Moffitt logo

COVID-19 Update: See the latest on our visitor policy here. Learn More

Clinical Trials Search

Clinical Trial 21224

Cancer Type: Healthy Subjects
Study Type: Prevention
NCT#: NCT04538482

Phase: N/A
Principal Investigator: Carson, Tiffany

Call 813-745-6100
or 1-800-679-0775 Learn More
Overview

Study Title

Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults

Summary

Objective

Specific Aim 1 - Examine the effect of a diet-specific ( DASH or standard American ) 4-week intervention on the gut microbiota of a racially diverse sample of adults and test for race effects Specific Aim 2 - Evaluate diet-specific effects on functional markers of the gut microbiota including production of secondary bile acids (e.g. lithocholic acid, deoxycholic acid), SCFAs (e.g, acetate, butyrate, propionate), and inflammatory markers (e.g., calprotectin, IL-6) and test for race effects

Treatments

Therapies

Medications

Inclusion Criteria

Inclusion Criteria:

  • Black or white race
  • Non-hispanic ethnicity
  • 19-65 years of age
  • Able to travel to the UAB Bionutrition Unit daily to retrieve meals

  • Exclusion Criteria

    Exclusion Criteria:

  • Gastrointestinal (GI) conditions i.e., irritable bowel, diverticulitis, peptic ulcers, Crohn's, GI cancers, and adenatomous polyps
  • Antibiotic or probiotic use in the previous 90 days
  • Smoking/tobacco use
  • Heavy alcohol consumption
  • Major medical conditions (e.g., renal disease, diabetes, cancer

  • If you are interested in learning more about clinical trials, our clinical trial navigators can discuss your options and recommend opportunities that may be suitable for you. Call 813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.