Ghassan <span>E.</span> El-Haddad, MD
Researcher

Ghassan E. El-Haddad, MD

Academic Rank: Assistant Member

Overview

Dr. El-Haddad's research interests include development of novel targeted and minimally invasive image-guided cancer therapies. 

Discipline

    • Diagnostic Imaging and Interventional Radiology
    • Cancer Imaging and Technology

Education & Training

    • Lebanese University, Lebanon, MD
    • Hospital of the University of Pennsylvania, Resident - Nuclear Medicine
    • Hospital of the University of Pennsylvania, Fellow - Nuclear Oncology
    • Children's Hospital of Philadelphia/Hospital of the University of Pennsylvania, Fellow - Pediatric Nuclear Medicine
    • St. Vincent's Medical Center/University of Connecticut, Resident - Radiology
    • Hospital of the University of Pennsylvania, Fellow - Vascular and Interventional Radiology
Research

To develop novel, targeted and minimally invasive image-guided cancer therapies and to investigate the use of molecular imaging in interventional oncology for planning, guiding and monitoring image-guided interventions.

Publications

  • Kis B, El-Haddad G, Sheth RA, Parikh NS, Ganguli S, Shyn PB, Choi J, Brown KT. Liver-Directed Therapies for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Cancer Control. 2017 Jul;24(3). Pubmedid: 28975829.
  • Strosberg J, El-Haddad G, Wolin E, Hendifar A, Yao J, Chasen B, Mittra E, Kunz PL, Kulke MH, Jacene H, Bushnell D, O'Dorisio TM, Baum RP, Kulkarni HR, Caplin M, Lebtahi R, Hobday T, Delpassand E, Van Cutsem E, Benson A, Srirajaskanthan R, Pavel M, Mora J, Berlin J, Grande E, Reed N, Seregni E, Öberg K, Lopera Sierra M, Santoro P, Thevenet T, Erion JL, Ruszniewski P, Kwekkeboom D, Krenning E. Phase 3 Trial of (177)Lu-Dotatate for Midgut Neuroendocrine Tumors. N Engl J Med. 2017 Jan;376(2):125-135. Pubmedid: 28076709.
  • Chen JX, Rose S, White SB, El-Haddad G, Fidelman N, Yarmohammadi H, Hwang W, Sze DY, Kothary N, Stashek K, Wileyto EP, Salem R, Metz DC, Soulen MC. Embolotherapy for Neuroendocrine Tumor Liver Metastases: Prognostic Factors for Hepatic Progression-Free Survival and Overall Survival. Cardiovasc Intervent Radiol. 2017 Jan;40(1):69-80. Pubmedid: 27738818.
  • Kis B, Shah J, Choi J, El-Haddad G, Sweeney J, Biebel B, Mellon E, Frakes JM, Hoffe SE, Fishman MN, Shridhar R. Transarterial Yttrium-90 Radioembolization Treatment of Patients with Liver-Dominant Metastatic Renal Cell Carcinoma. J Vasc Interv Radiol. 2017 Feb;28(2):254-259. Pubmedid: 27955832.
  • Mills M, Choi J, El-Haddad G, Sweeney J, Biebel B, Robinson L, Antonia S, Kumar A, Kis B. Retrospective analysis of technical success rate and procedure-related complications of 867 percutaneous CT-guided needle biopsies of lung lesions. Clin Radiol. 2017 Dec;72(12):1038-1046. Pubmedid: 28851490.
  • Abuodeh Y, Ahmed K, Echevarria M, Naghavi A, Grass GD, Robinson TJ, Tomblyn M, Shah B, Chavez J, Bello C, El-Haddad G, Harrison L, Kim S. Priming radioimmunotherapy with external beam radiation in patients with relapsed low grade non-Hodgkin lymphoma. Ther Adv Hematol. 2017 Apr;8(4):129-138. Pubmedid: 28491264. Pmcid: PMC5405899.
  • Mohammadi H, Abuodeh YA, Jin W, Frakes JM, Friedman M, Biebel B, Choi J, El-Haddad GE, Kis B, Sweeney J, Kim R, Pimiento JM, Malafa MP, Anaya D, Hoffe SE. Using the ALBI Grade as a Prognostic Marker for Radioembolization of Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2016 Oct;96(2S):E194-E195.
  • El-Haddad G. PET-Based Percutaneous Needle Biopsy. PET Clin. 2016 Jul;11(3):333-349. Pubmedid: 27321036.
  • Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE, El-Haddad G. Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization. World J Gastroenterol. 2016 Dec;22(47):10406-10414. Pubmedid: 28058021. Pmcid: PMC5175253.
  • Ahmed KA, Caudell JJ, El-Haddad G, Berglund AE, Welsh EA, Yue B, Hoffe SE, Naghavi AO, Abuodeh YA, Frakes JM, Eschrich SA, Torres-Roca JF. Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Aug;95(5):1399-1404. Pubmedid: 27319288.
