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Older Breast Cancer Patients: Risk For Cognitive Decline
The purpose of this study is to evaluate the effect of chemotherapy and hormonal treatment on the mind ("cognition") in older breast cancer patients. This research is being done because breast cancer is a major health problem facing older women and chemotherapy and hormonal treatments are some of the possible treatments offered to women. Because very few women 60 years of age and older have been invited to join past breast cancer studies, we don't have much information available on the effect of chemotherapy and hormonal treatment on the mind ("cognition").
1. To use patient and control data to measure the magnitide of the impace of systemic therapy on cognition. 2. To use patient data to explore whether cognitive decline varies by category of systemic therapy. 3. To use data from patients to examine whether cognitive decline is associated with QOL at follow up. 4. To use patient and control data to explore whether APOE polymorphisms moderate cognitive declines.