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CLINICAL TRIAL 17425

Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 17431

A Randomized Phase 3 Study of the Efficacy and Safety of Glufosfamide Compared with Fluorouracil (5-FU) in Patients with Metastatic Pancreatic Adenocarcinoma Previously Treated with Gemcitabine

Disease Site: Colon, Liver, Lung, Other Endocrine System, Pancreas, Small Intestine, Stomach

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CLINICAL TRIAL 17970

A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

Disease Site: Lung

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CLINICAL TRIAL 18610

A Phase I-II Study of Triciribine Phosphate Monohydrate (PTX-200) Plus Cytarabine in Refractory or Relapsed Acute Leukemia

Disease Site: Acute Leukemia (ALL, AML), Acute promyelocytic leukemia (APL), Chronic Leukemia (CLL, CML), Leukemia, other

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CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 18959

A Phase 2 Study to Evaluate the Safety, Tolerability and Efficacy of Cell Transfer Therapy Using Autologous Tumor Infiltrating Lymphocytes (LN-145) followed by IL-2 in Patients with Recurrent and/or Metastatic Cervical Carcinoma

Disease Site: Cervix

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CLINICAL TRIAL 18994

Phase II Randomized Trial of Radiotherapy with or without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 19319

InPACT- International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

Disease Site: Penis / penile cancer, Other Male Genital

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CLINICAL TRIAL 19414

A Phase 2 Study of Talimogene Laherparepvec (T-VEC) and Radiation in Localized Soft Tissue Sarcoma

Disease Site: Soft Tissue

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CLINICAL TRIAL 19435

Combination of Nivolumab Immunotherapy with Radiation Therapy and Androgen Deprivation Therapy in the Management of Gleason Group 5 Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 19441

Pilot Study of Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 19456

Phase III Randomized Study of Crenolanib versus Midostaurin Administered Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed Subjects with FLT3 Mutated Acute Myeloid Leukemia

Disease Site: Acute Leukemia (ALL, AML), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 19481

Phase I, Open Label Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of UCART123 (Allogeneic Engineered T Cells Expressing anti-CD123 Chimeric Antigen Receptor), Administered in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Disease Site: Acute Leukemia (ALL, AML), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 19487

A Phase Ib/II Study to Evaluate the Safety, Feasibility and Efficacy of Nivolumab or Nivolumab in Combination with Azacitidine in Patients with Recurrent, Resectable Osteosarcoma

Disease Site: Any Site, Osteosarcoma

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CLINICAL TRIAL 19580

A Phase 1/2 Dose Escalation and Dose Expansion Study of BA3011 in Patients with Advanced Solid Tumors

Disease Site: Any Site, Sarcoma

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CLINICAL TRIAL 19603

Single Arm, Open Label Phase 1b/2 Study of SGN-LIV1A in Combination with Pembrolizumab for First-Line Treatment of Patients with Unresectable Locally-Advanced or Metastatic Triple-Negative Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 19627

A Randomized Phase III Trial of Consolidation with Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients with Mantle Cell Lymphoma In Minimal Residual Disease-Negative First Complete Remission

Disease Site: Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 19635

A Phase 1b/2 Study Evaluating the Safety and Efficacy of Intravenous LB-100 in Patients with Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) who had Disease Progression or are Intolerant to Prior Therapy

Disease Site: Leukemia, other, Myelodysplastic syndrome (MDS)

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CLINICAL TRIAL 19646

Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients with Metastatic HER-2+ Breast Cancer, Phase III

Disease Site: Breast

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CLINICAL TRIAL 19658

A Phase 1, Open-Label, Dose-Escalation with Expansion Study of SX-682 in Subjects with Myelodysplastic Syndrome Who Had Disease Progression or are Intolerant to Prior Therapy

Disease Site: Myelodysplastic syndrome (MDS), Leukemia, other

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CLINICAL TRIAL 19662

Phase II study of stereotactic body radiation therapy and atezolizumab in the management of recurrent, persistent, or metastatic cervical cancer

Disease Site: Cervix

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CLINICAL TRIAL 19722

A Phase 2, Multi-Cohort, Open-Label, Multicenter Study To Determine The Efficacy And Safety Of Bb2121 In Subjects With Relapsed And Refractory Multiple Myeloma And In Subjects With High-Risk Multiple Myeloma Having Progressed Within One Year Of Initial Treatment

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 19732

Randomized, Double-Blinded Phase III Study of Cabozantinib Versus Placebo in Patients with Advanced Neuroendocrine Tumors after Progression on Everolimus (Cabinet)

Disease Site: Neuroendocrine, Other Endocrine System

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CLINICAL TRIAL 19742

Phase 1/1b Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 19776

A Phase 1/2 Dose Escalation and Dose Expansion Study of BA3021 Alone and in Combination with Nivolumab in Patients with Advanced Solid Tumors

Disease Site: Any Site, Bones and Joints, Breast, Esophagus, Larynx, Lung, Other Respiratory and Intrathoracic Organs, Soft Tissue

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CLINICAL TRIAL 19829

A Phase 1/2a, Open-label, Dose-escalation, Dose-expansion, Parallel Assignment Study to Evaluate the Safety and Clinical Activity of PBCAR0191 in Subjects with Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Disease Site: Lymphoid Leukemia, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 19862

A Phase 1/1b Safety Study of PRGN-3006 Adoptive Cellular Therapy in Patients with Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndrome

Disease Site: Acute Leukemia (ALL, AML), Myelodysplastic syndrome (MDS), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 19868

First in Human Phase I Study of 225Actinium-DOTA-Ahx-MC1RL (225Ac-MTI-201) in Metastatic Melanoma

Disease Site: Eye and Orbit, Melanoma, skin

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CLINICAL TRIAL 19870

A Phase 1, Multi-center, Open-label Study of IMGN632 Administered Intravenously in Patients with Relapsed/Refractory CD123-positive Acute Myeloid Leukemia and Other CD123-positive Hematologic Malignancies

Disease Site: Acute Leukemia (ALL, AML), Myeloid and Monocytic Leukemia, Other hematologic

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CLINICAL TRIAL 19948

A Phase 2 Study of Atezolizumab and Cobimetinib in PD-1/PD-L1 Inhibitor Resistant or Refractory Non-Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19989

Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel following Induction with sequential IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy for Locally Advanced Pancreatic Cancer

Disease Site: Pancreas

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CLINICAL TRIAL 20003-TREATMENT

LungMAP: A Master Protocol to Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Treatment Substudies)

Disease Site: Lung

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CLINICAL TRIAL 20026

A Phase I Study of NBTXR3 Activated by Radiotherapy for Patients with Advanced Cancers Treated with an Anti-PD1 Therapy

Disease Site: Lung

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CLINICAL TRIAL 20030

A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node or T3N0 Positive Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 20042

CD8 Depleted, Non-Engrafting, HLA Mismatched Unrelated Donor Lymphocyte Infusion in Patients with MDS and Secondary AML

Disease Site: Acute Leukemia (ALL, AML), Myelodysplastic syndrome (MDS), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20050

QUILT-3.032: A Multicenter Clinical Trial of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20056

Phase II Clinical Trial of Green Tea Catechins in Men on Active Surveillance (AS)

Disease Site: Prostate

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CLINICAL TRIAL 20069

A Phase 1, Multi-center, Open-label, Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of an Orally Available Small Molecule CC-99282 Alone and in Combination with Rituximab in Subjects with Relapsed and/or Refractory Diffuse Large B Cell Lymphoma (R/R DLBCL) and Indolent Non-Hodgkin Lymphoma (R/R iNHL)

Disease Site: Lymphoid Leukemia, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20117

A Phase 1/2 Study of Regn5678 (Anti-psmaxcd28) with Cemiplimab (Anti-pd-1) in Patients with Metastatic Castration-Resistant Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 20132

Phase 1/2 Dose-Escalation and Expansion Study of FLX475 Alone and in Combination with Pembrolizumab in Advanced Cancer

Disease Site: Any Site, Breast, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 20141

A Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients with Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 20144

A Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Second Line and CUE-101 Combination Therapy with Pembrolizumab in First Line Patients with HPV16+ Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Head & Neck, Larynx, Lip, Oral Cavity and Pharynx, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20149

A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients with Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)

