Exercise to Boost Response to Checkpoint Blockade Immunotherapy
Investigators will obtain preliminary data on an exercise intervention in participants who are receiving checkpoint blockade immunotherapy. Exercise is completed on the same day of immunotherapy infusion. Information collected during this study will inform how exercise may impact immunological biomarkers and disease outcome.
This pilot study will provide i) information on the feasibility of implementing an exercise intervention trial among patients with cutaneous cancers, including melanoma, squamous cell carcinoma (cuSCC), and Merkel cell carcinoma, scheduled to receive checkpoint blockade immunotherapy, and ii) preliminary data on the impact of a day-of-therapy exercise intervention.
Aim 1. To determine the acceptability of the exercise intervention and feasibility of patients to complete 20-30 minutes of supervised moderate exercise on the same day as receiving checkpoint blockade immunotherapy.
Aim 2. To estimate the impact of exercise on tumor immunological biomarkers and disease outcome.
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