Stuart Maudsley, PhD

My research theme involves the investigation of how disruptions of G protein-coupled receptor (GPCR) signaling networks underpin the genesis and etiology of cancers as well as other aging-related pathologies. Through my novel appreciation of the multidimensional signaling profiles of GPCRs I aim to introduce a new generation of precision and patient-specific receptor-based therapeutic interventions. In addition to this I also aim to employ this enhanced appreciation of GPCR biology for the creation of new cell/tissue-based diagnostic agents for early - non-invasive - cancer detection.

Associations

• Drug Discovery

My research interests primarily revolve around the exploitation of receptor signaling paradigms with respect to generating either theragnostics or ameliorative therapies for cancer and potentially driving morbidities such as metabolic syndrome or gastro-intestinal motility syndromes. My research combines high dimensionality data acquisition and analysis coupled with 'wet lab' molecular pharmacology approaches to advance drug discovery, design and development. My primary targets are G protein-coupled receptors but since these molecular targets are intrinsically associated with so many other signaling entities in cells then my interests in therapeutic targeting extend to several other signaling molecules such as proteases, kinases, transporters, scaffolding proteins and nucleotides. One of my current hypotheses is that an intracellular network of GPCRs and associayed signaling factors form a stress sensory network that maintain a monitoring and response system for all cells. This system and its integrity likely act as a gatekeeper for cells so that they can maintain a healthy cell cycle control and metabolic activity. I propose that the disintegration of this network may be one of the key features that predisposes cells to aberrant behavior that includes a potenial slip into oncogenic activity. I therefore plan to 'biohack' this sensory/response system to realign this GPCR monitoring of cell functionality in a cell- and patient-specific manner.

• Leopoldo M, Contino M, Maudsley S, Vrecl M. Editorial: Macromolecular interactions in signaling pathways: from classical approaches to virtual reality. Front Endocrinol (Lausanne). 2024 Feb.15:1388849. Pubmedid: 38481449. Pmcid: PMC10933126.
• Perry-Hauser N, Maudsley S, Berchiche YA, Slosky LM. Editorial: GPCRs: signal transduction. Front Mol Biosci. 2024 Apr.11:1403161. Pubmedid: 38660374. Pmcid: PMC11040204.
• Schreurs G, Maudsley S, Nast C, Praet M, Da Silva Fernandes S, Boor P, D'Haese P, De Broe ME, Vervaet BA. Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities. Sci Rep. 2023 Oct.13(1):18119. Pubmedid: 37872220. Pmcid: PMC10593944.
• Maudsley S, Schrauwen C, Harputluoğlu İ, Walter D, Leysen H, McDonald P. GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process. Int J Mol Sci. 2023 May.24(10). Pubmedid: 37239845. Pmcid: PMC10218176.
• Opdebeeck B, Neven E, Maudsley S, Leysen H, Walter D, Geryl H, D'Haese PC, Verhulst A. A Proteomic Screen to Unravel the Molecular Pathways Associated with Warfarin-Induced or TNAP-Inhibited Arterial Calcification in Rats. Int J Mol Sci. 2023 Feb.24(4). Pubmedid: 36835062. Pmcid: PMC9963640.
• Chadwick W, Maudsley S, Hull W, Havolli E, Boshoff E, Hill MDW, Goetghebeur PJD, Harrison DC, Nizami S, Bedford DC, Coope G, Real K, Thiemermann C, Maycox P, Carlton M, Cole SL. The oDGal Mouse: A Novel, Physiologically Relevant Rodent Model of Sporadic Alzheimer's Disease. Int J Mol Sci. 2023 Apr.24(8). Pubmedid: 37108119. Pmcid: PMC10138655.
• Maudsley S, Walter D, Schrauwen C, Van Loon N, Harputluoğlu İ, Lenaerts J, McDonald P. Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process. Int J Mol Sci. 2022 Nov.23(21). Pubmedid: 36362387. Pmcid: PMC9653598.
• Corremans R, Neven E, Maudsley S, Leysen H, De Broe ME, D'Haese PC, Vervaet BA, Verhulst A. Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats. Kidney Int. 2022 May.101(5):929-944. Pubmedid: 35271933.
• Van Meenen J, Leysen H, Chen H, Baccarne R, Walter D, Martin B, Maudsley S. Making Biomedical Sciences publications more accessible for machines. Med Health Care Phil. 2022 Jun.25(2):179-190. Pubmedid: 35039972.
• Leysen H, Walter D, Clauwaert L, Hellemans L, van Gastel J, Vasudevan L, Martin B, Maudsley S. The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease. Int J Mol Sci. 2022 Apr.23(8). Pubmedid: 35457203. Pmcid: PMC9027355.
• Van den Bergh G, De Moudt S, Van den Branden A, Neven E, Leysen H, Maudsley S, De Meyer GRY, D'Haese P, Verhulst A. Endothelial Contribution to Warfarin-Induced Arterial Media Calcification in Mice. Int J Mol Sci. 2021 Oct.22(21). Pubmedid: 34769044. Pmcid: PMC8583869.
• van Gastel J, Leysen H, Boddaert J, Vangenechten L, Luttrell LM, Martin B, Maudsley S. Aging-related modifications to G protein-coupled receptor signaling diversity. Pharmacol Ther. 2021 Jul.223:107793. Pubmedid: 33316288.
• Leysen H, Walter D, Christiaenssen B, Vandoren R, Harputluoğlu İ, Van Loon N, Maudsley S. GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease. Int J Mol Sci. 2021 Dec.22(24). Pubmedid: 34948182. Pmcid: PMC8708147.
• Coppens V, De Wachter O, Goossens J, Hendrix J, Maudsley S, Azmi A, van Gastel J, Van Saet A, Lauwers T, Morrens M. Profiling of the Peripheral Blood Mononuclear Cell Proteome in Schizophrenia and Mood Disorders for the Discovery of Discriminatory Biomarkers: A Proof-of-Concept Study. Neuropsychobiology. 2021 Apr.79(4-5):324-334. Pubmedid: 32392557.
• Moons R, van der Wekken-de Bruijne R, Maudsley S, Lemière F, Lambeir AM, Sobott F. Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study. Int J Mol Sci. 2020 Oct.21(21). Pubmedid: 33114222. Pmcid: PMC7660655.
