Older Breast Cancer Patients: Risk For Cognitive Decline
The purpose of this study is to evaluate the effect of chemotherapy and hormonal treatment on the mind ("cognition") in older breast cancer patients.
This research is being done because breast cancer is a major health problem facing older women and chemotherapy and hormonal treatments are some of the possible treatments offered to women. Because very few women 60 years of age and older have been invited to join past breast cancer studies, we don't have much information available on the effect of chemotherapy and hormonal treatment on the mind ("cognition").
1. To use patient and control data to measure the magnitide of the impact of systemic therapy on cognition.
2. To use patient data to explore whether cognitive decline varies by category of systemic therapy.
3. To use data from patients to examine whether cognitive decline is associated with QOL at follow up.
4. To use patient and control data to explore whether APOE polymorphisms moderate cognitive declines.
Participant report of a history of formal diagnosis of neurodegenerative disorders that affect cognition (i.e. Alzheimer's disease, Parkinson¿s disease, Multiple Sclerosis, Dementia, Seizure Disorders, etc.)
Participant report of a history of stroke or moderate to severe head trauma (loss of consciousness > 60 min or with evidence of structural brain changes on imaging)
Major depressive disorder (untreated or poorly treated), history of bipolar disorders, schizophrenia and other psychotic disorders, or substance abuse disorders (self reported and/or stated in medical record).
Participant report of a history of prior breast or other cancer (except non-melanoma skin)
Two synchronous primaries in the same or opposite breast
Visual, auditory, or other impairment that would preclude ability to complete interviews or neuropsychological testing, such as women with history of significant macular degeneration or being unable to correct hearing with hearing aids
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