Gage Redler, PhD

Dr. Redler’s research purpose is the advancement of technologies and techniques that make use of medical imaging modalities to more effectively guide radiation therapy. 

Associations

• Radiation Oncology

Education & Training

Graduate:

• University of Chicago, PhD - Medical Physics

Board Certification:

• Radiology -

Residency:

• Rush University Medical Center - Radiation Oncology Medical Physics

Dr. Redler’s research interests are the and advancement of technologies and techniques that make use of medical imaging modalities to more effectively guide radiation therapy. This includes development of novel imaging modalities (EPR oxygen imaging and Compton scatter imaging), preclinical radiation methodologies for preliminary investigations (3D printed compensator-based small animal IMRT), as well as investigation of how novel technologies can be better used to improve treatment efficacy (e.g., Adaptive Radiation Therapy using the ViewRay’s MR-Linac).

• Nasser N, Perez BA, Penagaricano JA, Caudell JJ, Oliver DE, Latifi K, Moros EG, Redler G. Technical feasibility of novel immunostimulatory low-dose radiation for polymetastatic disease with CBCT-based online adaptive and conventional approaches. J Appl Clin Med Phys. 2024 Feb.e14303. Pubmedid: 38377378.
• Naghavi AO, Bryant JM, Kim Y, Weygand J, Redler G, Sim AJ, Miller J, Coucoules K, Michael LT, Gloria WE, Yang G, Rosenberg SA, Ahmed K, Bui MM, Henderson-Jackson EB, Lee A, Lee CD, Gonzalez RJ, Feygelman V, Eschrich SA, Scott JG, Torres-Roca J, Latifi K, Parikh N, Costello J. Habitat escalated adaptive therapy (HEAT): a phase 2 trial utilizing radiomic habitat-directed and genomic-adjusted radiation dose (GARD) optimization for high-grade soft tissue sarcoma. BMC Cancer. 2024 Apr.24(1):437. Pubmedid: 38594603. Pmcid: PMC11003059.
• Weygand J, Armstrong T, Bryant JM, Andreozzi JM, Oraiqat IM, Nichols S, Liveringhouse CL, Latifi K, Yamoah K, Costello JR, Frakes JM, Moros EG, El Naqa IM, Naghavi AO, Rosenberg SA, Redler G. Accurate, repeatable, and geometrically precise diffusion-weighted imaging on a 0.35 T magnetic resonance imaging-guided linear accelerator. Phys Imaging Radiat Oncol. 2023 Oct.28:100505. Pubmedid: 38045642. Pmcid: PMC10692914.
• Bryant JM, Doniparthi A, Weygand J, Cruz-Chamorro R, Oraiqat IM, Andreozzi J, Graham J, Redler G, Latifi K, Feygelman V, Rosenberg SA, Yu HM, Oliver DE. Treatment of Central Nervous System Tumors on Combination MR-Linear Accelerators: Review of Current Practice and Future Directions. Cancers (Basel). 2023 Oct.15(21). Pubmedid: 37958374. Pmcid: PMC10649155.
• Sandoval ML, Sim AJ, Bryant JM, Bhandari M, Wuthrick EJ, Perez BA, Dilling TJ, Redler G, Andreozzi J, Nardella L, Feygelman V, Latifi K, Rosenberg SA. Magnetic Resonance-Guided Stereotactic Body Radiation Therapy/Hypofractionated Radiation therapy for Metastatic and Primary Central and Ultracentral Lung Lesions. JTO Clin Res Rep. 2023 May.4(5):100488. Pubmedid: 37159821. Pmcid: PMC10163640.
• Bryant JM, Weygand J, Keit E, Cruz-Chamorro R, Sandoval ML, Oraiqat IM, Andreozzi J, Redler G, Latifi K, Feygelman V, Rosenberg SA. Stereotactic Magnetic Resonance-Guided Adaptive and Non-Adaptive Radiotherapy on Combination MR-Linear Accelerators: Current Practice and Future Directions. Cancers (Basel). 2023 Mar.15(7). Pubmedid: 37046741. Pmcid: PMC10093051.
