G. Douglas Letson
Researcher

G. Douglas Letson

Academic Rank: Senior Member

Overview

Dr. Letson and his collaborators strive to develop novel surgical techniques for musculoskeletal tumors; tumor prosthesis for skeletal reconstruction; and navigational and robotic musculoskeletal tumor surgery.

Discipline

    • Sarcoma
    • Tumor Biology
    • Sarcoma
    • Chemical Biology and Molecular Medicine Program

Education & Training

    • Louisiana State University, MD
    • Louisiana State University Medical School Affiliated Hospitals, Resident - Orthopaedics
    • Massachusetts General Hospital – Harvard Medical School , Fellow - Musculoskeletal Oncology
Research

As an orthopaedic oncology surgeon, Dr. Letson’s research and clinical interests include matrix metalloproteinases; novel therapeutic agents to treat sarcoma; limb salvage for bone and soft tissue tumors; as well as segmental prosthesis, new hinge designs and a soft tissue attachment for metallic prosthesis.

Publications

  • Durfee RA, Sabo SA, Letson GD, Binitie O, Cheong D. Percutaneous Acetabuloplasty for Metastatic Lesions to the Pelvis. Orthopedics. 2017 Jan;40(1):e170-e175. Pubmedid: 27783835.
  • Reed DR, Oshrine B, Pratt C, Fridgen O, Elstner C, Wilson L, Soliman H, Lee MC, McLeod HL, Shah B, Donovan KA, Pabbathi S, Turney M, Binitie O, Healy C, Nieder M, Shaw PH, Galligan A, Letson GD, Stern M, Quinn GP, Davies S. Sink or Collaborate: How the Immersive Model Has Helped Address Typical Adolescent and Young Adult Barriers at a Single Institution and Kept the Adolescent and Young Adult Program Afloat. J Adolesc Young Adult Oncol. 2017 Aug. Pubmedid: 28777007.
  • Kubal T, Letson DG, Chiappori AA, Springett GM, Shimkhada R, Tamondong Lachica D, Peabody JW. Longitudinal cohort study to determine effectiveness of a novel simulated case and feedback system to improve clinical pathway adherence in breast, lung and GI cancers. BMJ Open. 2016 Sep;6(9):e012312. Pubmedid: 27625063. Pmcid: PMC5030551.
  • Caracciolo JT, Letson GD. Radiologic Approach to Bone and Soft Tissue Sarcomas. Surg Clin N Am. 2016 Oct;96(5):963-976. Pubmedid: 27542636.
  • Bertrand TE, Cruz A, Binitie O, Cheong D, Letson GD. Do Surgical Margins Affect Local Recurrence and Survival in Extremity, Nonmetastatic, High-grade Osteosarcoma?. Clin Orthop Relat Res. 2016 Mar;474(3):677-683. Pubmedid: 26013153. Pmcid: PMC4746163.
  • Naghavi AO, Gonzalez RJ, Scott JG, Mullinax JE, Abuodeh YA, Kim Y, Binitie O, Ahmed KA, Bui MM, Saini AS, Zager JS, Biagioli MC, Letson D, Harrison LB, Fernandez DC. Implications of staged reconstruction and adjuvant brachytherapy in the treatment of recurrent soft tissue sarcoma. Brachytherapy. 2016 Jul;15(4):495-503. Pubmedid: 27180128.
  • Doepker MP, Hanna KH, Thompson ZJ, Binitie OT, Letson DG, Gonzalez RJ. Recurrence and survival analysis of resected soft tissue sarcomas of pelvic retroperitoneal structures. J Surg Oncol. 2016 Jan;113(1):103-107. Pubmedid: 26744131.
  • Raj S, Bui MM, Springett G, Conley A, Lavilla-Alonso S, Zhao X, Chen D, Haysek R, Gonzalez R, Letson GD, Finkelstein SE, Chiappori AA, Gabrilovitch DI, Antonia SJ. Long-Term Clinical Responses of Neoadjuvant Dendritic Cell Infusions and Radiation in Soft Tissue Sarcoma. Sarcoma. 2016 Feb;2015:614736. Pubmedid: 26880867. Pmcid: PMC4735941.