• Moons R, Konijnenberg A, Mensch C, Van Elzen R, Johannessen C, Maudsley S, Lambeir AM, Sobott F. Metal ions shape α-synuclein. Sci Rep. 2020 Oct.10(1):16293. Pubmedid: 33004902. Pmcid: PMC7529799.
• Hendrickx JO, van Gastel J, Leysen H, Martin B, Maudsley S. High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases. Pharmacol Rev. 2020 Jan.72(1):191-217. Pubmedid: 31843941.
• De Ridder W, Azmi A, Clemen CS, Eichinger L, Hofmann A, Schröder R, Johnson K, Töpf A, Straub V, De Jonghe P, Maudsley S, De Bleecker JL, Baets J. Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation: A tale of the unexpected. Neurology. 2020 Feb.94(8):e785-e796. Pubmedid: 31848255.
• Opdebeeck B, Maudsley S, Azmi A, De Maré A, De Leger W, Meijers B, Verhulst A, Evenepoel P, D'Haese PC, Neven E. Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance. J Am Soc Nephrol. 2019 May.30(5):751-766. Pubmedid: 30940651. Pmcid: PMC6493976.
• De Maré A, Maudsley S, Azmi A, Hendrickx JO, Opdebeeck B, Neven E, D'Haese PC, Verhulst A. Sclerostin as Regulatory Molecule in Vascular Media Calcification and the Bone-Vascular Axis. Toxins (Basel). 2019 Jul.11(7). Pubmedid: 31330917. Pmcid: PMC6669501.
• van Gastel J, Hendrickx JO, Leysen H, Martin B, Veenker L, Beuning S, Coppens V, Morrens M, Maudsley S. Enhanced Molecular Appreciation of Psychiatric Disorders Through High-Dimensionality Data Acquisition and Analytics. Methods Mol Biol. 2019 Jul.2011:671-723. Pubmedid: 31273728.
• Anckaerts C, van Gastel J, Leysen V, Hinz R, Azmi A, Simoens P, Shah D, Kara F, Langbeen A, Bols P, Laloux C, Prevot V, Verhoye M, Maudsley S, Van der Linden A. Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. Neurobiol Aging. 2019 Feb.74:77-89. Pubmedid: 30439596.
• van Gastel J, Leysen H, Santos-Otte P, Hendrickx JO, Azmi A, Martin B, Maudsley S. The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage. Aging (Albany NY). 2019 Dec.11(23):11268-11313. Pubmedid: 31794429. Pmcid: PMC6932917.
• van Gastel J, Cai H, Cong WN, Chadwick W, Daimon C, Leysen H, Hendrickx JO, De Schepper R, Vangenechten L, Van Turnhout J, Verswyvel J, Becker KG, Zhang Y, Lehrmann E, Wood WH, Martin B, Maudsley S. Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. Mech Ageing Dev. 2019 Dec.184:111150. Pubmedid: 31574270.
• Santos-Otte P, Leysen H, van Gastel J, Hendrickx JO, Martin B, Maudsley S. G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence. Comput Struct Biotechnol J. 2019 Aug.17:1265-1277. Pubmedid: 31921393. Pmcid: PMC6944711.
• Leysen H, van Gastel J, Hendrickx JO, Santos-Otte P, Martin B, Maudsley S. G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes. Int J Mol Sci. 2018 Sep.19(10). Pubmedid: 30261591. Pmcid: PMC6213947.
• van Gastel J, Hendrickx JO, Leysen H, Santos-Otte P, Luttrell LM, Martin B, Maudsley S. β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders. Front Pharmacol. 2018 Nov.9:1369. Pubmedid: 30546309. Pmcid: PMC6280185.
• Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M. Aging and drug discovery. Aging (Albany NY). 2018 Nov.10(11):3079-3088. Pubmedid: 30425188. Pmcid: PMC6286828.
• van Gastel J, Boddaert J, Jushaj A, Premont RT, Luttrell LM, Janssens J, Martin B, Maudsley S. GIT2-A keystone in ageing and age-related disease. Ageing Res Rev. 2018 May.43:46-63. Pubmedid: 29452267.
• Miquel S, Champ C, Day J, Aarts E, Bahr BA, Bakker M, Bánáti D, Calabrese V, Cederholm T, Cryan J, Dye L, Farrimond JA, Korosi A, Layé S, Maudsley S, Milenkovic D, Mohajeri MH, Sijben J, Solomon A, Spencer JPE, Thuret S, Vanden Berghe W, Vauzour D, Vellas B, Wesnes K, Willatts P, Wittenberg R, Geurts L. Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions. Ageing Res Rev. 2018 Mar.42:40-55. Pubmedid: 29248758.
• Maudsley S, Devanarayan V, Martin B, Geerts H. Intelligent and effective informatic deconvolution of "Big Data" and its future impact on the quantitative nature of neurodegenerative disease therapy. Alzheimers Dement. 2018 Jul.14(7):961-975. Pubmedid: 29551332.
• Luttrell LM, Maudsley S, Gesty-Palmer D. Translating in vitro ligand bias into in vivo efficacy. Cell Signal. 2018 Jan.41:46-55. Pubmedid: 28495495. Pmcid: PMC5675828.
• Hendrickx JO, van Gastel J, Leysen H, Santos-Otte P, Premont RT, Martin B, Maudsley S. GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders. Front Pharmacol. 2018 Dec.9:1484. Pubmedid: 30618771. Pmcid: PMC6304357.
• Juneja M, Azmi A, Baets J, Roos A, Jennings MJ, Saveri P, Pisciotta C, Bernard-Marissal N, Schneider BL, Verfaillie C, Chrast R, Seeman P, Hahn AF, de Jonghe P, Maudsley S, Horvath R, Pareyson D, Timmerman V. PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease. J Neurol Neurosur Ps. 2018 Aug.89(8):870-878. Pubmedid: 29449460.
• Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S. Correction for Lu et al., "Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair". Mol Cell Biol. 2017 Sep.37(17). Pubmedid: 28801458. Pmcid: PMC5559679.
