Cancer Physiology

The Department of Cancer Physiology, previously known as Cancer Imaging and Metabolism, is focused on the characterization of cancer-related processes in situ (e.g. within their native environment), sometimes provided by non-invasive techniques such as intravital microscopy, radiographic imaging, ex vivo live microscopy, and metabolomics. This includes investigating of complex networks (metabolic, signaling) within living cells, complex cell-cell interactions between cancer cells and stoma within organoids, experimental animals, and human tissues and human patients. The data from these studies are quantitatively analyzed and increasingly used to inform mathematical models, in collaboration with the departments of Integrated Mathematical Oncology and Epidemiology, to develop new paradigms for carcinogenesis and cancer therapy. 

Examples of research areas include investigation of 1) the impact of re-dox and pH stressors on cancer and stromal cell metabolism; 2) the emergence of resistance to radiation, chemotherapy, targeted agents, and immunotherapies, as well as interventions to reverse resistance and re-sensitive patients to therapy; 3) development of cell-surface targeted agents for imaging and therapy; and 4) image analytics for improved diagnosis, prognosis, and prediction. Faculty members in Cancer Physiology actively collaborate with faculty at other institutions in the U.S. and throughout the world.

Cancer Physiology Department Members 

Primary: 
Robert J. Gillies, PhD
Gina DeNicola, PhD
Patsy McDonald, PhD
Andriy Marusyk, PhD
David L. Morse, PhD
Natarajan Raghunand, PhD
Ariosto S. Silva, PhD

Joint Appointments:

Jung W. Choi, MD, PhD
Ghassan E. El-Haddad, MD
Kujtim Latifi, PhD 
Eduardo Moros, PhD 
Nainesh Parikh, MD
Jingsong Zhang, MD, PhD 
Geoffrey G. Zhang, PhD