Qianxing Mo, PhD
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Qianxing Mo, PhD

Academic Rank: Associate Member

Email
Overview

Discipline

    • Biostatistics and Bioinformatics

Education & Training

    • Lehigh University, MS - Statistics
    • Lehigh University, PhD - Molecular Biology
Publications

  • Nguyen TM, Kabotyanski EB, Dou Y, Reineke LC, Zhang P, Zhang XH, Malovannaya A, Jung SY, Mo Q, Roarty KP, Chen Y, Zhang B, Neilson JR, Lloyd RE, Perou CM, Ellis MJ, Rosen JM. FGFR1-activated Translation of WNT Pathway Components with Structured 5' UTRs is Vulnerable to Inhibition of EIF4A-dependent Translation Initiation. Cancer Res. 2018 May. Pubmedid: 29844125.
  • Mo Q, Nikolos F, Chen F, Tramel Z, Lee YC, Hayashi K, Xiao J, Shen J, Chan KS. Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas. J Natl Cancer Inst. 2018 May;110(5):448-459. Pubmedid: 29342309.
  • Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018 Mar;8(8):2189-2201. Pubmedid: 29721072. Pmcid: PMC5928880.
  • Adams NR, Vasquez YM, Mo Q, Gibbons W, Kovanci E, DeMayo FJ. WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation, and migration in part through mitogen-activated protein kinase 7. Biol Reprod. 2017 Sep;97(3):400-412. Pubmedid: 29025069.
  • Agarwal N, Iyer D, Gabbi C, Saha P, Patel SG, Mo Q, Chang B, Goswami B, Schubert U, Kopp JB, Lewis DE, Balasubramanyam A. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017 Oct;7(1):13362. Pubmedid: 29042644. Pmcid: PMC5645472.
  • Tan YD, Zhang XHF, Mo Q. New statistical methods for estimation of recombination fractions in F2 population. BMC Bioinformatics. 2017 Oct;18(Suppl 11):404. Pubmedid: 28984187. Pmcid: PMC5629630.
  • Yang L, Liu L, Gao H, Pinnamaneni JP, Sanagasetti D, Singh VP, Wang K, Mathison M, Zhang Q, Chen F, Mo Q, Rosengart T, Yang J. The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis. J Hematol Oncol. 2017 Oct;10(1):159. Pubmedid: 28974232. Pmcid: PMC5627455.
  • Mo Q, Shen R, Guo C, Vannucci M, Chan KS, Hilsenbeck SG. A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data. Biostatistics. 2017 May. Pubmedid: 28541380.
  • Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun;2(11). Pubmedid: 28570265. Pmcid: PMC5453704.
  • Haller M, Mo Q, Imamoto A, Lamb DJ. Murine model indicates 22q11.2 signaling adaptor is a dosage-sensitive regulator of genitourinary development. Proc Natl Acad Sci U S A. 2017 05;114(19):4981-4986. Pubmedid: 28439006. Pmcid: PMC5441740.
  • Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May;7(18):26307-26330. Pubmedid: 27027445. Pmcid: PMC5041982.
  • Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016 Mar;9:24. Pubmedid: 26970896. Pmcid: PMC4789278.
  • Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 Jun;18(6):632-644. Pubmedid: 27183469. Pmcid: PMC4884142.
  • Woodfield SE, Guo RJ, Liu Y, Major AM, Hollingsworth EF, Indiviglio S, Whittle SB, Mo Q, Bean AJ, Ittmann M, Lopez-Terrada D, Zage PE. Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. Genes Cancer. 2016 Jan;7(1-2):13-26. Pubmedid: 27014418. Pmcid: PMC4773702.
  • Matatall KA, Jeong M, Chen S, Sun D, Chen F, Mo Q, Kimmel M, King KY. Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. Cell Rep. 2016 Dec;17(10):2584-2595. Pubmedid: 27926863. Pmcid: PMC5161248.
  • Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016 Dec;7(50):82609-82619. Pubmedid: 27655672. Pmcid: PMC5347718.
