Ganna Chornokur
Researcher

Ganna Chornokur

Overview

Discipline

    • Cancer Epidemiology Program

Education & Training

    • University of South Florida, PhD - Biomedical Engineering
    • University of South Florida, Postdoctoral Fellow - Electrical Engineering
    • Moffitt Cancer Center, Postdoctoral Fellow - Cancer Epidemiology
    • National University of Kiev-Mohyla Academy, MS - Environmental Sciences
Research

My research focuses on identification and understanding of the biological and genetic factors that contribute to cancer disparities, and ultimately developing and disseminating evidence-based, biologically sound and culturally appropriate preventive interventions. Seventy five percent of my current research effort is dedicated to the R21 work (CA179659, Chornokur PI). This is a basic science project which expands on our preliminary data suggesting that obese Black, but not White, men have increased prostate cancer risk. Further, the increased risk appears to be concentrated in the obese Black men that are carriers of rs7501939 C-allele in the HNF1B gene. Taken together, our preliminary data suggest that obesity may be a prostate cancer risk factor in Black men, and the extent of risk is determined by the individual’s genetic variation. To further investigate this hypothesis, I proposed to start with the gene expression profiles in prostate tumors of obese and non-obese Black and White men (Aim 1). Once the differentially expressed genes in obese vs non-obese men have been identified, their biological function(s) will be elucidated in the cell lines study (Aim 2), and their effects(s) on prostate cancer risk will be elucidated in the germline DNA genetic epidemiology study (Aim 3). Successfully completed, this project will not only provide epidemiological data connecting obesity to germline genetic variation in Black and White men, but also elucidate its underlying biology. The latter is especially important in light of the challenges to understand the functional significance of the gene-environmental interactions and the disease, and enable their translation into clinics. Twenty percent of my current effort is dedicated to ovarian cancer research, with the focus on health disparities. I have been involved in the SNP analysis for the Collaborative Oncological Gene-environment Study (COGS), and our data (which is in press in the PLOS One journal) suggest that SNPs in the iron metabolism genes modify epithelial ovarian cancer risk. Interestingly, while the leading candidate (rs17216603 in the iron transporter HEPH) was the same in women of European, Asian and African ethnicities, the risk direction was reversed in African women, compared to other ethnicities, possibly pointing at the differences in the biology of the disease. Although ovarian cancer disparities in survival are observed in the US and globally [Chornokur et al. Gynecol Oncol. 2013; 129(1): 258], little is known about their etiology. Unfortunately, ovarian cancer health disparities research is hampered by the lack of samples obtained from minority women. To address this gap, I will aim to establish recruitment of minority women, with the goal of investigating the biological and socio-cultural determinants of disparities. The remaining five percent of my effort is dedicated to the emerging research interest – health disparities in multiple myeloma (MM). MM is a rare hematologic malignancy with a 5-year survival rate of only 35%. The incidence in men of African descent is 2-3 fold higher, and the age of onset is 4 years younger, compared to their White counterparts. Very little is known about the etiology of disparities in MM. As Moffitt sees over 300 new MM patients a year, I am starting my research with analyzing the historical data available from the Total Cancer Care (TCC) – a sample biorepository linked to medical, epidemiological, treatment and survival data. The goal is to get preliminary data for a Research Fellow award submission to the MM Research Foundation.  

