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Gage Redler, PhD

Academic Rank: Assistant Member

Overview

Dr. Redler’s research purpose is the advancement of technologies and techniques that make use of medical imaging modalities to more effectively guide radiation therapy. 


Discipline

Education & Training

Board Certification:

  • Radiology

Fellowship:

  • University of Chicago, PhD - Medical Physics
  • Rush University Medical Center, - Radiation Oncology Medical Physics
Research

Dr. Redler’s research interests are the and advancement of technologies and techniques that make use of medical imaging modalities to more effectively guide radiation therapy. This includes development of novel imaging modalities (EPR oxygen imaging and Compton scatter imaging), preclinical radiation methodologies for preliminary investigations (3D printed compensator-based small animal IMRT), as well as investigation of how novel technologies can be better used to improve treatment efficacy (e.g., Adaptive Radiation Therapy using the ViewRay’s MR-Linac).

Publications

  • Jones KC, Turian JV, Redler G, Cifter G, Strologas J, Templeton A, Bernard D, Chu JCH. Scatter imaging during lung stereotactic body radiation therapy characterized with phantom studies. Phys Med Biol. 2020 May. Pubmedid: 32408276.
  • Korpics MC, Polley MY, Bhave SR, Redler G, Pitroda SP, Luke JJ, Chmura SJ. A Validated T Cell Radiomics Score is Associated with Clinical Outcomes Following Multi-site SBRT and Pembrolizumab. Int J Radiat Oncol Biol Phys. 2020 Jun. Pubmedid: 32569799.
  • Korpics MC, Rokni M, Degnan M, Aydogan B, Liauw SL, Redler G. Utilizing the TrueBeam Advanced Imaging Package to monitor intrafraction motion with periodic kV imaging and automatic marker detection during VMAT prostate treatments. J Appl Clin Med Phys. 2020 Jan.21(3):184-191. Pubmedid: 31981305. Pmcid: PMC7075383.
  • Redler G, Stevens T, Cammin J, Malin M, Green O, Mutic S, Pitroda S, Aydogan B. Dosimetric Feasibility of Utilizing the ViewRay Magnetic Resonance Guided Linac System for Image-guided Spine Stereotactic Body Radiation Therapy. Cureus. 2019 Dec.11(12):e6364. Pubmedid: 31938646. Pmcid: PMC6957030.
  • Qiao Z, Zhang Z, Pan X, Epel B, Redler G, Xia D, Halpern H. Optimization-based image reconstruction from sparsely sampled data in electron paramagnetic resonance imaging. J Magn Reson. 2018 Sep.294:24-34. Pubmedid: 30005191.
  • Qiao Z, Redler G, Qian Y, Tang S, Epel B, Halpern H. Investigation of the preconditioner-parameter in the preconditioned Chambolle-Pock algorithm applied to optimization-based image reconstruction. J Xray Sci Technol. 2018 Nov.26(3):435-448. Pubmedid: 29562580.
  • Redler G, Templeton A, Zhen H, Turian J, Bernard D, Chu JCH, Griem KL, Liao Y. Dosimetric effects of saline- versus water-filled balloon applicators for IORT using the model S700 electronic brachytherapy source. Brachytherapy. 2018 Mar.17(2):500-505. Pubmedid: 29229377.
  • Redler G, Jones KC, Templeton A, Bernard D, Turian J, Chu JCH. Compton scatter imaging: A promising modality for image guidance in lung stereotactic body radiation therapy. Med Phys. 2018 Mar.45(3):1233-1240. Pubmedid: 29360151. Pmcid: PMC5849250.
  • Millunchick CH, Zhen H, Redler G, Liao Y, Turian JV. A model for predicting the dose to the parotid glands based on their relative overlapping with planning target volumes during helical radiotherapy. J Appl Clin Med Phys. 2018 Mar.19(2):48-53. Pubmedid: 29105949. Pmcid: PMC5849840.
