Haibin Tian, PhD
Researcher

Haibin Tian, PhD

Academic Rank: Assistant Member

Overview

Discipline

    • Cancer Imaging and Metabolism
    • Diagnostic Imaging and Interventional Radiology
    • Chemical Biology and Molecular Medicine Program
    • Cancer Imaging and Technology

Education & Training

    • Chinese Academy of Sciences, MS - Inorganic Chemistry
    • Shanghai Institute of Nuclear Research, PhD - Radiochemistry
Research

My major research interest is in developing selective radiotracers for measuring its expression in vivo utilizing positron emission tomography (PET).  This research area has a lot of room for development and there is great prospects for synthesizing new imaging tracers that will be very useful in the iagnosis and treatment of cancer and neuronal systems.  My specialty in the fields of radiochemistry and organic sysnthesis with emphasis on the preparation of PET radiotracers with the isotopes of 18F 11C.  We conduct the basic chemical research for attaching various radioisotopes to biologically active molecules such as receptors or enzyme with the hope of developing new diagnostic agents for nuclear medicine.

Publications

  • Huang X, Pan Z, Doligalski ML, Xiao X, Ruiz E, Budzevich MM, Tian H. Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging. Oncotarget. 2017 Jul;8(29):46900-46914. Pubmedid: 28159919. Pmcid: PMC5564531.
  • Huang X, Xiao X, Gillies RJ, Tian H. Design and automated production of 11C-alpha-methyl-l-tryptophan (11C-AMT). Nucl Med Biol. 2016 May;43(5):303-308. Pubmedid: 27150033.
  • Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". Int J Cancer. 2015 Feb;136(4):E188-E196. Pubmedid: 25156304. Pmcid: PMC4262548.
  • Huang X, Gillies RJ, Tian H. Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58(4):156-162. Pubmedid: 25690452. Pmcid: PMC4655588.
  • Kuang Y, Wang F, Corn DJ, Tian H, Lee Z. Metabolism of radiolabeled methionine in hepatocellular carcinoma. Mol Imaging Biol. 2014 Feb;16(1):44-52. Pubmedid: 23921714. Pmcid: PMC4703316.
  • Kuang Y, Wang F, Corn DJ, Tian H, Lee Z. In vitro characterization of uptake mechanism of L-[methyl-(3)H]-methionine in hepatocellular carcinoma. Mol Imaging Biol. 2014 Aug;16(4):459-468. Pubmedid: 24488484. Pmcid: PMC4698986.
  • Wang X, Tian H, Lee Z, Heston WD. Structure-Activity Relationships of 2',5'-Oligoadenylate Analogue Modifications of Prostate-Specific Membrane Antigen (PSMA) Antagonists. Nucleosides Nucleotides Nucleic Acids. 2012 May;31(5):432-444. Pubmedid: 22497258.
  • Tafreshi NK, Huang X, Moberg VE, Barkey NM, Sondak VK, Tian H, Morse DL, Vagner J. Synthesis and characterization of a melanoma-targeted fluorescence imaging probe by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. Bioconjug Chem. 2012 Dec;23(12):2451-2459. Pubmedid: 23116461. Pmcid: PMC3563353.
  • Kolthammer JA, Corn DJ, Tenley N, Wu C, Tian H, Wang Y, Lee Z. PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline. Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1248-1256. Pubmedid: 21344223.
  • Salem N, Kuang Y, Corn D, Erokwu B, Kolthammer JA, Tian H, Wu C, Wang F, Wang Y, Lee Z. [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma. Mol Imaging Biol. 2011 Feb;13(1):140-151. Pubmedid: 20401538. Pmcid: PMC4851171.
  • Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y, Love ZB, Gerson SL, Lee Z. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiol Genomics. 2009 Mar;37(1):23-34. Pubmedid: 19116247. Pmcid: PMC2661103.