Clinical Trial 21224

Cancer Type: Healthy Subjects
Study Type: Prevention
NCT#: NCT04538482

Phase: N/A
Principal Investigator: Carson, Tiffany

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Overview

Study Title

Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults

Summary

Objective

Specific Aim 1 - Examine the effect of a diet-specific ( DASH or standard American ) 4-week intervention on the gut microbiota of a racially diverse sample of adults and test for race effects Specific Aim 2 - Evaluate diet-specific effects on functional markers of the gut microbiota including production of secondary bile acids (e.g. lithocholic acid, deoxycholic acid), SCFAs (e.g, acetate, butyrate, propionate), and inflammatory markers (e.g., calprotectin, IL-6) and test for race effects

Treatments

Therapies

Medications

Inclusion Criteria

Inclusion Criteria:

Black or white race

Non-hispanic ethnicity

19-65 years of age

Able to travel to the UAB Bionutrition Unit daily to retrieve meals

Exclusion Criteria

Exclusion Criteria:

Gastrointestinal (GI) conditions i.e., irritable bowel, diverticulitis, peptic ulcers, Crohn's, GI cancers, and adenatomous polyps

Antibiotic or probiotic use in the previous 90 days

Smoking/tobacco use

Heavy alcohol consumption

Major medical conditions (e.g., renal disease, diabetes, cancer

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