  • Yong LK, Lai S, Liang Z, Poteet E, Chen F, van Buren G, Fisher W, Mo Q, Chen C, Yao Q. Overexpression of Semaphorin-3E enhances pancreatic cancer cell growth and associates with poor patient survival. Oncotarget. 2016 Dec;7(52):87431-87448. Pubmedid: 27911862. Pmcid: PMC5349999.
  • Heller G, Mo Q. Estimating the concordance probability in a survival analysis with a discrete number of risk groups. Lifetime Data Anal. 2016 Apr;22(2):263-279. Pubmedid: 26022558. Pmcid: PMC4886856.
  • Tian G, Courtney AN, Jena B, Heczey A, Liu D, Marinova E, Guo L, Xu X, Torikai H, Mo Q, Dotti G, Cooper LJ, Metelitsa LS. CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo. J Clin Invest. 2016 06;126(6):2341-2355. Pubmedid: 27183388. Pmcid: PMC4887157.
  • Breaux M, Lewis K, Valanejad L, Iakova P, Chen F, Mo Q, Medrano E, Timchenko L, Timchenko N. p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. Mol Cell Biol. 2015 Sep;35(17):3005-3016. Pubmedid: 26100016. Pmcid: PMC4525310.
  • Holdman XB, Welte T, Rajapakshe K, Pond A, Coarfa C, Mo Q, Huang S, Hilsenbeck SG, Edwards DP, Zhang X, Rosen JM. Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer. Breast Cancer Res. 2015 Nov;17:141. Pubmedid: 26581390. Pmcid: PMC4652386.
  • Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul;5(7):752-767. Pubmedid: 26069190. Pmcid: PMC4497871.
  • Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh TT, Lay E, Ho PL, Chan KS. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 2015 Jan;517(7533):209-213. Pubmedid: 25470039. Pmcid: PMC4465385.
  • Maker AV, Ito H, Mo Q, Weisenberg E, Qin LX, Turcotte S, Maithel S, Shia J, Blumgart L, Fong Y, Jarnagin WR, DeMatteo RP, D'Angelica MI. Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases. Cancer Immunol Res. 2015 Apr;3(4):380-388. Pubmedid: 25600439. Pmcid: PMC4390462.
  • Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Singh RK, Hanna A, Mo Q, Hicks J, Hamilton S, Cooper TA. The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Hum Mol Genet. 2015 Apr;24(8):2360-2374. Pubmedid: 25575511. Pmcid: PMC4380076.
  • Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. PLoS Genet. 2015 Apr;11(4):e1005116. Pubmedid: 25830341. Pmcid: PMC4382186.
  • Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014 Nov;5(21):10665-10677. Pubmedid: 25359765. Pmcid: PMC4279401.
  • Mohammed S, Evans C, VanBuren G, Hodges SE, Silberfein E, Artinyan A, Mo Q, Issazadeh M, McElhany AL, Fisher WE. Treatment of bacteriobilia decreases wound infection rates after pancreaticoduodenectomy. HPB (Oxford). 2014 Jun;16(6):592-598. Pubmedid: 23992045. Pmcid: PMC4048081.
  • Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash S, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun. 2014 Jul;5:3361. Pubmedid: 24553445. Pmcid: PMC4017859.
  • Amirian ES, Bondy ML, Mo Q, Bainbridge MN, Scheurer ME. Presence of viral DNA in whole-genome sequencing of brain tumor tissues from the cancer genome atlas. J Virol. 2014 Jan;88(1):774. Pubmedid: 24353289. Pmcid: PMC3911725.
  • Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WE. A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg. 2014 Apr;259(4):605-612. Pubmedid: 24374513.
  • Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab. 2013 Sep;18(3):380-391. Pubmedid: 24011073. Pmcid: PMC3813599.
  • Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov;19(21):5901-5913. Pubmedid: 23989979. Pmcid: PMC3920728.
  • Ganly I, Ricarte Filho J, Eng S, Ghossein R, Morris LG, Liang Y, Socci N, Kannan K, Mo Q, Fagin JA, Chan TA. Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy. J Clin Endocrinol Metab. 2013 May;98(5):E962-E972. Pubmedid: 23543667. Pmcid: PMC5393465.
