Small Animal Imaging Lab - Key Publications Over the Last Five Years

1. Tafreshi NK, Enkemann SA, Bui MM, Lloyd MC, Abrahams D, Huynh AS, Kim J, Grobmyer SR, Carter WB, Vagner J, Gillies RJ, Morse DL. A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes. Cancer Res 2011 Feb; 71: (3) 1050-1059PMID: 21169406. PMCID: PMC4130564. IF: 9.329

2. Hashim AI, Zhang X, Wojtkowiak JW, Martinez GV, Gillies RJ. Imaging pH and metastasis. Nmr Biomed 2011 Jul; 24: (6) 582-591 PMID: 21387439. PMCID: PMC3740268. IF: 3.044

3. Balasis ME, Forinash KD, Chen YA, Fulp WJ, Coppola D, Hamilton AD, Cheng JQ, Sebti SM. Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice. Clin Cancer Res 2011 May; 17: (9) 2852-2862 PMID: 21536547. PMCID: PMC3156694. IF: 8.722

4. Martinez GV, Zhang X, García-Martín ML, Morse DL, Woods M, Sherry AD, Gillies RJ. Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. Nmr Biomed 2011 Dec; 24: (10) 1380-1391 PMID: 21604311. PMCID: PMC3693774.IF: 3.044

5. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. J Bone Miner Res 2011 Jun; 26: (6) 1252-1260 PMID: 21611966. PMCID: PMC3312757. IF: 6.832

6. Huynh AS, Abrahams DF, Torres MS, Baldwin MK, Gillies RJ, Morse DL. Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells. PLoS One 2011 Sep; 6: (5) e20330- PMID: 21647423. PMCID: PMC3103544. IF: 3.234

7. Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Reduction of metastasis using a non-volatile buffer. Clin Exp Metastas 2011 Dec; 28: (8) 841-849 PMID: 21861189. PMCID: PMC3213349. IF: 3.491

8. Rao V, Alleti R, Xu L, Tafreshi NK, Morse DL, Gillies RJ, Mash EA. A sucrose-derived scaffold for multimerization of bioactive peptides. Bioorg Med Chem 2011 Nov; 19: (21) 6474-6482 PMID: 21940174. PMCID: PMC3197697. IF: 2.793  

9. Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. J Med Chem 2011 Dec; 54: (23) 8078-8084 PMID: 22011200.PMCID: PMC3302579. IF: 5.447

10. Tafreshi NK, Bui MM, Bishop K, Lloyd MC, Enkemann SA, Lopez AS, Abrahams D, Carter WB, Vagner J, Gobmyer SR, Gillies RJ, Morse DL. Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes. Clin Cancer Res2012 Jan; 18: (1) 207-219 PMID: 22016510. PMCID: PMC4130557. IF: 8.722

11. Nair RR, Tolentino JH, Argilagos RF, Zhang L, Pinilla-Ibarz J, Hazlehurst LA. Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML. Leuk Res 2012 Jun; 36: (6) 756-763 PMID: 22209738. PMCID: PMC3331955. IF: 2.351  

12. Shah M, Huang D, Blick T, Connor A, Reiter LA, Hardink JR, Lynch CC, Waltham M, Thompson EW. An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One 2012 May; 7: (1) e29615- PMID: 22253746. PMCID: PMC3256168. IF: 3.234  

13. Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ. IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene 2013 Jan; 32: (2) 151-159 PMID: 22330135.PMCID: PMC4109158. IF: 8.459  

14. D'Silva L, Pola A, Dutta P, Martinez GV, Sprenger P, Gillies RJ, Kuchel PW, Sendhil Velan S. Slow relaxation of longitudinal multispin orders in weakly and strongly coupled two-spin systems. Magn Reson Chem 2012 Jun; 50: (6) 443-448 PMID: 22552892. PMCID: PMC4573577. IF: 1.179

15. Cárdenas-Rodríguez J, Li Y, Galons JP, Cornnell H, Gillies RJ, Pagel MD, Baker AF. Imaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model. Magn Reson Imaging 2012 Sep; 30: (7) 1002-1009 PMID: 22554971. PMCID: PMC3402593. IF: 2.090  

16. Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One 2012 Sep; 7: (4) e35566- PMID: 22563386. PMCID: PMC3338522. IF: 3.234

17. Ibrahim-Hashim A, Cornnell HH, Abrahams D, Lloyd M, Bui M, Gillies RJ, Gatenby RA. Systemic buffers inhibit carcinogenesis in TRAMP mice. J Urol 2012 Aug; 188: (2) 624-631 PMID: 22704445. PMCID: PMC3694604. IF: 4.471

18. Xu CX, Xu M, Tan L, Yang H, Permuth-Wey J, Kruk PA, Wenham RM, Nicosia SV, Lancaster JM, Sellers TA, Cheng JQ. MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem 2012 Oct; 287: (42) 34970-34978 PMID: 22927443. PMCID: PMC3471722. IF: 4.573

19. Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res 2012 Dec; 72: (24) 6362-6370 PMID: 23066036. PMCID: PMC3525750. IF: 9.329

20. Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proc Natl Acad Sci U S A 2012 Dec; 109: (52) 21295-21300 PMID: 23236171. PMCID: PMC3535626. IF: 9.674

21. Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 2013 Mar; 73: (5) 1524-1535 PMID: 23288510. PMCID: PMC3594450. IF: 9.329

22. Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer Therapy for Cancer. J Nutr Food Sci 2012 Aug; 2: 6- PMID: 24371544. PMCID: PMC3872072.

23. Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY, Cheng JQ. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene 2014 Feb; 33: (6) 679-689 PMID: 23353819. PMCID: PMC3925335. IF: 8.459

24. Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, Mash EA. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorg Med Chem Lett 2013 Apr; 23: (7) 2061-2064 PMID: 23481651. PMCID: PMC3602218. IF: 2.420

25. Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One 2013 Sep; 8: (3) e57523- PMID: 23520471.PMCID: PMC3592874. IF: 3.234

26. Rejniak KA, Estrella V, Chen T, Cohen AS, Lloyd MC, Morse DL. The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study. Front Oncol 2013 May; 3: 111- PMID: 23717812. PMCID: PMC3650652.

27. Tafreshi NK, Silva A, Estrella VC, McCardle TW, Chen T, Jeune-Smith Y, Lloyd MC, Enkemann SA, Smalley KS, Sondak VK, Vagner J, Morse DL. In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma.Mol Pharm 2013 Aug; 10: (8) 3175-3185 PMID: 23763620. PMCID: PMC3785103. IF: 4.384

28. Barkey NM, Preihs C, Cornnell HH, Martinez GV, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. J Med Chem 2013 Aug; 56: (16) 6330-6338 PMID: 23863078. PMCID: PMC3807968. IF: 5.447

29. Tafreshi NK, Gillies RJ, Morse DL. Molecular imaging of breast cancer lymph node metastasis. Eur J Radiol 2012 Sep; 81 Suppl 1: S160-S161 PMID: 23083574. PMCID: PMC4529025. IF: 2.369  

30. Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.Bioorg Med Chem 2013 Sep; 21: (17) 5029-5038 PMID: 23890524. PMCID: PMC3773999. IF: 2.793

31. Tafreshi NK, Lloyd MC, Bui MM, Gillies RJ, Morse DL. Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases. Subcell Biochem 2013 Sep; 75: 221-254 PMID: 24146382. PMCID: PMC4282494.

32. Luhach I, Idiyatullin D, Lynch CC, Corum C, Martinez GV, Garwood M, Gillies RJ. Rapid ex vivo imaging of PAIII prostate to bone tumor with SWIFT-MRI. Magn Reson Med 2014 Sep; 72: (3) 858-863 PMID: 24155275. PMCID: PMC3997623. IF: 3.571

33. Zheng XQ, Guo JP, Yang H, Kanai M, He LL, Li YY, Koomen JM, Minton S, Gao M, Ren XB, Coppola D, Cheng JQ. Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer. Oncogene 2014 Oct; 33: (42) 4985-4996 PMID: 24166501. PMCID: PMC4002670. IF: 8.459  

34. Cubitt CL, Menth J, Dawson J, Martinez GV, Foroutan P, Morse DL, Bui MM, Letson GD, Sullivan DM, Reed DR. Rapid screening of novel agents for combination therapy in sarcomas. Sarcoma 2013 Nov; 2013: 365723- PMID: 24282374. PMCID: PMC3824404.  

