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Robert Engelman, DVM, PhD

Overview


Associations

    • Non-Programmatically Aligned
    • Immuno-Oncology

Education & Training

Graduate:

  • Oklahoma State University - PhD - Veteninary Pathology
Publications

  • Sudan R, Fernandes S, Srivastava N, Pedicone C, Meyer ST, Chisholm JD, Engelman RW, Kerr WG. LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism. Front Immunol. 2022 May.13:830961. Pubmedid: 35603158. Pmcid: PMC9116273.
  • Tafreshi NK, Pandya DN, Tichacek CJ, Budzevich MM, Wang Z, Reff JN, Engelman RW, Boulware DC, Chiappori AA, Strosberg JR, Ji H, Wadas TJ, El-Haddad G, Morse DL. Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms. Eur J Nucl Med Mol Imaging. 2021 Oct.48(11):3408-3421. Pubmedid: 33772332.
  • Tafreshi NK, Kil H, Pandya DN, Tichacek CJ, Doligalski ML, Budzevich MM, Delva NC, Langsen ML, Vallas JA, Boulware DC, Engelman RW, Gage KL, Moros EG, Wadas TJ, McLaughlin ML, Morse DL. Lipophilicity Determines Routes of Uptake and Clearance, and Toxicity of an Alpha-Particle-Emitting Peptide Receptor Radiotherapy. ACS Pharmacol Transl Sci. 2021 Apr.4(2):953-965. Pubmedid: 33860213. Pmcid: PMC8033749.
  • Hamaidi I, Zhang L, Kim N, Wang MH, Iclozan C, Fang B, Liu M, Koomen JM, Berglund AE, Yoder SJ, Yao J, Engelman RW, Creelan BC, Conejo-Garcia JR, Antonia SJ, Mulé JJ, Kim S. Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. Cell Metab. 2020 Sep.32(3):420-436.e12. Pubmedid: 32768387. Pmcid: PMC7484212.
  • Tichacek CJ, Tafreshi NK, Kil H, Engelman RW, Doligalski ML, Budzevich MM, Gage KL, McLaughlin ML, Wadas TJ, Silva A, Moros E, Morse DL. Biodistribution and Multicompartment Pharmacokinetic Analysis of a Targeted α Particle Therapy. Mol Pharm. 2020 Nov.17(11):4180-4188. Pubmedid: 32960613.
  • Miedel EL, Ragland NH, Slate AR, Engelman RW. Persistent Corynebacterium bovis Infectious Hyperkeratotic Dermatitis in Immunocompetent Epidermal-Mutant dep/dep Mice. Vet Pathol. 2020 Jul.57(4):586-589. Pubmedid: 32347166.
  • Ragland NH, Miedel EL, Engelman RW. PCR Prevalence of Murine Opportunistic Microbes and their Mitigation by Using Vaporized Hydrogen Peroxide. J Am Assoc Lab Anim Sci. 2019 Mar.58(2):208-215. Pubmedid: 30795821. Pmcid: PMC6433363.
  • Vedder AR, Miedel EL, Ragland NH, Balasis ME, Letson CT, Engelman RW, Padron E. Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice. Comp Med. 2019 Aug.69(4):276-282. Pubmedid: 31349880. Pmcid: PMC6733163.
  • Tyagi RK, Tandel N, Deshpande R, Engelman RW, Patel SD, Tyagi P. Humanized Mice Are Instrumental to the Study of Plasmodium falciparum Infection. Front Immunol. 2018 Dec.9:2550. Pubmedid: 30631319. Pmcid: PMC6315153.
  • Gumbleton M, Sudan R, Fernandes S, Engelman RW, Russo CM, Chisholm JD, Kerr WG. Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival. Sci Signal. 2017 Oct.10(500). Pubmedid: 29018171.
  • Ragland NH, Miedel EL, Gomez JM, Engelman RW. PCR-validated Decontamination of Murine Individually Ventilated Cage Racks and Air Handling Units by Using 'Active-Closed' Exposure to Vaporized Hydrogen Peroxide. J Am Assoc Lab Anim Sci. 2017 Nov.56(6):742-751. Pubmedid: 29256369. Pmcid: PMC5710153.
  • Ruiz A, Rockfield S, Taran N, Haller E, Engelman RW, Flores I, Panina-Bordignon P, Nanjundan M. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis. Cell Death Dis. 2016 Jan.7:e2059. Pubmedid: 26775710. Pmcid: PMC4816166.
  • Engelman R. Six Billion in Africa. Sci Am. 2016 Feb.314(2):56-63. Pubmedid: 26930829.
  • Park MY, Sudan R, Srivastava N, Neelam S, Youngs C, Wang JW, Engelman RW, Kerr WG. LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation. Sci Rep. 2016 11.6:36568. Pubmedid: 27824136. Pmcid: PMC5099895.