  • Groundland JS, Ambler SB, Houskamp LD, Orriola JJ, Binitie OT, Letson GD. Surgical and Functional Outcomes After Limb-Preservation Surgery for Tumor in Pediatric Patients: A Systematic Review. JBJS Rev. 2016 Feb;4(2). Pubmedid: 27490132.
  • Niu X, Xu H, Inwards CY, Li Y, Ding Y, Letson GD, Bui MM. Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota. Arch Pathol Lab Med. 2015 Sep;139(9):1149-1155. Pubmedid: 25978765.
  • DeVito N, Henderson E, Han G, Reed D, Bui MM, Lavey R, Robinson L, Zager JS, Gonzalez RJ, Sondak VK, Letson GD, Conley A. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience. PLoS One. 2015 Oct;10(10):e0140362. Pubmedid: 26469269. Pmcid: PMC4607370.
  • Kubal T, Peabody JW, Friedman E, Levine R, Pursell S, Letson DG. Using Vignettes to Measure and Encourage Adherence to Clinical Pathways in a Quality-Based Oncology Network: An Early Report on the Moffitt Oncology Network Initiative. Manag Care. 2015 Oct;24(10):56-64. Pubmedid: 26665718.
  • Xu H, Nugent D, Monforte HL, Binitie OT, Ding Y, Letson GD, Cheong D, Niu X. Chondroblastoma of bone in the extremities: a multicenter retrospective study. J Bone Joint Surg Am. 2015 Jun;97(11):925-931. Pubmedid: 26041854.
  • Henderson ER, Gao J, Groundland J, Binitie O, Letson GD. Expandable Total Humeral Replacement in a Child with Osteosarcoma. Case Rep Orthop. 2015 Jun;2015:690159. Pubmedid: 26090254. Pmcid: PMC4452195.
  • Dossett LA, Toloza EM, Fontaine J, Robinson LA, Reed D, Druta M, Letson DG, Zager JS, Gonzalez RJ. Outcomes and clinical predictors of improved survival in a patients undergoing pulmonary metastasectomy for sarcoma. J Surg Oncol. 2015 Jul;112(1):103-106. Pubmedid: 26179670.
  • Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P, Gorlick R, Windhager R, Helmke K, Eriksson M, Hoogerbrugge PM, Schomberg P, Tunn PU, Kühne T, Jürgens H, van den Berg H, Böhling T, Picton S, Renard M, Reichardt P, Gerss J, Butterfass-Bahloul T, Morris C, Hogendoorn PC, Seddon B, Calaminus G, Michelagnoli M, Dhooge C, Sydes MR, Bernstein M. Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Respons. J Clin Oncol. 2015 Jul;33(20):2279-2287. Pubmedid: 26033801. Pmcid: PMC4486345.
  • Xu H, Niu X, Li Y, Binitie OT, Letson GD, Cheong D. What are the results using the modified trapdoor procedure to treat chondroblastoma of the femoral head?. Clin Orthop Relat Res. 2014 Nov;472(11):3462-3467. Pubmedid: 25115583. Pmcid: PMC4182374.
  • Haddox CL, Han G, Anijar L, Binitie O, Letson GD, Bui MM, Reed DR. Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma. 2014 Jun;2014:402509. Pubmedid: 24976784. Pmcid: PMC4021746.
  • Wu H, Zhang L, Shao H, Sokol L, Sotomayor E, Letson D, Bui MM. Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. Brit J Haematol. 2014 Jul;166(1):60-68. Pubmedid: 24673481.
  • Wu H, Bui MM, Leston DG, Shao H, Sokol L, Sotomayor EM, Zhang L. Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas. BMC Cancer. 2014 Dec;14:900. Pubmedid: 25465716. Pmcid: PMC4265495.
  • Kreahling JM, Foroutan P, Reed D, Martinez G, Razabdouski T, Bui MM, Raghavan M, Letson D, Gillies RJ, Altiok S. Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas. PLoS One. 2013 Sep;8(3):e57523. Pubmedid: 23520471. Pmcid: PMC3592874.
