Patrick Grogan, MD, PhD

Associations

• Neuro-Oncology

 Dr. Grogan's research focus involves evaluating novel therapeutic strategies for high-grade gliomas, both preclinically and clinically, and understanding disease growth characteristics as they relate to molecular driver alterations that can impact the treatment approaches. We are actively working to expand glioma/glioblastoma clinical trial access at Moffitt to provide patients with unique opportunities to receive promising new therapies before those options are made widely available.

Clinical Trial 20110
GBM Agile: Global Adaptive Trial Master Protocol
Condition: Neurologic Oncology
Intervention: ADI-PEG 20 (); BAY 73-4506 (Regorafenib); Lomustine (CeeNU); Paxalisib (); Regorafenib (Stivarga); Temodal (Temozolomide); Temozolomide (); Troriluzole (); VAL-083 (); VT1021 ()
Status: Open

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

• Harari CM, Burr AR, Morris BA, Tomé WA, Bayliss A, Bhatia A, Grogan PT, Robins HI, Howard SP. Pulsed reduced-dose rate re-irradiation for patients with recurrent grade 2 gliomas. Neurooncol Adv. 2024 May.6(1):vdae073. Pubmedid: 38845694. Pmcid: PMC11154132.
• Grogan PT, Helgager JJ, Deming DA, Howard SP, Jenkins RB, Robins HI. Case report: Radiographic complete response of radiation-induced glioblastoma to front-line radiotherapy: A report and molecular characterization of two unique cases. Front Neurol. 2023 Mar.14:1099424. Pubmedid: 37025206. Pmcid: PMC10070702.
• Grogan PT, Deming DA, Helgager J, Ruszkiewicz T, Baskaya MK, Howard SP, Robins HI. Entrectinib demonstrates prolonged efficacy in an adult case of radiation-refractory NTRK fusion glioblastoma. Neurooncol Adv. 2022 Apr.4(1):vdac046. Pubmedid: 35673607. Pmcid: PMC9167633.
• Subramanian C, Grogan PT, Wang T, Bazzill J, Zuo A, White PT, Kalidindi A, Kuszynski D, Wang G, Blagg BSJ, Cohen MS. Novel C-terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self-renewal, and epithelial-mesenchymal transition. Mol Oncol. 2020 Sep.14(9):2058-2068. Pubmedid: 32255264. Pmcid: PMC7463342.
• Sharifi MN, Anandan A, Grogan P, O'Regan RM. Therapy after cyclin-dependent kinase inhibition in metastatic hormone receptor-positive breast cancer: Resistance mechanisms and novel treatment strategies. Cancer. 2020 Aug.126(15):3400-3416. Pubmedid: 32426848.
• Johnson KA, DeStefanis RA, Emmerich PB, Grogan PT, Kratz JD, Makkar SK, Clipson L, Deming DA. Human Colon Organoids and Other Laboratory Strategies to Enhance Patient Treatment Selection. CURR TREAT OPTION ON. 2020 Apr.21(5):35. Pubmedid: 32328818. Pmcid: PMC7924903.
• Subramanian C, Grogan PT, Opipari VP, Timmermann BN, Cohen MS. Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-κB activation. Oncotarget. 2018 Mar.9(18):14509-14523. Pubmedid: 29581860. Pmcid: PMC5865686.
• Nguyen HTN, Grogan P, Robins HI. Go, no-go decision making for phase 3 clinical trials: ACT IV revisited. Lancet Oncol. 2017 Dec.18(12):e708. Pubmedid: 29208432.
• Sim MW, Grogan PT, Subramanian C, Bradford CR, Carey TE, Forrest ML, Prince ME, Cohen MS. Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells. Laryngoscope. 2016 May.126(5):E184-E190. Pubmedid: 26690734. Pmcid: PMC4842141.
• Zhao J, Zhao H, Hall JA, Brown D, Brandes E, Bazzill J, Grogan PT, Subramanian C, Vielhauer G, Cohen MS, Blagg BS. Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors. Medchemcomm. 2014 Sep.5(9):1317-1323. Pubmedid: 25328661. Pmcid: PMC4198308.
• Cao CM, Zhang H, Gallagher RJ, Day VW, Kindscher K, Grogan P, Cohen MS, Timmermann BN. Withanolides from Physalis hispida. J Nat Prod. 2014 Mar.77(3):631-639. Pubmedid: 24456028.
• Grogan PT, Sarkaria JN, Timmermann BN, Cohen MS. Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation. Invest New Drugs. 2014 Aug.32(4):604-617. Pubmedid: 24718901. Pmcid: PMC4380174.
