Geoffrey <span>G.</span> Zhang, PhD
Researcher

Geoffrey G. Zhang, PhD

Academic Rank: Senior Member

Overview

Discipline

    • Radiation Oncology
    • Cancer Imaging and Metabolism
    • Cancer Imaging and Technology

Education & Training

    • University of Texas MD Anderson Cancer Center, Postdoctoral Fellow - Department of Radiation Physics
    • Carleton University, PhD - Medical Physics
    • Institute of High Energy Physics, Chinese Academy of Sciences, MS - Particle Physics
Research

Research interests include Ventilation calculation using 4DCT and deformable image registration,  Four-dimensional (4D) dosimetry in radiotherapy, Monte Carlo dose calculation in radiotherapy,   Medical image texture analysis,  Image guided radiotherapy and Radiation dose delivery measurement in radiotherapy.  

Publications

  • Zhang GG, Latifi K, Feygelman V, Chou KT, Huang TC, Dilling TJ, Perez BA, Moros EG. Ventilation Series Similarity: A Study for Ventilation Calculation Using Deformable Image Registration and 4DCT to Avoid Motion Artifacts. Contrast Media Mol Imaging. 2017 Sep;2017:9730380. Pubmedid: 29097945. Pmcid: PMC5623778.
  • Oliver JA, Budzevich M, Hunt D, Moros EG, Latifi K, Dilling TJ, Feygelman V, Zhang G. Sensitivity of Image Features to Noise in Conventional and Respiratory-Gated PET/CT Images of Lung Cancer: Uncorrelated Noise Effects. Technol Cancer Res Treat. 2017 Oct;16(5):595-608. Pubmedid: 27502957. Pmcid: PMC5665151.
  • Ahmed S, Nelms B, Gintz D, Caudell J, Zhang G, Moros EG, Feygelman V. A method for a priori estimation of best feasible DVH for organs-at-risk: Validation for head and neck VMAT planning. Med Phys. 2017 Oct;44(10):5486-5497. Pubmedid: 28777469.
  • Altazi BA, Zhang GG, Fernandez DC, Montejo ME, Hunt D, Werner J, Biagioli MC, Moros EG. Reproducibility of F18-FDG PET radiomic features for different cervical tumor segmentation methods, gray-level discretization, and reconstruction algorithms. J Appl Clin Med Phys. 2017 Nov;18(6):32-48. Pubmedid: 28891217.
  • Ahmed S, Hunt D, Kapatoes J, Hayward R, Zhang G, Moros EG, Feygelman V. Validation of a GPU-Based 3D dose calculator for modulated beams. J Appl Clin Med Phys. 2017 May;18(3):73-82. Pubmedid: 28371377.
  • Shafiq-Ul-Hassan M, Zhang GG, Latifi K, Ullah G, Hunt DC, Balagurunathan Y, Abdalah MA, Schabath MB, Goldgof DG, Mackin D, Court LE, Gillies RJ, Moros EG. Intrinsic dependencies of CT radiomic features on voxel size and number of gray levels. Med Phys. 2017 Mar;44(3):1050-1062. Pubmedid: 28112418. Pmcid: PMC5462462.
  • Oliver JA, Venkat P, Frakes JM, Klapman J, Harris C, Montilla-Soler J, Dhadham GC, Altazi BA, Zhang GG, Moros EG, Shridhar R, Hoffe SE, Latifi K. Fiducial markers coupled with 3D PET/CT offer more accurate radiation treatment delivery for locally advanced esophageal cancer. Endosc Int Open. 2017 Jun;5(6):E496-E504. Pubmedid: 28573183. Pmcid: PMC5451282.
  • Yang SN, Chiou YR, Zhang GG, Chou KT, Huang TC. The clinical outcome correlations between radiation dose and pretreatment metabolic tumor volume for radiotherapy in head and neck cancer: A retrospective analysis. Medicine. 2017 Jun;96(26):e7186. Pubmedid: 28658110. Pmcid: PMC5500032.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Hoffe S, Frakes J, Zhang GG. Superficial and peripheral dose in compensator-based FFF beam IMRT. J Appl Clin Med Phys. 2017 Jan;18(1):151-156. Pubmedid: 28291940.
  • Ahmed S, Nelms B, Kozelka J, Zhang G, Moros E, Feygelman V. Validation of an improved helical diode array and dose reconstruction software using TG-244 datasets and stringent dose comparison criteria. J Appl Clin Med Phys. 2016 Nov;17(6):163-178. Pubmedid: 28297274.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 May;17(3):331-346. Pubmedid: 28297346.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 Mar;17(2):550-560. Pubmedid: 28297411.
