Clinical Trial 22605

• Overview

  Study Title:

  Investigation of Microplastic Pollution in the Human Respiratory System and Its Relationship to Lung Cancer

  Summary:

  In this protocol we plan to interrogate BALF for Microplastics (MPs) in Moffitt patients undergoing bronchoscopy /bronchoalvelolar levage (BAL) in order to provide insights on the relationships of MPs with lung cancer.

  Objective:

  The primary objective of this project is to study and characterize MP burden in the lungs of patients undergoing BAL in thoracic clinics at Moffitt. The secondary objective is to compare the concentration and type of MPs recovered in BAL fluid in patients found to have a lung neoplasm versus patients in whom a diagnosis of lung cancer is excluded.

• Inclusion Criteria

  Inclusion Criteria:
  • English speaking patients scheduled for bronchoscopy/BAL in thoracic clinics at Moffitt will be considered eligible.

• Exclusion Criteria

  Exclusion Criteria:
  • Patients with a known prior history of lung cancer or that have undergone a BAL procedure at any time in the past in the involved lung targeted for BAL will be ineligible.
  • Patients that underwent any prior lung or thoracic or surgeries or procedures (examples: removal of lung or portions of the involved lung (lobectomy, pneumonectomy, wedge resection/segmentectomy) will also be ineligible.
  • Patients with specimens that are considered to be non-adequate as true BALF (i.e., absence of alveolar macrophages) after pathologist's evaluation will be excluded from the study.

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