Dmitry <span>B.</span> Goldgof
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Dmitry B. Goldgof

Overview

Discipline

    • Chemical Biology and Molecular Medicine Program

Education & Training

    • Renselaer Polytechnic Institute, Troy, N.Y., MS - Electrical, Computer & Systems Engineering
    • University of Illinois at Urbana-Champaign, PhD - Electrical & Computer Engineering
Research

The majority of Dr. Goldgof’s work focuses on the identification of novel biomarker strategies using genomics and other emerging technologies to guide clinical decision making and the identification and implementation of molecular imaging approaches to guide clinical decision making.His team’s work is related to several directions: (a) medical image analysis for identification of image features related to cancer detection and progress as well as novel molecular imaging technologies, (b) data mining methods to discover gene features related to cancer, and (c) combination of anatomical imaging features with gene features for improved outcome prediction with recent concentration on (c). Dr. Goldgof and colleagues investigated the impact on classification accuracy of gene selection approaches on filtered-to-200-gene datasets, using four datasets with 3 filters: t-test, information gain, and reliefF. They applied Iterative Feature Perturbation (IFP) and Recursive Feature Elimination (SVM-RFE) for further gene selection. They conducted a statistical analysis of accuracy across the best 50 genes using the Friedman/Holm test, which showed that IFP and SVMRFE were significantly more accurate more often when applied to the t-test-filtered gene sets. Surprisingly, the simple t-test, applied as a filter, results in the best overall SVM accuracy and is at least as accurate as the other, more complicated filter methods.