  • Mo Q, Wang S, Seshan VE, Olshen AB, Schultz N, Sander C, Powers RS, Ladanyi M, Shen R. Pattern discovery and cancer gene identification in integrated cancer genomic data. Proc Natl Acad Sci U S A. 2013 Mar;110(11):4245-4250. Pubmedid: 23431203. Pmcid: PMC3600490.
  • Kollmeier MA, Fidaleo A, Pei X, Cohen G, Zaider M, Mo Q, Cox B, Yamada Y, Zelefsky MJ. Favourable long-term outcomes with brachytherapy-based regimens in men ≤60 years with clinically localized prostate cancer. BJU Int. 2013 Jun;111(8):1231-1236. Pubmedid: 23551568.
  • Ito H, Mo Q, Qin LX, Viale A, Maithel SK, Maker AV, Shia J, Kingham P, Allen P, DeMatteo RP, Fong Y, Jarnagin WR, D'Angelica M. Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer. PLoS One. 2013 Dec;8(12):e81680. Pubmedid: 24339954. Pmcid: PMC3858250.
  • Kobos R, Nagai M, Tsuda M, Merl MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Ostrovnaya I, Antczak C, Djaballah H, Ladanyi M. Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol. 2013 Apr;229(5):743-754. Pubmedid: 23288701. Pmcid: PMC4083568.
  • Shen R, Wang S, Mo Q. SPARSE INTEGRATIVE CLUSTERING OF MULTIPLE OMICS DATA SETS. Ann Appl Stat. 2013 Apr;7(1):269-294. Pubmedid: 24587839. Pmcid: PMC3935438.
  • , Mo Q. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep;489(7417):519-525. Pubmedid: 22960745. Pmcid: PMC3466113.
  • Morrogh M, Andrade VP, Patil AJ, Qin LX, Mo Q, Sakr R, Arroyo CD, Brogi E, Morrow M, King TA. Differentially expressed genes in window trials are influenced by the wound-healing process: lessons learned from a pilot study with anastrozole. J Surg Res. 2012 Jul;176(1):121-132. Pubmedid: 21777924. Pmcid: PMC4509686.
  • Tonorezos ES, Vega GL, Sklar CA, Chou JF, Moskowitz CS, Mo Q, Church TS, Ross R, Janiszewski PM, Oeffinger KC. Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia. Pediatr Blood Cancer. 2012 Jan;58(1):31-36. Pubmedid: 21254377. Pmcid: PMC3520427.
  • Mo Q. A fully Bayesian hidden Ising model for ChIP-seq data analysis. Biostatistics. 2012 Jan;13(1):113-128. Pubmedid: 21914728.
  • Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012 Aug;150(4):764-779. Pubmedid: 22901808. Pmcid: PMC3711709.
  • Shen R, Mo Q, Schultz N, Seshan VE, Olshen AB, Huse J, Ladanyi M, Sander C. Integrative subtype discovery in glioblastoma using iCluster. PLoS One. 2012 Apr;7(4):e35236. Pubmedid: 22539962. Pmcid: PMC3335101.
  • Koutcher L, Sherman E, Fury M, Wolden S, Zhang Z, Mo Q, Stewart L, Schupak K, Gelblum D, Wong R, Kraus D, Shah J, Zelefsky M, Pfister D, Lee N. Concurrent cisplatin and radiation versus cetuximab and radiation for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011 Nov;81(4):915-922. Pubmedid: 20947269.
  • Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci Transl Med. 2011 Mar;3(75):75ra25. Pubmedid: 21430268. Pmcid: PMC3146366.
  • Affer M, Dao S, Liu C, Olshen AB, Mo Q, Viale A, Lambek CL, Marr TG, Clarkson BD. Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent Stem/Progenitor Cells and Correlations with Biological Abnormalities. J Oncol. 2011 Jul;2011:798592. Pubmedid: 21436996. Pmcid: PMC3062978.
  • Deutsch I, Zelefsky MJ, Zhang Z, Mo Q, Zaider M, Cohen G, Cahlon O, Yamada Y. Comparison of PSA relapse-free survival in patients treated with ultra-high-dose IMRT versus combination HDR brachytherapy and IMRT. Brachytherapy. 2011 Feb;9(4):313-318. Pubmedid: 20685176.