  • Permuth JB, Choi J, Balarunathan Y, Kim J, Chen DT, Chen L, Orcutt S, Doepker MP, Gage K, Zhang G, Latifi K, Hoffe S, Jiang K, Coppola D, Centeno BA, Magliocco A, Li Q, Trevino J, Merchant N, Gillies R, Malafa M, On Behalf Of The Florida Pancreas Collaborative . Combining radiomic features with a miRNA classifier may improve prediction of malignant pathology for pancreatic intraductal papillary mucinous neoplasms. Oncotarget. 2016 Dec;7(52):85785-85797. Pubmedid: 27589689. Pmcid: PMC5349874.
  • Ahmed S, Nelms B, Kozelka J, Zhang G, Moros E, Feygelman V. Validation of an improved helical diode array and dose reconstruction software using TG-244 datasets and stringent dose comparison criteria. J Appl Clin Med Phys. 2016 11;17(6):163-178. Pubmedid: 27929491.
  • Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016 05;17(3):331-346. Pubmedid: 27167292.
  • Zhang GG, Latifi K, Du K, Reinhardt JM, Christensen GE, Ding K, Feygelman V, Moros EG. Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods. J Appl Clin Med Phys. 2016 03;17(2):550-560. Pubmedid: 27074479.
  • Feygelman V, Tonner B, Stambaugh C, Hunt D, Zhang G, Moros E, Nelms BE. Technical Note: Motion-perturbation method applied to dosimetry of dynamic MLC target tracking--A proof-of-concept. Med Phys. 2015 Nov;42(11):6147-6151. Pubmedid: 26520707.
  • Stambaugh C, Nelms B, Wolf T, Mueller R, Geurts M, Opp D, Moros E, Zhang G, Feygelman V. Measurement-guided volumetric dose reconstruction for helical tomotherapy. J Appl Clin Med Phys. 2015 Mar;16(2):5298. Pubmedid: 26103199.
  • Oliver JA, Budzevich M, Zhang GG, Dilling TJ, Latifi K, Moros EG. Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of Lung Cancer. Transl Oncol. 2015 Dec;8(6):524-534. Pubmedid: 26692535. Pmcid: PMC4700295.
  • Nelms B, Stambaugh C, Hunt D, Tonner B, Zhang G, Feygelman V. Methods, software and datasets to verify DVH calculations against analytical values: Twenty years late(r). Med Phys. 2015 Aug;42(8):4435-4448. Pubmedid: 26233174.
  • Zhang DG, Feygelman V, Moros EG, Latifi K, Zhang GG. Monte carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy. PLoS One. 2014 Oct;9(10):e109389. Pubmedid: 25275550. Pmcid: PMC4183586.
  • Saeed N, Latifi K, Hoffe SE, Cruz A, Opp DW, Moros EG, Zhang GG, Budzevich MM, Shridhar R, Dilling TJ. Optimizing Options for Re-irradiation With Deformable Image Registration of Prior Plans. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S16-S17. Pubmedid: 24674497.
  • Zhang GG, Latifi K, Huang T, Feygelman V, Stevens CW, Dilling TJ, Moros EG, Elmpt Wv, Dekker A. Effects of Noise in 4D CT on Deformable Image Registration and Derived Ventilation Data. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S7-S8. Pubmedid: 24674566.
  • Stambaugh C, Opp D, Wasserman S, Zhang G, Feygelman V. Evaluation of semiempirical VMAT dose reconstruction on a patient dataset based on biplanar diode array measurements. J Appl Clin Med Phys. 2014 Mar;15(2):4705. Pubmedid: 24710459.
  • Figura N, Latifi K, Dilling TJ, Kuykendall CC, Eikman EA, Moros EG, Zhang GG, Leuthold S, Mehra C, Hoffe SE. Dosimetric Implications of Treating 4D PET/CT-Defined Maximum Inhale Versus Exhale Target Volumes in Esophageal Cancer. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S34-S35. Pubmedid: 24674556.
  • Latifi K, Dilling TJ, Hoffe SE, Stevens CW, Moros EG, Zhang GG. Evaluating Effects of Radiation Therapy Treatment on 4DCT-Calculated Lung Ventilation. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S6-S7. Pubmedid: 24674563.
  • Feygelman V, Stambaugh C, Opp D, Zhang G, Moros EG, Nelms BE. Cross-validation of two commercial methods for volumetric high-resolution dose reconstruction on a phantom for non-coplanar VMAT beams. Radiother Oncol. 2014 Mar;110(3):558-561. Pubmedid: 24440044.
