Clinical Trial 22153

• Overview

  Study Title:

  Feasibility of Exercise Prehabilitation Among Older Patients with Hepatobiliary Cancer Planning for Surgery

  Summary:

  The purpose of the study is to evaluate an exercise program for individuals with hepatobiliary cancer planning for surgery.

  Objective:

  Objectives: Specific Aim 1: Evaluate the feasibility, safety, and acceptability of a remote, multimodal exercise intervention as prehabilitation for older cancer patient having Hepatobiliary surgery. Hypothesis 1: The intervention will be feasible, safe, and acceptable based on published metrics. Specific Aim 2: Assess changes in objective and self-reported physical functioning, aerobic fitness, skeletal muscle mass and radiodensity, Geriatric outcomes (loss of functionality; loss of capacity to perform activities of daily living; non programmed hospitalization; discharge to nursing facility) and health-related quality of life among intervention participants. Hypothesis 2: Participants will show favorable changes in exploratory outcome measures over the course of the exercise intervention. Specific Aim 3: Compare changes in skeletal muscle mass and radiodensity, inflammatory Aging biomarkers (Neutrophil/lymphocyte ratio, modified Glasgow prognostic score), health-related quality of life, and clinical outcomes (Clavien-Dindo III-V events, length of hospital stay and ICU admissions,) between exercise participants and retrospectively identified, non-intervention patients who received standard care. Hypothesis 3: Exercise participants will show favorable changes in exploratory outcome measures compared to the retrospective, non-intervention patients.

• Inclusion Criteria

  • Age >65 years
  • Resectable Hepatocellular carcinoma, Cholangiocarcinoma, or Liver metastasis with Liver resection planned >4 weeks
  • ECOG 0-2
  • Able to sign consent

• Exclusion Criteria

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