Disease Site: Any Site

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CLINICAL TRIAL 20159

A Phase 1 Study of ZW49 in Patients with Locally Advanced (Unresectable) or Metastatic HER2-Expressing Cancers

Disease Site: Esophagus, Breast

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CLINICAL TRIAL 20162

Phase 1 Trial of Intralesional Immunotherapy with IFx-Hu2.0 Vaccine in Patients with Advanced Merkel Cell Carcinoma or Cutaneous Squamous Cell Carcinoma

Disease Site: Melanoma, skin, Merkel cell carcinoma, Other Skin, Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20163

EA5163/S1709 INSIGNA: A Randomized, Phase III Study of Firstline Immunotherapy alone or in Combination with Chemotherapy in Induction/Maintenance or Postprogression in Advanced Nonsquamous Non©\Small Cell Lung Cancer (NSCLC) with Immunobiomarker SIGNature©\driven Analysis

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20178

An Open-Label Randomized Phase II Study of Combining Osimertinib with and without Ramucirumab in TKI-naïve EGFR-mutant Locally Advanced or Metastatic NSCLC

Disease Site: Non small cell lung cancer, Lung

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CLINICAL TRIAL 20251

A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR T cells in subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (SPEARHEAD 1 Study)

Disease Site: Any Site

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CLINICAL TRIAL 20253

Open Label, Multi-Center, Phase 1b Clinical Trial to Evaluate the Safety and Efficacy of Autologous CAR-BCMA T cells (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 20270

A Phase 2, Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-144 or LN-145) in Patients with Solid Tumors (IOV-COM-202)

Disease Site: Lung, Melanoma, skin, Non small cell lung cancer

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CLINICAL TRIAL 20287

A Phase 1b/2 Study of IMGN632 as Monotherapy or Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20305

Phase 1/1b Trial of Donor gamma delta T-cell Infusion for Treatment of Patients with Acute Myeloid Leukemia at High Risk of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Disease Site: Leukemia, other, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20313

Neoadjuvant Immunotherapy with Intratumoral Tavokinogene Telseplasmid (Tavo) plus Electroporation in Combination with Intravenous Nivolumab in Patients with Operable Locally- Regionally Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20336

A Phase II Trial of Ribociclib (LEE011) plus Letrozole in Women with Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube or Peritoneum

Disease Site: Ovarian, Ovary, Reproductive System

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CLINICAL TRIAL 20339

Evolutionary Inspired Therapy for Newly Diagnosed, Metastatic, Fusion Positive Rhabdomyosarcoma

Disease Site: Bones and Joints, Rhabdomyosarcoma

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CLINICAL TRIAL 20345

Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) with Simultaneously Integrated Boost to the High Margin for Retroperitoneal Sarcomas

Disease Site: Anal, Colon, Kidney, Other genitourinary, Pancreas, Rectum, Sarcoma

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CLINICAL TRIAL 20353

S1806, Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer

Disease Site: Urinary Bladder

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CLINICAL TRIAL 20373

TH-138: Phase II Randomized Trial of Carboplatin + Pemetrexed + Bevacizumab, With or Without Atezolizumab in Stage IV Non-Squamous NSCLC Patients who Harbor a Sensitizing EGFR Mutation or Have Never Smoked

Disease Site: Non small cell lung cancer, Lung

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CLINICAL TRIAL 20409

A Phase I/II, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Anti-Tumor Efficacy of DZD9008 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with EGFR or HER2 Mutation

Disease Site: Lung

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CLINICAL TRIAL 20415

A Phase III, Open-Label, Multicenter, Randomized Study Evaluating The Safety And Efficacy Of Polatuzumab Vedotin In Combination With RituximabI Plus Gemcitabine Plus Oxaliplatin (R-Gemox) Versus R-Gemox Alone In Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20419

Phase II Study of Short Course FOLFOX Chemotherapy with Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L)

Disease Site: Esophagus, Other Digestive Organ

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CLINICAL TRIAL 20484

A Phase 2 Study of Donor-Derived Multi-Tumor-Associated Antigen Specific T Cells (MT-401) Administered to Patients with Acute Myeloid Leukemia (AML) following Hematopoietic Stem Cell Transplantation

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast, Leptomeningeal (LMD)

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CLINICAL TRIAL 20490

Keystroke: A Randomized Phase II Study of Pembrolizumab (Keytruda) Plus Stereotactic Re-irradiation versus SBRT Alone For Locoregionally Recurrent or Second Primary Head and Neck Carcinoma

Disease Site: Other Skin

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CLINICAL TRIAL 20491

A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase III Trial of Alpha 1 Antitrypsin (AAT) Combined with Corticosteroids vs Corticosteroids Alone for the Treatment of High Risk Acute Graft-versus-Host Disease (GVHD Following Allogeneic Hematopoietic Stem Cell Transplant

Disease Site: Graft vs Host Disease (GVHD), Unknown Sites

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CLINICAL TRIAL 20494

A Phase II Study of High Dose Bolus IL2 in Combination with Low Dose Ipilimumab Followed Sequentially by Nivolumab in Patients with Inoperable Stage III or Stage IV Melanoma Who Have Failed Prior Anti-PD1 Immunotherapy

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20497

A Multicenter, Open-Label Phase 1/2 Trial Evaluating the Safety, Tolerability and Efficacy of MORAb-202, a Folate Receptor Alpha (FRA)-Targeting Antibody-Drug Conjugate (ADC) in Subjects with Selected Tumor Types

Disease Site: Ovary

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CLINICAL TRIAL 20530

Multicenter, Phase II, Neoadjuvant and Adjuvant Study of Alectinib, Entrectinib, or Vemurafenib Plus Cobimetinib in Patients with Stages I-III Non-Small Cell Lung Cancer with ALK, ROS1, NTRK, or BRAF V600E Molecular Alterations

Disease Site: Lung

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CLINICAL TRIAL 20552

A Phase 1b/2 Study Evaluating the Safety and Efficacy of Canakinumab with Darbepoetin alfa in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) who have Failed Erythropoietin Stimulating Agents (ESA)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20578

A Single-Arm, Open-Label, Phase 1/2 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmocodynamics of ALLO-501A, an Anti-CD19 Allogeneic Car T Cell Therapy in Subjects with Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

Disease Site: Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20608

A Phase 1/2 Study Evaluating the Safety and Efficacy of IOV-2001 in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Disease Site: Chronic Leukemia (CLL, CML), Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20631

Randomized Prospective Trial of Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 20641

A Randomized Pilot Trial of Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib and Binimetinib in Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20712

A Phase I Study of Ipilimumab and Nivolumab in Advanced HIV- Associated Solid Tumors, with Expansion Cohorts in HIV-Associated Solid tumors and a Cohort of HIV- Associated Classical Hodgkin Lymphoma

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20720

S1827, MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Disease Site: Small cell lung cancer, Lung

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CLINICAL TRIAL 20722

Phase III Randomized Trial of Pleurectomy/Decortication plus Chemotherapy with or without Adjuvant Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) for Malignant Pleural Mesothelioma (MPM)

Disease Site: Lung

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CLINICAL TRIAL 20731

Phase 2 Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

Disease Site: Other Skin, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 20733

A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzomab Ozogamicin (a conjugated anti-CD22 monoclonal antibody) to Frontline Therapy in Young Adults (ages 18-39 years) with Newly Diagnosed Precusor B-cell ALL

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20737

Expanded Access Protocol (EAP) for Subjects Receiving Lisocabtagene Maraleucel That is Nonconforming for Commercial Release

Disease Site: Hodgkin's Lymphoma, Lymphoid Leukemia, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20743

A Multiple-center Phase 2 Study of Acalabrutinib-Lenalidomide-Rituximab in Patients with Previous Untreated Mantle Cell Lymphoma

Disease Site: Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20749

A Phase 1, Open Label Dose Escalation Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients with Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Disease Site: Leukemia, other, Lymphoid Leukemia, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20751

A Phase 1/2, Open-Label, Dose-Escalation Trial of GEN3013 in Patients with Relapsed, Progressive or Refractory B-Cell Lymphoma

Disease Site: Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 20752

A Phase 1 Study of Vyxeos Plus Gilteritinib in Relapsed or Refractory, FLT3-Mutated Acute Myeloid Leukemia

Disease Site: Leukemia, other, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20760

