Younghoon Kee
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Younghoon Kee

Overview

Discipline

    • Cancer Biology and Evolution Program

Education & Training

    • Dana-Farber Cancer Institute/Harvard Medical School, Fellow
    • Hankuk University of Foreign Studies, MS
    • University of Texas at Austin, PhD - Cell and Molecular Biology
Research

I am interested in investigating the function and regulation of protein ubiquitination machineries, particularly in DNA damage response.  Protein ubiquitination has emerged as a key mechanism for regulating DNA repair signaling, such as in the case of the Fanconi Anemia (FA) pathway.  I am interested in further elucidating the role of protein ubiquitination machineries in regulating the FA pathway and DNA damage response in general.

Publications

  • Sanchez A, De Vivo A, Uprety N, Kim J, Stevens SM, Kee Y. BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin. Proc Natl Acad Sci U S A. 2016 Oct;113(40):11243-11248. Pubmedid: 27647897. Pmcid: PMC5056041.
  • Kee Y. Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?. Mol Cell Oncol. 2016 Oct;3(6):e1244513. Pubmedid: 28090582. Pmcid: PMC5160387.
  • Cukras S, Lee E, Palumbo E, Benavidez P, Moldovan GL, Kee Y. The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair. Cell Cycle. 2016 Oct;15(19):2636-2646. Pubmedid: 27463890. Pmcid: PMC5053553.
  • Kee Y, Huang TT. Role of Deubiquitinating Enzymes in DNA Repair. Mol Cell Biol. 2015 Dec;36(4):524-544. Pubmedid: 26644404. Pmcid: PMC4751696.
  • Polito D, Cukras S, Wang X, Spence P, Moreau L, D'Andrea AD, Kee Y. The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem. 2014 Mar;289(10):7003-7010. Pubmedid: 24451376. Pmcid: PMC3945361.
  • Cukras S, Morffy N, Ohn T, Kee Y. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases. PLoS One. 2014;9(7):e101844. Pubmedid: 25025768. Pmcid: PMC4099125.
  • Kee Y, D'Andrea AD. Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest. 2012 Nov;122(11):3799-3806. Pubmedid: 23114602. Pmcid: PMC3484428.
  • Kee Y, D'Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Gene Dev. 2010 Aug;24(16):1680-1694. Pubmedid: 20713514. Pmcid: PMC2922498.
  • Kee Y, Yang K, Cohn MA, Haas W, Gygi SP, D'Andrea AD. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem. 2010 Apr;285(15):11252-11257. Pubmedid: 20147737. Pmcid: PMC2857003.
  • Kee Y, Kim JM, D'Andrea AD, D'Andrea A. Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Gene Dev. 2009 Mar;23(5):555-560. Pubmedid: 19270156. Pmcid: PMC2658523.
  • Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 2009 Feb;284(8):5343-5351. Pubmedid: 19075014. Pmcid: PMC2643494.
  • Kim JM, Kee Y, Gurtan A, D'Andrea AD. Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood. 2008 May;111(10):5215-5222. Pubmedid: 18174376. Pmcid: PMC2384144.
  • Kee Y, Muñoz W, Lyon N, Huibregtse JM. The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae. J Biol Chem. 2006 Dec;281(48):36724-36731. Pubmedid: 17028178.
  • Kee Y, Lyon N, Huibregtse JM. The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme. Embo J. 2005 Jul;24(13):2414-2424. Pubmedid: 15933713. Pmcid: PMC1173151.
  • Shcherbik N, Kee Y, Lyon N, Huibregtse JM, Haines DS. A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p. J Biol Chem. 2004 Dec;279(51):53892-53898. Pubmedid: 15466864.