• Kozee M, Weygand J, Andreozzi JM, Hunt D, Perez BA, Graham JA, Redler G. Methodology for computed tomography characterization of commercially available 3D printing materials for use in radiology/radiation oncology. J Appl Clin Med Phys. 2023 Jun.24(6):e13999. Pubmedid: 37096305. Pmcid: PMC10243336.
• Nasser N, Yang GQ, Koo J, Bowers M, Greco K, Feygelman V, Moros EG, Caudell JJ, Redler G. A head and neck treatment planning strategy for a CBCT-guided ring-gantry online adaptive radiotherapy system. J Appl Clin Med Phys. 2023 Dec.24(12):e14134. Pubmedid: 37621133. Pmcid: PMC10691641.
• Graham JA, Redler G, Delozier KB, Yu HM, Oliver DE, Rosenberg SA. Dosimetric feasibility of hippocampal avoidance whole brain radiotherapy with an MRI-guided linear accelerator. J Appl Clin Med Phys. 2022 Jun.23(6):e13587. Pubmedid: 35344266. Pmcid: PMC9195042.
• Ericsson-Szecsenyi R, Zhang G, Redler G, Feygelman V, Rosenberg S, Latifi K, Ceberg C, Moros EG. Robustness Assessment of Images From a 0.35T Scanner of an Integrated MRI-Linac: Characterization of Radiomics Features in Phantom and Patient Data. Technol Cancer Res Treat. 2022 Jan.21. Pubmedid: 35521966. Pmcid: PMC9083059.
• Linkowski LC, Sim AJ, Redler G, Brohl AS, Rosenberg SA, Wuthrick EJ. Delivery of Online Adaptive MRI-Guided Radiation Therapy for a Deaf Patient. Cureus. 2022 Aug.14(8):e27558. Pubmedid: 36059359. Pmcid: PMC9429821.
• Liu X, Van Slyke AL, Pearson E, Shoniyozov K, Redler G, Wiersma RD. Improving the efficiency of small animal 3D-printed compensator IMRT with beamlet intensity total variation regularization. Med Phys. 2022 Aug.49(8):5400-5408. Pubmedid: 35608256.
• Rokni MB, Pointer KB, George J, Luke JJ, Chmura SJ, Redler G. Radiation treatment planning study to investigate feasibility of delivering Immunotherapy in Combination with Ablative Radiosurgery to Ultra-High DoSes (ICARUS). J Appl Clin Med Phys. 2021 Mar.22(3):196-206. Pubmedid: 33626240. Pmcid: PMC7984482.
• Redler G, Pearson E, Liu X, Gertsenshteyn I, Epel B, Pelizzari C, Aydogan B, Weichselbaum R, Halpern HJ, Wiersma RD. Small Animal IMRT Using 3D-Printed Compensators. Int J Radiat Oncol Biol Phys. 2021 Jun.110(2):551-565. Pubmedid: 33373659. Pmcid: PMC8122034.
• Qiao Z, Redler G, Epel B, Halpern H. A balanced total-variation-Chambolle-Pock algorithm for EPR imaging. J Magn Reson. 2021 Jul.328:107009. Pubmedid: 34058712.
• Koo J, Nardella L, Degnan M, Andreozzi J, Yu HM, Penagaricano J, Johnstone PAS, Oliver D, Ahmed K, Rosenberg SA, Wuthrick E, Diaz R, Feygelman V, Latifi K, Moros EG, Redler G. Triggered kV Imaging During Spine SBRT for Intrafraction Motion Management. Technol Cancer Res Treat. 2021 Jan.20. Pubmedid: 34855577. Pmcid: PMC8649431.
• Saini A, Tichacek C, Johansson W, Redler G, Zhang G, Moros EG, Qayyum M, Feygelman V. Unlocking a closed system: dosimetric commissioning of a ring gantry linear accelerator in a multivendor environment. J Appl Clin Med Phys. 2021 Feb.22(2):21-34. Pubmedid: 33452738. Pmcid: PMC7882119.
• Korpics MC, Polley MY, Bhave SR, Redler G, Pitroda SP, Luke JJ, Chmura SJ. A Validated T Cell Radiomics Score Is Associated With Clinical Outcomes Following Multisite SBRT and Pembrolizumab. Int J Radiat Oncol Biol Phys. 2020 Sep.108(1):189-195. Pubmedid: 32569799.