Open-Label, Multicenter, Phase 1b /2 Clinical Trial to Evaluate the Safety and Efficacy of Autologous Anti-claudin18.2 Chimeric Antigen Receptor T-cell Therapy in Subjects with Advanced Gastric, Pancreatic, or Other Specified Digestive System Cancers

Disease Site: Pancreas, Stomach

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CLINICAL TRIAL 20767

Integration of Immunotherapy into Adjuvant Therapy For Resected NSCLC: Alchemist Chemo-IO

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20773

Neoadjuvant Lenvatinib Plus Pembrolizumab in Resectable Merkel Cell Carcinoma

Disease Site: Other Skin, Merkel cell carcinoma

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CLINICAL TRIAL 20778

Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym M (ALVR-105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant

Disease Site: Unknown Sites

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CLINICAL TRIAL 20794

Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma: Safety and Biomarker Analysis

Disease Site: Other Skin, Merkel cell carcinoma

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CLINICAL TRIAL 20825

A First-in-human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with Intrahepatic Cholangiocarcinoma (ICC) and Other Advanced Solid Tumors

Disease Site: Other Digestive Organ, Bile Duct Cancer / Cholangiocarcinoma

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CLINICAL TRIAL 20827

An Open-Label, Multi-Center Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T cells in Patients with Advanced Non-Small Cell Lung Cancer (CHIRON)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20832

A Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization in Patients with Localized Prostate Carcinoma and Obstructive Lower Urinary Tract Symptoms

Disease Site: Prostate

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CLINICAL TRIAL 20837

Envasarc: A Pivitol Trial of Envafolimab, and Envafolimab in Combination with Ipilimumab, in Patients with Advanced or Metastatic Undifferentiated Pleomorphic Sarcoma or Myxofibrosarcoma Who Have Progressed on Prior Chemotherapy

Disease Site: Bones and Joints, Sarcoma

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CLINICAL TRIAL 20838

A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation, With a Substudy in Subjects With Relapsed or Refractory Myelodysplastic Syndrome and a Substudy in Subjects With Advanced Hematologic Malignancies With Organ Impairment

Disease Site: Leukemia, other, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20848

Phase I/II Study of REGN5668 (MUC16 x CD28, A Costimulatory Bispecific) Administered In Combination With Cemiplimab or REGN4018 (MUC16 x CD3)

Disease Site: Other Female Genital, Ovary

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CLINICAL TRIAL 20854

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

Disease Site: Melanoma, skin, Other Skin

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CLINICAL TRIAL 20871

A Phase 3, Open-label, Randomized, Multicenter Study of Ravulizumab in Adult and Adolescent Participants who have Thrombotic Microangiopathy (TMA) after Hematopoietic Stem Cell Transplant (HSCT)

Disease Site: Unknown Sites

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CLINICAL TRIAL 20872

An Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204)

Disease Site: Other Female Genital

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CLINICAL TRIAL 20873

A Phase 1b, Open-Label Study of Relacorilant in Combination with Pembrolizumab for Patients with Adrenocortical Carcinoma with Excess Glucocorticoid Production

Disease Site: Adrenal, Adrenalcortical cancer

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CLINICAL TRIAL 20877

A Phase Ib /Randomized Phase III Trial of Patients with Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation with Either Orca-T, a T-cell-Depleted Graft with Additional Infusion of Conventional T cells and Regulatory T cells, or Standard-of-Care Allogeneic Graft

Disease Site: Leukemia, other, Lymphoid Leukemia, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20894

Acalabrutinib for Chronic Graft-versus-Host Disease

Disease Site: Unknown Sites

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CLINICAL TRIAL 20897

Phase 1 Dose-Escalation, Dose-Expansion Trial of Intratumoral HER2- and HER3-Primed Dendritic Cells Injections for the Treatment of Early-Stage TNBC and ER Low Positive Breast Cancer (DecipHER)

Disease Site: Breast

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CLINICAL TRIAL 20898

A Modular Phase 2a Multicentre Open-Label Study to Investigate DNA-damage Response Agents (or Combinations) in Patients With Advanced Cancer Whose Tumours Contain Molecular Alterations (PLANETTE)

Disease Site: Any Site, Breast, Colorectal, Endometrial/Uterine, Extrapulmonary small cell lung cancer, Gallbladder, Gastric / Stomach, Gastrinoma, Gastrointestinal, Liver, Lung, Non small cell lung cancer, Other genitourinary, Other GI, Pancreas, Prostate, Reproductive System, Urinary Bladder, Uterus

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CLINICAL TRIAL 20899

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20904

A Randomized Phase 2 Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in Braf-V600 Mutant Melanoma with Brain Metastases

Disease Site: Melanoma, skin

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CLINICAL TRIAL 20911

MRI Guided Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma to Enhance Complete Response

Disease Site: Rectum

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CLINICAL TRIAL 20919

An Open-label, Single-arm, Multicohort, Phase 2 Study to Assess the Efficacy and Safety of Tabelecleucel in Subjects with Epstein-Barr Virus-associated Diseases

Disease Site: Other Hematopoietic

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CLINICAL TRIAL 20923

A Phase I/II Trial of Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms

Disease Site: Leukemia, other, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20936

DuRvalumab (MEDI4736) with ChEmotherapy as First Line TreAtment in Advanced Pleural Mesothelioma - A Phase 3 Randomised Trial (DREAM3R)

Disease Site: Lung, Mesothelioma

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CLINICAL TRIAL 20937

A Multicenter, Phase II Trial of Pembrolizumab and Sunitinib In Refractory Advanced Thymic Carcinoma

Disease Site: Other Respiratory and Intrathoracic Organs

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CLINICAL TRIAL 20938

A Randomized Phase II Trial of Adjuvant Pembrolizumab Versus Observation Following Curative Resection for Stage I Non-Small Cell Lung Cancer (NSCLC) with Primary Tumors Between 1-4 cm

Disease Site: Lung

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CLINICAL TRIAL 20943

Combination of Ipi/Nivo Plus Sacituzumab Govitecan in Metastatic Cisplatin Ineligible Urothelial Carcinoma Patients

Disease Site: Other Urinary, Urinary Bladder, Urothelial Cancer

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CLINICAL TRIAL 20950

A Phase I/II, Open Label, Multi-center, Non-randomized Dose Escalation and Dose Expansion Study of AMXI-5001 in Patients with Advanced Malignancies

Disease Site: Any Site

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CLINICAL TRIAL 20955

A Phase II Study of Binimetinib plus Belinostat for Subjects with Metastatic Uveal Melanoma

Disease Site: Other Skin

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CLINICAL TRIAL 20963

A Phase 2 Study of Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21023

Open Label, Multicenter Phase II Study of the C5A- Antibody IFX-1 Alone or IFX-1 + Pembrolizumab in Patients with PD-1- or PD-L1-Resistant/Refractory Locally Advanced or Metastatic Cutaneous Squamous Cell Carcinoma (CSCC)

Disease Site: Other Skin

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CLINICAL TRIAL 21027

A Phase 2 Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Metastatic Non-Small-Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 21035

A Pilot Study of Siltuximab in Large Granular Lymphocytic Leukemia (LGLL)

Disease Site: Lymphoid Leukemia

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CLINICAL TRIAL 21038

GRECO-2: A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in combination with GC4711 in the Treatment of Unresectable or Borderline Resectable, Nonmetastatic Pancreatic Cancer

Disease Site: Pancreas

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CLINICAL TRIAL 21039

A Pivotal Randomized, Open-Label Study Of OPTUNE(R)(TTFIELDS, 200KHZ) Concomitant With Radiation Therapy And Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 21046

Phase I Trial with Expansion Cohort of Obp-301 (Telomelysintm) And Definitive Chemoradiation For Patients with Locally Advanced Esophageal And Gastroesophageal Adenocarcinoma Who Are Not Candidates For Surgery

Disease Site: Esophagus

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CLINICAL TRIAL 21056

A Phase 1b/2, Open-Label, Safety and Efficacy Study of Epcoritamab (GEN3013; DuoBody®-CD3 X CD20) in Relapsed/Refractory Chronic Lymphocytic Leukemia

Disease Site: Lymphoid Leukemia

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CLINICAL TRIAL 21057

A Randomized, Double-Blind, Phase 3 Study Evaluating the Safety and Efficacy of Venetoclax in Combination with Azacitidine in Patients Newly Diagnosed with Higher-Risk Myelodysplastic Syndrome (Higher-Risk MDS)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21060

