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Filippo Veglia, PhD

Academic Rank: Assistant Member

Overview

  Dr. Veglia’s research interest is to investigate metabolic and molecular mechanisms of immune response to cancers. His current research efforts are focused on the study of the role of myeloid cells in thwarting immune and therapeutic responses to glioblastoma (GBM). His research is also focused on the design of novel strategies for the therapeutic targeting of myeloid cells.   


Discipline

    • Immunology
    • Neuro-Oncology
    • Immunology

Education & Training

Fellowship:

  • Tor Vergata University, PhD - Immunology and Applied Biotechnology
  • University of Rome "Sapienza", MS - Biology Applied to Biomedical Research
Research

  Dr. Veglia’s research interest is to investigate metabolic and molecular mechanisms of immune response to cancers. His current research efforts are focused on the study of the role of myeloid cells in thwarting immune and therapeutic responses to glioblastoma (GBM). His research is also focused on the design of novel strategies for the therapeutic targeting of myeloid cells.   

Publications

  • Ugolini A, Tyurin V, Tyurina Y, Tsyganov E, Donthireddy L, Kagan VE, Gabrilovich DI, Veglia F. Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer. JCI Insight. 2020 Jun.5(15). Pubmedid: 32584791. Pmcid: PMC7455061.
  • Mastio J, Condamine T, Dominguez G, Kossenkov AV, Donthireddy L, Veglia F, Lin C, Wang F, Fu S, Zhou J, Viatour P, Lavilla-Alonso S, Polo AT, Tcyganov EN, Mulligan C, Nam B, Bennett J, Masters G, Guarino M, Kumar A, Nefedova Y, Vonderheide RH, Languino LR, Abrams SI, Gabrilovich DI. Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs. J Exp Med. 2019 Sep.216(9):2150-2169. Pubmedid: 31239386. Pmcid: PMC6719429.
  • Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019 May.569(7754):73-78. Pubmedid: 30996346. Pmcid: PMC6557120.
  • Veglia F, Perego M, Gabrilovich D. Myeloid-derived suppressor cells coming of age. Nat Immunol. 2018 Feb.19(2):108-119. Pubmedid: 29348500. Pmcid: PMC5854158.
  • Veglia F, Tyurin VA, Mohammadyani D, Blasi M, Duperret EK, Donthireddy L, Hashimoto A, Kapralov A, Amoscato A, Angelini R, Patel S, Alicea-Torres K, Weiner D, Murphy ME, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI. Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer. Nat Commun. 2017 Dec.8(1):2122. Pubmedid: 29242535. Pmcid: PMC5730553.
  • Veglia F, Gabrilovich DI. Dendritic cells in cancer: the role revisited. Curr Opin Immunol. 2017 Apr.45:43-51. Pubmedid: 28192720. Pmcid: PMC5449252.
  • Guerra-Pérez N, Aravantinou M, Veglia F, Goode D, Truong R, Derby N, Blanchard J, Grasperge B, Gettie A, Robbiani M, Martinelli E. Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination. PLoS One. 2016 Feb.11(2):e0149491. Pubmedid: 26886938. Pmcid: PMC4757571.
  • Guerra-Pérez N, Frank I, Veglia F, Aravantinou M, Goode D, Blanchard JL, Gettie A, Robbiani M, Martinelli E. Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection. J Immunol. 2015 Mar.194(5):2415-2423. Pubmedid: 25624458. Pmcid: PMC4339396.
  • Ramakrishnan R, Tyurin VA, Tuyrin VA, Veglia F, Condamine T, Amoscato A, Mohammadyani D, Johnson JJ, Zhang LM, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol. 2014 Mar.192(6):2920-2931. Pubmedid: 24554775. Pmcid: PMC3998104.
  • Martinelli E, Veglia F, Goode D, Guerra-Perez N, Aravantinou M, Arthos J, Piatak M, Lifson JD, Blanchard J, Gettie A, Robbiani M. The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection. J Acquir Immune Defic Syndr. 2013 Dec.64(4):325-331. Pubmedid: 23797688. Pmcid: PMC3815485.
  • Veglia F, Sciaraffia E, Riccomi A, Pinto D, Negri DR, De Magistris MT, Vendetti S. Cholera toxin impairs the differentiation of monocytes into dendritic cells, inducing professional antigen-presenting myeloid cells. Infect Immun. 2011 Mar.79(3):1300-1310. Pubmedid: 21149590. Pmcid: PMC3067507.
  • Zizzari IG, Veglia F, Taurino F, Rahimi H, Quaglino E, Belleudi F, Riccardo F, Antonilli M, Napoletano C, Bellati F, Benedetti-Panici P, Torrisi MR, Frati L, Nuti M, Rughetti A. HER2-based recombinant immunogen to target DCs through FcγRs for cancer immunotherapy. J Mol Med (Berl). 2011 Dec.89(12):1231-1240. Pubmedid: 21845448. Pmcid: PMC3218291.
  • Vendetti S, Davidson TS, Veglia F, Riccomi A, Negri DR, Lindstedt R, Pasquali P, Shevach EM, De Magistris MT. Polyclonal Treg cells enhance the activity of a mucosal adjuvant. Immunol Cell Biol. 2010 Oct.88(7):698-706. Pubmedid: 20585335.
  • Vendetti S, Riccomi A, Negri DR, Veglia F, Sciaraffia E, De Magistris MT. Development of antigen-specific T cells in mediastinal lymph nodes after intranasal immunization. Methods. 2009 Dec.49(4):334-339. Pubmedid: 19426804.