• Vermeulen Z, Hervent AS, Dugaucquier L, Vandekerckhove L, Rombouts M, Beyens M, Schrijvers DM, De Meyer GRY, Maudsley S, De Keulenaer GW, Segers VFM. Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung. Am J Physiol Heart Circ Physiol. 2017 Nov.313(5):H934-H945. Pubmedid: 28822966.
• Janssens J, Lu D, Ni B, Chadwick W, Siddiqui S, Azmi A, Etienne H, Jushaj A, van Gastel J, Martin B, Maudsley S. Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases. Vitam Horm. 2017 Nov.104:263-311. Pubmedid: 28215298.
• Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S. Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Aging (Albany NY). 2017 Mar.9(3):706-740. Pubmedid: 28260693. Pmcid: PMC5391227.
• Martin B, Wang R, Cong WN, Daimon CM, Wu WW, Ni B, Becker KG, Lehrmann E, Wood WH, Zhang Y, Etienne H, van Gastel J, Azmi A, Janssens J, Maudsley S. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. J Biol Chem. 2017 Jul.292(27):11508-11530. Pubmedid: 28522608. Pmcid: PMC5500814.
• Geerts H, Dacks PA, Devanarayan V, Haas M, Khachaturian ZS, Gordon MF, Maudsley S, Romero K, Stephenson D. Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge. Alzheimers Dement. 2016 Sep.12(9):1014-1021. Pubmedid: 27238630.
• Grammatikakis I, Zhang P, Panda AC, Kim J, Maudsley S, Abdelmohsen K, Yang X, Martindale JL, Motiño O, Hutchison ER, Mattson MP, Gorospe M. Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2. Cell Rep. 2016 May.15(5):926-934. Pubmedid: 27117401. Pmcid: PMC4856555.
• Maudsley S, Martin B, Janssens J, Etienne H, Jushaj A, van Gastel J, Willemsen A, Chen H, Gesty-Palmer D, Luttrell LM. Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation. Methods. 2016 Jan.92:51-63. Pubmedid: 25986936. Pmcid: PMC4646739.
• Martin B, Chadwick W, Janssens J, Premont RT, Schmalzigaug R, Becker KG, Lehrmann E, Wood WH, Zhang Y, Siddiqui S, Park SS, Cong WN, Daimon CM, Maudsley S. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Front Endocrinol (Lausanne). 2016 Jan.6:191. Pubmedid: 26834700. Pmcid: PMC4716144.
• Luttrell LM, Maudsley S, Bohn LM. Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism. Mol Pharmacol. 2015 Sep.88(3):579-588. Pubmedid: 26134495. Pmcid: PMC4551052.
• Mou Z, Hyde TM, Lipska BK, Martinowich K, Wei P, Ong CJ, Hunter LA, Palaguachi GI, Morgun E, Teng R, Lai C, Condarco TA, Demidowich AP, Krause AJ, Marshall LJ, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Nalls MA, Zonderman AB, Singleton AB, Evans MK, Martin B, Maudsley S, Tsao JW, Kleinman JE, Yanovski JA, Han JC. Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. Cell Rep. 2015 Nov.13(6):1073-1080. Pubmedid: 26526993. Pmcid: PMC4644471.
• Daimon CM, Jasien JM, Wood WH, Zhang Y, Becker KG, Silverman JL, Crawley JN, Martin B, Maudsley S. Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder. Front Physiol. 2015 Nov.6:324. Pubmedid: 26635614. Pmcid: PMC4656818.
• Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, Ivanoiu A, Vandenbulcke M, Vandenberghe R, Cras P, De Deyn PP, Martin JJ, Maudsley S, Haass C, Cruts M, Van Broeckhoven C. Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains. Acta Neuropathol Commun. 2015 Nov.3:68. Pubmedid: 26555887. Pmcid: PMC4641381.
• Hardies K, de Kovel CG, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, Azmi A, May P, Brilstra E, Becker F, Barisic N, Craiu D, Braun KP, Lal D, Thiele H, Schubert J, Weber Y, van 't Slot R, Nürnberg P, Balling R, Timmerman V, Lerche H, Maudsley S, Helbig I, Suls A, Koeleman BP, De Jonghe P. Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia. Brain. 2015 Nov.138(Pt 11):3238-3250. Pubmedid: 26384929.
• Cong WN, Chadwick W, Wang R, Daimon CM, Cai H, Amma J, Wood WH, Becker KG, Martin B, Maudsley S. Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model. J Biol Chem. 2015 Jan.290(5):2728-2743. Pubmedid: 25505248. Pmcid: PMC4317004.
• Maudsley S, Martin B, Gesty-Palmer D, Cheung H, Johnson C, Patel S, Becker KG, Wood WH, Zhang Y, Lehrmann E, Luttrell LM. Delineation of a conserved arrestin-biased signaling repertoire in vivo. Mol Pharmacol. 2015 Apr.87(4):706-717. Pubmedid: 25637603. Pmcid: PMC4366796.
• Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S. Nuclear GIT2 is an ATM substrate and promotes DNA repair. Mol Cell Biol. 2015 Apr.35(7):1081-1096. Pubmedid: 25605334. Pmcid: PMC4355538.
• Janssens J, Etienne H, Idriss S, Azmi A, Martin B, Maudsley S. Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System. Front Endocrinol (Lausanne). 2014 Sep.5:142. Pubmedid: 25225492. Pmcid: PMC4150252.
• Jasien JM, Daimon CM, Wang R, Shapiro BK, Martin B, Maudsley S. The effects of aging on the BTBR mouse model of autism spectrum disorder. Front Aging Neurosci. 2014 Sep.6:225. Pubmedid: 25225482. Pmcid: PMC4150363.
• Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ. Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. J Exp Med. 2014 Nov.211(12):2373-2383. Pubmedid: 25366964. Pmcid: PMC4235633.
• Cai H, Daimon CM, Cong WN, Wang R, Chirdon P, de Cabo R, Sévigny J, Maudsley S, Martin B. Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators. J Gerontol A-Biol. 2014 May.69(5):532-544. Pubmedid: 24077597. Pmcid: PMC3991138.