A Pilot Study of Ibrutinib and R-da-EPOCH for Front Line Treatment of AIDS-Related Lymphomas

Disease Site: Any Site

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CLINICAL TRIAL 21074

A Phase 2 Randomized Study of Osimertinib Versus Osimertinib Plus Chemotherapy for Patients with Metastatic EGFR-Mutant Lung Cancers That Have Detectable EGFRMutant cfDNA in Plasma After Initiation of Osimertinib

Disease Site: Lung

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CLINICAL TRIAL 21080

A Phase 1, Open-Label, Dose-Escalation, and Dose-Expansion Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SRK-181 Administered Alone or in Combination with a Checkpoint Inhibitor in Patients with Locally Advanced or Metastatic Solid Tumors (DRAGON)

Disease Site: Any Site, Lung, Melanoma, skin, Urinary Bladder

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CLINICAL TRIAL 21090

A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects with IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) that is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) Treatment

Disease Site: Myelodysplastic syndrome (MDS), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21094

An Open Label, Multi-Cohort, Multi-Center Phase II Study Evaluating the Efficacy and Safety of IPH4102 Alone or in Combination with Chemotherapy in Patients with Advanced T-cell Lymphoma

Disease Site: Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21096

A Phase I Study of Duvelisib in Combination with CC-486 in Lymphoid Malignancy

Disease Site: Lymphoid Leukemia, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21112

Phase 2 Study of Axitinib + Ipilimumab in Advanced Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21113

A Phase I Clinical Trial of an Infusion of Autologous T Cells Genetically Engineered with a Chimeric Receptor to Target the Follicle-Stimulating Hormone Receptor in Patients with Recurrent Ovarian Cancer

Disease Site: Ovary

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CLINICAL TRIAL 21116

Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx, Head & Neck, Squamous Cell Carcinoma (SCC)

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CLINICAL TRIAL 21117

A Phase 1 Multicenter Study Evaluating the Safety and Efficacy of ALLO-316 Following ALLO-647 Containing Conditioning Regimen in Subjects with Advanced or Metastatic Clear Cell Renal Cell Carcinoma (ccRCC)

Disease Site: Kidney

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CLINICAL TRIAL 21119

A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Alone and In Combination with Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

Disease Site: Ovary

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CLINICAL TRIAL 21122

A Multicenter, Phase 1, Open-label, Dose-escalation and Expansion Study of TNB-486, a Bispecific Antibody Targeting CD19 in Subjects with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Disease Site: Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21126

A Phase 1 Open-label, Multicenter Study Evaluating the Safety of KITE-222, an Autologous Anti-CLL-1 CAR T-cell Therapy, in Subjects with Relapsed/Refractory Acute Myeloid Leukemia

Disease Site: Leukemia, other

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CLINICAL TRIAL 21129

A Phase 1/1b, Open-Label, Multicenter, Dose-Escalation Study of RMC-5552 Monotherapy in Adult Subjects with Relapsed/Refractory Solid Tumors

Disease Site: Any Site

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CLINICAL TRIAL 21131

A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21135

Randomized, Placebo-Controlled, Phase II Trial Examining Ustekinumab for Prevention of Graft vs. Host Disease after Allogeneic Hematopoietic Cell Transplantation

Disease Site: Unknown Sites

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CLINICAL TRIAL 21136

Phase 2 Clinical Trial of Radiomic Habitat-Directed Radiation Dose Escalation for High-Grade Soft Tissue Sarcoma

Disease Site: Soft Tissue

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CLINICAL TRIAL 21139

A Phase IIA Study of Sequential ("first strike, second strike") Therapies, Modeled on Evolutionary Dynamics of Anthropocene Extinctions, for High Risk Metastatic Castration Sensitive Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 21140

Phase I Trial With Expansion Cohort Of DNA-PK Inhibition And IMRT In Cisplatin-Ineligible Patients With Stage 3-4 Local-Regionally Advanced Head And Neck Squamous Cell Carcinoma (HNSCC)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21142

A Phase 1b, Multicenter, Open-label Platform Study of Select Drug Combinations in Adult Patients with Lower Risk (Very Low, Low, or Intermediate Risk) Myelodysplastic Syndrome (CMBG453E12101)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21157

A Phase I/Ib Open-Label, Multi-Center, Dose-Escalation Study To Investigate The Safety, Pharmacokinetics And Preliminary Efficacy Of Intravenous NBF-006 In Patients With Non-Small Cell Lung, Pancreatic, Or Colorectal Cancer Followed By A Dose Expansion Study In Patients With KRAS-Mutated Non-Small Cell Lung Cancer

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 21163

A Phase 1/2 Study of Regn7075 (Egfrxcd28 Costimulatory Bispecific Antibody) in Combination with Cemiplimab in Patients with Advanced Solid Tumors

Disease Site: Anus, Breast, Cervix, Colon, Esophagus, Kidney, Lip, Oral Cavity and Pharynx, Lung, Other Digestive Organ, Other Female Genital, Other Male Genital, Other Skin, Other Urinary, Pancreas, Prostate, Stomach

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CLINICAL TRIAL 21167

A Phase 1/2 Open-label Study Investigating the Safety, Tolerability and Efficacy of ASP7517 in Subjects with Relapsed/Refractory Acute Myeloid Leukemia (AML) and Relapsed/Refractory Higher Risk Myelodysplastic Syndrome (MDS)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21180

A First-in-Human, Two-Part, Open-Label, Clinical Study to Assess the Safety, Tolerability and Activity of Intravenous Doses of ICT01 as Monotherapy and in Combination with an Immune Checkpoint Inhibitor, in Patients with Advanced-Stage, Relapsed/Refractory Cancer (EVICTION Study)

Disease Site: Any Site, Breast, Colon, Larynx, Leukemia, other, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Ovary, Prostate, Stomach, Urinary Bladder

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CLINICAL TRIAL 21186

ACCESS: A Multi-Center, Phase II Trial of HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide for Patients with Hematologic Malignancies

Disease Site: Leukemia, other, Lymphoid Leukemia, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21192

A Phase 2 Study of the Combination Dostarlimab with Niraparib In Patients with Penile Carcinoma Who Have Progressed Following Chemotherapy

Disease Site: Other Male Genital

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CLINICAL TRIAL 21209

A Phase 1, Open Label, Multiple-Ascending Dose Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Efficacy of KD033 In Subjects With Metastatic Or Locally Advanced Solid Tumors

Disease Site: Any Site

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CLINICAL TRIAL 21213

A Single-Arm, Open-Label Phase 1b Study of Hyper-CVAD + Calaspargase pegol in Young Adults with Newly Diagnosed Acute Lymphoblastic Leukemia

Disease Site: Lymphoid Leukemia

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CLINICAL TRIAL 21222

Older Non-Small Cell Lung Cancer Patients (>/= 70 Years of Age) Treated With First-Line Mk-3475 (Pembrolizumab) +/- Chemotherapy (Oncologist s/Patient s Choice) A171901

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 21227

A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients with Treatment Naïve Metastatic Pancreatic Cancer (GIANT)

Disease Site: Pancreas

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CLINICAL TRIAL 21228

A Phase 1/2 Open-Label, Dose-Escalation and Clinical Response Study of Quaratusugene Ozeplasmid in Combination with Pembrolizumab versus Docetaxel with or without Ramucirumab in Patients with Previously Treated Non-Small Cell Lung Cancer (Acclaim 2)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 21239

Randomized Phase II/III Study of Nivolumab plus Ipilimumab plus Sargramostim versus Nivolumab plus Ipilimumab in Patients with Unresectable Stage III or Stage IV Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21248

A Phase 3, Randomized, Open-Label Study Evaluating the Safety and Efficacy of Magrolimab in Combination with Azacitidine versus Physician s Choice of Venetoclax in Combination with Azacitidine or Intensive Chemotherapy in Previously Untreated Patients with TP53 Mutant Acute Myeloid Leukemia

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21249

A Phase 2, Open-Label, Multi-Center Study of Venetoclax in Combination with Carfilzomib and Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 21257

A Phase 1 First-in-Human Study with ABBV-155 Alone and in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors

