Allogeneic Stem Cell Transplant Information

An allogeneic stem cell transplant is a procedure in which healthy stem cells are collected from a donor and transplanted into a patient through a blood transfusion. An allogeneic transplant may be recommended for patients with leukemia, aplastic anemia, an inherited abnormality that affects blood cells or another condition that damages or compromises the bone marrow. It may also be used to restore stem cells in patients who have undergone high-dose chemotherapy or another cancer treatment that can damage stem cells.

At Moffitt Cancer Center, the multispecialty team within our Blood and Marrow Transplant and Cellular Immunotherapy Program collaborates to ensure each patient receives an individualized treatment plan that’s tailored to his or her needs. If an allogeneic transplant is recommended as part of your treatment, the first step involves finding a donor. An allogeneic transplant requires that someone donate marrow or blood stem cells for you. The donor may be:

  • A close relative, such as a sibling or parent
  • An anonymous volunteer donor from the National Marrow Donor Program ("Be The Match")

While an appropriate match is being found, the patient will receive conditioning to prepare for the transplant. Chemotherapy or immunotherapy may be used to help prepare the patient’s body to receive the healthy stem cells. Once a donor has been found, the patient will receive the stem cell infusion through a central venous catheter (central line).

Patients undergoing an allogeneic transplant will be admitted to our specialized blood and bone marrow transplant inpatient unit to receive their preparative chemotherapy and transplant. Patients may remain in the hospital for several days to weeks and will be closely monitored by our medical team until it is safe for the patient to be discharged to an outpatient setting. Upon discharge, patients who have received an allogeneic transplant are required to remain close to Moffitt for follow-up care, which is provided in our outpatient clinic and treatment center. Moffitt’s transplant program has several options for local lodging; please discuss with your assigned social worker.

For more information on receiving an allogeneic stem cell transplant at Moffitt, call 1-888-663-3488 or complete a new patient registration form online.