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Ghassan El-Haddad, MD

Academic Rank: Associate Member

Overview

Dr. El-Haddad's research interests include development of novel targeted and minimally invasive image-guided cancer therapies. 


Discipline

    • Diagnostic Imaging and Interventional Radiology
    • Cancer Physiology
    • Cancer Imaging and Technology
    • Chemical Biology and Molecular Medicine Program

Education & Training

Board Certification:

  • Diagnostic Radiology

Fellowship:

  • Lebanese University, Lebanon, MD -
  • Hospital of the University of Pennsylvania, Resident - Nuclear Medicine
  • Hospital of the University of Pennsylvania, Fellow - Nuclear Oncology
  • Children's Hospital of Philadelphia/Hospital of the University of Pennsylvania, Fellow - Pediatric Nuclear Medicine
  • St. Vincent's Medical Center/University of Connecticut, Resident - Radiology
  • Hospital of the University of Pennsylvania, Fellow - Vascular and Interventional Radiology
Research

To develop novel, targeted and minimally invasive image-guided cancer therapies and to investigate the use of molecular imaging in interventional oncology for planning, guiding and monitoring image-guided interventions.

Publications

  • Strosberg JR, Al-Toubah T, Pellè E, Smith J, Haider M, Hutchinson T, Fleming JB, El-Haddad G. Risk of bowel obstruction in patients with mesenteric/peritoneal disease receiving peptide receptor radionuclide therapy (PRRT). J Nucl Med. 2020 May. Pubmedid: 32444368.
  • Kayaleh R, Krzyston H, Rishi A, Naziri J, Frakes J, Choi J, El-Haddad G, Parikh N, Sweeney J, Kis B. Transarterial Radioembolization Treatment of Pancreatic Cancer Patients with Liver-Dominant Metastatic Disease Using Yttrium-90 Glass Microspheres: A Single-Institution Retrospective Study. J Vasc Interv Radiol. 2020 Jun.31(7):1060-1068. Pubmedid: 32534978.
  • Krzyston H, Morse B, Deperalta D, Rishi A, Kayaleh R, El-Haddad G, Smith J, Druta M, Kis B. Liver-directed treatments of liver-dominant metastatic leiomyosarcoma. Diagn Interv Radiol. 2020 Jul.26(5):449-455. Pubmedid: 32673206.
  • Bhutani MS, Klapman JB, Tuli R, El-Haddad G, Hoffe S, Wong FCL, Chasen B, Fogelman DR, Lo SK, Nissen NN, Hendifar AE, Varadhachary G, Katz MHG, Erwin WD, Koay EJ, Tamm EP, Singh BS, Mehta R, Wolff RA, Soman A, Cazacu IM, Herman JM. An open-label, single-arm pilot study of EUS-guided brachytherapy with phosphorus-32 microparticles in combination with gemcitabine +/- nab-paclitaxel in unresectable locally advanced pancreatic cancer (OncoPaC-1): Technical details and study protocol. Endosc Ultrasound. 2020 Jan.9(1):24-30. Pubmedid: 31670288. Pmcid: PMC7038730.
  • Majdalany BS, El-Haddad G. Contemporary lymphatic interventions for post-operative lymphatic leaks. Transl Androl Urol. 2020 Jan.9(Suppl 1):S104-S113. Pubmedid: 32055491. Pmcid: PMC6995849.
  • Hope TA, Bodei L, Chan JA, El-Haddad G, Fidelman N, Kunz PL, Mailman J, Menda Y, Metz DC, Mittra ES, Pryma DA, Reidy-Lagunes DL, Singh S, Strosberg JR. NANETS/SNMMI Consensus Statement on Patient Selection and Appropriate Use of 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy. J Nucl Med. 2020 Feb.61(2):222-227. Pubmedid: 32015164.
  • Lam MGEH, Hunt SJ, El-Haddad GE, Alavi A. Evolving Role of PET in Interventional Radiology-Based Oncology Procedures. PET Clin. 2019 Oct.14(4):xiii-xxiv. Pubmedid: 31472747.
  • Das S, Al-Toubah T, El-Haddad G, Strosberg J. 177Lu-DOTATATE for the treatment of gastroenteropancreatic neuroendocrine tumors. Expert Rev Gastroenterol Hepatol. 2019 Oct.13(11):1023-1031. Pubmedid: 31652074. Pmcid: PMC7227421.