Disease Site: Breast, Lung

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CLINICAL TRIAL 21273

A Randomized, Pilot Study to Evaluate the Molecular and Cellular Response to Treatment with Nivolumab with either Adjuvant Ipilimumab or Relatlimab in Adult Patients with Surgically Resectable Melanoma Brain Metastases

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21336

A Phase I/Ib Global, Multicenter, Open-Label Umbrella Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients with Metastatic Colorectal Cancer (Intrinsic)

Disease Site: Colon

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CLINICAL TRIAL 21344

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients with Melanoma (Morpheus-Melanoma)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21366

Administration of HIV-specific T Cells to HIV+ Patients Receiving High Dose Chemotherapy Followed by Autologous Stem Cell Rescue -Auto-RESIST

Disease Site: Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21372

A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY314 as a Single Agent and In Combination with Pembrolizumab in Subjects with Advanced Solid Tumors

Disease Site: Ill-Defined Sites

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CLINICAL TRIAL 21378

Phase 1 Study of Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine and Pepinemab / Trastuzumab in Patients with Metastatic HER2-Positive Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 21381

A Phase 1b Dose Escalation Study of BOLD-100 in Combination with FOLFOX Chemotherapy in Patients with Advanced Solid Tumours

Disease Site: Pancreas

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CLINICAL TRIAL 21383

A Prospective, Randomized, Controlled, Open-label, Multicenter Trial to Evaluate Efficacy, Safety and Patient-reported Outcomes of Peptide Receptor Radionuclide Therapy (PRRT) with Lutetium (177Lu) Edotreotide compared to Best Standard of Care in Patients with Well-differentiated Aggressive Grade 2 and Grade 3, Somatostatin Receptor-positive (SSTR+), Neuroendocrine Tumors of GastroEnteric or Pancreatic Origin (COMPOSE)

Disease Site: Other Digestive Organ, Other Endocrine System

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CLINICAL TRIAL 21399

Phase I Study of MEM-288 Oncolytic Virus in Solid Tumors Including Non-Small Cell Lung Cancer (NSCLC)

Disease Site: Lung

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CLINICAL TRIAL 21405

Phase 2, Single Arm Study of Luspatercept for the Treatment of Anemia in lower Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21410

A Phase 1 Study of ZN-c3 as a Single Agent in Subjects with Solid Tumors

Disease Site: Ovary

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CLINICAL TRIAL 21412

A Phase 3 Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of AB-205 plus Standard of Care versus Placebo plus Standard of Care in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT-AHCT) (E-CELERATE)

Disease Site: Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21421

A Phase 3 (Pivotal Stage) Study of NBTXR3 Activated by Investigators Choice of Radiotherapy Alone or Radiotherapy in Combination with Cetuximab for Platinum-based Chemotherapy-ineligible Elderly Patients with Locally Advanced Head & Neck Squamous Cell Carcinoma

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21433

A Phase 1 and 2a open-label trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity of LAVA-1207, a PSMA-targeting bispecific γδ-T cell engager, in patients with therapy refractory metastatic castration resistant prostate cancer

Disease Site: Other

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CLINICAL TRIAL 21450

A Phase 1/1b Dose Escalation and Expansion of CPX-351 in Combination with Gemtuzumab Ozogamicin in Newly Diagnosed Acute Myeloid Leukemia

Disease Site: Myeloid and Monocytic Leukemia, Acute Leukemia (ALL, AML)

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CLINICAL TRIAL 21459

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

Disease Site: Colon

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CLINICAL TRIAL 21460

Phase Ib Trial of Erdafitinib Combined with Enfortumab Vedotin Following Platinum and PD1/L1 Inhibitors for Metastatic Urothelial Carcinoma with FGFR2/3 Genetic Alterations

Disease Site: Other Urinary

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CLINICAL TRIAL 21513

A Phase 1 Study of KZR-261, a Small Molecule Sec61 Inhibitor, in Subjects with Advanced Solid Malignancies

Disease Site: Any Site

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CLINICAL TRIAL 21518

A Phase 1/1b Open-Label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN-2787 in Participants with BRAF and/or NRAS Mutation Positive Solid Tumors

Disease Site: Any Site

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CLINICAL TRIAL 21534

Randomized Phase III Trial of MEDI4736 (Durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC

Disease Site: Lung

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CLINICAL TRIAL 21550

A Phase 1, Multi-center, Open-label, Dose Finding Study of CC-92328 in Subjects with Relapsed and/or Refractory Multiple Myeloma

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 21553

A Multicenter, Randomized, Double-Blind Phase 3 Study of HBI-8000 Combined with Nivolumab versus Placebo with Nivolumab in Patients with Unresectable or Metastatic Melanoma Not Previously Treated with PD-1 or PD-L1 Inhibitors

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21573

An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients with Hepatic Dominant Ocular Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21580

A Phase 1 Study of PBCAR19B in Subjects with CD19-expressing Malignancies

Disease Site: Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21587

A Dose-escalation Study of the Safety and Pharmacology of DAN 222 in Subjects with Metastatic Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 21606

Phase 1/2, Double-Blind, Placebo-Controlled, Dose Escalation and Expansion Study of ALVR106 in Addition to Standard of Care for the Treatment of High-Risk Patients with Respiratory Viral Infections After Hematopoietic Cell Transplant

Disease Site: Unknown Sites

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CLINICAL TRIAL 21609

A Phase I Dose Escalation And Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, And Anti-Tumor Activity Of PF-07260437 In Advanced Or Metastatic Solid Tumors

Disease Site: Breast

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CLINICAL TRIAL 21622

A Phase 1/1b Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients with Advanced Hematologic and Solid Tumor Malignancies

Disease Site: Breast, Hodgkin's Lymphoma, Leukemia, other

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CLINICAL TRIAL 21623

A Phase 1/2 Study of bbT369, a Dual Targeting CAR T cell Drug Product with a Gene Edit, in Relapsed and/or Refractory B cell Non-Hodgkin s Lymphoma

Disease Site: Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21636

A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors

Disease Site: Breast, Colon, Prostate, Urinary Bladder

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CLINICAL TRIAL 21641

First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGF_ Fusion Protein BCA101 Alone and in Combination with Pembrolizumab in Patients With EGFR-Driven Advanced Solid Tumors

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21652

An Open-label, Multicenter, Phase 2 Study of Sacituzumab Govitecan Combinations in First-line Treatment of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) Without Actionable Genomic Alterations

Disease Site: Lung

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CLINICAL TRIAL 21657

Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21664

Phase 1b/3 z=Global, Randomized, Controlled, Open-Label Trial Comparing Treatment with RYZ101 to Standard of Care (SoC) Therapy in Subjects with Inoperable, Advanced, Somatostatin Receptor Expressing (SSTR+), Well-Differentiated Gastro-Enteropancreatic Neuroendocrine Tumors (GEP-NETs) that have Progressed Following Prior 177Lulabelled Somatostatin Analogue (177Lu-SSA) Therapy (ACTION-1).

Disease Site: Esophagus, Other Digestive Organ, Pancreas, Small Intestine, Stomach

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CLINICAL TRIAL 21665

Randomized Phase II Trial of Postoperative Adjuvant Capecitabine And Temozolomide Versus Observation in High-Risk Pancreatic Neuroendocrine Tumors

Disease Site: Other Digestive Organ, Pancreas

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CLINICAL TRIAL 21666

A Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of TST001 in Patients with Locally Advanced or Metastatic Solid Tumors

Disease Site: Other Digestive Organ

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CLINICAL TRIAL 21673

A Randomized, Multicenter, Placebo-controlled, Phase 3 study to Evaluate the Efficacy and Safety ofHER2/neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/neu Positive Subjects with Residual Disease or High-Risk PCR after both Neoadjuvant and Postoperative Adjuvant Trastuzumab-based Therapy(FLAMINGO-01)

Disease Site: Breast

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CLINICAL TRIAL 21691

A Multi-center, Double-Blind, Randomized Phase 3 Study to Compare the Efficacy and Safety of Belzutifan (MK-6482) plus Pembrolizumab (MK- 3475) Versus Placebo plus Pembrolizumab, in the Adjuvant Treatment of Clear Cell Renal Cell Carcinoma (ccRCC) Post Nephrectomy (6482-022)