  • Jones KC, Redler G, Templeton A, Bernard D, Turian JV, Chu JCH. Characterization of Compton-scatter imaging with an analytical simulation method. Phys Med Biol. 2018 Jan.63(2):025016. Pubmedid: 29243663. Pmcid: PMC5849266.
  • Qiao Z, Redler G, Gui Z, Qian Y, Epel B, Halpern H. Three novel accurate pixel-driven projection methods for 2D CT and 3D EPR imaging. J Xray Sci Technol. 2018 Jan.26(1):83-102. Pubmedid: 29036875.
  • Christodoulou AG, Redler G, Clifford B, Liang ZP, Halpern HJ, Epel B. Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors. J Magn Reson. 2016 Sep.270:176-182. Pubmedid: 27498337. Pmcid: PMC5127203.
  • Epel B, Redler G, Tormyshev V, Halpern HJ. Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging. Adv Exp Med Biol. 2016 May.876:363-369. Pubmedid: 26782233. Pmcid: PMC4745973.
  • Epel B, Redler G, Pelizzari C, Tormyshev VM, Halpern HJ. Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy. Adv Exp Med Biol. 2016 May.876:185-193. Pubmedid: 26782211. Pmcid: PMC4747097.
  • Qiao Z, Redler G, Epel B, Qian Y, Halpern H. 3D pulse EPR imaging from sparse-view projections via constrained, total variation minimization. J Magn Reson. 2015 Sep.258:49-57. Pubmedid: 26225440. Pmcid: PMC4827344.
  • Qiao Z, Redler G, Epel B, Qian Y, Halpern H. Implementation of GPU-accelerated back projection for EPR imaging. J Xray Sci Technol. 2015 Jul.23(4):423-433. Pubmedid: 26410654. Pmcid: PMC4825055.
  • Redler G, Epel B, Halpern HJ. Maximally spaced projection sequencing in electron paramagnetic resonance imaging. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb.45(1):33-45. Pubmedid: 26185490. Pmcid: PMC4500539.
  • Redler G, Qiao Z, Epel B, Halpern HJ. Real-Time Image Reconstruction for Pulse EPR Oxygen Imaging Using a GPU and Lookup Table Parameter Fitting. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb.45(1):46-57. Pubmedid: 26167137. Pmcid: PMC4493913.
  • Qiao Z, Redler G, Epel B, Halpern HJ. Comparison of parabolic filtration methods for 3D filtered back projection in pulsed EPR imaging. J Magn Reson. 2014 Nov.248:42-53. Pubmedid: 25314081. Pmcid: PMC4324566.
  • Redler G, Epel B, Halpern HJ. EPR image based oxygen movies for transient hypoxia. Adv Exp Med Biol. 2014 Mar.812:127-133. Pubmedid: 24729224. Pmcid: PMC4313543.
  • Epel B, Redler G, Halpern HJ. How in vivo EPR measures and images oxygen. Adv Exp Med Biol. 2014 Mar.812:113-119. Pubmedid: 24729222. Pmcid: PMC4319367.
  • Redler G, Epel B, Halpern HJ. Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo. Magn Reson Med. 2014 Jan.71(1):440-450. Pubmedid: 23401214. Pmcid: PMC3796058.
  • Redler G, Epel B, Halpern HJ. What we learn from in vivo EPR oxygen images. Adv Exp Med Biol. 2014 Aug.812:121-126. Pubmedid: 24729223. Pmcid: PMC4313544.
  • Redler G, Barth ED, Bauer KS, Kao JP, Rosen GM, Halpern HJ. In vivo electron paramagnetic resonance imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl. Magn Reson Med. 2014 Apr.71(4):1650-1656. Pubmedid: 23776127. Pmcid: PMC4321903.
  • Qiao Z, Redler G, Halpern H. A simplified Katsevich algorithm motivated by the distribution properties of k-lines. J Electron Imaging. 2013 Oct.22(4):043002. Pubmedid: 25774077. Pmcid: PMC4357848.
  • Redler G, Elas M, Epel B, Barth ED, Halpern HJ. Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors. Adv Exp Med Biol. 2013 Jun.789:399-404. Pubmedid: 23852521. Pmcid: PMC4319364.
  • Lampropoulos C, Redler G, Data S, Abboud KA, Hill S, Christou G. Binding of higher alcohols onto Mn(12) single-molecule magnets (SMMs): access to the highest barrier Mn(12) SMM. Inorg Chem. 2010 Feb.49(4):1325-1336. Pubmedid: 20092341.