  • Sweeney J, Parikh N, El-Haddad G, Kis B. Ablation of Intrahepatic Cholangiocarcinoma. Semin Intervent Radiol. 2019 Oct.36(4):298-302. Pubmedid: 31680720. Pmcid: PMC6823041.
  • Tafreshi NK, Doligalski ML, Tichacek CJ, Pandya DN, Budzevich MM, El-Haddad G, Khushalani NI, Moros EG, McLaughlin ML, Wadas TJ, Morse DL. Development of Targeted Alpha Particle Therapy for Solid Tumors. Molecules. 2019 Nov.24(23). Pubmedid: 31779154. Pmcid: PMC6930656.
  • Haider M, Al-Toubah T, El-Haddad G, Strosberg J. Molecular imaging and radionuclide therapy of neuroendocrine tumors. Curr Opin Endocrinol Diabetes Obes. 2019 Nov.27(1):16-21. Pubmedid: 31789833.
  • Chatzkel J, Mocha J, Smith J, Zhou JM, Kim Y, El-Haddad G, Zhang J. Circulating tumor cells and γH2AX as biomarkers for responsiveness to radium-223 in advanced prostate cancer patients. Future Sci OA. 2019 Dec.6(1):FSO437. Pubmedid: 31915536. Pmcid: PMC6920735.
  • Tafreshi NK, Tichacek CJ, Pandya DN, Doligalski ML, Budzevich MM, Kil H, Bhatt NB, Kock ND, Messina JL, Ruiz EE, Delva NC, Weaver A, Gibbons WR, Boulware DC, Khushalani NI, El-Haddad G, Triozzi PL, Moros EG, McLaughlin ML, Wadas T, Morse D. Melanocortin 1 Receptor-Targeted α-Particle Therapy for Metastatic Uveal Melanoma. J Nucl Med. 2019 Aug.60(8):1124-1133. Pubmedid: 30733316. Pmcid: PMC6681690.
  • Devulapalli KK, Fidelman N, Soulen MC, Miller M, Johnson MS, Addo E, El-Haddad G, Nutting C, Morrison J, Farsad K, Lokken RP, Gaba RC, Fleming J, Brown DB, Kwan SW, Rose SC, Pennycooke KA, Liu DM, White SB, Gandhi R, Lazar AA, Kerlan RK. Y Radioembolization for Hepatic Malignancy in Patients with Previous Biliary Intervention: Multicenter Analysis of Hepatobiliary Infections. Radiology. 2018 Sep.288(3):774-781. Pubmedid: 29737954.
  • Addo E, Kong MJ, El-Haddad G. Embolization-sclerotherapy of a refractory large volume post-operative pelvic lymphocele. Urol Case Rep. 2018 Sep.20:43-44. Pubmedid: 29988753. Pmcid: PMC6031223.
  • Mohammadi H, Abuodeh Y, Jin W, Frakes J, Friedman M, Biebel B, Choi J, El-Haddad G, Kis B, Sweeney J, Hoffe S. Using the Albumin-Bilirubin (ALBI) grade as a prognostic marker for radioembolization of hepatocellular carcinoma. J Gastrointest Oncol. 2018 Oct.9(5):840-846. Pubmedid: 30505583. Pmcid: PMC6219966.
  • Frakes JM, Abuodeh YA, Naghavi AO, Echevarria MI, Shridhar R, Friedman M, Kim R, El-Haddad G, Kis B, Biebel B, Sweeney J, Choi J, Anaya D, Giuliano AR, Hoffe SE. Viral hepatitis associated hepatocellular carcinoma outcomes with yttrium-90 radioembolization. J Gastrointest Oncol. 2018 Jun.9(3):546-552. Pubmedid: 29998020. Pmcid: PMC6006034.
  • Majdalany BS, Khayat M, Downing T, Killoran TP, El-Haddad G, Khaja MS, Saad WA. Lymphatic interventions for isolated, iatrogenic chylous ascites: A multi-institution experience. Eur J Radiol. 2018 Dec;109:41-47. Pubmedid: 30527310.
  • Gangi A, Shah J, Hatfield N, Smith J, Sweeney J, Choi J, El-Haddad G, Biebel B, Parikh N, Arslan B, Hoffe SE, Frakes JM, Springett GM, Anaya DA, Malafa M, Chen DT, Chen Y, Kim RD, Shridhar R, Kis B. Intrahepatic Cholangiocarcinoma Treated with Transarterial Yttrium-90 Glass Microsphere Radioembolization: Results of a Single Institution Retrospective Study. J Vasc Interv Radiol. 2018 Aug;29(8):1101-1108. Pubmedid: 30042074.
  • Kis B, El-Haddad G, Sheth RA, Parikh NS, Ganguli S, Shyn PB, Choi J, Brown KT. Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Cancer Control. 2017 Jul.24(3). Pubmedid: 28975829. Pmcid: PMC5937250.