• Wang R, Ross CA, Cai H, Cong WN, Daimon CM, Carlson OD, Egan JM, Siddiqui S, Maudsley S, Martin B. Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients. Front Physiol. 2014 Jun.5:231. Pubmedid: 25002850. Pmcid: PMC4066441.
• Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R. Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab. 2014 Jul.20(1):183-190. Pubmedid: 24882067. Pmcid: PMC4254394.
• Wang R, van Keeken NM, Siddiqui S, Dijksman LM, Maudsley S, Derval D, van Dam PS, Martin B. Higher TNF-α, IGF-1, and Leptin Levels are Found in Tasters than Non-Tasters. Front Endocrinol (Lausanne). 2014 Jul.5:125. Pubmedid: 25120532. Pmcid: PMC4114300.
• Okun E, Griffioen KJ, Rothman S, Wan R, Cong WN, De Cabo R, Martin-Montalvo A, Levette A, Maudsley S, Martin B, Arumugam TV, Mattson MP. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism. Brain Behav Immun. 2014 Feb.36:90-100. Pubmedid: 24145051. Pmcid: PMC3947180.
• Cai H, Maudsley S, Martin B. What is the role of metabolic hormones in taste buds of the tongue. Front Horm Res. 2014 Dec.42:134-146. Pubmedid: 24732931.
• Ravichandran S, Singh N, Donnelly D, Migliore M, Johnson P, Fishwick C, Luke BT, Martin B, Maudsley S, Fugmann SD, Moaddel R. Pharmacophore model of the quercetin binding site of the SIRT6 protein. J Mol Graph Model. 2014 Apr.49:38-46. Pubmedid: 24491483. Pmcid: PMC3980043.
• Mo J, Maudsley S, Martin B, Siddiqui S, Cheung H, Johnson CA. Classification of Alzheimer Diagnosis from ADNI Plasma Biomarker Data. ACM Conf Bioinform Comput Biol Biomed Inform (2013). 2013 Sep.2013:569. Pubmedid: 25599092. Pmcid: PMC4295502.
• Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S. Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PLoS One. 2013 Oct.8(10):e76553. Pubmedid: 24124572. Pmcid: PMC3790684.
• Harvie M, Wright C, Pegington M, McMullan D, Mitchell E, Martin B, Cutler RG, Evans G, Whiteside S, Maudsley S, Camandola S, Wang R, Carlson OD, Egan JM, Mattson MP, Howell A. The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr. 2013 Oct.110(8):1534-1547. Pubmedid: 23591120. Pmcid: PMC5857384.
• Chen H, Martin B, Daimon CM, Siddiqui S, Luttrell LM, Maudsley S. Textrous!: extracting semantic textual meaning from gene sets. PLoS One. 2013 Nov.8(4):e62665. Pubmedid: 23646135. Pmcid: PMC3639949.
• Daimon CM, Chirdon P, Maudsley S, Martin B. The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. Am J Alzheimers Dis (Columbia). 2013 Jun.1(1). Pubmedid: 24199031. Pmcid: PMC3817016.
• Cai H, Chen H, Yi T, Daimon CM, Boyle JP, Peers C, Maudsley S, Martin B. VennPlex--a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints. PLoS One. 2013 Jul.8(1):e53388. Pubmedid: 23308210. Pmcid: PMC3538763.
• Martin B, Chen H, Daimon CM, Chadwick W, Siddiqui S, Maudsley S. Plurigon: three dimensional visualization and classification of high-dimensionality data. Front Physiol. 2013 Jul.4:190. Pubmedid: 23885241. Pmcid: PMC3717481.
• Chen H, Martin B, Daimon CM, Maudsley S. Effective use of latent semantic indexing and computational linguistics in biological and biomedical applications. Front Physiol. 2013 Jan.4:8. Pubmedid: 23386833. Pmcid: PMC3558626.
• Chen H, Martin B, Cai H, Fiori JL, Egan JM, Siddiqui S, Maudsley S. Pancreas++: automated quantification of pancreatic islet cells in microscopy images. Front Physiol. 2013 Jan.3:482. Pubmedid: 23293605. Pmcid: PMC3535421.
• Maudsley S, Siddiqui S, Martin B. Systems analysis of arrestin pathway functions. Prog Mol Biol Transl Sci. 2013 Jan.118:431-467. Pubmedid: 23764064.
• Gesty-Palmer D, Yuan L, Martin B, Wood WH, Lee MH, Janech MG, Tsoi LC, Zheng WJ, Luttrell LM, Maudsley S. β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo. Mol Endocrinol. 2013 Feb.27(2):296-314. Pubmedid: 23315939. Pmcid: PMC3683806.
• Cong WN, Wang R, Cai H, Daimon CM, Scheibye-Knudsen M, Bohr VA, Turkin R, Wood WH, Becker KG, Moaddel R, Maudsley S, Martin B. Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One. 2013 Aug.8(8):e70257. Pubmedid: 23950916. Pmcid: PMC3737213.
• Cong WN, Cai H, Wang R, Daimon CM, Maudsley S, Raber K, Canneva F, von Hörsten S, Martin B. Altered hypothalamic protein expression in a rat model of Huntington's disease. PLoS One. 2013 Apr.7(10):e47240. Pubmedid: 23094041. Pmcid: PMC3475691.
• Siddiqui S, Cong WN, Daimon CM, Martin B, Maudsley S. BRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality. Front Endocrinol (Lausanne). 2013 Apr.4:46. Pubmedid: 23577003. Pmcid: PMC3620488.
• Martin B, Chadwick W, Cong WN, Pantaleo N, Daimon CM, Golden EJ, Becker KG, Wood WH, Carlson OD, Egan JM, Maudsley S. Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy. J Biol Chem. 2012 Sep.287(38):31766-31782. Pubmedid: 22822065. Pmcid: PMC3442511.
• Chadwick W, Martin B, Chapter MC, Park SS, Wang L, Daimon CM, Brenneman R, Maudsley S. GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats. PLoS One. 2012 Oct.7(5):e36975. Pubmedid: 22606319. Pmcid: PMC3351446.
• Martin B, Chadwick W, Yi T, Park SS, Lu D, Ni B, Gadkaree S, Farhang K, Becker KG, Maudsley S. VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis. PLoS One. 2012 Oct.7(5):e36911. Pubmedid: 22606307. Pmcid: PMC3351456.
