Cancer Type: Gastrointestinal Tumor
Study Type: Treatment
Phase: Phase I
Principal Investigator: Mehta, Rutika
Phase I Trial with Expansion Cohort of Obp-301 (Telomelysintm) And Definitive Chemoradiation For Patients with Locally Advanced Esophageal And Gastroesophageal Adenocarcinoma Who Are Not Candidates For Surgery
This phase I trial studies the side effects of OBP-301 when given together with carboplatin, paclitaxel, and radiation therapy in treating patients with esophageal or gastroesophageal cancer that invades local or regional structures. OBP-301 is a virus that has been designed to infect and destroy tumor cells (although there is a small risk that it can also infect normal cells). Chemotherapy drugs, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving OBP-301 with chemotherapy and radiation therapy may work better than standard chemotherapy and radiation therapy in treating patients with esophageal or gastroesophageal cancer.
Primary Objective To determine if the addition of OBP-301 to chemoradiation with carboplatin/paclitaxel is safe. Secondary Objectives 1.2.1 To assess toxicities associated with the addition of OBP-301 to chemoradiation. 1.2.2 To assess the number of clinical complete responses (cCR). 1.2.3 To assess the number of patients alive/without progression (PFS) and the number of patients alive (OS) at 1 and 2 years.
Chemotherapy (NOS); Radiotherapy; Therapy (NOS)
OBP-301 (); Paraplatin (carboplatin); Taxol (paclitaxel); carboplatin (); paclitaxel ()
If you are interested in learning more about clinical trials, our clinical trial navigators can discuss your options and recommend opportunities that may be suitable for you. Call 813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form.
Back to top
Please call 1-888-663-3488 for support from a Moffitt representative. New Patients and Healthcare Professionals can submit an online form by selecting the appropriate button below. Existing patients can call 1-888-663-3488. Click here for a current list of insurances accepted at Moffitt.
NEW PATIENTS To request a new patient appointment, please fill out the online form or call 1-888-663-3488.
REFERRING PHYSICIANS Providers and medical staff can refer patients by submitting our online referral form.
Moffit now offers Virtual Visits for patients. If you are eligible for a virtual appointment, our scheduling team will discuss this option further with you.
Moffitt Cancer Center is committed to the health and safety of our patients and their families. For more information on how we’re protecting our new and existing patients, visit our COVID-19 Info Hub
A secure website for patients to access their medical care at Moffitt.
An online resource for referring physicians and their staff.
For Moffitt faculty & staff members to access MoffittNet applications.
Our patient services specialists can assist you with scheduling an appointment, questions about medical records, insurance, billing and more.
Patient Appointment Center Hours: 7 a.m. to 7 p.m. Monday - Friday; 8 a.m. to noon Saturday