• Sim AJ, Palm RF, DeLozier KB, Feygelman V, Latifi K, Redler G, Washington IR, Wuthrick EJ, Rosenberg SA. MR-guided stereotactic body radiation therapy for intracardiac and pericardial metastases. Clin Transl Radiat Oncol. 2020 Nov.25:102-106. Pubmedid: 33204858. Pmcid: PMC7653008.
• Slagowski JM, Redler G, Malin MJ, Cammin J, Lobb EC, Lee BH, Sethi A, Roeske JC, Flores-Martinez E, Stevens T, Yenice KM, Green O, Mutic S, Aydogan B. Dosimetric feasibility of brain stereotactic radiosurgery with a 0.35 T MRI-guided linac and comparison vs a C-arm-mounted linac. Med Phys. 2020 Nov.47(11):5455-5466. Pubmedid: 32996591.
• Korpics MC, Rokni M, Degnan M, Aydogan B, Liauw SL, Redler G. Utilizing the TrueBeam Advanced Imaging Package to monitor intrafraction motion with periodic kV imaging and automatic marker detection during VMAT prostate treatments. J Appl Clin Med Phys. 2020 Mar.21(3):184-191. Pubmedid: 31981305. Pmcid: PMC7075383.
• Sim AJ, Redler G, Peacock J, Naso C, Wasserman S, McNitt KB, Hoffe SE, Johnstone PAS, Harrison LB, Rosenberg SA. Harnessing COVID-Driven Technical Innovations for Improved Multi-Disciplinary Cancer Care in the Post-COVID Era: The Virtual Patient Room. Cancer Control. 2020 Jan.27(1). Pubmedid: 33023342. Pmcid: PMC7791470.
• Jones KC, Turian JV, Redler G, Cifter G, Strologas J, Templeton A, Bernard D, Chu JCH. Scatter imaging during lung stereotactic body radiation therapy characterized with phantom studies. Phys Med Biol. 2020 Aug.65(15):155013. Pubmedid: 32408276. Pmcid: PMC8341471.
• Redler G, Stevens T, Cammin J, Malin M, Green O, Mutic S, Pitroda S, Aydogan B. Dosimetric Feasibility of Utilizing the ViewRay Magnetic Resonance Guided Linac System for Image-guided Spine Stereotactic Body Radiation Therapy. Cureus. 2019 Dec.11(12):e6364. Pubmedid: 31938646. Pmcid: PMC6957030.
• Qiao Z, Zhang Z, Pan X, Epel B, Redler G, Xia D, Halpern H. Optimization-based image reconstruction from sparsely sampled data in electron paramagnetic resonance imaging. J Magn Reson. 2018 Sep.294:24-34. Pubmedid: 30005191.
• Qiao Z, Redler G, Qian Y, Tang S, Epel B, Halpern H. Investigation of the preconditioner-parameter in the preconditioned Chambolle-Pock algorithm applied to optimization-based image reconstruction. J Xray Sci Technol. 2018 Nov.26(3):435-448. Pubmedid: 29562580.
• Redler G, Jones KC, Templeton A, Bernard D, Turian J, Chu JCH. Compton scatter imaging: A promising modality for image guidance in lung stereotactic body radiation therapy. Med Phys. 2018 Mar.45(3):1233-1240. Pubmedid: 29360151. Pmcid: PMC5849250.
• Redler G, Templeton A, Zhen H, Turian J, Bernard D, Chu JCH, Griem KL, Liao Y. Dosimetric effects of saline- versus water-filled balloon applicators for IORT using the model S700 electronic brachytherapy source. Brachytherapy. 2018 Mar.17(2):500-505. Pubmedid: 29229377.
• Millunchick CH, Zhen H, Redler G, Liao Y, Turian JV. A model for predicting the dose to the parotid glands based on their relative overlapping with planning target volumes during helical radiotherapy. J Appl Clin Med Phys. 2018 Mar.19(2):48-53. Pubmedid: 29105949. Pmcid: PMC5849840.
• Qiao Z, Redler G, Gui Z, Qian Y, Epel B, Halpern H. Three novel accurate pixel-driven projection methods for 2D CT and 3D EPR imaging. J Xray Sci Technol. 2018 Jan.26(1):83-102. Pubmedid: 29036875.