  • Brownlow ML, Joly-Amado A, Azam S, Elza M, Selenica ML, Pappas C, Small B, Engelman R, Gordon MN, Morgan D. Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition. Behav Brain Res. 2014 Sep.271:79-88. Pubmedid: 24925454.
  • Park MY, Srivastava N, Sudan R, Viernes DR, Chisholm JD, Engelman RW, Kerr WG. Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice. Mucosal Immunol. 2014 Nov.7(6):1429-1439. Pubmedid: 24781051. Pmcid: PMC4205272.
  • Todd TE, Morse JM, Casagni TJ, Engelman RW. Corrigendum: Monitoring and mitigating isoflurane emissions during inhalational anesthesia of mice. Lab Anim (Ny). 2014 Mar.43(4):148. Pubmedid: 24651794.
  • Kim S, Amankwah EK, Connors S, Park HY, Rincon M, Cornnell HH, Chornokur G, Ibrahim-Hashim A, Choi J, Tsai YY, Engelman R, Kumar NB, Park JY. Safety and chemopreventive effect of Polyphenon E in preventing early and metastatic progression of prostate cancer in TRAMP mice. Cancer Prev Res (Phila). 2014 Apr.7(4):435-444. Pubmedid: 24501325. Pmcid: PMC4123218.
  • Maxwell MJ, Srivastava N, Park MY, Tsantikos E, Engelman RW, Kerr WG, Hibbs ML. SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation. Genes Immun. 2014 Apr.15(4):233-240. Pubmedid: 24598798.
  • Todd TE, Morse JM, Casagni TJ, Engelman RW. Monitoring and mitigating isoflurane emissions during inhalational anesthesia of mice. Lab Anim (Ny). 2013 Sep.42(10):371-379. Pubmedid: 24051641.
  • Hopewell EL, Bronk CC, Massengill M, Engelman RW, Beg AA. IKKβ-induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector. Eur J Immunol. 2012 Mar.42(3):681-687. Pubmedid: 22161279. Pmcid: PMC3415707.
  • Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun.287(26):22112-22122. Pubmedid: 22566699. Pmcid: PMC3381169.
  • Engelman RW, Kerr WG. Assessing inflammatory disease at mucosal surfaces in murine genetic models. Methods Mol Biol. 2012.900:433-441. Pubmedid: 22933082.
  • Kerr WG, Park MY, Maubert M, Engelman RW. SHIP deficiency causes Crohn's disease-like ileitis. Gut. 2011 Feb.60(2):177-188. Pubmedid: 20940287. Pmcid: PMC3022365.
  • Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One. 2010 Mar.5(3):e9646. Pubmedid: 20333297. Pmcid: PMC2841635.
  • Brooks R, Fuhler GM, Iyer S, Smith MJ, Park MY, Paraiso KH, Engelman RW, Kerr WG. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J Immunol. 2010 Apr.184(7):3582-3589. Pubmedid: 20200281. Pmcid: PMC4123216.
  • Collazo MM, Wood D, Paraiso KH, Lund E, Engelman RW, Le CT, Stauch D, Kotsch K, Kerr WG. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood. 2009 Mar.113(13):2934-2944. Pubmedid: 19136659. Pmcid: PMC2662640.
  • Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA. PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest. 2009 Dec.119(12):3774-3786. Pubmedid: 19907075. Pmcid: PMC2786796.
  • Kline CL, Jackson R, Engelman R, Pledger WJ, Yeatman TJ, Irby RB. Src kinase induces tumor formation in the c-SRC C57BL/6 mouse. Int J Cancer. 2008 Jun.122(12):2665-2673. Pubmedid: 18351644.
  • Paraiso K, Ghansah T, Costello A, Engelman R, Kerr W. Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. J Immunol. 2007 Mar.178(5):2893-2900. Pubmedid: 17312133.
  • Engelman R, Jackson R, Coppola D, Wharton W, Cantor A, Pledger W. Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol. 2007 Jun.82(3):234-244. Pubmedid: 17207793. Pmcid: PMC2039892.
  • Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE. Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol Aging. 2005 Jul.26(7):995-1000. Pubmedid: 15748777.