• Zhang H, Bazzill J, Gallagher RJ, Subramanian C, Grogan PT, Day VW, Kindscher K, Cohen MS, Timmermann BN. Antiproliferative withanolides from Datura wrightii. J Nat Prod. 2013 Mar.76(3):445-449. Pubmedid: 23252848. Pmcid: PMC3606642.
• Cen L, Carlson BL, Pokorny JL, Mladek AC, Grogan PT, Schroeder MA, Decker PA, Anderson SK, Giannini C, Wu W, Ballman KV, Kitange GJ, Sarkaria JN. Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models. Neurooncol. 2013 Jun.15(6):735-746. Pubmedid: 23479134. Pmcid: PMC3661094.
• Grogan PT, Sleder KD, Samadi AK, Zhang H, Timmermann BN, Cohen MS. Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways. Invest New Drugs. 2013 Jun.31(3):545-557. Pubmedid: 23129310. Pmcid: PMC3677827.
• Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol. 2012 Dec.110(3):349-357. Pubmedid: 23054561. Pmcid: PMC3535329.
• Olin MR, Andersen BM, Litterman AJ, Grogan PT, Sarver AL, Robertson PT, Liang X, Chen W, Parney IF, Hunt MA, Blazar BR, Ohlfest JR. Oxygen is a master regulator of the immunogenicity of primary human glioma cells. Cancer Res. 2011 Nov.71(21):6583-6589. Pubmedid: 21908554. Pmcid: PMC3360979.
• Olin MR, Andersen BM, Zellmer DM, Grogan PT, Popescu FE, Xiong Z, Forster CL, Seiler C, SantaCruz KS, Chen W, Blazar BR, Ohlfest JR. Superior efficacy of tumor cell vaccines grown in physiologic oxygen. Clin Cancer Res. 2010 Oct.16(19):4800-4808. Pubmedid: 20858839. Pmcid: PMC3016438.
• Staley J, Grogan P, Samadi AK, Cui H, Cohen MS, Yang X. Growth of melanoma brain tumors monitored by photoacoustic microscopy. J Biomed Opt. 2010 Jul.15(4):040510. Pubmedid: 20799777.
• Pluhar GE, Grogan PT, Seiler C, Goulart M, Santacruz KS, Carlson C, Chen W, Olin MR, Lowenstein PR, Castro MG, Haines SJ, Ohlfest JR. Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine. 2010 Apr.28(19):3371-3378. Pubmedid: 20197146. Pmcid: PMC2854671.
• Carlson BL, Grogan PT, Mladek AC, Schroeder MA, Kitange GJ, Decker PA, Giannini C, Wu W, Ballman KA, James CD, Sarkaria JN. Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. Int J Radiat Oncol Biol Phys. 2009 Sep.75(1):212-219. Pubmedid: 19695438. Pmcid: PMC2773462.
• Kitange GJ, Carlson BL, Mladek AC, Decker PA, Schroeder MA, Wu W, Grogan PT, Giannini C, Ballman KV, Buckner JC, James CD, Sarkaria JN. Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model. J Neurooncol. 2009 Mar.92(1):23-31. Pubmedid: 19011762. Pmcid: PMC2790867.
• Kitange GJ, Carlson BL, Schroeder MA, Grogan PT, Lamont JD, Decker PA, Wu W, James CD, Sarkaria JN. Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. Neurooncol. 2009 Jun.11(3):281-291. Pubmedid: 18952979. Pmcid: PMC2718972.
• Clarke MJ, Mulligan EA, Grogan PT, Mladek AC, Carlson BL, Schroeder MA, Curtin NJ, Lou Z, Decker PA, Wu W, Plummer ER, Sarkaria JN. Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol Cancer Ther. 2009 Feb.8(2):407-414. Pubmedid: 19174557. Pmcid: PMC2692390.
• Yang L, Clarke MJ, Carlson BL, Mladek AC, Schroeder MA, Decker P, Wu W, Kitange GJ, Grogan PT, Goble JM, Uhm J, Galanis E, Giannini C, Lane HA, James CD, Sarkaria JN. PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Clin Cancer Res. 2008 Jun.14(12):3993-4001. Pubmedid: 18559622. Pmcid: PMC3972037.
• Sarkaria JN, Yang L, Grogan PT, Kitange GJ, Carlson BL, Schroeder MA, Galanis E, Giannini C, Wu W, Dinca EB, James CD. Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther. 2007 Mar.6(3):1167-1174. Pubmedid: 17363510.
• Sarkaria JN, Schwingler P, Schild SE, Grogan PT, Mladek AC, Mandrekar SJ, Tan AD, Kobayashi T, Marks RS, Kita H, Miller RC, Limper AH, Leof EB. Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer. J Thorac Oncol. 2007 Aug.2(8):751-757. Pubmedid: 17762343.
• Sarkaria JN, Carlson BL, Schroeder MA, Grogan P, Brown PD, Giannini C, Ballman KV, Kitange GJ, Guha A, Pandita A, James CD. Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response. Clin Cancer Res. 2006 Apr.12(7 Pt 1):2264-2271. Pubmedid: 16609043.