• Jones KC, Redler G, Templeton A, Bernard D, Turian JV, Chu JCH. Characterization of Compton-scatter imaging with an analytical simulation method. Phys Med Biol. 2018 Jan.63(2):025016. Pubmedid: 29243663. Pmcid: PMC5849266.
• Christodoulou AG, Redler G, Clifford B, Liang ZP, Halpern HJ, Epel B. Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors. J Magn Reson. 2016 Sep.270:176-182. Pubmedid: 27498337. Pmcid: PMC5127203.
• Epel B, Redler G, Pelizzari C, Tormyshev VM, Halpern HJ. Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy. Adv Exp Med Biol. 2016 May.876:185-193. Pubmedid: 26782211. Pmcid: PMC4747097.
• Epel B, Redler G, Tormyshev V, Halpern HJ. Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging. Adv Exp Med Biol. 2016 May.876:363-369. Pubmedid: 26782233. Pmcid: PMC4745973.
• Qiao Z, Redler G, Epel B, Qian Y, Halpern H. 3D pulse EPR imaging from sparse-view projections via constrained, total variation minimization. J Magn Reson. 2015 Sep.258:49-57. Pubmedid: 26225440. Pmcid: PMC4827344.
• Qiao Z, Redler G, Epel B, Qian Y, Halpern H. Implementation of GPU-accelerated back projection for EPR imaging. J Xray Sci Technol. 2015 Jul.23(4):423-433. Pubmedid: 26410654. Pmcid: PMC4825055.
• Redler G, Epel B, Halpern HJ. Maximally spaced projection sequencing in electron paramagnetic resonance imaging. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb.45(1):33-45. Pubmedid: 26185490. Pmcid: PMC4500539.
• Redler G, Qiao Z, Epel B, Halpern HJ. Real-Time Image Reconstruction for Pulse EPR Oxygen Imaging Using a GPU and Lookup Table Parameter Fitting. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb.45(1):46-57. Pubmedid: 26167137. Pmcid: PMC4493913.
• Qiao Z, Redler G, Epel B, Halpern HJ. Comparison of parabolic filtration methods for 3D filtered back projection in pulsed EPR imaging. J Magn Reson. 2014 Nov.248:42-53. Pubmedid: 25314081. Pmcid: PMC4324566.
• Epel B, Redler G, Halpern HJ. How in vivo EPR measures and images oxygen. Adv Exp Med Biol. 2014 Mar.812:113-119. Pubmedid: 24729222. Pmcid: PMC4319367.
• Redler G, Epel B, Halpern HJ. EPR image based oxygen movies for transient hypoxia. Adv Exp Med Biol. 2014 Mar.812:127-133. Pubmedid: 24729224. Pmcid: PMC4313543.
• Redler G, Epel B, Halpern HJ. Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo. Magn Reson Med. 2014 Jan.71(1):440-450. Pubmedid: 23401214. Pmcid: PMC3796058.
• Redler G, Epel B, Halpern HJ. What we learn from in vivo EPR oxygen images. Adv Exp Med Biol. 2014 Aug.812:121-126. Pubmedid: 24729223. Pmcid: PMC4313544.
• Redler G, Barth ED, Bauer KS, Kao JP, Rosen GM, Halpern HJ. In vivo electron paramagnetic resonance imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl. Magn Reson Med. 2014 Apr.71(4):1650-1656. Pubmedid: 23776127. Pmcid: PMC4321903.
• Qiao Z, Redler G, Halpern H. A simplified Katsevich algorithm motivated by the distribution properties of k-lines. J Electron Imaging. 2013 Oct.22(4):043002. Pubmedid: 25774077. Pmcid: PMC4357848.
• Redler G, Elas M, Epel B, Barth ED, Halpern HJ. Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors. Adv Exp Med Biol. 2013 Jun.789:399-404. Pubmedid: 23852521. Pmcid: PMC4319364.
• Lampropoulos C, Redler G, Data S, Abboud KA, Hill S, Christou G. Binding of higher alcohols onto Mn(12) single-molecule magnets (SMMs): access to the highest barrier Mn(12) SMM. Inorg Chem. 2010 Feb.49(4):1325-1336. Pubmedid: 20092341.