  • Lippman CR, Hajjar M, Abshire B, Martin G, Engelman RW, Cahill DW. Cervical spine fusion with bioabsorbable cages. Neurosurg Focus. 2004 Mar.16(3):E4. Pubmedid: 15198492.
  • Cahill D, Martin GJ J, Hajjar M, Sonstein W, Graham L, Engelman R. Suitability of bioresorbable cages for anterior cervical fusion. J Neurosurg. 2003 Mar.98(2 Suppl):195-201. Pubmedid: 12650405.
  • Jackson R, Engelman R, Coppola D, Cantor A, Wharton W, Pledger W. p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res. 2003 Jun.63(12):3021-3025. Pubmedid: 12810620.
  • Lindzey J, Gower W, Mushinsky H, Owens U, Graham L, Gografe S, Van Etten J, Engelman R. A unique application to the IACUC for studies of wild animals in or from natural settings. Contemp Top Lab Anim Sci. 2002 Nov.41(6):33-36. Pubmedid: 12456158.
  • Gower WR J, Sanberg P, Brown P, Salyani S, Pasqual C, McGrogan M, GoodRA, Engelman R. hNT neurons express an immunosuppressive protein that blocks T-lymphocyte proliferation and interleukin-2 production. J Neuroimmunol. 2002 Apr.125(1-2):103-113. Pubmedid: 11960646.
  • Cuenca A, Cress W, Good R, Marikar Y, Engelman R. Calorie restriction influences cell cycle protein expression and DNA synthesis during liver regeneration. Exp Biol Med (Maywood). 2001 Dec.226(11):1061-1067. Pubmedid: 11743143.
  • Kirzner R, Engelman R, Mizutani H, Specter S, Good R. Prevention of coronary vascular disease by transplantation of T-cell-depleted bone marrow and hematopoietic stem cell preparation in autoimmune-prone w/BF(1) mice. Biol Blood Marrow Tr. 2000.6(5):513-522. Pubmedid: 11063380.
  • Boucek R, Miracle A, Anderson M, Engelman R, Atkinson J, Dodd D. Persistent effects of doxorubicin on cardiac gene expression. J Mol Cell Cardiol. 1999.31(8):1435-1446. Pubmedid: 10423342.
  • Cherry, Engelman R, Wang B, Kinjoh K, Good R. Calorie restriction delays the crescentic glomerulonephritis of SCG/Kj mice. Proc Soc Exp Biol Med. 1998 Jul.218(3):218-222. Pubmedid: 9648939.
  • Cherry, Engelman R, Wang B, Kinjoh K, Good R. Prevention of crescentic glomerulonephritis in SCG/Kj mice by bone marrow transplantation. Proc Soc Exp Biol Med. 1998 Jul.218(3):223-228. Pubmedid: 9648940.
  • Haraguchi S, Good R, Engelman R, Greene S, Day N. Prolactin, epidermal growth factor or transforming growth factor-alpha activate a mammary cell-specific enhancer in mouse mammary tumor virus-long terminal repeat. Mol Cell Endocrinol. 1997 May.129(2):145-155. Pubmedid: 9202398.
  • Haraguchi S, Good R, Cianciolo G, Engelman R, Day N. Immunosuppressive retroviral peptides: immunopathological implications for immunosuppressive influences of retroviral infections. J Leukoc Biol. 1997.61(6):654-666. Pubmedid: 9201256.
  • Kraus L, Bradley W, Engelman R, Brown K, Good R, Day N. Relationship between tumor necrosis factor alpha and feline immunodeficiency virus expressions. J Virol. 1996 Jan.70(1):566-569. Pubmedid: 8523571. Pmcid: PMC189845.
  • Mizutani H, Engelman R, Kinjoh K, Good R. Gastrointestinal vasculitis in autoimmune-prone (NZW X BXSB)F1 mice: association with anticardiolipin autoantibodies. Proc Soc Exp Biol Med. 1995 Jul.209(3):279-285. Pubmedid: 7777589.
  • Engelman R, Owens U, Bradley W, Day N, Good R. Mammary and submandibular gland epidermal growth factor expression is reduced by calorie restriction. Cancer Res. 1995.55:1289-1295. Pubmedid: 7882324.
  • Mizutani H, Engelman RW, Kurata Y, Ikehara S, Good RA. Energy restriction prevents and reverses immune thrombocytopenic purpura (ITP) and increases life span of ITP-prone (NZW x BXSB) F1 mice. J Nutr. 1994 Oct.124(10):2016-2023. Pubmedid: 7931711.