Publications

  • Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, Earp MA, Lyra PC, Lee JM, Coetzee S, Beesley J, McGuffog L, Soucy P, Dicks E, Lee A, Barrowdale D, Lecarpentier J, Leslie G, Aalfs CM, Aben KK, Adams M, Adlard J, Andrulis IL, Anton-Culver H, Antonenkova N, Aravantinos G, Arnold N, Arun BK, Arver B, Azzollini J, Balmaña J, Banerjee SN, Barjhoux L, Barkardottir RB, Bean Y, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bermisheva M, Bernardini MQ, Birrer MJ, Bjorge L, Black A, Blankstein K, Blok MJ, Bodelon C, Bogdanova N, Bojesen A, Bonanni B, Borg Å, Bradbury AR, Brenton JD, Brewer C, Brinton L, Broberg P, Brooks-Wilson A, Bruinsma F, Brunet J, Buecher B, Butzow R, Buys SS, Caldes T, Caligo MA, Campbell I, Cannioto R, Carney ME, Cescon T, Chan SB, Chang-Claude J, Chanock S, Chen XQ, Chiew YE, Chiquette J, Chung WK, Claes KB, Conner T, Cook LS, Cook J, Cramer DW, Cunningham JM, D'Aloisio AA, Daly MB, Damiola F, Damirovna SD, Dansonka-Mieszkowska A, Dao F, Davidson R, DeFazio A, Delnatte C, Doheny KF, Diez O, Ding YC, Doherty JA, Domchek SM, Dorfling CM, Dörk T, Dossus L, Duran M, Dürst M, Dworniczak B, Eccles D, Edwards T, Eeles R, Eilber U, Ejlertsen B, Ekici AB, Ellis S, Elvira M, Eng KH, Engel C, Evans DG, Fasching PA, Ferguson S, Ferrer SF, Flanagan JM, Fogarty ZC, Fortner RT, Fostira F, Foulkes WD, Fountzilas G, Fridley BL, Friebel TM, Friedman E, Frost D, Ganz PA, Garber J, García MJ, Garcia-Barberan V, Gehr ...
  • Luu HN, Lin HY, Sørensen KD, Ogunwobi OO, Kumar N, Chornokur G, Phelan C, Jones D, Kidd L, Batra J, Yamoah K, Berglund A, Rounbehler RJ, Yang M, Lee SH, Kang N, Kim SJ, Park JY, Di Pietro G. miRNAs associated with prostate cancer risk and progression. BMC Urol. 2017 Mar;17(1):18. Pubmedid: 28320379. Pmcid: PMC5359825.
  • Jim HS, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Chornokur G, Chen Z, Chen AY, Permuth-Wey J, Aben KK, Anton-Culver H, Antonenkova N, Bruinsma F, Bandera EV, Bean YT, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, du Bois A, Despierre E, Sieh W, Doherty JA, Dörk T, Dürst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hillemanns P, Hogdall CK, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kellar M, Kiemeney LA, Krakstad C, Kjaer SK, Kupryjanczyk J, Vierkant RA, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lim BK, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Thomsen L, Moysich KB, Ness RB, Nevanlinna H, Eilber U, Odunsi K, Olson SH, Orlow I, Orsulic S, Palmieri Weber R, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Schernhammer E, Risch HA, Rosen B, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Teo SH, Terry KL, Thompson PJ, Tangen IL, Tworoger SS, van Altena ...
  • Kumar NB, Pow-Sang J, Egan KM, Spiess PE, Dickinson S, Salup R, Helal M, McLarty JW, Williams CR, Schreiber F, Parnes HL, Sebti S, Kazi A, Kang L, Quinn GP, Smith T, Yue B, Diaz K, Chornokur G, Crocker T, Schell MJ. Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention. Cancer Prev Res (Phila). 2015 Oct;8(10):879-887. Pubmedid: 25873370. Pmcid: PMC4596745.
  • Chornokur G, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Amankwah EK, Qu X, Tsai YY, Jim HS, Chen Z, Chen AY, Permuth-Wey J, Aben KK, Anton-Culver H, Antonenkova N, Bruinsma F, Bandera EV, Bean YT, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, du Bois A, Despierre E, Dicks E, Doherty JA, Dörk T, Dürst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harrington P, Harter P, Hein A, Heitz F, Hildebrandt MA, Hillemanns P, Hogdall CK, Hogdall E, Hosono S, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kelemen LE, Kellar M, Kiemeney LA, Krakstad C, Kjaer SK, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lim BK, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Moysich KB, Ness RB, Nevanlinna H, Eilber U, Odunsi K, Olson SH, Orlow I, Orsulic S, Weber RP, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Risch HA, Rosen B, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schernhammer E, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Spiewankiewicz B, Sucheston L, Teo SH, Terry KL, Thompson PJ, Thomsen L, Tangen IL, Tworoger SS, ...