  • Stambaugh C, Opp D, Wassrman S, Zhang G, Feygelman V. Evaluation of semiempirical VMAT dose reconstruction on a patient dataset based on biplanar diode array measurements. J Appl Clin Med Phys. 2014 Mar;15(2):169-180. Pubmedid: 28296076.
  • Kuykendall CC, Budzevich MM, Latifi K, Moros EG, Hoffe SE, Dilling TJ, Zhang GG, Montilla-Soler JL, Eikman EA. 4D PET/CT: Radiology Imaging to Radiation Therapy. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S28. Pubmedid: 24674534.
  • Budzevich MM, Kuykendall CC, Latifi K, Oliver J, Dilling TJ, Hoffe SE, Eikman EA, Montilla-Soler JI, Zhang GG, Moros EG. A Method to Determine the Optimal Number of Bins in 4D PET. Pract Radiat Oncol. 2014 Mar;3(2 Suppl 1):S25. Pubmedid: 24674527.
  • Nelms BE, Opp D, Zhang G, Moros E, Feygelman V. Motion as perturbation. II. Development of the method for dosimetric analysis of motion effects with fixed-gantry IMRT. Med Phys. 2014 Jun;41(6):061704. Pubmedid: 24877799.
  • Javedan K, Feygelman V, Zhang RR, Moros EG, Correa CR, Trotti A, Li W, Zhang GG. Monte Carlo comparison of superficial dose between flattening filter free and flattened beams. Phys Med. 2014 Jun;30(4):503-508. Pubmedid: 24662096.
  • Latifi K, Oliver J, Baker R, Dilling TJ, Stevens CW, Kim J, Yue B, Demarco M, Zhang GG, Moros EG, Feygelman V. Study of 201 non-small cell lung cancer patients given stereotactic ablative radiation therapy shows local control dependence on dose calculation algorithm. Int J Radiat Oncol Biol Phys. 2014 Apr;88(5):1108-1113. Pubmedid: 24529716.
  • Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep;40(9):091710. Pubmedid: 24007143.
  • Latifi K, Huang TC, Feygelman V, Budzevich MM, Moros EG, Dilling TJ, Stevens CW, van Elmpt W, Dekker A, Zhang GG. Effects of quantum noise in 4D-CT on deformable image registration and derived ventilation data. Phys Med Biol. 2013 Nov;58(21):7661-7672. Pubmedid: 24113375.
  • Opp D, Forster K, Li W, Zhang G, Harris EE. Evaluation of bolus electron conformal therapy compared with conventional techniques for the treatment of left chest wall postmastectomy in patients with breast cancer. Med Dosim. 2013 Nov;38(4):448-453. Pubmedid: 24200221.
  • Robinson J, Opp D, Zhang G, Feygelman V. Evaluation of inhomogeneity correction factors for 6 MV flattening filter-free beams with brass compensators. J Appl Clin Med Phys. 2013 May;14(3):3990. Pubmedid: 23652238.
  • Pritz J, Forster KM, Saini AS, Biagioli MC, Zhang GG. Calculating prescription doses for new sources by biologically effective dose matching. Brachytherapy. 2013 May;11(6):521-527. Pubmedid: 22436519.
  • Opp D, Nelms BE, Zhang G, Stevens C, Feygelman V. Validation of measurement-guided 3D VMAT dose reconstruction on a heterogeneous anthropomorphic phantom. J Appl Clin Med Phys. 2013 Jul;14(4):4154. Pubmedid: 23835381.
  • Latifi K, Forster KM, Hoffe SE, Dilling TJ, Dekker A, Van Elmpt W, Zhang GG. Dependence of ventilation image derived from 4D CT on deformable image registration and ventilation algorithms. J Appl Clin Med Phys. 2013 Jul;14(4):4247. Pubmedid: 23835389.
  • Latifi K, Zhang G, Stawicki M, Van Elmpt W, Dekker A, Forster K. Validation of three deformable image registration algorithms for the thorax. J Appl Clin Med Phys. 2013 Jan;14(1):3834. Pubmedid: 23318377.
  • Zhang RR, Feygelman V, Harris ER, Rao N, Moros EG, Zhang GG. Is wax equivalent to tissue in electron conformal therapy planning? A Monte Carlo study of material approximation introduced dose difference. J Appl Clin Med Phys. 2013 Jan;14(1):3991. Pubmedid: 23318384.
  • Feygelman V, Stambaugh C, Zhang G, Hunt D, Opp D, Wolf TK, Nelms BE. Motion as a perturbation: measurement-guided dose estimates to moving patient voxels during modulated arc deliveries. Med Phys. 2013 Feb;40(2):021708. Pubmedid: 23387731.