• Wu WW, Shen RF, Park SS, Martin B, Maudsley S. Precursor ion exclusion for enhanced identification of plasma biomarkers. Proteom Clin Appl. 2012 Jun.6(5-6):304-308. Pubmedid: 22641611. Pmcid: PMC5916817.
• Park SS, Wu WW, Zhou Y, Shen RF, Martin B, Maudsley S. Effective correction of experimental errors in quantitative proteomics using stable isotope labeling by amino acids in cell culture (SILAC). J Proteomics. 2012 Jun.75(12):3720-3732. Pubmedid: 22575385. Pmcid: PMC3394155.
• Hallböök T, Ji S, Maudsley S, Martin B. The effects of the ketogenic diet on behavior and cognition. Epilepsy Res. 2012 Jul.100(3):304-309. Pubmedid: 21872440. Pmcid: PMC4112040.
• Abdelmohsen K, Srikantan S, Tominaga K, Kang MJ, Yaniv Y, Martindale JL, Yang X, Park SS, Becker KG, Subramanian M, Maudsley S, Lal A, Gorospe M. Growth inhibition by miR-519 via multiple p21-inducing pathways. Mol Cell Biol. 2012 Jul.32(13):2530-2548. Pubmedid: 22547681. Pmcid: PMC3434494.
• Schwartz CM, Tavakoli T, Jamias C, Park SS, Maudsley S, Martin B, Phillips TM, Yao PJ, Itoh K, Ma W, Rao MS, Arenas E, Mattson MP. Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. J Neurosci Res. 2012 Jul.90(7):1367-1381. Pubmedid: 22535492. Pmcid: PMC3350575.
• Maudsley S, Chadwick W. Progressive and unconventional pharmacotherapeutic approaches to Alzheimer's disease therapy. Curr Alzheimer Res. 2012 Jan.9(1):1-4. Pubmedid: 22329648. Pmcid: PMC5915359.
• Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B. Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr Alzheimer Res. 2012 Jan.9(1):5-17. Pubmedid: 22329649. Pmcid: PMC4097094.
• Stranahan AM, Martin B, Maudsley S. Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Curr Alzheimer Res. 2012 Jan.9(1):86-92. Pubmedid: 22329653. Pmcid: PMC4445413.
• Chadwick W, Mitchell N, Martin B, Maudsley S. Therapeutic targeting of the endoplasmic reticulum in Alzheimer's disease. Curr Alzheimer Res. 2012 Jan.9(1):110-119. Pubmedid: 22329655. Pmcid: PMC4682200.
• Siddiqui S, Fang M, Ni B, Lu D, Martin B, Maudsley S. Central role of the EGF receptor in neurometabolic aging. Int J Endocrinol. 2012 Aug.2012:739428. Pubmedid: 22754566. Pmcid: PMC3382947.
• Maudsley S. G protein-coupled receptor biased agonism: development towards future selective therapeutics. Mini Rev Med Chem. 2012 Aug.12(9):803. Pubmedid: 22757722.
• Maudsley S, Patel SA, Park SS, Luttrell LM, Martin B. Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics. Mini Rev Med Chem. 2012 Aug.12(9):831-840. Pubmedid: 22681251. Pmcid: PMC6013268.
• Jasien J, Daimon CM, Maudsley S, Shapiro BK, Martin B. Aging and bone health in individuals with developmental disabilities. Int J Endocrinol. 2012 Aug.2012:469235. Pubmedid: 22888344. Pmcid: PMC3408668.
• Stranahan AM, Martin B, Chadwick W, Park SS, Wang L, Becker KG, Woodiii WH, Zhang Y, Maudsley S. Metabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventions. Int J Endocrinol. 2012 Aug.2012:732975. Pubmedid: 22934110. Pmcid: PMC3427989.
• Driscoll I, Martin B, An Y, Maudsley S, Ferrucci L, Mattson MP, Resnick SM. Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults. PLoS One. 2012 Aug.7(4):e35217. Pubmedid: 22523577. Pmcid: PMC3327651.
• Chadwick W, Keselman A, Park SS, Zhou Y, Wang L, Brenneman R, Martin B, Maudsley S. Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. J Signal Transduct. 2012 Aug.2011:636951. Pubmedid: 21258655. Pmcid: PMC3023409.
• Shin YK, Cong WN, Cai H, Kim W, Maudsley S, Egan JM, Martin B. Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity. J Gerontol A-Biol. 2012 Apr.67(4):336-344. Pubmedid: 22056740. Pmcid: PMC3410661.
• Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Martin B, Maudsley S, Shen RF. Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). J Proteomics. 2012 Apr.75(8):2480-2487. Pubmedid: 22397766. Pmcid: PMC3321122.
• Maudsley S, Martin B, Egan JM. To be or not to be--obese. Endocrinology. 2011 Oct.152(10):3592-3596. Pubmedid: 21937750. Pmcid: PMC3176656.
• Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Maudsley S, Martin B, Shen RF. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). J Am Soc Mass Spectrom. 2011 Oct.22(10):1753-1762. Pubmedid: 21952889. Pmcid: PMC3183836.
• Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, Cuzick J, Jebb SA, Martin B, Cutler RG, Son TG, Maudsley S, Carlson OD, Egan JM, Flyvbjerg A, Howell A. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond). 2011 May.35(5):714-727. Pubmedid: 20921964. Pmcid: PMC3017674.
• Zhou Y, Yi T, Park SS, Chadwick W, Shen RF, Wu WW, Martin B, Maudsley S. Rapid and enhanced proteolytic digestion using electric-field-oriented enzyme reactor. J Proteomics. 2011 Jun.74(7):1030-1035. Pubmedid: 21338726. Pmcid: PMC3102135.
• Park SS, Stranahan AM, Chadwick W, Zhou Y, Wang L, Martin B, Becker KG, Maudsley S. Cortical gene transcription response patterns to water maze training in aged mice. BMC Neurosci. 2011 Jun.12:63. Pubmedid: 21714909. Pmcid: PMC3142531.
• DePina AS, Iser WB, Park SS, Maudsley S, Wilson MA, Wolkow CA. Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms. BMC Physiol. 2011 Jul.11:11. Pubmedid: 21749693. Pmcid: PMC3160409.
