Biostatistics

Shared ResourcesPurpose
The overall goal of the Biostatistics Core (BC) is to provide statistical design and analysis expertise supporting the research efforts of Moffitt Cancer Center (MCC) members. Service begins with analytical design and determination of sample size (e.g., grant and clinical trial submissions), leading to project conduct, monitoring of accumulating research data on active projects, data quality evaluation, statistical analysis, and manuscript development. The BC provides key quantitative analytical results, including tables, figures, and scientific conclusions. Faculty biostatisticians provide education and training in biostatistics, participate actively in the Scientific Review Committees (SRC) and Protocol Review & Monitoring Committee (PRMC), and serve as reviewers for internal grant applications.

Services

  • Design
    • The BC supports project developmentand analytical planning for clinical protocols and research studies including determining sample size, performing power analysis, and assisting grant development.
  • Monitoring
    • Clinical trial randomization, data collection monitoring, and data quality evaluation.
  • Analysis
    • The BC provides statistical analysis for a full range of studies, including clinical trials, pre-clinical and animal studies, correlative science studies, observational and epidemiological studies, gene microarrays, tissue microarrays, SNPs, biomarkers, proteomics, retrospective reviews, group randomized trials, and behavioral intervention trials.
  • Reporting and Summarization
    • The BC prepares and/or reviews the analytical aspects of reports, abstracts, conference presentations, and manuscripts, including methods sections, tables, and figures.
  • Other
    • BC continually advances the latest statistical methods, through implementation of new techniques developed internally or externally. This includes teaching short courses in statistical analysis for cancer researchers.

Software

  • Sample Size Calculation: PASS, nQuery Advisor, StatXact, SAS
  • Analysis: SAS, R, Matlab, StatXact, LogXact, SPSS, Mplus, SOLAS, IRTPRO, Stata, MARS

Statistical Expertise includes:

     Advanced Clinical Trial Methods                     Gene Expression Analysis

     SNP Analysis                                                Gene Mutation Analysis             

     Proteomics                                                   Imaging Analysis/Radiomics         

     Microbiome Studies                                       Biomarker Analysis

     Advanced Survival Analysis                           Latent Growth Curve Models                 

     Structural Equation Modeling                          Multiple  Imputation

Location
The BC is located in the Moffitt Research Center (MRC) on the 2nd, Room 263.

Scheduling
The BC uses a Laboratory Information Management Suite (LIMS) located on the Moffittnet for billing and usage tracking.

Publications
All publications based on work conducted in the Biostatistics Core should acknowledge the facility.  A suggested statement is as follows:

This work has been supported in part by the Biostatistics Core at the H. Lee Moffitt Cancer Center & Research Institute, a comprehensive cancer center designated by the National Cancer Institute.

If a Core Staff member(s) significantly contributes or participates in a project, investigators are encouraged to consider including the individual(s) in the list of authors.

Contacts
Scientific Director
Michael Schell, PhD - michael.schell@moffitt.org
Office: 813-745-6061

Core Facility Manager
Richard Reich, PhD - richie.reich@moffitt.org
Office: 813-745-6210