  • Latifi K, Feygelman V, Moros EG, Dilling TJ, Stevens CW, Zhang GG. Normalization of ventilation data from 4D-CT to facilitate comparison between datasets acquired at different times. PLoS One. 2013 Dec;8(12):e84083. Pubmedid: 24358330. Pmcid: PMC3866128.
  • Pritz J, Forster KM, Saini AS, Biagioli MC, Zhang GG. Providing a fast conversion of total dose to biological effective dose (BED) for hybrid seed brachytherapy. J Appl Clin Med Phys. 2012 Sep;13(5):3800. Pubmedid: 22955644.
  • Javedan K, Zhang GG, Hoffe S, Feygelman V, Forster K. Comparing dose in the build-up region between compensator- and MLC-based IMRT. J Appl Clin Med Phys. 2012 Sep;13(5):3748. Pubmedid: 22955641.
  • Park CK, Pritz J, Zhang GG, Forster KM, Harris EE. Validating fiducial markers for image-guided radiation therapy for accelerated partial breast irradiation in early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2012 Mar;82(3):e425-e431. Pubmedid: 22284037.
  • Zhang GG, Ku L, Dilling TJ, Stevens CW, Zhang RR, Li W, Feygelman V. Volumetric modulated arc planning for lung stereotactic body radiotherapy using conventional and unflattened photon beams: a dosimetric comparison with 3D technique. Radiat Oncol. 2012 Mar;6:152. Pubmedid: 22070866. Pmcid: PMC3354344.
  • Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA: measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul;39(7):4228-4238. Pubmedid: 22830756.
  • Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA: Measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul;39(7Part1):4228-4238. Pubmedid: 28516597.
  • Robinson J, Opp D, Zhang G, Cashon K, Kozelka J, Hunt D, Walker L, Hoffe S, Shridhar R, Feygelman V. Evaluating dosimetric accuracy of flattening filter free compensator-based IMRT: measurements with diode arrays. Med Phys. 2012 Jan;39(1):342-352. Pubmedid: 22225304.
  • Kozelka J, Robinson J, Nelms B, Zhang G, Savitskij D, Feygelman V. Optimizing the accuracy of a helical diode array dosimeter: a comprehensive calibration methodology coupled with a novel virtual inclinometer. Med Phys. 2011 Sep;38(9):5021-5032. Pubmedid: 21978046.
  • Zhang G, Huang TC, Dilling T, Stevens C, Forster K. Comments on 'Ventilation from four-dimensional computed tomography: density versus Jacobian methods'. Phys Med Biol. 2011 Jun;56(11):3445-3446. Pubmedid: 21572233.
  • Saini AS, Zhang GG, Finkelstein SE, Biagioli MC. Dose reduction study in vaginal balloon packing filled with contrast for HDR brachytherapy treatment. Int J Radiat Oncol Biol Phys. 2011 Jul;80(4):1263-1267. Pubmedid: 20950949.
  • Feygelman V, Zhang G, Stevens C, Nelms BE. Evaluation of a new VMAT QA device, or the "X" and "O" array geometries. J Appl Clin Med Phys. 2011 Jan;12(2):3346. Pubmedid: 21587178.
  • Zhang G, Feygelman V, Stevens C, Li W, Leuthold S, Springett G, Hoffe S. Re-planning for compensator-based IMRT with original compensators. Med Dosim. 2011 Feb;36(1):102-108. Pubmedid: 20207532.
  • Zhang G, Feygelman V, Huang TC, Stevens C, Li W, Dilling T. Motion-weighted target volume and dose-volume histogram: a practical approximation of four-dimensional planning and evaluation. Radiother Oncol. 2011 Apr;99(1):67-72. Pubmedid: 21397967.
  • Zhang G, Huang TC, Feygelman V, Stevens C, Forster K. Generation of composite dose and biological effective dose (BED) over multiple treatment modalities and multistage planning using deformable image registration. Med Dosim. 2010 Sep;35(2):143-150. Pubmedid: 19931027.
  • Huang TC, Liang JA, Dilling T, Wu TH, Zhang G. Four-dimensional dosimetry validation and study in lung radiotherapy using deformable image registration and Monte Carlo techniques. Radiat Oncol. 2010 May;5:45. Pubmedid: 20509955. Pmcid: PMC2890615.
