Cancer Type: Malignant Hematology
Study Type: Treatment
Phase: Phase I
Principal Investigator: Bello, Celeste
A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas
The purpose of this study is to test whether giving acalabrutinib is safe and effective in controlling relapsed central nervous system (CNS) lymphoma
1. Determine overall response rate (ORR) in subjects with relapsed/refractory primary and secondary CNS lymphoma receiving acalabrutinib; 2. Assess toxicity of acalabrutinib in subjects with relapsed/refractory primary and secondary CNS lymphoma; 3. Determine clinical activity of acalabrutinib in subjects with relapsed/refractory primary and secondary CNS lymphoma by assessment of the median progression free survival (PFS); 4. Determine the complete response (CR) rate of acalabrutinib for the treatment of relapsed/refractory primary and secondary CNS lymphoma; 5. Determine duration of response (DoR) in subjects with relapsed/refractory primary and secondary CNS lymphoma receiving acalabrutinib; 6. Determine overall survival (OS) in subjects with relapsed/refractory primary and secondary CNS lymphoma receiving acalabrutinib.
ACP-196 (Acalabrutinib); Acalabrutinib (); Isavuconazole ()
If you are interested in learning more about clinical trials, our clinical trial navigators can discuss your options and recommend opportunities that may be suitable for you. Call 813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.
Back to top
Please call 1-888-663-3488 for support from a Moffitt representative. New Patients and Healthcare Professionals can submit an online form by selecting the appropriate button below. Existing patients can call 1-888-663-3488. Click here for a current list of insurances accepted at Moffitt.
NEW PATIENTS To request a new patient appointment, please fill out the online form or call 1-888-663-3488.
REFERRING PHYSICIANS Providers and medical staff can refer patients by submitting our online referral form.
Moffit now offers Virtual Visits for patients. If you are eligible for a virtual appointment, our scheduling team will discuss this option further with you.
Moffitt Cancer Center is committed to the health and safety of our patients and their families. For more information on how we’re protecting our new and existing patients, visit our COVID-19 Info Hub
A secure website for patients to access their medical care at Moffitt.
An online resource for referring physicians and their staff.
For Moffitt faculty & staff members to access MoffittNet applications.
Our patient services specialists can assist you with scheduling an appointment, questions about medical records, insurance, billing and more.
Patient Appointment Center Hours: 7 a.m. to 7 p.m. Monday - Friday; 8 a.m. to noon Saturday