  • Perez MC, Padhya TA, Messina JL, Jackson RS, Gonzalez RJ, Bui MM, Letson GD, Cruse CW, Lavey RS, Cheong D, Forster MR, Fulp WJ, Sondak VK, Zager JS. Cutaneous angiosarcoma: a single-institution experience. Ann Surg Oncol. 2013 Oct;20(11):3391-3397. Pubmedid: 23835652. Pmcid: PMC4509495.
  • Deneve JL, Messina JL, Bui MM, Marzban SS, Letson GD, Cheong D, Gonzalez RJ, Sondak VK, Zager JS. Cutaneous leiomyosarcoma: treatment and outcomes with a standardized margin of resection. Cancer Control. 2013 Oct;20(4):307-312. Pubmedid: 24077407. Pmcid: PMC4504421.
  • Cubitt CL, Menth J, Dawson J, Martinez GV, Foroutan P, Morse DL, Bui MM, Letson GD, Sullivan DM, Reed DR. Rapid screening of novel agents for combination therapy in sarcomas. Sarcoma. 2013 Nov;2013:365723. Pubmedid: 24282374. Pmcid: PMC3824404.
  • Binitie O, Tejiram S, Conway S, Cheong D, Temple HT, Letson GD. Adult soft tissue sarcoma local recurrence after adjuvant treatment without resection of core needle biopsy tract. Clin Orthop Relat Res. 2013 Mar;471(3):891-898. Pubmedid: 22968531. Pmcid: PMC3563812.
  • Vohra NA, Turaga KK, Gonzalez RJ, Conley A, Reed D, Bui MM, Cheong D, Letson DG, Zager JS. The use of isolated limb infusion in limb threatening extremity sarcomas. Int J Hyperthermia. 2013 Jun;29(1):1-7. Pubmedid: 23205633. Pmcid: PMC4509503.
  • Mavrogenis AF, Lenze U, Rechl H, Letson GD, Ruggieri P. Recent developments in the surgical treatment of bone tumors and their impact on quality of life. Sarcoma. 2013 Aug;2013:826432. Pubmedid: 23935391. Pmcid: PMC3725717.
  • Alexander GE, Gutierrez S, Nayak A, Palumbo BT, Cheong D, Letson GD, Santoni BG. Biomechanical model of a high risk impending pathologic fracture of the femur: lesion creation based on clinically implemented scoring systems. Clin Biomech (Bristol, Avon). 2013 Apr;28(4):408-414. Pubmedid: 23597777.
  • Henderson ER, Marulanda GA, Cheong D, Temple HT, Letson GD. Hip abductor moment arm--a mathematical analysis for proximal femoral replacement. J Orthop Surg Res. 2012 Mar;6:6. Pubmedid: 21266066. Pmcid: PMC3247065.
  • Henderson ER, Pepper AM, Marulanda G, Binitie OT, Cheong D, Letson GD. Outcome of lower-limb preservation with an expandable endoprosthesis after bone tumor resection in children. J Bone Joint Surg Am. 2012 Mar;94(6):537-547. Pubmedid: 22438003.
  • Isakoff MS, Barkauskas DA, Ebb D, Morris C, Letson GD. Poor survival for osteosarcoma of the pelvis: a report from the Children's Oncology Group. Clin Orthop Relat Res. 2012 Jul;470(7):2007-2013. Pubmedid: 22354612. Pmcid: PMC3369072.
  • Kreahling JM, Gemmer JY, Reed D, Letson D, Bui M, Altiok S. MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells. Mol Cancer Ther. 2012 Jan;11(1):174-182. Pubmedid: 22084170. Pmcid: PMC4545500.
  • Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, Noyes DR, Cheong D, Gonzalez RJ, Heysek RV, Berman C, Lenox BC, Janssen W, Zager JS, Sondak VK, Letson GD, Antonia SJ, Gabrilovich DI. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys. 2012 Feb;82(2):924-932. Pubmedid: 21398051. Pmcid: PMC4241354.
  • Parsons CM, Pimiento JM, Cheong D, Marzban SS, Gonzalez RJ, Johnson D, Letson GD, Zager JS. The role of radical amputations for extremity tumors: a single institution experience and review of the literature. J Surg Oncol. 2012 Feb;105(2):149-155. Pubmedid: 21837679. Pmcid: PMC4504014.