Disease Site: Kidney

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CLINICAL TRIAL 21696

A Phase 1/2 Dose-Escalation and Dose-Expansion of the Safety and Efficacy of Anti-CD7 Allogeneic CAR-T cells (WU-CART-007) in Patients with Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia /Lymphoblastic Lymphoma (T-ALL)/Lymphoblastic Lymphoma (LBL)

Disease Site: Lymphoid Leukemia, Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21698

A Phase 2, Multicenter, Open-Label Study of Lurbinectedin Efficacy and Safety in Participants with Advanced or Metastatic Solid Tumors

Disease Site: Ill-Defined Sites, Lung, Urinary Bladder

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CLINICAL TRIAL 21701

A Phase 1/1b Dose Escalation/Expansion Study of NGM831 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

Disease Site: Any Site, Breast, Cervix, Esophagus, Kidney, Larynx, Lip, Oral Cavity and Pharynx, Liver, Lung, Other Digestive Organ, Ovary

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CLINICAL TRIAL 21707

A Proof of Concept Study of TBio-4101 (an autologous selected and expanded tumor infiltrating lymphocyte [TIL] therapy) using Short-Term Cultured, Selected Autologous TIL Following a Lymphodepleting Chemotherapy Regimen and Followed by IL-2 for Patients with Relapsed or Refractory Melanoma (Phase 1)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21712

A Phase 2 Open Label Study to Evaluate the Safety and Effectiveness of 212Pb-DOTAMTATE in PRRT Naïve Subjects with Somatostatin Receptor Expressing Neuroendocrine Tumors

Disease Site: Any Site, Liver, Lung, Other Digestive Organ, Other Endocrine System, Pancreas, Rectum, Small Intestine, Stomach

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CLINICAL TRIAL 21728

A Phase I/II Study of TTI-621 in Combination with Doxorubicin in Patients with Unresectable or Metastatic High-Grade Leiomyosarcoma

Disease Site: Soft Tissue

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CLINICAL TRIAL 21731

A Phase II Trial of Olaparib in Combination with Pembrolizumab for Advanced Uveal Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21741

A Phase 1 Study of AGEN2373, an Anti-CD137 Monoclonal Antibody, as Monotherapy and in Combination with AGEN1181, an Fc-Enqineered Anti-CTLA-4 Monoclonal Antibody, in Patients with Advanced Cancer

Disease Site: Any Site

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CLINICAL TRIAL 21756

A Phase 3 Study of the Hepcidin Mimetic Rusfertide (PTG-300) in Patients with Polycythemia Vera

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21757

Phase II Study of Genomically Guided Radiation Dose Personalization in the Management of Triple Negative Breast Cancer

Disease Site: Breast

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CLINICAL TRIAL 21761

A Phase 1 First-in-Human Dose-escalation and Dose-expansion Study of BMF-219, an Oral Irreversible Menin Inhibitor, in Adult Patients with Acute Leukemia Including Those with an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Disease Site: Lymphoid Leukemia, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21778

An Open-Label Phase 1A/1B Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPα-Fc-CD40L) in Combination With Azacitidine or With Azacitidine and Venetoclax for the Treatment of Subjects With Higher-Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)

Disease Site: Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21850

Phase 1/1b, Multicenter, Open-Label, Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects with Advanced KRASG12C Mutant Solid Tumors

Disease Site: Lung

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CLINICAL TRIAL 21870

A Phase 2 trial of Nirogacestat in Patients with Recurrent Ovarian Granulosa Cell Tumors

Disease Site: Ovary

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CLINICAL TRIAL 21879

Phase 1 Study of the PKMYT1 Inhibitor RP-6306 in Combination With FOLFIRI for the Treatment of Advanced Solid Tumors (MINOTAUR Study)

Disease Site: Esophagus, Other Digestive Organ

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CLINICAL TRIAL 21880

Risk-Adapted Therapy of HIV-Associated Anal Cancer

Disease Site: Anus

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CLINICAL TRIAL 21892

A Phase 2, Single-Arm, Open-Label Study using Itacitinib as Pre-Modulation in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Receiving CAR-T-Cell Therapy

Disease Site: Non-Hodgkin's Lymphoma

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CLINICAL TRIAL 21894

Phase 1 Clinical Trial of lntravesical Adoptive Cell Therapy {ACT) with Tumor Infiltrating Lymphocytes (TIL) for Patients with BCG Unresponsive High Grade Non-Muscle Invasive Bladder Cancer {NMIBC)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 21899

Phase Ib Expansion Study of CX-5461 in Patients with Solid Tumours and BRCA2 and/or PALB2 Mutation

Disease Site: Breast, Other Female Genital, Ovary, Pancreas, Prostate

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CLINICAL TRIAL 21901

Phase 1 Study of the PKMYT1 Inhibitor RP-6306 in Combination with Gemcitabine for the Treatment of Advanced Solid Tumors (MAGNETIC Study)

Disease Site: Ovary

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CLINICAL TRIAL 21913

A Phase 3 Study of CG0070 In Patients with Non- Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG)

Disease Site: Urinary Bladder

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CLINICAL TRIAL 21937

A Prospective, Multi-Center, Randomized, Double-Arm Trial to Determine the Impact of the SELENE System on Positive Margin Rates in Breast Conservation Surgery

Disease Site: Breast

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CLINICAL TRIAL 21945

Phase 2, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Topically Administered LUT014 in Metastatic Colorectal Cancer Patients with EGFR Inhibitor Induced Acneiform Lesions Protocol

Disease Site: Colon

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CLINICAL TRIAL 21964

Phase 2, Multicenter, Open-Label Basket Study of Navicixizumab Monotherapy or in Combination with Paclitaxel or Irinotecan in Patients with Select Advanced Solid Tumors

Disease Site: Other Digestive Organ

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CLINICAL TRIAL 21971

Phase I Clinical Trial of CD40L-augmented Tumor Infiltrating Lymphocytes (CD40L TIL) for Patients with Oncogene-Driven Advanced Non-Small Cell Lung Cancer (NSCLC)

Disease Site: Lung

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CLINICAL TRIAL 21989

Pivotal Study of the NanoKnife System for Ablation of Prostate Tissue in an Intermediate-Risk Patient Population

Disease Site: Prostate

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CLINICAL TRIAL 21997

Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

Disease Site: Other Skin

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CLINICAL TRIAL 22003

A Phase II Randomized Study of Sipuleucel-T with or without Continuing New Hormonal Agents (NHA) in Metastatic Prostate Cancer with PSA Progression while on NHA and LHRH Analog

Disease Site: Prostate

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CLINICAL TRIAL 22068

A Phase 1 Study of the SHP2 Inhibitor BBP-398 (formerly known as IACS-15509) in Combination with the Programmed Death Receptor-1 Blocking Antibody Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer with a KRAS Mutation

Disease Site: Lung

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CLINICAL TRIAL 22071

Melanoma Margins Trial (MelMarT): A Phase III, multi-centre, multi-national randomised control trial investigating 1cm v 2cm wide excision margins for primary cutaneous melanoma

Disease Site: Other

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CLINICAL TRIAL 22102

A Phase 1b, First-in-human, Dose Escalation and Expansion, Multicenter Study of XMT-1660 in Participants with Solid Tumors

Disease Site: Breast, Other Female Genital, Ovary

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CLINICAL TRIAL 22112

A Phase 1, Open-Label, Dose Escalation and Expansion Study of CUE-102 Monotherapy in HLA-A*0201 Positive Patients with WTl Positive Recurrent/Metastatic Cancers

Disease Site: Esophagus, Other Digestive Organ

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CLINICAL TRIAL 22449

Expanded Access Program for belantamab mafodotin in Patients with Relapsed/Refractory Multiple Myeloma who are Refractory to a Proteasome Inhibitor, and an Immunomodulatory Agent, and an Anti-CD38 Antibody

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 90001

A Phase 2, Multicenter, Single-Arm Study of Retreatment with Brentuximab Vedotin in Subjects with Relapsed or Refractory Classic Hodgkin lymphoma (cHL) or CD30-Expressing Peripheral T Cell Lymphoma (PTCL)

Disease Site: Hodgkin's Lymphoma

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CLINICAL TRIAL 90005

Phase Ib First in Human Dose Escalation of GT103 in Refractory, Advanced Stage Non-Small Cell Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 90009

A Multicentre, Open-label, Non-randomised First in Human Study of NG-641, an Oncolytic Transgene Expressing Adenoviral Vector, in Patients With Metastatic or Advanced Epithelial Tumours (STAR)