• Park SS, Maudsley S. Discontinuous pH gradient-mediated separation of TiO2-enriched phosphopeptides. Anal Biochem. 2011 Feb.409(1):81-88. Pubmedid: 20946866. Pmcid: PMC3002755.
• Chadwick W, Mitchell N, Caroll J, Zhou Y, Park SS, Wang L, Becker KG, Zhang Y, Lehrmann E, Wood WH, Martin B, Maudsley S. Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS One. 2011 Dec.6(6):e21660. Pubmedid: 21738757. Pmcid: PMC3124550.
• Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med. 2011 Dec.18(1):153-158. Pubmedid: 22179319. Pmcid: PMC4551453.
• Maudsley S, Chadwick W, Wang L, Zhou Y, Martin B, Park SS. Bioinformatic approaches to metabolic pathways analysis. Methods Mol Biol. 2011 Dec.756:99-130. Pubmedid: 21870222. Pmcid: PMC4698828.
• Chadwick W, Boyle JP, Zhou Y, Wang L, Park SS, Martin B, Wang R, Becker KG, Wood WH, Zhang Y, Peers C, Maudsley S. Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PLoS One. 2011 Dec.6(6):e21638. Pubmedid: 21738745. Pmcid: PMC3124552.
• Kim W, Doyle ME, Liu Z, Lao Q, Shin YK, Carlson OD, Kim HS, Thomas S, Napora JK, Lee EK, Moaddel R, Wang Y, Maudsley S, Martin B, Kulkarni RN, Egan JM. Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes. 2011 Apr.60(4):1198-1209. Pubmedid: 21346174. Pmcid: PMC3064093.
• Shin YK, Martin B, Kim W, White CM, Ji S, Sun Y, Smith RG, Sévigny J, Tschöp MH, Maudsley S, Egan JM. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One. 2010 Sep.5(9):e12729. Pubmedid: 20856820. Pmcid: PMC2939079.
• Kim BJ, Zhou J, Martin B, Carlson OD, Maudsley S, Greig NH, Mattson MP, Ladenheim EE, Wustner J, Turner A, Sadeghi H, Egan JM. Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides. J Pharmacol Exp Ther. 2010 Sep.334(3):682-692. Pubmedid: 20498254. Pmcid: PMC2939671.
• Maudsley S. New frontiers in G protein-coupled receptor regulation of neurological disorders. CNS Neurol Disord Drug Targets. 2010 Nov.9(5):525. Pubmedid: 20632974.
• Pantaleo N, Chadwick W, Park SS, Wang L, Zhou Y, Martin B, Maudsley S. The mammalian tachykinin ligand-receptor system: an emerging target for central neurological disorders. CNS Neurol Disord Drug Targets. 2010 Nov.9(5):627-635. Pubmedid: 20632965. Pmcid: PMC2967650.
• Cong WN, Golden E, Pantaleo N, White CM, Maudsley S, Martin B. Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction. CNS Neurol Disord Drug Targets. 2010 Nov.9(5):557-563. Pubmedid: 20632971. Pmcid: PMC2967656.
• Wang L, Chadwick W, Park SS, Zhou Y, Silver N, Martin B, Maudsley S. Gonadotropin-releasing hormone receptor system: modulatory role in aging and neurodegeneration. CNS Neurol Disord Drug Targets. 2010 Nov.9(5):651-660. Pubmedid: 20632963. Pmcid: PMC2967575.
• White CM, Ji S, Cai H, Maudsley S, Martin B. Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders. CNS Neurol Disord Drug Targets. 2010 Nov.9(5):661-666. Pubmedid: 20632962. Pmcid: PMC2967653.
• Stranahan AM, Lee K, Becker KG, Zhang Y, Maudsley S, Martin B, Cutler RG, Mattson MP. Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging. 2010 Nov.31(11):1937-1949. Pubmedid: 19070401. Pmcid: PMC2889222.
• Martin B, Shin YK, White CM, Ji S, Kim W, Carlson OD, Napora JK, Chadwick W, Chapter M, Waschek JA, Mattson MP, Maudsley S, Egan JM. Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes. 2010 May.59(5):1143-1152. Pubmedid: 20150284. Pmcid: PMC2857894.
• Terracciano A, Martin B, Ansari D, Tanaka T, Ferrucci L, Maudsley S, Mattson MP, Costa PT. Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits. Genes Brain Behav. 2010 Jul.9(5):512-518. Pubmedid: 20345896. Pmcid: PMC2907437.
• Chapter MC, White CM, DeRidder A, Chadwick W, Martin B, Maudsley S. Chemical modification of class II G protein-coupled receptor ligands: frontiers in the development of peptide analogs as neuroendocrine pharmacological therapies. Pharmacol Ther. 2010 Jan.125(1):39-54. Pubmedid: 19686775. Pmcid: PMC2815023.
• Stranahan AM, Zhou Y, Martin B, Maudsley S. Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem. 2010 Feb.16(35):4668-4678. Pubmedid: 19903142. Pmcid: PMC2821702.
• Chadwick W, Brenneman R, Martin B, Maudsley S. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. Int J Alzheimers Dis. 2010 Dec.2010:604792. Pubmedid: 21151659. Pmcid: PMC2997345.
• Chadwick W, Zhou Y, Park SS, Wang L, Mitchell N, Stone MD, Becker KG, Martin B, Maudsley S. Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec.5(12):e14352. Pubmedid: 21179406. Pmcid: PMC3003681.
• Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, Driscoll I, Ferrucci L, Martin B, Mattson MP. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One. 2010 Apr.5(4):e10099. Pubmedid: 20404913. Pmcid: PMC2852401.
• Martin B, Ji S, Maudsley S, Mattson MP. "Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A. 2010 Apr.107(14):6127-6133. Pubmedid: 20194732. Pmcid: PMC2852022.
• Martin B, Maudsley S, McNeilly J, Nicol L, Crawford J, Millar M, Sharpe RM, McNeilly AS. Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery. Neuromolecular Med. 2009 Oct.11(2):76-86. Pubmedid: 19565361. Pmcid: PMC5918691.
• Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, Mattson MP. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus. 2009 Oct.19(10):951-961. Pubmedid: 19280661. Pmcid: PMC2755651.
• Wang L, Martin B, Brenneman R, Luttrell LM, Maudsley S. Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders. J Pharmacol Exp Ther. 2009 Nov.331(2):340-348. Pubmedid: 19667132. Pmcid: PMC2775272.
• Martin B, Maudsley S, White CM, Egan JM. Hormones in the naso-oropharynx: endocrine modulation of taste and smell. Trends Endocrinol Metab. 2009 May.20(4):163-170. Pubmedid: 19359194. Pmcid: PMC2732121.
• Mattson MP, Maudsley S. Live longer sans the AT1A receptor. Cell Metab. 2009 May.9(5):403-405. Pubmedid: 19416709. Pmcid: PMC2697617.
• Martin B, Dotson CD, Shin YK, Ji S, Drucker DJ, Maudsley S, Munger SD. Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann Ny Acad Sci. 2009 Jul.1170:98-101. Pubmedid: 19686117. Pmcid: PMC3731136.
• Martin B, Brenneman R, Golden E, Walent T, Becker KG, Prabhu VV, Wood W, Ladenheim B, Cadet JL, Maudsley S. Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses. J Biol Chem. 2009 Jan.284(4):2493-2511. Pubmedid: 19038969. Pmcid: PMC2629109.
• Gulyani S, Earley CJ, Camandola S, Maudsley S, Ferré S, Mughal MR, Martin B, Cheng A, Gleichmann M, Jones BC, Allen RP, Mattson MP. Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol. 2009 Feb.215(2):236-242. Pubmedid: 19013457. Pmcid: PMC2784599.
• Martin B, Pearson M, Brenneman R, Golden E, Wood W, Prabhu V, Becker KG, Mattson MP, Maudsley S. Gonadal transcriptome alterations in response to dietary energy intake: sensing the reproductive environment. PLoS One. 2009 Feb.4(1):e4146. Pubmedid: 19127293. Pmcid: PMC2607546.
• Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, Frank BP, Thomas S, Chadwick WA, Greig NH, Bates GP, Sathasivam K, Bernier M, Maudsley S, Mattson MP, Egan JM. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes. 2009 Feb.58(2):318-328. Pubmedid: 18984744. Pmcid: PMC2628604.
• Chadwick W, Magnus T, Martin B, Keselman A, Mattson MP, Maudsley S. Targeting TNF-alpha receptors for neurotherapeutics. Trends Neurosci. 2008 Oct.31(10):504-511. Pubmedid: 18774186. Pmcid: PMC2574933.
• Pawson AJ, Faccenda E, Maudsley S, Lu ZL, Naor Z, Millar RP. Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization. Endocrinology. 2008 Mar.149(3):1415-1422. Pubmedid: 18039780.
• Martin B, Pearson M, Brenneman R, Golden E, Keselman A, Iyun T, Carlson OD, Egan JM, Becker KG, Wood W, Prabhu V, de Cabo R, Maudsley S, Mattson MP. Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One. 2008 Jun.3(6):e2398. Pubmedid: 18545695. Pmcid: PMC2405949.
• Martin B, Brenneman R, Becker KG, Gucek M, Cole RN, Maudsley S. iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PLoS One. 2008 Jul.3(7):e2750. Pubmedid: 18648646. Pmcid: PMC2453232.
• Martin B, Golden E, Carlson OD, Egan JM, Mattson MP, Maudsley S. Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev. 2008 Jul.7(3):209-224. Pubmedid: 18329344. Pmcid: PMC2634963.
• Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem. 2008 Jul.106(1):455-463. Pubmedid: 18397368. Pmcid: PMC2629996.
• López de Maturana R, Pawson AJ, Lu ZL, Davidson L, Maudsley S, Morgan K, Langdon SP, Millar RP. Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling. Mol Endocrinol. 2008 Jul.22(7):1711-1722. Pubmedid: 18467526. Pmcid: PMC5419441.
• Martin B, Golden E, Keselman A, Stone M, Mattson MP, Egan JM, Maudsley S. Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Histol Histopathol. 2008 Feb.23(2):237-250. Pubmedid: 17999380. Pmcid: PMC2657556.
• Martin B, Golden E, Egan JM, Mattson MP, Maudsley S. Reduced energy intake: the secret to a long and healthy life?. IBS J Sci. 2007 Sep.2(2):35-39. Pubmedid: 18985162. Pmcid: PMC2577199.
• Martin B, Pearson M, Kebejian L, Golden E, Keselman A, Bender M, Carlson O, Egan J, Ladenheim B, Cadet JL, Becker KG, Wood W, Duffy K, Vinayakumar P, Maudsley S, Mattson MP. Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology. 2007 Sep.148(9):4318-4333. Pubmedid: 17569758. Pmcid: PMC2622430.
• Maudsley S, Davidson L, Pawson AJ, Freestone SH, López de Maturana R, Thomson AA, Millar RP. Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5. Neuroendocrinology. 2007 May.84(5):285-300. Pubmedid: 17202804.
• Nelson RL, Guo Z, Halagappa VM, Pearson M, Gray AJ, Matsuoka Y, Brown M, Martin B, Iyun T, Maudsley S, Clark RF, Mattson MP. Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol. 2007 May.205(1):166-176. Pubmedid: 17368447. Pmcid: PMC1979096.
• Maudsley S, Naor Z, Bonfil D, Davidson L, Karali D, Pawson AJ, Larder R, Pope C, Nelson N, Millar RP, Brown P. Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene. Mol Endocrinol. 2007 May.21(5):1216-1233. Pubmedid: 17327421. Pmcid: PMC1951533.
• Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Telljohann R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radical Bio Med. 2007 Mar.42(5):665-674. Pubmedid: 17291990. Pmcid: PMC1859864.
• Maudsley S, Martin B, Luttrell LM. G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics. Curr Alzheimer Res. 2007 Feb.4(1):3-19. Pubmedid: 17316162.
• Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J, Mattson MP. Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism. 2007 Dec.56(12):1729-1734. Pubmedid: 17998028. Pmcid: PMC2121099.
