Michael Fradley, MD
Researcher

Michael Fradley, MD

Overview

Dr. Fradley's current research interests involve the treatment and prevention of cardiovascular disease in cancer patients and survivors. 

Discipline

    • Thoracic Oncology
    • Health Outcomes & Behavior Program

Education & Training

    • Johns Hopkins School of Medicine, MD
    • Johns Hopkins School of Medicine, Resident - Internal Medicine
    • Massachusetts General Hospital, Harvard Medical School, Fellow - Cardiology
    • Massachusetts General Hospital, Harvard Medical School, Fellow - Clinical Cardiac Electrophysiology
Research

Dr. Fradley's research interests involve investigating cardiovascular complications associated with cancer therapy. Current research projects include a prospective trial evaluating a risk reduction program in women with breast cancer receiving cardiotoxic chemotherapy as well as several retrospective studies evaluating risk factors for the development of CHF/cardiomyopathy, hypertension and atrial fibrillation with different chemotherapy regimens. He is lso particularly interested in the development, management and prevention of arrhythmias associated with cancer therapy.

Publications

  • Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J. Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma. Brit J Haematol. 2017 Oct. Pubmedid: 29048105.
  • Fradley MG, Brown AC, Shields B, Viganego F, Damrongwatanasuk R, Patel AA, Hartlage G, Roper N, Jaunese J, Roy L, Ismail-Khan R. Developing a Comprehensive Cardio-Oncology Program at a Cancer Institute: The Moffitt Cancer Center Experience. Oncol Rev. 2017 Jul;11(2):340. Pubmedid: 28781723. Pmcid: PMC5523022.
  • Sajjad M, Fradley M, Sun W, Kim J, Zhao X, Pal T, Ismail-Khan R. An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity. Genes (Basel). 2017 Feb;8(2). Pubmedid: 28157161. Pmcid: PMC5333048.
  • Damrongwatanasuk R, Fradley MG. Cardiovascular Complications of Targeted Therapies for Chronic Myeloid Leukemia. Curr Treat Options Cardiovasc Med. 2017 Apr;19(4):24. Pubmedid: 28316033.
  • Jeong D, Patel A, Francois CJ, Gage KL, Fradley MG. Cardiac Magnetic Resonance Imaging in Oncology. Cancer Control. 2017 Apr;24(2):147-160. Pubmedid: 28441369.
  • Fradley MG. The evolving field of cardio-oncology: beyond anthracyclines and heart failure. Eur Heart J. 2016 Sep;37(36):2740-2742. Pubmedid: 27694540.
  • Diwadkar S, Patel AA, Fradley MG. Bortezomib-Induced Complete Heart Block and Myocardial Scar: The Potential Role of Cardiac Biomarkers in Monitoring Cardiotoxicity. Case Rep Cardiol. 2016 Mar;2016:3456287. Pubmedid: 26942019. Pmcid: PMC4749759.
  • Lenihan DJ, Hartlage G, DeCara J, Blaes A, Finet JE, Lyon AR, Cornell F, Moslehi J, Oliviera G, Murtagh G, Fisch M, Zeevi G, Iakobishvili Z, Witteles R, Patel A, Harrison E, Fradley M, Curigliano G, Lenneman CG, Magalhaes A, Krone R, Porter C, Parasher S, Dent S, Douglas P, Carver J. Cardio-Oncology Training: A Proposal From the International Cardioncology Society and Canadian Cardiac Oncology Network for a New Multidisciplinary Specialty. J Card Fail. 2016 Jun;22(6):465-471. Pubmedid: 27038642.
  • Fradley MG, Moslehi J. QT Prolongation and Oncology Drug Development. Card Electrophysiol Clin. 2015 Jun;7(2):341-355. Pubmedid: 26002398.
  • Pinilla-Ibarz J, Sweet K, Emole J, Fradley M. Long-term BCR-ABL1 Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia. Anticancer Res. 2015 Dec;35(12):6355-6364. Pubmedid: 26637844.
  • Fradley MG, Barrett CD, Clark JR, Francis SA. Ventricular fibrillation cardiac arrest due to 5-fluorouracil cardiotoxicity. Tex Heart Inst J. 2013 Oct;40(4):472-476. Pubmedid: 24082383. Pmcid: PMC3783134.
  • Fradley MG, Thakuria JV, Collins AB, Moore SA, Stone JR. Direct tissue evaluation via immunofluorescence: in the diagnosis of hereditary transthyretin cardiac amyloidosis. Tex Heart Inst J. 2012 Mar;39(1):71-75. Pubmedid: 22412233. Pmcid: PMC3298917.
  • Coglianese EE, Larson MG, Vasan RS, Ho JE, Ghorbani A, McCabe EL, Cheng S, Fradley MG, Kretschman D, Gao W, O'Connor G, Wang TJ, Januzzi JL. Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study. Clin Chem. 2012 Dec;58(12):1673-1681. Pubmedid: 23065477. Pmcid: PMC3557515.
  • Fradley MG, Drachman DE. A Rare Case of Acute Myocardial Infarction due to Coronary Artery Dissection and Heparin-Induced Thrombocytopenia. Case Rep Med. 2012 Aug;2012:196020. Pubmedid: 22719771. Pmcid: PMC3375156.
  • Fradley MG, Larson MG, Cheng S, McCabe E, Coglianese E, Shah RV, Levy D, Vasan RS, Wang TJ. Reference limits for N-terminal-pro-B-type natriuretic peptide in healthy individuals (from the Framingham Heart Study). Am J Cardiol. 2011 Nov;108(9):1341-1345. Pubmedid: 21864812. Pmcid: PMC3209520.
  • Kittleson MM, Bead V, Fradley M, St John ME, Champion HC, Kasper EK, Russell SD, Wittstein IS, Hare JM. Elevated uric acid levels predict allograft vasculopathy in cardiac transplant recipients. J Heart Lung Transpl. 2007 May;26(5):498-503. Pubmedid: 17449420.