Clinical Trial 22115

Cancer Type: Malignant Hematology
Study Type: Supportive Care
NCT#: NCT05763563

Phase: N/A
Principal Investigator: Parker, Nathan (Nate)

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Overview

Study Title

Feasibility Of Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy

Summary

The purpose of the study is to evaluate an exercise program for individuals preparing for Chimeric Antigen Receptor (CAR) T-cell immunotherapy for hematological malignancies.

Objective

The primary goal of this project is to determine the feasibility, safety, and acceptability of a home-based exercise program designed to improve fitness and treatment tolerance among older patients referred for CAR-T.

Treatments

Therapies

Medications

Inclusion Criteria

Age > 65 years

Lymphoma, leukemia, or myeloma with commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment

Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Able to read and speak English fluently

Capable of providing informed consent

Exclusion Criteria

Regular engagement in RT (2x/week targeting all major muscle groups)

Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions (described in detail below).

Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).

Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT using body weight

Numeric pain rating scale of ≥ 7 out of 10

Myopathic or rheumatologic disease that impacts physical function

Cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients’ treating oncologists and specified in clinic notes outlining disease history).

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