  • Chen JX, Rose S, White SB, El-Haddad G, Fidelman N, Yarmohammadi H, Hwang W, Sze DY, Kothary N, Stashek K, Wileyto EP, Salem R, Metz DC, Soulen MC. Embolotherapy for Neuroendocrine Tumor Liver Metastases: Prognostic Factors for Hepatic Progression-Free Survival and Overall Survival. Cardiovasc Intervent Radiol. 2017 Jan;40(1):69-80. Pubmedid: 27738818.
  • Strosberg J, El-Haddad G, Wolin E, Hendifar A, Yao J, Chasen B, Mittra E, Kunz PL, Kulke MH, Jacene H, Bushnell D, O'Dorisio TM, Baum RP, Kulkarni HR, Caplin M, Lebtahi R, Hobday T, Delpassand E, Van Cutsem E, Benson A, Srirajaskanthan R, Pavel M, Mora J, Berlin J, Grande E, Reed N, Seregni E, Öberg K, Lopera Sierra M, Santoro P, Thevenet T, Erion JL, Ruszniewski P, Kwekkeboom D, Krenning E. Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors. N Engl J Med. 2017 Jan.376(2):125-135. Pubmedid: 28076709. Pmcid: PMC5895095.
  • Kis B, Shah J, Choi J, El-Haddad G, Sweeney J, Biebel B, Mellon E, Frakes JM, Hoffe SE, Fishman MN, Shridhar R. Transarterial Yttrium-90 Radioembolization Treatment of Patients with Liver-Dominant Metastatic Renal Cell Carcinoma. J Vasc Interv Radiol. 2017 Feb;28(2):254-259. Pubmedid: 27955832.
  • Mills M, Choi J, El-Haddad G, Sweeney J, Biebel B, Robinson L, Antonia S, Kumar A, Kis B. Retrospective analysis of technical success rate and procedure-related complications of 867 percutaneous CT-guided needle biopsies of lung lesions. Clin Radiol. 2017 Dec.72(12):1038-1046. Pubmedid: 28851490.
  • Abuodeh Y, Ahmed K, Echevarria M, Naghavi A, Grass GD, Robinson TJ, Tomblyn M, Shah B, Chavez J, Bello C, El-Haddad G, Harrison L, Kim S. Priming radioimmunotherapy with external beam radiation in patients with relapsed low grade non-Hodgkin lymphoma. Ther Adv Hematol. 2017 Apr.8(4):129-138. Pubmedid: 28491264. Pmcid: PMC5405899.
  • Mohammadi H, Abuodeh YA, Jin W, Frakes JM, Friedman M, Biebel B, Choi J, El-Haddad GE, Kis B, Sweeney J, Kim R, Pimiento JM, Malafa MP, Anaya D, Hoffe SE. Using the ALBI Grade as a Prognostic Marker for Radioembolization of Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E194-E195.
  • El-Haddad G. PET-Based Percutaneous Needle Biopsy. PET Clin. 2016 Jul;11(3):333-349. Pubmedid: 27321036.
  • Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE, El-Haddad G. Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization. World J Gastroenterol. 2016 Dec.22(47):10406-10414. Pubmedid: 28058021. Pmcid: PMC5175253.
  • Ahmed KA, Caudell JJ, El-Haddad G, Berglund AE, Welsh EA, Yue B, Hoffe SE, Naghavi AO, Abuodeh YA, Frakes JM, Eschrich SA, Torres-Roca JF. Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Aug.95(5):1399-1404. Pubmedid: 27319288.
  • Abbott AM, Kim R, Hoffe SE, Arslan B, Biebel B, Choi J, El-Haddad G, Kis B, Sweeney J, Meredith KL, Almhanna K, Strosberg J, Shibata D, Fulp WJ, Shridhar R. Outcomes of Therasphere Radioembolization for Colorectal Metastases. Clin Colorectal Cancer. 2015 Sep;14(3):146-153. Pubmedid: 25795047.
  • Samim M, El-Haddad GE, Molenaar IQ, Prevoo W, van den Bosch MA, Alavi A, Lam MG. [18F]Fluorodeoxyglucose PET for Interventional Oncology in Liver Malignancy. PET Clin. 2014 Oct;9(4):469-95, vi. Pubmedid: 26050948.
  • Mathew AS, El-Haddad G, Lilien DL, Takalkar AM. Costosternal chondrodynia simulating recurrent breast cancer unveiled by FDG PET. Clin Nucl Med. 2008 May;33(5):330-332. Pubmedid: 18431146.