Disease Site: Any Site

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CLINICAL TRIAL 90016

A Phase 1b Open-Label Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination with Other Anti-cancer Agents in Patients with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Disease Site: Other Hematopoietic

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CLINICAL TRIAL 90035

A Phase Ib, Open-Label, Multicenter, Single Arm Study Evaluating The Preliminary Efficacy, Safety, And Pharmacokinetics Of Glofitamab In Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate In Patients With Relapsed/Refractory Transplant Eligible Diffuse B-Cell Lymphoma

Disease Site: Unknown Sites

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CLINICAL TRIAL 22177

Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (cilta-cel) Out-of-Specification (OOS) in Patients with Multiple Myeloma

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain metastasis, Gliomas, Leptomeningeal (LMD), Meningiomas

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CLINICAL TRIAL 20413

Phase III Study Of Daratumumab/Rhuph20 (Nsc- 810307) + Lenalidomide Or Lenalidomide As Post-Autologous Stem Cell Transplant Maintenance Therapy In Patients With Multiple Myeloma (MM) Using Minimal Residual Disease To Direct Therapy Duration (DRAMMATIC STUDY)

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 20479

Efficacy of SOAR (Survivors Overcoming and Achieving Resiliency) Survivorship Workshop for Breast Cancer Survivors

Disease Site: Breast

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CLINICAL TRIAL 20551

Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress Among Young Adults with Cancer

Disease Site: Any Site

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CLINICAL TRIAL 20561

Randomized Trial of Prolonged Use of Negative Pressure Wound Therapy in Patients Undergoing Surgical Procedures for the Management of Gastrointestinal Malignancies

Disease Site: Other Digestive Organ

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CLINICAL TRIAL 21742

Tele-Resistance Training During Chemotherapy For Advanced Upper Gastrointestinal Cancer

Disease Site: Esophagus, Small Intestine, Stomach

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CLINICAL TRIAL 21795

Early Supportive Care and Nutritional Support in Adults with Pancreatic Cancer.

Disease Site: Pancreas

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CLINICAL TRIAL 21889

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Gastroesophageal Cancer (GEC) Patients

Disease Site: Esophagus

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CLINICAL TRIAL 22082

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Pancreatic Cancer Patients

Disease Site: Pancreas

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CLINICAL TRIAL 22110

AutoFOCUS: A Mindfulness-Based Intervention for Autologous HCT Cancer Caregivers

Disease Site: Other Hematopoietic

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CLINICAL TRIAL 22115

Feasibility Of Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy

Disease Site: Leukemia, other, Multiple Myeloma

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CLINICAL TRIAL 22117

STRONG-PD: Support Through Remote Observation And Nutrition Guidance (STRONG) Program For Cancer Patients With Peritoneal Disease

Disease Site: Colon, Other Digestive Organ

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CLINICAL TRIAL 22330

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors: A Randomized Clinical Trial

Disease Site: Larynx, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 19305

CD40-L Blockade for Prevention of Acute Graft-Versus-Host Disease

Disease Site: Other hematologic, Unknown Sites, Leukemia, other

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CLINICAL TRIAL 19622

Phase II Trial of Investigational Agents to Modulate Intermediate Endpoint Biomarkers, Including Pulmonary Nodules, in Former and Current Smokers

Disease Site: Lung

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CLINICAL TRIAL 20154

Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers

Disease Site: Other

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CLINICAL TRIAL 20337

Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living with HIV

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 21224

Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults

Disease Site: Unknown Sites

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CLINICAL TRIAL 21236

Improving Weight Loss Outcomes of Black Women Using a Culturally-Relevant Stress-Management Enhanced Behavioral Weight Loss Intervention

Disease Site: Unknown Sites

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CLINICAL TRIAL 21426

Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of Posoleucel (ALVR105, Viralym-M) Compared to Placebo for the Prevention of AdV, BKV, CMV, EBV, HHV-6, and JCV Infection and/or Disease, in High-Risk Patients After Allogeneic Hematopoietic Cell Transplant

Disease Site: Unknown Sites

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CLINICAL TRIAL 21885

Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)

Disease Site: Cervix

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CLINICAL TRIAL 21902

HPV Multilevel Intervention Strategies Targeting Immunization in Community Settings (HPV MISTICS)

Disease Site: Unknown Sites

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CLINICAL TRIAL 21940

M4OC-Prevent 2.0: Phase IIb Trial of Metformin for Oral Cancer Prevention

Disease Site: Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 19291

The Utility of PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men with High GC Decipher® Test Scores: A Sub-aim of the VANDAAM Study (MCC #18523)

Disease Site: Prostate

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CLINICAL TRIAL 19974

Contrast-Enhanced Ultrasound for the Evaluation of Changes in Tumor Blood Flow and the Surrounding Hepatic Parenchyma before, during and after Hepatic Artery Embolization

Disease Site: Liver

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CLINICAL TRIAL 20786

Efficacy Of A Mindfulness-Based Stress Management Program For Allogeneic HCT Caregivers

Disease Site: Other Hematopoietic

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CLINICAL TRIAL 21235

Clinical Trials Outreach & Education

Disease Site: Unknown Sites

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CLINICAL TRIAL 21767

Phase 2: Using Biomarkers for Diagnosis, Risk Stratification of Post-Treatment Recurrence and Long-Term Surveillance of Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 22152

Comparative effectiveness of Juntos Después del Cáncer (JDC) among Breast Cancer Survivors and their Intimate Partners

Disease Site: Breast

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CLINICAL TRIAL 21355

Prospective Cohort Study Of The Immune Response To Severe Acute Respiratory Coronavirus 2 (SARS-Cov2) In Oncology Workers: Protect Covid-19 Study

Disease Site: Unknown Sites

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CLINICAL TRIAL 14690

Total Cancer Care Protocol: A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer

Disease Site: Any Site

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CLINICAL TRIAL 15768

Total Lung Care (TLC): Epidemiology of Lung Cancer

Disease Site: Lung

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CLINICAL TRIAL 16028

Transdisciplinary Research in Colorectal Cancer: The ColoCare Study

Disease Site: Colorectal, Colon, Rectum

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CLINICAL TRIAL 16933

Older Breast Cancer Patients: Risk For Cognitive Decline

Disease Site: Breast

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CLINICAL TRIAL 17716

A Biomarker-related Approach to Screening for HPV-related Oropharyngeal Cancer

Disease Site: Larynx, Throat, Lip, Oral Cavity and Pharynx

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CLINICAL TRIAL 17723

Expansion of Enduring Infrastructure to Support Lung Cancer Screening Research

Disease Site: Lung

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CLINICAL TRIAL 18926

The National Myelodysplastic Syndromes (MDS) Study

Disease Site: Leukemia, other, Lymphoid Leukemia, Multiple Myeloma, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 19209

Combined Imaging and Blood Biomarkers for Breast Cancer Diagnosis

Disease Site: Breast

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CLINICAL TRIAL 19943

Somatostatin receptor expression in poorly-differentiated neuroendocrine carcinomas of the GI tract: analysis using 68Ga-dotatate PET scan

Disease Site: Pancreas, Gastrointestinal, Neuroendocrine, Other Endocrine System, Unknown Sites

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CLINICAL TRIAL 20010

IRONMAN: International Registry for Men with Advanced Prostate Cancer

Disease Site: Prostate

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CLINICAL TRIAL 20105

Using Radiogenomics to Noninvasively Predict the Malignant Potential of Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas and Uncover Hidden Biology

Disease Site: Pancreas

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CLINICAL TRIAL 20156

Mindfulness in AYA Patients Undergoing Hematopoietic Stem Cell Transplantation: A Pilot Proposal

Disease Site: Multiple Myeloma, Unknown Sites, Leukemia, other

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CLINICAL TRIAL 20256

CemiplimAb Survivorship Epidemiology (CASE) Study

Disease Site: Squamous Cell Carcinoma (SCC), Other Skin

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CLINICAL TRIAL 20335

Physician Initiated Evaluation of EnVisio SmartClip for Intraoperative Localization of Breast Masses

Disease Site: Breast

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CLINICAL TRIAL 20585

Development of a Quality of Life Decision-Making Model for Older Patients with Acute Myeloid Leukemia

