Xiaohong (Mary) Zhang, PhD

Xiaohong (Mary) Zhang, PhD



    • Cancer Biology and Evolution Program

Education & Training

    • U.T.M.D. Anderson Cancer Center, MS - Molecular Pathology
    • U.T.M.D. Anderson Cancer Center, PhD - Molecular Biology
    • H. Lee Moffitt Cancer Center, Postdoctoral Fellow - Molecular Oncology

Post translational modifications, such as phosphorylation and acetylation, play important roles in a variety of cellular processes. Alterations of these modifications may lead to human diseases including cancer. Our lab is interested in how these posttranslational modifications, particularly acetylation, influence biological functions such as gene expression, cell motility etc., in normal and aberrant settings. Our ultimate goal is to apply our knowledge to cure human diseases. Our lab is interested in studying the roles of HDAC6 and cortactin, a novel HDAC6 substrate in human cancers, particularly in ovarian and breast cancers. Our previous investigation showed that HDAC6 and cortactin are associated with cell migration. We will further determine whether HDAC6 and cortactin, especially the deacetylated form of cortactin, are involved in ovarian and breast cancer metastasis.


  • Niu X, Zhao J, Ma J, Xie C, Edwards H, Wang G, Caldwell JT, Xiang S, Zhang X, Chu R, Wang ZJ, Lin H, Taub JW, Ge Y. Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells. Clin Cancer Res. 2016 Sep;22(17):4440-4451. Pubmedid: 27103402. Pmcid: PMC5010519.
  • Sun Y, Sun J, Lungchukiet P, Quarni W, Yang S, Zhang X, Bai W. Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation. Sci Rep. 2015 Jul;5:11529. Pubmedid: 26166158. Pmcid: PMC4499803.
  • Lungchukiet P, Sun Y, Kasiappan R, Quarni W, Nicosia SV, Zhang X, Bai W. Suppression of epithelial ovarian cancer invasion into the omentum by 1α,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem -. 2015 Apr;148:138-147. Pubmedid: 25448740. Pmcid: PMC4465764.
  • Nelson N, Xiang S, Zhang X, Gilvary D, Djeu J, Husain K, Malafa M, Vohra N, Pilon-Thomas S, Ghansah T. Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis. PLoS One. 2015;10(1):e0115546. Pubmedid: 25629611. Pmcid: PMC4309586.
  • Haakenson J, Wu JY, Xiang S, Williams KA, Bai W, Zhang X. HDAC6-Dependent Functions in Tumor Cells: Crossroad with the MAPK Pathways. Crit Rev Oncog. 2015;20(1-2):65-81. Pubmedid: 25746105.
  • Kasiappan R, Sun Y, Lungchukiet P, Quarni W, Zhang X, Bai W. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 2014 Nov;74(21):6194-6204. Pubmedid: 25252917. Pmcid: PMC4216743.
  • Sun Y, Kasiappan R, Tang J, Webb PL, Quarni W, Zhang X, Bai W. A novel function of the Fe65 neuronal adaptor in estrogen receptor action in breast cancer cells. J Biol Chem. 2014 May;289(18):12217-12231. Pubmedid: 24619425. Pmcid: PMC4007422.
  • Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, Shan B, Fang B, Radhakrishnan R, Glazer PM, Matthias P, Koomen J, Seto E, Bepler G, Nicosia SV, Chen J, Li C, Gu L, Li GM, Bai W, Wang H, Zhang X. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell. 2014 Jul;55(1):31-46. Pubmedid: 24882211. Pmcid: PMC4188514.
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. J Biol Chem. 2013 Nov;288(46):33156-33170. Pubmedid: 24089523. Pmcid: PMC3829163.
  • Haakenson J, Zhang X. HDAC6 and Ovarian Cancer. Int J Mol Sci. 2013 May;14(5):9514-9535. Pubmedid: 23644884. Pmcid: PMC3676797.
  • Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia SV, Khochbin S, Bepler G, Zhang X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PLoS One. 2013 Feb;7(9):e44265. Pubmedid: 22957056. Pmcid: PMC3434198.
  • Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E, Tao J. Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity. Leukemia. 2013 Dec;27(12):2341-2350. Pubmedid: 23538750. Pmcid: PMC4015113.
  • Kasiappan R, Shen Z, Tse AK, Jinwal U, Tang J, Lungchukiet P, Sun Y, Kruk P, Nicosia SV, Zhang X, Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. J Biol Chem. 2012 Nov;287(49):41297-41309. Pubmedid: 23055531. Pmcid: PMC3510828.
  • Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 Jul;30(19):2207-2218. Pubmedid: 21242980. Pmcid: PMC3093431.
  • Zhang X, Bui MM, Caracciolo J, Field TL, Zhang L. Adult anaplastic large cell lymphoma involving the central nervous system: a rare clinical scenario. Ann Hematol. 2011 Jun;90(6):721-723. Pubmedid: 20838823.
  • Zhang J, Shang Z, Zhang X, Zhang Y. Modeling and analysis of Schistosoma Argonaute protein molecular spatial conformation. Asian Pac J Trop Biomed. 2011 Aug;1(4):275-278. Pubmedid: 23569774. Pmcid: PMC3614238.
  • Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem. 2009 May;284(21):13987-14000. Pubmedid: 19321440. Pmcid: PMC2682847.
  • Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009 Jul;284(27):18210-18217. Pubmedid: 19433578. Pmcid: PMC2709385.
  • Ma Q, Fu W, Li P, Nicosia SV, Jenster G, Zhang X, Bai W. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Mol Endocrinol. 2009 Feb;23(2):213-225. Pubmedid: 19074551. Pmcid: PMC2646622.
  • Yuan Z, Rezai-Zadeh N, Zhang X, Seto E. Histone deacetylase activity assay. Methods Mol Biol. 2009;523:279-293. Pubmedid: 19381932.
  • Zhang X, Cromwell J, Kunjummen B, Yee D, Garcia-Aguilar J. The alpha2 and alpha3 integrins are required for morphologic differentiation of an intestinal epithelial cell line. Surgery. 2003;133(4):429-437. Pubmedid: 12717361.
  • Hu X, Bryington M, Fisher AB, Liang X, Zhang X, Cui D, Datta I, Zuckerman KS. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. J Biol Chem. 2002 May;277(19):16528-16537. Pubmedid: 11864973.
  • Dong A, Yoder J, Zhang X, Zhou T, Bestor T, Cheng X. Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res. 2001;29(2):439-448. Pubmedid: 11139614.
  • Zhang X, Wharton W, Donovan M, Coppola D, Croxton R, Cress WD, Pledger WJ. Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1). Mol Biol Cell. 2000 Jun;11(6):2117-2130. Pubmedid: 10848633.
  • Smith D, Gao G, Zhang X, Wang G, Dou Q. Regulation of tumor cell apoptotic sensitivity during the cell cycle. Int J Mol Med. 2000;6(5):503-507. Pubmedid: 11029514.
  • Kitada S, Anderson J, Akar S, Zapata J, Schiffer C, Takayama S, Krajewski S, Wang H, Zhang X, Bullrich F, Croce C, Rai K, Hines J, Reed J. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood. 1998;91(9):3379-3389. Pubmedid: 9558396.
  • Kitada S, Krajewska M, Zhang X, Scudiero D, Zapata J, Wang H, Shabaik A, Tudor G, Krajewski S, Myers T, Johnson G, Sausville E, Reed J. Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines. Am J Pathol. 1998;152(1):51-61. Pubmedid: 9422523.
  • Liu Y, Lee M, Wang H, Hashimoto Y, Klaus M, Reed J, Zhang X. Retinoic acid receptor mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol. 1996;16:1138-1149. Pubmedid: 8622658.