  • Abbott AM, Kim R, Hoffe SE, Arslan B, Biebel B, Choi J, El-Haddad G, Kis B, Sweeney J, Meredith KL, Almhanna K, Strosberg J, Shibata D, Fulp WJ, Shridhar R. Outcomes of Therasphere Radioembolization for Colorectal Metastases. Clin Colorectal Cancer. 2015 Sep;14(3):146-153. Pubmedid: 25795047.
  • Samim M, El-Haddad GE, Molenaar IQ, Prevoo W, van den Bosch MA, Alavi A, Lam MG. [18F]Fluorodeoxyglucose PET for Interventional Oncology in Liver Malignancy. PET Clin. 2014 Oct;9(4):469-95, vi. Pubmedid: 26050948.
  • Mathew AS, El-Haddad G, Lilien DL, Takalkar AM. Costosternal chondrodynia simulating recurrent breast cancer unveiled by FDG PET. Clin Nucl Med. 2008 May;33(5):330-332. Pubmedid: 18431146.
  • Takalkar AM, El-Haddad G, Lilien DL, Patterson JC. Simultaneous demonstration of metabolic lesions consistent with Alzheimer disease and brain metastases on FDG-PET imaging. Clin Nucl Med. 2008 Jun;33(6):438-440. Pubmedid: 18496460.
  • Servaes S, El-Haddad G, Zhuang H. Intense octreotide activity in a thrombus. Clin Nucl Med. 2008 Feb;33(2):140-141. Pubmedid: 18209542.
  • Takalkar AM, Bruno GL, Makanjoula AJ, El-Haddad G, Lilien DL, Payne DK. A Potential Role for F-18 FDG PET/CT in Evaluation and Management of Fibrosing Mediastinitis. Clin Nucl Med. 2007 Sep;32(9):703-706. Pubmedid: 17710023.
  • Mahne A, El-Haddad G, Alavi A, Houseni M, Moonis G, Mong A, Hernandez-Pampaloni M, Torigian DA. Assessment of age-related morphological and functional changes of selected structures of the head and neck by computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med. 2007 Mar;37(2):88-102. Pubmedid: 17289457.
  • Yang H, Bathaii M, Houseni M, El-Haddad G, Zhuang H, Alavi A, Araujo L. False-positive reversible septal myocardial perfusion defect caused by diaphragmatic hernia. Clin Nucl Med. 2007 Mar;32(3):231-233. Pubmedid: 17314607.
  • Prasad S, El-Haddad G, Zhuang H, Khella S. Intracranial hypotension following chiropractic spinal manipulation. Headache. 2006 Oct;46(9):1456-1458. Pubmedid: 17040344.
  • Bural GG, Torigian DA, Chamroonrat W, Alkhawaldeh K, Houseni M, El-Haddad G, Alavi A. Quantitative assessment of the atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: a new concept. Nucl Med Biol. 2006 Nov;33(8):1037-1043. Pubmedid: 17127178.
  • Chamroonrat W, Zhuang H, Houseni M, Mavi A, El-Haddad G, Bhutain C, Alavi A. Malignant lesions can mimic gastric uptake on FDG PET. Clin Nucl Med. 2006 Jan;31(1):37-38. Pubmedid: 16374124.
  • El-Haddad G, Kumar R, Pamplona R, Alavi A. PET/MRI depicts the exact location of meniscal tear associated with synovitis. Eur J Nucl Med Mol Imaging. 2006 Apr;33(4):507-508. Pubmedid: 16496195.
  • El-Haddad G, Alavi A, Zhuang H. Value of 18-Fluoro-2-Deoxyglucose PET in the Management of Patients with Fever of Unknown Origin. PET Clin. 2006 Apr;1(2):163-177. Pubmedid: 27157082.
  • Yu JQ, Zhuang H, Xiu Y, El-Haddad G, Kumar R, Alavi A. Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report. J Nucl Med Technol. 2005 Mar;33(1):31-33. Pubmedid: 15731018.
  • Chamroonrat W, Posteraro A, El-Haddad G, Zhuang H, Alavi A. Radiation myelopathy visualized as increased FDG uptake on positron emission tomography. Clin Nucl Med. 2005 Aug;30(8):560. Pubmedid: 16024956.
  • Kumar R, Xiu Y, Mavi A, El-Haddad G, Zhuang H, Alavi A. FDG-PET imaging in primary bilateral adrenal lymphoma: a case report and review of the literature. Clin Nucl Med. 2005 Apr;30(4):222-230. Pubmedid: 15764875.
  • El-Haddad G, Zhuang H, Gupta N, Alavi A. Evolving role of positron emission tomography in the management of patients with inflammatory and other benign disorders. Semin Nucl Med. 2004 Oct;34(4):313-329. Pubmedid: 15493008.
  • El-Haddad G, Alavi A, Mavi A, Bural G, Zhuang H. Normal variants in [18F]-fluorodeoxyglucose PET imaging. Radiol Clin North Am. 2004 Nov;42(6):1063-81, viii. Pubmedid: 15488558.
  • Kumar R, Xiu Y, Yu JQ, Takalkar A, El-Haddad G, Potenta S, Kung J, Zhuang H, Alavi A. 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med. 2004 Dec;45(12):2058-2062. Pubmedid: 15585482.
  • El-Haddad G, Chamroonrat W, Houseni M, Alavi A, Zhuang H. Beware of mosquitoes: the first instance of a mosquito bite detected by fluorodeoxyglucose positron emission tomography. Pediatr Dermatol. 24(3):344-345. Pubmedid: 17542908.