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Clinical Trial 21224

Cancer Type: Healthy Subjects
Study Type: Prevention
NCT#: NCT04538482

Phase: N/A
Principal Investigator: Carson, Tiffany

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or 1-800-679-0775 Learn More

Study Title

Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults



Specific Aim 1 - Examine the effect of a diet-specific ( DASH or standard American ) 4-week intervention on the gut microbiota of a racially diverse sample of adults and test for race effects Specific Aim 2 - Evaluate diet-specific effects on functional markers of the gut microbiota including production of secondary bile acids (e.g. lithocholic acid, deoxycholic acid), SCFAs (e.g, acetate, butyrate, propionate), and inflammatory markers (e.g., calprotectin, IL-6) and test for race effects




Inclusion Criteria

Inclusion Criteria:

  • Black or white race
  • Non-hispanic ethnicity
  • 19-65 years of age
  • Able to travel to the UAB Bionutrition Unit daily to retrieve meals

  • Exclusion Criteria

    Exclusion Criteria:

  • Gastrointestinal (GI) conditions i.e., irritable bowel, diverticulitis, peptic ulcers, Crohn's, GI cancers, and adenatomous polyps
  • Antibiotic or probiotic use in the previous 90 days
  • Smoking/tobacco use
  • Heavy alcohol consumption
  • Major medical conditions (e.g., renal disease, diabetes, cancer

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