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Clinical Trial 22115

Cancer Type: Malignant Hematology
Study Type: Supportive Care
NCT#: NCT05763563

Phase: N/A
Principal Investigator: Parker, Nathan (Nate)

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or 1-800-679-0775 Learn More

Study Title

Feasibility Of Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For Chimeric Antigen Receptor (CAR) T-Cell Immunotherapy


The purpose of the study is to evaluate an exercise program for individuals preparing for Chimeric Antigen Receptor (CAR) T-cell immunotherapy for hematological malignancies.


The primary goal of this project is to determine the feasibility, safety, and acceptability of a home-based exercise program designed to improve fitness and treatment tolerance among older patients referred for CAR-T.




Inclusion Criteria

  • Age > 65 years
  • Lymphoma, leukemia, or myeloma with commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Able to read and speak English fluently
  • Capable of providing informed consent

  • Exclusion Criteria

  • Regular engagement in RT (2x/week targeting all major muscle groups)
  • Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions (described in detail below).
  • Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
  • Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT using body weight
  • Numeric pain rating scale of ≥ 7 out of 10
  • Myopathic or rheumatologic disease that impacts physical function
  • Cognitive, visual, or auditory limitations that preclude safe engagement in remotely-supervised resistance training sessions or independent aerobic exercise (as determined by patients’ treating oncologists and specified in clinic notes outlining disease history).

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