  • Faygelman V, Hunt D, Walker L, Mueller R, Demarco ML, Dilling T, Stevens C, Zhang G. Validation of Pinnacle treatment planning system for use with Novalis delivery unit. J Appl Clin Med Phys. 2010 Jun;11(3):3240. Pubmedid: 20717094.
  • Feygelman V, Opp D, Javedan K, Saini AJ, Zhang G. Evaluation of a 3D diode array dosimeter for helical tomotherapy delivery QA. Med Dosim. 2010 Jan;. Pubmedid: 20097061.
  • Feygelman V, Zhang GG, Stevens CW. Initial dosimetric evaluation of SmartArc - a novel VMAT treatment planning module implemented in a multi-vendor delivery chain. J Appl Clin Med Phys. 2010 Jan;11(1):3169. Pubmedid: 20160702.
  • Javedan K, Zhang G, Mueller R, Harris E, Berk L, Forster K. Skin dose study of chest wall treatment with tomotherapy. Jpn J Radiol. 2009 Nov;27(9):355-362. Pubmedid: 19943146.
  • Wu CC, Zhang G, Huang TC, Lin KP. Red blood cell velocity measurements of complete capillary in finger nail-fold using optical flow estimation. Microvasc Res. 2009 Dec;78(3):319-324. Pubmedid: 19647002.
  • Heinzerling JH, Papiez L, Chien S, Anderson J, Forster K, Zhang G, Timmerman R. Stereotactic body radiation therapy: evaluation of setup accuracy and targeting methods for a new couch integrated immobilization system. Technol Cancer Res Treat. 2008 Jun;7(3):197-206. Pubmedid: 18473491.
  • Zhang G, Huang T, Guerrero T, Lin K, Stevens C, Starkschall G, Forster K. Use of three-dimensional (3D) optical flow method in mapping 3D anatomic structure and tumor contours across four-dimensional computed tomography data. J Appl Clin Med Phys. 2008 Feb;9(1):2738. Pubmedid: 18449166.
  • Heinzerling JH, Anderson JF, Papiez L, Boike T, Chien S, Zhang G, Abdulrahman R, Timmerman R. Four-dimensional computed tomography scan analysis of tumor and organ motion at varying levels of abdominal compression during stereotactic treatment of lung and liver. Int J Radiat Oncol Biol Phys. 2008 Apr;70(5):1571-1578. Pubmedid: 18374231.
  • Zhang G, Huang T, Forster K, Lin K, Stevens C, Harris E, Guerrero T. Dose mapping: Validation in 4D dosimetry with measurements and application inradiotherapy follow-up evaluation. Comput Methods Programs Biomed. 2008 Apr;90(1):25-37. Pubmedid: 18178288.
  • Park C, Zhang G, Choy H. 4-Dimensional conformal radiation therapy: image-guided radiation therapy and its application in lung cancer treatment. Clin Lung Cancer. 2006 Nov;8(3):187-194. Pubmedid: 17239294.
  • Huang TC, Zhang G, Guerrero T, Starkschall G, Lin KP, Forster K. Semi-automated CT segmentation using optic flow and Fourier interpolation techniques. Comput Methods Programs Biomed. 2006 Dec;84(2-3):124-134. Pubmedid: 17027116.
  • Guerrero T, Zhang G, Segars W, Huang TC, Bilton S, Ibbott G, Dong L, ForsterK, Lin KP. Elastic image mapping for 4-D dose estimation in thoracic radiotherapy. Radiat Prot Dosimetry. 2005;115(1-4):497-502. Pubmedid: 16381774.
  • Guerrero T, Zhang G, Huang TC, Lin KP. Intrathoracic tumour motion estimation from CT imaging using the 3D optical flow method. Phys Med Biol. 2004 Sep;49(17):4147-4161. Pubmedid: 15470929.
  • Zhang GG, Rogers DW, Cygler JE, Mackie TR. Monte Carlo investigation of electron beam output factors versus size of square cutout. Med Phys. 1999 May;26(5):743-750. Pubmedid: 10360536.
  • Ding GX, Cygler JE, Zhang GG, Yu MK. Evaluation of a commercial three-dimensional electron beam treatment planning system. Med Phys. 1999 Dec;26(12):2571-2580. Pubmedid: 10619241.
  • Zhang GG, Rogers DW, Cygler JE, Mackie TR. Effects of changes in stopping-power ratios with field size on electron beam relative output factors. Med Phys. 1998 Sep;25(9):1711-1716. Pubmedid: 9775377 .
  • Zhang GG, Rogers DW, Cygler JE, Mackie TR. Effects of changes in stopping-power ratios with field size on electron beam relative output factors. Med Phys. 1998 Sep;25(9):1711-1716. Pubmedid: 9775377.