  • Amankwah EK, Lin HY, Tyrer JP, Lawrenson K, Dennis J, Chornokur G, Aben KK, Anton-Culver H, Antonenkova N, Bruinsma F, Bandera EV, Bean YT, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bunker CH, Butzow R, Campbell IG, Carty K, Chen Z, Chen YA, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, du Bois A, Despierre E, Dicks E, Doherty JA, Dörk T, Dürst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harrington P, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hillemanns P, Hogdall CK, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Jim H, Kellar M, Kiemeney LA, Krakstad C, Kjaer SK, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lim BK, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Moysich KB, Ness RB, Nevanlinna H, Eilber U, Odunsi K, Olson SH, Orlow I, Orsulic S, Weber RP, Paul J, Pearce CL, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Risch HA, Rosen B, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schernhammer E, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Teo SH, Terry KL, Thompson PJ, Thomsen L, Tangen IL, Tworoger ...
  • Chornokur G, Amankwah EK, Davis SN, Phelan CM, Park JY, Pow-Sang J, Kumar NB. Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study. Prostate Cancer. 2014 Jan;2013:384594. Pubmedid: 24386569. Pmcid: PMC3872424.
  • Kim S, Amankwah EK, Connors S, Park HY, Rincon M, Cornnell HH, Chornokur G, Ibrahim-Hashim A, Choi J, Tsai YY, Engelman R, Kumar NB, Park JY. Safety and chemopreventive effect of Polyphenon E in preventing early and metastatic progression of prostate cancer in TRAMP mice. Cancer Prev Res (Phila). 2014 Apr;7(4):435-444. Pubmedid: 24501325. Pmcid: PMC4123218.
  • Chornokur G, Han G, Tanner R, Lin HY, Green BL, Pow-Sang J, Phelan CM. High grade prostate intraepithelial neoplasia (PIN) is a PSA-independent risk factor for prostate cancer in African American men: results from a pilot study. Cancer Lett. 2013 May;331(2):154-157. Pubmedid: 23268329. Pmcid: PMC3603576.
  • Chornokur G, Kumar NB. Prostate cancer chemoprevention in men of African descent: current state of the art and opportunities for future research. Cancer Causes Control. 2013 Aug;24(8):1465-1480. Pubmedid: 23737026. Pmcid: PMC4184029.
  • Kumar N, Crocker T, Smith T, Pow-Sang J, Spiess PE, Connors S, Chornukur G, Dickinson SI, Bai W, Williams CR, Salup R, Fu W. Prostate Cancer Chemoprevention Targeting High Risk Populations: Model for Trial Design and Outcome Measures. J Cancer Sci Ther. 2012 Mar;2011(S3). Pubmedid: 22422102. Pmcid: PMC3300067.
  • Connors SK, Chornokur G, Kumar NB. New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer. Nutr Cancer. 2012 Jul;64(1):4-22. Pubmedid: 22098273. Pmcid: PMC3665011.
  • Kumar N, Chornokur G. Molecular Targeted Therapies Using Botanicals for Prostate Cancer Chemoprevention. Transl Med (Sunnyvale). 2012 Dec;Suppl 2:005. Pubmedid: 24527269. Pmcid: PMC3920581.
  • Chornokur G, Dalton K, Borysova ME, Kumar NB. Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer. Prostate. 2011 Jun;71(9):985-997. Pubmedid: 21541975. Pmcid: PMC3083484.
  • Venugopal M, Arya SK, Chornokur G, Bhansali S. A Realtime and Continuous Assessment of Cortisol in ISF Using Electrochemical Impedance Spectroscopy. Sens Actuators A Phys. 2011 Dec;172(1):154-160. Pubmedid: 22163154. Pmcid: PMC3234992.
  • Arya SK, Chornokur G, Venugopal M, Bhansali S. Dithiobis(succinimidyl propionate) modified gold microarray electrode based electrochemical immunosensor for ultrasensitive detection of cortisol. Biosens Bioelectron. 2010 Jun;25(10):2296-2301. Pubmedid: 20382518. Pmcid: PMC2869627.
  • Arya SK, Chornokur G, Venugopal M, Bhansali S. Antibody functionalized interdigitated micro-electrode (IDmicroE) based impedimetric cortisol biosensor. Analyst. 2010 Aug;135(8):1941-1946. Pubmedid: 20589269.