  • Gupta A, Young RJ, Karimi S, Sood S, Zhang Z, Mo Q, Gutin PH, Holodny AI, Lassman AB. Isolated diffusion restriction precedes the development of enhancing tumor in a subset of patients with glioblastoma. Ajnr Am J Neuroradiol. 2011 Aug;32(7):1301-1306. Pubmedid: 21596805. Pmcid: PMC4040369.
  • Suzuki K, Kachala SS, Kadota K, Shen R, Mo Q, Beer DG, Rusch VW, Travis WD, Adusumilli PS. Prognostic immune markers in non-small cell lung cancer. Clin Cancer Res. 2011 Aug;17(16):5247-5256. Pubmedid: 21659461.
  • Gerecitano J, Portlock C, Hamlin P, Moskowitz CH, Noy A, Straus D, Schulman P, Dumitrescu O, Sarasohn D, Pappanicholaou J, Iasonos A, Zhang Z, Mo Q, Horanlli E, Rojas CN, Zelenetz AD, O'Connor OA. Phase I trial of weekly and twice-weekly bortezomib with rituximab, cyclophosphamide, and prednisone in relapsed or refractory non-Hodgkin lymphoma. Clin Cancer Res. 2011 Apr;17(8):2493-2501. Pubmedid: 21346146. Pmcid: PMC5639472.
  • Goodman KA, Wiegner EA, Maturen KE, Zhang Z, Mo Q, Yang G, Gibbs IC, Fisher GA, Koong AC. Dose-escalation study of single-fraction stereotactic body radiotherapy for liver malignancies. Int J Radiat Oncol Biol Phys. 2010 Oct;78(2):486-493. Pubmedid: 20350791.
  • Fuchsjäger MH, Pucar D, Zelefsky MJ, Zhang Z, Mo Q, Ben-Porat LS, Shukla-Dave A, Wang L, Reuter VE, Hricak H. Predicting post-external beam radiation therapy PSA relapse of prostate cancer using pretreatment MRI. Int J Radiat Oncol Biol Phys. 2010 Nov;78(3):743-750. Pubmedid: 20133067. Pmcid: PMC2891893.
  • Mo Q, Liang F. A hidden Ising model for ChIP-chip data analysis. Bioinformatics. 2010 Mar;26(6):777-783. Pubmedid: 20110277.
  • Mo Q, Liang F. Bayesian modeling of ChIP-chip data through a high-order Ising model. Biometrics. 2010 Dec;66(4):1284-1294. Pubmedid: 20128774.
  • Popovic N, Bridenbaugh EA, Neiger JD, Hu JJ, Vannucci M, Mo Q, Trzeciakowski J, Miller MW, Fossum TW, Humphrey JD, Wilson E. Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2044-H2053. Pubmedid: 19717726. Pmcid: PMC2793137.
  • Small CM, Carney GE, Mo Q, Vannucci M, Jones AG. A microarray analysis of sex- and gonad-biased gene expression in the zebrafish: evidence for masculinization of the transcriptome. BMC Genomics. 2009 Dec;10:579. Pubmedid: 19958554. Pmcid: PMC2797025.
  • Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M. Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 2009 Aug;106(31):12759-12764. Pubmedid: 19549847. Pmcid: PMC2722286.
  • Mo Q, Lu S, Garippa C, Brownstein MJ, Simon NG. Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus. J Steroid Biochem -. 2009 Apr;114(3-5):135-143. Pubmedid: 19429443.
  • Dahl DB, Bohannan Z, Mo Q, Vannucci M, Tsai J. Assessing side-chain perturbations of the protein backbone: a knowledge-based classification of residue Ramachandran space. J Mol Biol. 2008 May;378(3):749-758. Pubmedid: 18377931. Pmcid: PMC2440669.
  • Simon NG, Mo Q, Hu S, Garippa C, Lu SF. Hormonal pathways regulating intermale and interfemale aggression. Int Rev Neurobiol. 2006 Aug;73:99-123. Pubmedid: 16737902.
  • Mo Q, Lu SF, Simon NG. Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity. J Steroid Biochem -. 2006 Apr;99(1):50-58. Pubmedid: 16524719.
  • Mo Q, Lu SF, Hu S, Simon NG. DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity. Brain Res Mol Brain Res. 2004 Jul;126(2):165-172. Pubmedid: 15249140.
  • Lu SF, Mo Q, Hu S, Garippa C, Simon NG. Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity. J Neurobiol. 2003 Nov;57(2):163-171. Pubmedid: 14556282.