• Gardner S, Maudsley S, Millar RP, Pawson AJ. Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope. Mol Endocrinol. 2007 Dec.21(12):3028-3038. Pubmedid: 17717075.
• López de Maturana R, Martin B, Millar RP, Brown P, Davidson L, Pawson AJ, Nicol MR, Mason JI, Barran P, Naor Z, Maudsley S. GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells. Neuromolecular Med. 2007 Dec.9(3):230-248. Pubmedid: 17914181.
• Zhou J, Livak MF, Bernier M, Muller DC, Carlson OD, Elahi D, Maudsley S, Egan JM. Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets. Am J Physiol Endocrinol Metab. 2007 Aug.293(2):E538-E547. Pubmedid: 17505054. Pmcid: PMC2640485.
• Martin B, Mattson MP, Maudsley S. Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev. 2006 Aug.5(3):332-353. Pubmedid: 16899414. Pmcid: PMC2622429.
• Maudsley S, Mattson MP. Protein twists and turns in Alzheimer disease. Nat Med. 2006 Apr.12(4):392-393. Pubmedid: 16598285.
• Pawson AJ, Maudsley S, Morgan K, Davidson L, Naor Z, Millar RP. Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment. Endocrinology. 2005 Jun.146(6):2639-2649. Pubmedid: 15761034.
• Martin B, Lopez de Maturana R, Brenneman R, Walent T, Mattson MP, Maudsley S. Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular Med. 2005 Dec.7(1-2):3-36. Pubmedid: 16052036. Pmcid: PMC2636744.
• Maudsley S, Martin B, Luttrell LM. The origins of diversity and specificity in g protein-coupled receptor signaling. J Pharmacol Exp Ther. 2005 Aug.314(2):485-494. Pubmedid: 15805429. Pmcid: PMC2656918.
• Maudsley S, Davidson L, Pawson AJ, Chan R, López de Maturana R, Millar RP. Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor. Cancer Res. 2004 Oct.64(20):7533-7544. Pubmedid: 15492280.
• Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004 Oct.27(10):589-594. Pubmedid: 15374669.
• Mattson MP, Maudsley S, Martin B. A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing Res Rev. 2004 Nov.3(4):445-464. Pubmedid: 15541711.
• Davidson L, Pawson AJ, López de Maturana R, Freestone SH, Barran P, Millar RP, Maudsley S. Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src. J Biol Chem. 2004 Mar.279(12):11906-11916. Pubmedid: 14707140.
• Sales KJ, Maudsley S, Jabbour HN. Elevated prostaglandin EP2 receptor in endometrial adenocarcinoma cells promotes vascular endothelial growth factor expression via cyclic 3',5'-adenosine monophosphate-mediated transactivation of the epidermal growth factor receptor and extracellular sign. Mol Endocrinol. 2004 Jun.18(6):1533-1545. Pubmedid: 15044590.
• Davidson L, Pawson AJ, Millar RP, Maudsley S. Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor. J Biol Chem. 2004 Jan.279(3):1980-1993. Pubmedid: 14559894.
• Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. Gonadotropin-releasing hormone receptors. Endocr Rev. 2004 Apr.25(2):235-275. Pubmedid: 15082521.
• Pawson AJ, Morgan K, Maudsley SR, Millar RP. Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology. Reproduction. 2003 Sep.126(3):271-278. Pubmedid: 12968935.
• Gault PM, Maudsley S, Lincoln GA. Evidence that gonadotropin-releasing hormone II is not a physiological regulator of gonadotropin secretion in mammals. J Neuroendocrinol. 2003 Sep.15(9):831-839. Pubmedid: 12899677.
• Pawson AJ, Maudsley SR, Lopes J, Katz AA, Sun YM, Davidson JS, Millar RP. Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical. Endocrinology. 2003 Sep.144(9):3860-3871. Pubmedid: 12933659.
• Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R, Faurholm B, Scobie G, Kuestner R, Terasawa E, Katz A. A novel mammalian receptor for the evolutionarily conserved type II GnRH. Proc Natl Acad Sci U S A. 2001 Aug.98(17):9636-9641. Pubmedid: 11493674. Pmcid: PMC55504.
• Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA. Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Mol Cell Biol. 2000 Nov.20(22):8352-8363. Pubmedid: 11046132. Pmcid: PMC102142.
• Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y, Lefkowitz RJ, Luttrell LM. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem. 2000 Mar.275(13):9572-9580. Pubmedid: 10734107.
• Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem. 2000 Jul.275(29):22583-22589. Pubmedid: 10807918.
• Seo B, Choy EW, Maudsley S, Miller WE, Wilson BA, Luttrell LM. Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor. J Biol Chem. 2000 Jan.275(3):2239-2245. Pubmedid: 10636931.
• Pierce KL, Maudsley S, Daaka Y, Luttrell LM, Lefkowitz RJ. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A. 2000 Feb.97(4):1489-1494. Pubmedid: 10677489. Pmcid: PMC26461.
• Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem. 2000 Apr.275(15):11312-11319. Pubmedid: 10753943.
• Della Rocca GJ, Maudsley S, Daaka Y, Lefkowitz RJ, Luttrell LM. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. J Biol Chem. 1999 May.274(20):13978-13984. Pubmedid: 10318809.
• Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem. 1999 Jan.274(3):1185-1188. Pubmedid: 9880482.
• Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan.283(5402):655-661. Pubmedid: 9924018.
• Donnelly D, Maudsley S, Gent JP, Moser RN, Hurrell CR, Findlay JB. Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications. Biochem J. 1999 Apr.339 ( Pt 1)(Pt 1):55-61. Pubmedid: 10085227. Pmcid: PMC1220127.
• Maudsley S, Gent JP, Findlay JB, Donnelly D. The relationship between the agonist-induced activation and desensitization of the human tachykinin NK2 receptor expressed in Xenopus oocytes. Br J Pharmacol. 1998 Jun.124(4):675-684. Pubmedid: 9690859. Pmcid: PMC1565444.
• Phenna S, Carpenter E, Peers C, Maudsley S, Gent JP. Inhibition of Ca(2+)-sensitive K+ currents in NG 108-15 cells by substance P and related tachykinins. Br J Pharmacol. 1996 Sep.119(2):315-320. Pubmedid: 8886415. Pmcid: PMC1915845.