Disease Site: Acute Leukemia (ALL, AML), Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 20788

An Advanced MRI Abdomen Protocol to Evaluate Pancreatic Ductal Adenocarcinoma in Surgically Resectable and Borderline Resectable Disease for Loco-Regional Heterogeneity and To Evaluate Treatment Response Status Post Surgery and MRI-GRT

Disease Site: Pancreas

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CLINICAL TRIAL 20816

Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 20888

Predicting the Quality of Response to Specific Treatments (PQRST) Chronic GVHD Cohort

Disease Site: Unknown Sites

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CLINICAL TRIAL 21184

Thoracic Program Trial Selection Protocol

Disease Site: Lung

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CLINICAL TRIAL 21233

The PAWN-Q Study: An Exploratory Analysis of Perceived Needs Regarding Physical Activity, Appearance, Weight, Nutrition, and Quality of Life in Adolescent and Young Adult Cancer Survivors

Disease Site: Unknown Sites

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CLINICAL TRIAL 21261

Characterizing the Gut Microbiome in Cancer Patients with Underlying HIV Infection

Disease Site: Any Site

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CLINICAL TRIAL 21268

Biobanking for Breast Cancer Prevention and Disparity Research in Florida

Disease Site: Any Site

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CLINICAL TRIAL 21353

A Prospective Randomized Trial Comparing Pre-Anesthesia Evaluation Remotely via Telemedicine Versus in Person for Surgical Patients at H. Lee Moffitt Cancer Center

Disease Site: Any Site

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CLINICAL TRIAL 21448

Phase II Study of Screening Brain MRIs in Stage IV Breast Cancer

Disease Site: Breast, Brain metastasis

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CLINICAL TRIAL 21552

Assessment of Cognition Performance in Adolescent and Young Adult Cancer Survivors

Disease Site: Any Site

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CLINICAL TRIAL 21589

BASECAMP-1: An Observational Study Obtaining Solid Tumor Tissue from Subjects with Primary Surgical Resection and Leukapheresis for CAR T-Cell Therapy Manufacturing

Disease Site: Breast, Colon, Esophagus, Lip, Oral Cavity and Pharynx, Lung, Ovary, Pancreas, Rectum, Stomach

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CLINICAL TRIAL 21610

The Influence of Psychosocial Factors on Opioid Decision-Making among Breast Cancer Survivors

Disease Site: Breast

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CLINICAL TRIAL 21737

A Pilot Study of Advanced Multi-parametric MRI to Evaluate De Novo Glioblastoma Tumors Prior to Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 21752

Chimeric Antigen Receptor T-Cell Therapy: Neurocognitive Effects and Patient-Reported Outcomes

Disease Site: Hodgkin's Lymphoma, Leukemia, other, Lymphoid Leukemia, Multiple Myeloma, Myeloid and Monocytic Leukemia, Non-Hodgkin's Lymphoma, Other Hematopoietic

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CLINICAL TRIAL 21760

Nutrition and Lifestyle Needs and Behaviors After Breast Cancer Diagnosis

Disease Site: Breast

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CLINICAL TRIAL 21783

A Pilot Study of Advanced Multi-Parametric MRI and MR Elastography to Evaluate Malignant Liver Tumors and Response to Neoadjuvant Therapy Prior to Surgical Resection

Disease Site: Liver

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CLINICAL TRIAL 21786

The "COACH" Study: Individualized COaching in Young Adult Cancer Survivors to Encourage Healthy Behaviors

Disease Site: Any Site

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CLINICAL TRIAL 21793

Cancer-Related Cognitive Impairment: Real-Time Evaluation and Assessment of Long-Term Impact of Treatment on Young Adult Survivors (CRCI REALITY)

Disease Site: Any Site

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CLINICAL TRIAL 21876

Exploring Men s Prostate Cancer Genetic Risk Perceptions and Willingness to Give a Biospecimen for Genetic Risk Testing

Disease Site: Prostate

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CLINICAL TRIAL 21962

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Disease Site: Pancreas

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CLINICAL TRIAL 22083

Real-World Clinical and Patient-Reported Outcomes Among Patients With Relapsed/Refractory Multiple Myeloma treated With Commercial CAR-T Therapy

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 22156

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Disease Site: Pancreas

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CLINICAL TRIAL 22157

A Mixed-Methods Study to Inform the Use of Patient Education and Digital Technology to Increase the Racial/Ethnic Diversity of Clinical Trial Participants

Disease Site: Breast

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CLINICAL TRIAL 22176

Pilot to Create and Refine eHealth Genetic Education for Early-Onset Colorectal Cancer Patients (Nest-CRC Pilot)

Disease Site: Colon, Rectum

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CLINICAL TRIAL 22179

Determinants of Cancer Survivorship Among People Living with HIV (HIV/AIDS/AGING/CANCER)

Disease Site: Any Site

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CLINICAL TRIAL 22334

Global Cardio Oncology Registry Protocol (G-COR)

Disease Site: Any Site

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CLINICAL TRIAL 17971

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Disease Site: Lung

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CLINICAL TRIAL 19000

Evaluation of Anti-Her2 and Anti-Her3 T-Helper Response in Primary Breast Cancer

Disease Site: Breast - Female

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CLINICAL TRIAL 19724

Managed Access Program (MAP) To Provide Access To CTL019, For Acute Lymphoblastic Leukemia (ALL) Or Diffuse Large B-Cell Lymphoma (DLBCL) Patients With Out Of Specification Leukapheresis Product And/Or Manufactured Tisagenlecleucel Out Of Specification For Commercial Release

Disease Site: Acute Leukemia (ALL, AML), Leukemia, other

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CLINICAL TRIAL 19950

Linking the Skin and Gut Microbiome to Immunosuppression in Skin Cancer

Disease Site: Other Skin

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CLINICAL TRIAL 20003

LungMAP: A Master Protocol to Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer(Lung-MAP Screening Study)

Disease Site: Lung, Non small cell lung cancer

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CLINICAL TRIAL 20187

Development of Intra-tumor Driver Mutation Prevalence as a Predictor of Efficacy of Targeted Agents

Disease Site: Reproductive System, Any Site

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CLINICAL TRIAL 21065

Tumor Stroma in Pancreatic Adenocarcinoma

Disease Site: Any Site

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CLINICAL TRIAL 21125

MElanoma Research Lymph Node Prediction Implementation National_001 (MERLIN_001)

Disease Site: Melanoma, skin

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CLINICAL TRIAL 21219

Predicting Progression of Developing Myeloma in a High-Risk Screened Population

Disease Site: Multiple Myeloma

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CLINICAL TRIAL 21266

Gut Metabolome-Can it be Developed As A Biomarker of Response to Immunotherapy in Metastatic Renal Cell Cancer

Disease Site: Kidney

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CLINICAL TRIAL 21351

A Prospective Analysis of Biochemical Markers for Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy in Adults

Disease Site: Unknown Sites

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CLINICAL TRIAL 21452

Evaluating Gut Microbiome As A Biomarker Of Pathological Complete Response In Patients With Early Triple Negative Breast Cancer - A Pilot Study (TCC)

Disease Site: Breast

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CLINICAL TRIAL 21561

Assessment of Chimerism and Relapse Post-Bone Marrow / Hematopoietic Cell Transplant (HCT) using ALLOHEME Test (ACROBAT)

Disease Site: Leukemia, other, Lymphoid Leukemia, Myeloid and Monocytic Leukemia

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CLINICAL TRIAL 21908

A Systematic Review of Supplements Applicable in Treatment of Pancreatic Adenocarcinoma with Action on the mTOR Complex

Disease Site: Pancreas

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CLINICAL TRIAL 21942

Characterization of Lymphoid Aggregates in Desmoplastic Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 22258

Impact of Methotrexate Dosing on Acute Graft-Versus-Host Disease Risk in Allogeneic Hematopoietic Cell Transplant Patients

Disease Site: Bones and Joints

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CLINICAL TRIAL 50401

Creation of Cell Lines and Corresponding DNA and RNA Analysis from Acral Lentiginous Malignant Melanoma

Disease Site: Melanoma, skin

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CLINICAL TRIAL 50428

Metabolite Consumption in Patient-Derived Explants to Predict Therapeutic Response in Aggressive and Oligometastatic Prostate Cancer in African American Men

Disease Site: Prostate

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