35. Mignion L, Dutta P, Martinez GV, Foroutan P, Gillies RJ, Jordan BF. Monitoring chemotherapeutic response by hyperpolarized 13C-fumarate MRS and diffusion MRI. Cancer Res 2014 Feb; 74: (3) 686-694 PMID: 24285723. PMCID: PMC4461058. IF: 9.329

36. Foroutan P, Kreahling JM, Morse DL, Grove O, Lloyd MC, Reed D, Raghavan M, Altiok S, Martinez GV, Gillies RJ. Diffusion MRI and novel texture analysis in osteosarcoma xenotransplants predicts response to anti-checkpoint therapy. PLoS One 2013 ; 8: (12) e82875- PMID: 24358232.PMCID: PMC3865096. IF: 3.234

37. Schneeberger VE, Luetteke N, Ren Y, Berns H, Chen L, Foroutan P, Martinez GV, Haura EB, Chen J, Coppola D, Wu J. SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis 2014 Aug; 35: (8) 1717-1725 PMID: 24480804. PMCID: PMC4123642. IF: 5.334  

38. Kim S, Amankwah EK, Connors S, Park HY, Rincon M, Cornnell HH, Chornokur G, Ibrahim-Hashim A, Choi J, Tsai YY, Engelman R, Kumar NB, Park JY. Safety and chemopreventive effect of Polyphenon E in preventing early and metastatic progression of prostate cancer in TRAMP mice. Cancer Prev Res (Phila) 2014 Apr; 7: (4) 435-444 PMID: 24501325. PMCID: PMC4123218. IF: 4.891

39. Bailey KM, Wojtkowiak JW, Cornnell HH, Ribeiro MC, Balagurunathan Y, Hashim AI, Gillies RJ. Mechanisms of buffer therapy resistance. Neoplasia 2014 Apr; 16: (4) 354-64.e1 PMID: 24862761. PMCID: PMC4094835. IF: 4.252

40. Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer 2015 Feb; 136: (4) E188-E196 PMID: 25156304. PMCID: PMC4262548. IF: 5.085

41. Bailey KM, Cornnell HH, Ibrahim-Hashim A, Wojtkowiak JW, Hart CP, Zhang X, Leos R, Martinez GV, Baker AF, Gillies RJ. Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer. PLoS One 2014 ; 9: (12) e113586- PMID: 25532146. PMCID: PMC4273999. IF: 3.234

42. Richards EJ, Zhang G, Li ZP, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D, Mao WM, Sellers TA, Cheng JQ. Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) β: LncRNA-hit-mediated TGFβ-induced epithelial to mesenchymal transition in mammary epithelia. J Biol Chem 2015 Mar; 290: (11) 6857-6867 PMID: 25605728. PMCID: PMC4358111. IF: 4.573

43. Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer Metab 2015 ; 3: (1) 2- PMID: 25635223. PMCID: PMC4310189.  

44. Huynh AS, Estrella V, Stark VE, Cohen AS, Chen T, Casagni TJ, Josan JS, Lloyd MC, Johnson J, Kim J, Hruby VJ, Vagner J, Morse DL. Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5. Mol Pharm 2016 Jan; In Press PMID: 26713599. IF: 4.384

45. Dutta P, Le A, Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ. Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors. Cancer Res 2013 Jul; 73: (14) 4190-4195 PMID: 23722553. PMCID: PMC3736580. IF: 9.329

46. Wang B, Zhao Q, Barkey NM, Morse DL, Jiang H. Photoacoustic tomography and fluorescence molecular tomography: a comparative study based on indocyanine green. Med Phys 2012 May; 39: (5) 2512-2517 PMID: 22559621. PMCID: PMC4108689. IF: 2.635