Brain Cancer Clinical Trials

Moffitt Cancer Center’s Neuro-Oncology Program is actively working to improve treatment options, outcomes and quality of life for brain cancer patients now and into the future through our nationally renowned clinical trial program. Before novel treatments are made widely available, they must go through clinical trials that allow researchers to identify when they are most effective, how they interact with other therapies and their success against various types of brain cancer. Advances in understanding the biology of cancer, and efforts to develop new, more effective therapeutics, ultimately result in the development of novel treatments.

What are brain cancer clinical trials?

Clinical trials are controlled medical studies that are used to assess the effectiveness of innovative treatment options. Physicians and scientists are frequently exploring new therapies, such as chemotherapy combinations, biologic therapies and vaccines. Today’s most widely used brain cancer treatments were once evaluated in clinical trials.

Brain cancer clinical trials at Moffitt

Moffitt spearheads one of the largest cancer clinical trial programs in the nation. Clinical trials within our brain cancer program include investigations into:

• New ways to use immunotherapy to fight brain cancer
• Gene therapy for brain cancer
• Treatment of leptomeningeal disease (LMD), which currently has few effective treatments
• Use of personalized approaches to match the treatment to the genetics of a patient’s tumor
• Direct delivery of novel therapeutics to tumor tissue
• Imaging techniques
• Immunotherapies
• Radiation therapies
• Vaccine therapies
• Brain metastases diagnostics and treatments
• Neurologic complications of cancers (neuropathies or paraneoplastic syndromes) and its therapies (immunologic therapies, CAR-T therapies, etc.)

Why choose Moffitt?

Research and clinical trials raise the standard of cancer care and continue to bring us closer to a cure. Thanks to Moffitt’s robust clinical trial program and ongoing research efforts, we have been awarded multiple research grants and are recognized as a Comprehensive Cancer Center by the National Cancer Institute. We are currently the only cancer center based in Florida to hold this prestigious designation. Furthermore, our team includes specialists who focus exclusively on brain cancer (primary brain tumors, brain metastases and leptomeningeal disease) and improving treatment options for these diseases, allowing our patients to receive care under the supervision of uniquely experienced professionals.

The decision to participate in a clinical trial is a highly personal one that requires careful consideration. If you would like to receive more information about brain cancer clinical trials at Moffitt and whether or not you are a candidate, contact 1-813-745-6100 or 1-800-679-0775 (toll-free) to speak with a knowledgeable clinical navigator. You may also submit a clinical trials inquiry form online at your convenience.

Medically Reviewed by Dr. Michael Vogelbaum, Program Leader, Department of Neuro-Oncology.