  • Henderson ER, Pepper AM, Letson GD. What are estimated reimbursements for lower extremity prostheses capable of surgical and nonsurgical lengthening?. Clin Orthop Relat Res. 2012 Apr;470(4):1194-1203. Pubmedid: 22125242. Pmcid: PMC3293973.
  • Palumbo BT, Henderson E, Letson D, Cheong D. Biology, classification, and management of recurrent myxofibrosarcoma 21 years after resection. Am J Orthop (Belle Mead NJ). 2011 Nov;40(11):579-582. Pubmedid: 22263212.
  • Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011 Mar;93(5):418-429. Pubmedid: 21368074.
  • Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, Letson GD, Cheong D, Tyler DS, Zager JS. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul;146(7):870-875. Pubmedid: 21768436. Pmcid: PMC4515974.
  • Cheong D, Letson GD. Computer-assisted navigation and musculoskeletal sarcoma surgery. Cancer Control. 2011 Jul;18(3):171-176. Pubmedid: 21666579.
  • Palumbo BT, Henderson ER, Groundland JS, Cheong D, Pala E, Letson GD, Ruggieri P. Advances in segmental endoprosthetic reconstruction for extremity tumors: a review of contemporary designs and techniques. Cancer Control. 2011 Jul;18(3):160-170. Pubmedid: 21666578.
  • Henderson ER, Jennings JM, Marulanda GA, Groundland JS, Cheong D, Letson GD. Enhancing soft tissue ingrowth in proximal femoral arthroplasty with aortograft sleeve a novel technique and early results. J Arthroplasty. 2011 Jan;26(1):161-163. Pubmedid: 20801613.
  • Mavrogenis AF, Lesensky J, Romagnoli C, Alberghini M, Letson GD, Ruggieri P. Atypical Lipomatous Tumors/Well-differentiated Liposarcomas: Clinical Outcome of 67 Patients. Orthopedics. 2011 Dec;34(12):e893-e898. Pubmedid: 22146207.
  • Kraybill WG, Harris J, Spiro IJ, Ettinger DS, DeLaney TF, Blum RH, Lucas DR, Harmon DC, Letson GD, Eisenberg B. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. Cancer. 2010 Oct;116(19):4613-4621. Pubmedid: 20572040. Pmcid: PMC3780573.
  • Marulanda GA, Henderson E, Cheong D, Letson GD. Proximal and total humerus reconstruction with the use of an aortograft mesh. Clin Orthop Relat Res. 2010 Nov;468(11):2896-2903. Pubmedid: 20568029. Pmcid: PMC2947671.
  • Henderson ER, Pepper AM, Marulanda GA, Millard JD, Letson GD. What is the emotional acceptance after limb salvage with an expandable prosthesis?. Clin Orthop Relat Res. 2010 Nov;468(11):2933-2938. Pubmedid: 20632139. Pmcid: PMC2947674.
  • Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, Heslin MJ, Hutchinson RJ, Kane JM, Letson GD, McGarry SV, O'Donnell RJ, Paz IB, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schupak KD, Schwartz HS, Thornton K, von Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Ne. 2010 Jun;8(6):630-674. Pubmedid: 20581298.
  • Henderson ER, Jennings JM, Marulanda GA, Palumbo BT, Cheong D, Letson GD. Purse-string capsule repair to reduce proximal femoral arthroplasty dislocation for tumor--a novel technique with results. J Arthroplasty. 2010 Jun;25(4):654-657. Pubmedid: 20097040.
  • Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Netw. 2010 Jun;8(6):688-712. Pubmedid: 20581300.
  • Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Letson GD, Messina JL, Cimmino VM, Sondak VK. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug;17(8):2112-2118. Pubmedid: 20354798.
  • Alexander GE, Henderson ER, Rodriguez AR, Bui MM, Cheong D, Letson GD. Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. Orthopedics. 2009 Dec;32(12):919. Pubmedid: 19968226.
  • Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009 Dec;18(4):343-349. Pubmedid: 18835153.
  • Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticancer Ther. 2008 Jun;8(6):949-956. Pubmedid: 18533804.
  • Marulanda G, Henderson E, Palumbo B, Alexander G, Cheong D, Letson G. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devic. 2008 Jul;5(4):467-474. Pubmedid: 18573046.
  • Bui M, Smith P, Agresta S, Cheong D, Letson G. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008 Jan;15(1):7-12. Pubmedid: 18094656.
  • Marulanda G, Henderson E, Johnson D, Letson G, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008 Jan;15(1):13-20. Pubmedid: 18094657.
  • Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 2007 Mar;67(6):2800-2808. Pubmedid: 17363602.
  • Demetri G, Baker L, Benjamin R, Casper E, Conrad EU 3rd, D'Amato G, Delaney T, Ettinger D, Heck R J, Heslin M, Hutchinson R, Jacobs C, Kiel K, Kraybill W, Letson G, O'donnell R, Paz I, Pfeifer J, Pollock R, Randall R, Sasson A, Schupak K, Tyler D, Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw. 2007 Apr;5(4):364-399. Pubmedid: 17442230.
  • Biermann J, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica F, George S, Healey J, Heck R J, Letson G, Mayerson J, McGarry S, O'donnell R, Patt J, Randall R, Santana V, Satcher R, Schmidt R, Siegel H, Wong M, Yasko A. Bone cancer. J Natl Compr Canc Netw. 2007 Apr;5(4):420-437. Pubmedid: 17442233.
  • Kraybill W, Harris J, Spiro I, Ettinger D, DeLaney T, Blum R, Lucas DR, Harmon D, Letson G, Eisenberg B. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006 Feb;24(4):619-625. Pubmedid: 16446334.
  • Knapp E, Kransdorf M, Letson G. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan;12(1):22-26. Pubmedid: 15668649.
  • Letson G. Soft tissue sarcoma: status in 2005. Cancer Control. 2005 Jan;12(1):2-2. Pubmedid: 15668647.
  • Saba HI, Morelli GA, Azam RR, Klein CJ, Letson GD. Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors. Haemophilia. 2003 Jan;9(1):131-136. Pubmedid: 12558792.
  • Neel M, Letson G. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001;8(4):344-348. Pubmedid: 11483888.
  • Letson G, Muro-Cacho C. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001;8(3):239-251. Pubmedid: 11378650.
  • Strickland L, Letson GD, Muro-Cacho C. Gastrointestinal stromal tumors. Cancer Control. 2001;8(3):252-261. Pubmedid: 11378651.
  • Kim C, Puleo C, Letson G, Reintgen D. Hyperthermic isolated limb perfusion for extremity sarcoma. Cancer Control. 2001;8(3):269-273. Pubmedid: 11378653.
  • Letson G, Ward W. Appropriate follow-up of orthopaedic oncology patients. Instr Course Lect. 1999 May;48:603-606. Pubmedid: 10098088.
  • Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998;15(8):557-567.
  • Letson G, Greenfield G, Heinrich S. Evaluation of the child with a bone or soft-tissue neoplasm. Orthop Clin North Am. 1996;27(3):431-451. Pubmedid: 8649727.