Research Focus

The Machine Learning Department and its members conduct a wide array of research involving the development and application of artificial intelligence (AI), machine and deep learning (ML/DL) algorithms to translational cancer research and discovery that include quantitative image analysis (radiomics), digital pathology (pathomics), cancer diagnosis and prognosis, information retrieval and data integration, outcomes and behavioral sciences, molecular and computational biology. This is in addition to basic ML/DL research in pertinent areas to oncology such as visual analytics and explainable AI, automated ML/DL, and information-theoretic approaches.

Research projects include: 

Optimal Decision Making in Radiotherapy Using Panomics Analytics

Funding resource: NIH/NCI R01 CA233487

The long-term goal of this project is to overcome barriers related to prediction uncertainties and human-computer interactions, which are currently limiting the ability to make personalized clinical decisions for real-time response-based adaptation in radiotherapy from available data.

Patient Knowledge and Response graphic

Combined Radiation Acoustics and Ultrasound Imaging for Real-Time Guidance in Radiotherapy

Funding resource: NIH/NCI R37 CA222215

To develop an evaluated and integrated tomographic feedback system that uses X-ray acoustics (XACT) and advanced ultrasound (US) images to monitor a patient’s present status during radiotherapy delivery.

Radiation Acoustics Linac Machine graphic

Cerenkov Multi-Spectral Imaging (CMSI) for Adaptation and Real-Time Imaging in Radiotherapy

Funding resource: NIH/NCI R41 CA243722

Sight of Radiation and Sound of Radiation graphicSponsor: Endectra LLC

In this STTR proposal, Endectra will work with oncology researchers at Moffitt to develop and evaluate a novel Cerenkov Multi-Spectral Imaging (CMSI) technique using new solid-state on-body probes to conduct routine optical measurements of radiation dose and molecular imaging during cancer radiotherapy delivery. This approach is expected to provide more accurate tumor physiological representation and dose adaptation during treatment, reduce overall patient exposure to radiation, and allow for ongoing assessment of tumor physiological parameters. If successful, Endectra will develop CMSI as an alternative cost-saving and effective molecular imaging/targeting modality for routine radiotherapy applications, greatly improving radiotherapy outcomes and yielding a major impact on public health.

Classification of DNA Structural Mutational Profiles

DNA mutation profile graphicDetection and classification tools are urgently needed to improve cancer patients’ survival. It has been demonstrated that mutations due to structural DNA aberrations are a better measure of DNA damage. Hence, in this project we aim to use information about DNA conformation to better classify cancer types and to predict therapeutic response. Our goal is to advance cancer classification by developing a computational tool that uses structural (conformational) descriptors of the human genome. The resulting computational model will facilitate future analyses of tumor metabolism, morphology, drug screening, and treatment optimization. Karolak Lab Page

Human-in-the-Loop Adaptive Radiotherapy for Cancer Cure

The objective of adaptive radiotherapy is to change the radiation treatment plan delivered to a patient during a course of radiotherapy based on patients’ responses by balancing a trade-off of obtaining tumor local control (LC) while limiting radiation-induced toxicities (RITs). LC and RITs may depend on radiation dose, the patient’s physical, clinical, biological, imaging, and genomic characteristics before and during the radiotherapy. While general machine Learning approaches have the potential to explore useful patterns over the treatment process from these data, they may not be employed for clinical decision-making until they gain physicians’ trust. Therefore, the purpose of this project is to develop human-in-the-loop adaptive mechanisms by allowing physicians to participate in the processes of integrating diverse multimodal information, predicting radiation treatment outcomes, and identifying the optimal robust treatment plans before and during the radiotherapy.

Graphic of human-in-the-loop radiotherapy

Customized Healthcare Policy to Improve Cancer Patients’ Healthcare Quality for a Specific Area

The healthcare quality of cancer patients not only can be evaluated from public health services such as their accessibility and affordability, screening utilization, adjuvant therapy, the delays of biopsy and treatment, but also depends on their treatment outcomes such as overall survival and their associated racial disparities. The quality of healthcare is not the same for different regions due to their area resources, socioeconomic conditions, etc. Authorities’ policies have the potential to improve patients’ healthcare quality in a region by re-organizing the delivery of the public health services among healthcare providers and patients. However, interactions of all the stakeholders in response to different policies are unknown. Choosing an appropriate strategy for patients’ healthcare quality improvement in the area is still challenging. The purpose of this project is to develop data-driven and model-based approaches to evaluate the impact of potential healthcare policies on cancer patients’ healthcare quality and customize the most suitable policy for the region by balancing the multiple criteria of healthcare quality.

Graphic of customized healthcare policy research study

Read more about these research projects on our team's Lab pages found under the corresponding faculty members here