Image Response Assessment Team

Shared Resources

The overall goal of the Image Response Assessment Team (IRAT) Shared Resource is to enhance the scientific quality of clinical studies, by offering a single point of entry for Moffitt Cancer Center (MCC) members to access traditional and advanced quantitative image analysis services. 

Efforts are organized around three Specific Aims, which are to:

Aim 1: maintain and improve the high reliability and fast turnaround times for RECIST (Response Evaluation Criteria in Solid Tumors)and other standard tumor assessment metrics;

Aim 2: improve therapeutic trials at MCC by translating research advances in radiomics and multi-parameter MRI (mpMRI) analyses into turnkey imaging biomarker services; and

Aim 3: provide members with access to non-traditional imaging endpoints for therapeutic trials.

IRAT provides quantitative image-based tumor metrics to support investigator-initiated, cooperative group, and industry-sponsored clinical trials at MCC, and is part of the national consortium of Cancer Center IRATs. IRAT provides the support and services necessary to integrate both traditional and innovative imaging endpoints into clinical trials and provides quality assurance and control throughout the process to yield scientifically valid results. With rapid advances in treatment paradigms such as immunotherapies, IRAT provides improved imaging endpoints to meet the needs of these cutting-edge studies of MCC members.

CONTACTS

Scientific Director:
Natarajan Raghunand, PhD

Medical Director:
Donald Klippenstein, MD  - (813) 745-2058

Core Facility Manager:
Olya Stringfield, PhD

The core is supported in part by the National Cancer Institute (P30-CA076292, Cancer Center Support Grant).