Brain Cancer Clinical Trials

clinical trials

Moffitt Cancer Center’s Neuro-Oncology Program is actively working to improve treatment options, outcomes and quality of life for brain cancer patients now and into the future through our nationally renowned clinical trial program. Before novel treatments are made widely available, they must go through clinical trials that allow researchers to identify when they are most effective, how they interact with other therapies and their success against various types of brain cancer. Advances in understanding the biology of cancer, and efforts to develop new, more effective therapeutics, ultimately result in the development of novel treatments.

What are brain cancer clinical trials?

Clinical trials are controlled medical studies that are used to assess the effectiveness of innovative treatment options. Physicians and scientists are frequently exploring new therapies, such as chemotherapy combinations, biologic therapies and vaccines. Today’s most widely used brain cancer treatments were once evaluated in clinical trials.

Brain cancer clinical trials at Moffitt

Moffitt spearheads one of the largest cancer clinical trial programs in the nation. Clinical trials within our brain cancer program include investigations into:

  • New ways to use immunotherapy to fight brain cancer
  • Gene therapy for brain cancer
  • Treatment of leptomeningeal disease (LMD), which currently has few effective treatments
  • Use of personalized approaches to match the treatment to the genetics of a patient’s tumor
  • Direct delivery of novel therapeutics to tumor tissue
  • Imaging techniques
  • Immunotherapies
  • Radiation therapies
  • Vaccine therapies
  • Brain metastases diagnostics and treatments
  • Neurologic complications of cancers (neuropathies or paraneoplastic syndromes) and its therapies (immunologic therapies, CAR-T therapies, etc.)

Why choose Moffitt?

Research and clinical trials raise the standard of cancer care and continue to bring us closer to a cure. Thanks to Moffitt’s robust clinical trial program and ongoing research efforts, we have been awarded multiple research grants and are recognized as a Comprehensive Cancer Center by the National Cancer Institute. We are currently the only cancer center based in Florida to hold this prestigious designation. Furthermore, our team includes specialists who focus exclusively on brain cancer (primary brain tumors, brain metastases and leptomeningeal disease) and improving treatment options for these diseases, allowing our patients to receive care under the supervision of uniquely experienced professionals.

The decision to participate in a clinical trial is a highly personal one that requires careful consideration. If you would like to receive more information about brain cancer clinical trials at Moffitt and whether or not you are a candidate, contact 1-813-745-6100 or 1-800-679-0775 (toll-free) to speak with a knowledgeable clinical navigator. You may also submit a clinical trials inquiry form online at your convenience.

Medically Reviewed by Dr. Michael Vogelbaum, Program Leader, Department of Neuro-Oncology.

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Open Clinical Trials:

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CLINICAL TRIAL 18752

ACTION Trial- Adoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas (Phase I)

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 19327

A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients with Metastatic Melanoma or Non-small Cell Lung Cancer with Untreated Brain Metastases

Disease Site: Non small cell lung cancer, Brain and Nervous System, Lung, Melanoma, skin, Gliomas

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CLINICAL TRIAL 19970

A Pilot Trial of Intratumorally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy (IND 117,240)

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 20145

A Pilot Study of Intratumorally and Intraparenchymally Administered OS2966 using Convection-enhanced Delivery in Patients with Recurrent/Progressive High-grade Glioma Undergoing a Clinically-indicated Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 20487

Phase I/II Study of Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Disease Site: Brain and Nervous System, Breast, Leptomeningeal (LMD)

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CLINICAL TRIAL 20637

Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease

Disease Site: Brain and Nervous System, Brain metastasis

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CLINICAL TRIAL 20899

Phase I/II Study of Stereotactic Radiation and Abemaciclib in the Management of Hormone Receptor Positive HER2 Negative Breast Cancer Brain Metastases

Disease Site: Brain and Nervous System, Breast

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CLINICAL TRIAL 20956

A Two-Part, Phase 1a/B, Open-Label, Multicenter Trial Evaluating Pharmacokinetics, Safety and Efficacy Of PF-07284890 (ARRY-461) In Participants With BRAF V600-Mutant Solid Tumors With And Without Brain Involvement

Disease Site: Any Site, Brain and Nervous System, Larynx, Lip, Oral Cavity and Pharynx, Lung, Melanoma, skin, Other Skin, Brain metastasis, Gliomas

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CLINICAL TRIAL 20964

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Disease Site: Brain and Nervous System, Breast, Ill-Defined Sites, Lung, Other Digestive Organ, Urinary Bladder, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21022

A Phase 1b/2, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 (pINN sotorasib) in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation

Disease Site: Any Site, Brain and Nervous System, Lung, Pancreas, Rectum, Brain metastasis, Leptomeningeal (LMD)

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CLINICAL TRIAL 21039

A Pivotal Randomized, Open-Label Study Of OPTUNE(R)(TTFIELDS, 200KHZ) Concomitant With Radiation Therapy And Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma

Disease Site: Brain and Nervous System, Gliomas

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CLINICAL TRIAL 21193

Pre-operative Hypofractionated Stereotactic Radiosurgery for Resectable Brain Metastases

Disease Site: Brain and Nervous System, Brain metastasis

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CLINICAL TRIAL 21681

A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma

Disease Site: Brain and Nervous System

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CLINICAL TRIAL 19731

Electronic Social Network Assessment Program (eSNAP) + Caregiver Navigator Intervention for Neuro-Oncology Couples

Disease Site: Brain and Nervous System, Brain metastasis, Gliomas, Leptomeningeal (LMD), Meningiomas

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CLINICAL TRIAL 21448

Phase II Study of Screening Brain MRIs in Stage IV Breast Cancer

Disease Site: Breast, Brain metastasis

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CLINICAL TRIAL 21737

A Pilot Study of Advanced Multi-parametric MRI to Evaluate De Novo Glioblastoma Tumors Prior to Surgical Resection

Disease Site: Brain and Nervous System, Gliomas

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