GG. Dependence of ventilation image derived from 4D CT on deformable image registration and ventilation algorithms. J Appl Clin Med Phys. 2013 Jul;14(4):4247. Pubmedid: 23835389.
  • Latifi K, Feygelman V, Moros EG, Dilling TJ, Stevens CW, Zhang GG. Normalization of ventilation data from 4D-CT to facilitate comparison between datasets acquired at different times. PLoS One. 2013 Dec;8(12):e84083. Pubmedid: 24358330. Pmcid: PMC3866128.
  • Harris EE, Latifi K, Rusthoven C, Javedan K, Forster K. Assessment of organ motion in postoperative endometrial and cervical cancer patients treated with intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2011 Nov;81(4):e645-e650. Pubmedid: 21640508.