  • Takalkar AM, El-Haddad G, Lilien DL, Patterson JC. Simultaneous demonstration of metabolic lesions consistent with Alzheimer disease and brain metastases on FDG-PET imaging. Clin Nucl Med. 2008 Jun;33(6):438-440. Pubmedid: 18496460.
  • Servaes S, El-Haddad G, Zhuang H. Intense octreotide activity in a thrombus. Clin Nucl Med. 2008 Feb;33(2):140-141. Pubmedid: 18209542.
  • Takalkar AM, Bruno GL, Makanjoula AJ, El-Haddad G, Lilien DL, Payne DK. A Potential Role for F-18 FDG PET/CT in Evaluation and Management of Fibrosing Mediastinitis. Clin Nucl Med. 2007 Sep;32(9):703-706. Pubmedid: 17710023.
  • El-Haddad G, Chamroonrat W, Houseni M, Alavi A, Zhuang H. Beware of mosquitoes: the first instance of a mosquito bite detected by fluorodeoxyglucose positron emission tomography. Pediatr Dermatol. 2007 May;24(3):344-345. Pubmedid: 17542908.
  • Yang H, Bathaii M, Houseni M, El-Haddad G, Zhuang H, Alavi A, Araujo L. False-positive reversible septal myocardial perfusion defect caused by diaphragmatic hernia. Clin Nucl Med. 2007 Mar;32(3):231-233. Pubmedid: 17314607.
  • Mahne A, El-Haddad G, Alavi A, Houseni M, Moonis G, Mong A, Hernandez-Pampaloni M, Torigian DA. Assessment of age-related morphological and functional changes of selected structures of the head and neck by computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med. 2007 Mar;37(2):88-102. Pubmedid: 17289457.
  • Prasad S, El-Haddad G, Zhuang H, Khella S. Intracranial hypotension following chiropractic spinal manipulation. Headache. 2006 Oct;46(9):1456-1458. Pubmedid: 17040344.
  • Bural GG, Torigian DA, Chamroonrat W, Alkhawaldeh K, Houseni M, El-Haddad G, Alavi A. Quantitative assessment of the atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: a new concept. Nucl Med Biol. 2006 Nov;33(8):1037-1043. Pubmedid: 17127178.
  • Chamroonrat W, Zhuang H, Houseni M, Mavi A, El-Haddad G, Bhutain C, Alavi A. Malignant lesions can mimic gastric uptake on FDG PET. Clin Nucl Med. 2006 Jan;31(1):37-38. Pubmedid: 16374124.
  • El-Haddad G, Kumar R, Pamplona R, Alavi A. PET/MRI depicts the exact location of meniscal tear associated with synovitis. Eur J Nucl Med Mol Imaging. 2006 Apr;33(4):507-508. Pubmedid: 16496195.
  • El-Haddad G, Alavi A, Zhuang H. Value of 18-Fluoro-2-Deoxyglucose PET in the Management of Patients with Fever of Unknown Origin. PET Clin. 2006 Apr;1(2):163-177. Pubmedid: 27157082.
  • Yu JQ, Zhuang H, Xiu Y, El-Haddad G, Kumar R, Alavi A. Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report. J Nucl Med Technol. 2005 Mar;33(1):31-33. Pubmedid: 15731018.
  • Chamroonrat W, Posteraro A, El-Haddad G, Zhuang H, Alavi A. Radiation myelopathy visualized as increased FDG uptake on positron emission tomography. Clin Nucl Med. 2005 Aug;30(8):560. Pubmedid: 16024956.
  • Kumar R, Xiu Y, Mavi A, El-Haddad G, Zhuang H, Alavi A. FDG-PET imaging in primary bilateral adrenal lymphoma: a case report and review of the literature. Clin Nucl Med. 2005 Apr;30(4):222-230. Pubmedid: 15764875.
  • El-Haddad G, Zhuang H, Gupta N, Alavi A. Evolving role of positron emission tomography in the management of patients with inflammatory and other benign disorders. Semin Nucl Med. 2004 Oct.34(4):313-329. Pubmedid: 15493008.
  • El-Haddad G, Alavi A, Mavi A, Bural G, Zhuang H. Normal variants in [18F]-fluorodeoxyglucose PET imaging. Radiol Clin North Am. 2004 Nov;42(6):1063-81, viii. Pubmedid: 15488558.
  • Kumar R, Xiu Y, Yu JQ, Takalkar A, El-Haddad G, Potenta S, Kung J, Zhuang H, Alavi A. 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med. 2004 Dec;45(12):2058-2062. Pubmedid: 15585482.