  • Mizutani H, Engelman R, Kinjoh K, Kurata Y, Ikehara S, Matsuzawa Y, Good R. Calorie restriction prevents the occlusive coronary vascular disease of autoimmune (NZW x BXSP) F(1) mice. Proc Natl Acad Sci U S A. 1994.91:4402-4406.
  • Engelman R, Day N, Good R. Calorie intake during mammary development influences cancer risk: lasting inhibition of C3H/HeOu mammary tumorigenesis by peripubertal calorie restriction (1). Cancer Res. 1994.54:5724-5730.
  • Mizutani H, Engelman R, Kurata Y, Ikehara S, Good R. Energy restriction prevents and reverses autoimmune throbocytopenic purpura (ITP) and increases life span of ITP-prone (NZW x BXSB)F(1) mice. J Nutr. 1994.124:2016-2023.
  • Walker R, Engelman R, Pross S, Bercu B. Effects of growth hormone secretagogues on age-related changes in the rat immune system. Endocrine. 1994.2:857-862.
  • Tomita Y, Jyonouchi H, Engelman R, Day N, Good R. Preventive action of carotenoids on the development of lymphadenopathy and proteinuaria in MRL-lpr/lpr mice. Autoimmunity. 1993.16:95-102.
  • Engelman R, Day N, Good R. Calories, parity, and prolactin influence mammary epithelial kinetics and differentiation and alter mouse mammary tumor risk (1). Cancer Res. 1993.53:1188-1194.
  • Engelman R, Day N, Good R. Calories, cell proliferation and proviral expression in autoimmunity and cancer. Proc Soc Exp Biol Med. 1993.203:13-17.
  • Mizutani H, Engelman R, Kurate Y, Ikehara S, Good R. Development and characterization of monoclonal antiplatelet autoantibodies from autoimmunce thrombocytopenic purpura-prone (NZW x BXSB) F(1) mice. Blood. 1993.82:837-844.
  • Mizutani H, Engelman R, Kinjoh K, Kurata Y, Ikehara S, Good R. Prevention and induction of occlusive coronary vascular disease in autoimmune (W/B)F(1) mice by haploidentical bone marrow transplantation: possible role for anticardiolipin autoantibodies. Blood. 1993.82:3091-3097.
  • Tomita Y, Engelman R, Bauer-Sardina I, Day N, Good R. Improved enzyme immunosorbent assay for mouse prolactin using penicillinase as label. J Immunol Methods. 1992.151:269-275.
  • Hackney J, Engelman R, Good R. Ethanol calories do not enhance breast cancer in Isocaloric fed c3G/Ou mice. Nutr Cancer. 1992.18:245-253.
  • Himeno Y, Engelman R, Good R. Influence of calorie restriction on oncogene expression and DNA synthesis during liver regeneration. Proc Natl Acad Sci U S A. 1992.89:5497-5501.
  • Haraguchi S, Good R, Engelman R, Day N. Human prolactin induces the regulatory elements in MMTV LTR transfected into a human breast carcinoma cell line through synergistic interaction with steroid hormones. Int J Cancer. 1992.52:928-933.
  • Shields BA, Engelman RW, Fukaura Y, Good RA, Day NK. Calorie restriction suppresses subgenomic mink cytopathic focus-forming murine leukemia virus transcription and frequency of genomic expression while impairing lymphoma formation. Proc Natl Acad Sci U S A. 1991 Dec.88(24):11138-11142. Pubmedid: 1763029. Pmcid: PMC53089.
  • Chen RF, Good RA, Engelman RW, Hamada N, Tanaka A, Nonoyama M, Day NK. Suppression of mouse mammary tumor proviral DNA and protooncogene expression: association with nutritional regulation of mammary tumor development. Proc Natl Acad Sci U S A. 1990 Apr.87(7):2385-2389. Pubmedid: 2157199. Pmcid: PMC53693.
  • Engelman RW, Machida K, Longley RE, Liu WT, Trang LQ, Good RA, Day NK. Characterization of a newly established feline lymphoma-derived cell line (BKD) lacking T and B cell surface markers. In Vitro Cell Dev Biol. 1986 May.22(5):273-279. Pubmedid: 2423498.
  • Engelman RW, Gengozian N, Good RA, Day NK. Polyclonal induction of immunoglobulin synthesis by feline leukocytes as identified in a reverse hemolytic plaque assay. J Immunol Methods. 1985 Jul.81(1):65-71. Pubmedid: 3894522.