Publications

  • Mouton PR, Phoulady HA, Goldgof D, Hall LO, Gordon M, Morgan D. Unbiased estimation of cell number using the automatic optical fractionator. J Chem Neuroanat. 2017 Mar;80:A1-A8. Pubmedid: 27988177. Pmcid: PMC5303677.
  • Zhou M, Chaudhury B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA. Identifying spatial imaging biomarkers of glioblastoma multiforme for survival group prediction. J Magn Reson Imaging. 2017 Jul;46(1):115-123. Pubmedid: 27678245.
  • Phoulady HA, Goldgof D, Hall LO, Mouton PR. A framework for nucleus and overlapping cytoplasm segmentation in cervical cytology extended depth of field and volume images. Comput Med Imag Grap. 2017 Jul;59:38-49. Pubmedid: 28701280.
  • Beichel RR, Smith BJ, Bauer C, Ulrich EJ, Ahmadvand P, Budzevich MM, Gillies RJ, Goldgof D, Grkovski M, Hamarneh G, Huang Q, Kinahan PE, Laymon CM, Mountz JM, Muzi JP, Muzi M, Nehmeh S, Oborski MJ, Tan Y, Zhao B, Sunderland JJ, Buatti JM. Multi-site quality and variability analysis of 3D FDG PET segmentations based on phantom and clinical image data. Med Phys. 2017 Feb;44(2):479-496. Pubmedid: 28205306.
  • Hawkins S, Wang H, Liu Y, Garcia A, Stringfield O, Krewer H, Li Q, Cherezov D, Gatenby RA, Balagurunathan Y, Goldgof D, Schabath MB, Hall L, Gillies RJ. Predicting Malignant Nodules from Screening CT Scans. J Thorac Oncol. 2016 Dec;11(12):2120-2128. Pubmedid: 27422797. Pmcid: PMC5545995.
  • Paul R, Hawkins SH, Balagurunathan Y, Schabath MB, Gillies RJ, Hall LO, Goldgof DB. Deep Feature Transfer Learning in Combination with Traditional Features Predicts Survival Among Patients with Lung Adenocarcinoma. Tomography. 2016 Dec;2(4):388-395. Pubmedid: 28066809. Pmcid: PMC5218828.
  • Kalpathy-Cramer J, Mamomov A, Zhao B, Lu L, Cherezov D, Napel S, Echegaray S, Rubin D, McNitt-Gray M, Lo P, Sieren JC, Uthoff J, Dilger SK, Driscoll B, Yeung I, Hadjiiski L, Cha K, Balagurunathan Y, Gillies R, Goldgof D. Radiomics of Lung Nodules: A Multi-Institutional Study of Robustness and Agreement of Quantitative Imaging Features. Tomography. 2016 Dec;2(4):430-437. Pubmedid: 28149958. Pmcid: PMC5279995.
  • Kalpathy-Cramer J, Zhao B, Goldgof D, Gu Y, Wang X, Yang H, Tan Y, Gillies R, Napel S. A Comparison of Lung Nodule Segmentation Algorithms: Methods and Results from a Multi-institutional Study. J Digit Imaging. 2016 Aug;29(4):476-487. Pubmedid: 26847203. Pmcid: PMC4942386.
  • Chaudhury B, Zhou M, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Patel BK, Weinfurtner RJ, Drukteinis JS. Heterogeneity in intratumoral regions with rapid gadolinium washout correlates with estrogen receptor status and nodal metastasis. J Magn Reson Imaging. 2015 Nov;42(5):1421-1430. Pubmedid: 25884277. Pmcid: PMC5017794.
  • Balagurunathan Y, Gu Y, Wang H, Kumar V, Grove O, Hawkins S, Kim J, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ. Reproducibility and Prognosis of Quantitative Features Extracted from CT Images. Transl Oncol. 2014 Feb;7(1):72-87. Pubmedid: 24772210. Pmcid: PMC3998690.
  • Zhou M, Hall L, Goldgof D, Russo R, Balagurunathan Y, Gillies R, Gatenby R. Radiologically defined ecological dynamics and clinical outcomes in glioblastoma multiforme: preliminary results. Transl Oncol. 2014 Feb;7(1):5-13. Pubmedid: 24772202. Pmcid: PMC3998688.
  • Balagurunathan Y, Kumar V, Gu Y, Kim J, Wang H, Liu Y, Goldgof DB, Hall LO, Korn R, Zhao B, Schwartz LH, Basu S, Eschrich S, Gatenby RA, Gillies RJ. Test-retest reproducibility analysis of lung CT image features. J Digit Imaging. 2014 Dec;27(6):805-823. Pubmedid: 24990346. Pmcid: PMC4391075.
  • Gu Y, Kumar V, Hall LO, Goldgof DB, Li CY, Korn R, Bendtsen C, Velazquez ER, Dekker A, Aerts H, Lambin P, Li X, Tian J, Gatenby RA, Gillies RJ. Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach. Pattern Recognit. 2013 Mar;46(3):692-702. Pubmedid: 23459617. Pmcid: PMC3580869.
  • Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
  • Rios Velazquez E, Aerts HJ, Gu Y, Goldgof DB, De Ruysscher D, Dekker A, Korn R, Gillies RJ, Lambin P. A semiautomatic CT-based ensemble segmentation of lung tumors: comparison with oncologists' delineations and with the surgical specimen. Radiother Oncol. 2012 Nov;105(2):167-173. Pubmedid: 23157978. Pmcid: PMC3749821.
  • Elozory DT, Kramer KA, Chaudhuri B, Bonam OP, Goldgof DB, Hall LO, Mouton PR. Automatic section thickness determination using an absolute gradient focus function. J Microsc. 2012 Dec;248(3):245-259. Pubmedid: 23078150. Pmcid: PMC4465598.
  • Hore P, Hall LO, Goldgof DB. A Scalable Framework For Cluster Ensembles. Pattern Recognit. 2009 May;42(5):676-688. Pubmedid: 20160846. Pmcid: PMC2654620.
  • Hore P, Hall LO, Goldgof DB, Gu Y, Maudsley AA, Darkazanli A. A Scalable Framework For Segmenting Magnetic Resonance Images. J Signal Process Syst. 2009 Jan;54(1-3):183-203. Pubmedid: 20046893. Pmcid: PMC2771942.
  • Kramer KA, Hall LO, Goldgof DB, Remsen A, Luo T. Fast support vector machines for continuous data. Ieee Trans Syst Man Cybern B Cybern. 2009 Aug;39(4):989-1001. Pubmedid: 19336328. Pmcid: PMC4467789.
  • Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, Yu Y, Ebel A, Frew A, Goldgof D, Gu Y, Pagare R, Rousseau F, Sivasankaran K, Soher BJ, Weber P, Young K, Zhu X. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. Nmr Biomed. 2006 Jun;19(4):492-503. Pubmedid: 16763967. Pmcid: PMC2673915.
  • Luo T, Kramer K, Goldgof D, Hall L, Samson S, Remsen A, Hopkins T. Active Learning to Recognize Multiple Types of Plankton. J Machine Learn Res. 2005;6:589-613. Pubmedid: noPMID.
  • Chen L, Li L, Goldgof D, George F, Chen Z, Rao A, Cragun J, Sutphen R, Lancaster J. Improving Reliability of Response Prediction to Platinum-Based Therapy by AdaBoost and Multiple Classifiers. Conf Proc IEEE Eng Med Biol Soc. 2005;5:4822-4825. Pubmedid: 17281321.
  • Li L, Chen L, Goldgof D, George F, Chen Z, Rao A, Cragun J, Sutphen R, Lancaster J. Integration of clinical information and gene expression profiles for prediction of chemo-response for ovarian cancer. Conf Proc IEEE Eng Med Biol Soc. 2005;5:4818-4821. Pubmedid: 17281320.
  • Luo T, Kramer K, Goldgof D, Hall L, Samson S, Remsen A, Hopkins T. Recognizing plankton images from the shadow image particle profiling evaluation recorder. Ieeetrans Syst Man Cybern B Cybern. 2004;34(4):1753-1762. Pubmedid: 15462442.
  • Fink E, Kokku P, Nikiforou S, Hall L, Goldgof D, Krischer J. Selection of patients for clinical trials: an interactive web-based system. Artif Intell Med. 2004;31(3):241-254. Pubmedid: 15302090.
  • Qiu Y, Li L, Goldgof D, Sarkar S, Sorin A, Clark R. Three dimensional finite element model for lesion correspondence in breast imaging. Proc Spie Med Imag. 2004;5370:1372-1379. Pubmedid: noPMID.
  • Zhang Y, Goldgof D, Sarkar S, Tsap L. A modeling approach for burn scar assessment using natural features and elastic property. Ieee Trans Med Imaging. 2004;23(10):1325-1329. Pubmedid: 15493699.
  • Powell M, Sarkar S, Goldgof D, Ivanov K. A methodology for extracting objective color from images. Ieee Trans Syst Man Cybern B Cybern. 2004;34(5):1964-1978. Pubmedid: 15503493.
  • Eschrich S, Ke J, Hall LO, Goldgof DB. Fast Accurate Fuzzy Clustering through Data Reduction. Ieee Trans Fuzzy Systems. 2003;11(2):262-270. Pubmedid: noPMID.
  • Zhang M, Hall L, Goldgof D. A genetic knowledge-guided image segmentation and labeling system using fuzzy clustering algorithm. Ieee Transactions On Systems, Man And Cybernetics. 2002;32(5):571-582. Pubmedid: noPMID.
  • Fletcher-Heath L, Hall L, Goldgof D, Reed F. Automatic segmentation of non-enhancing brain tumors in magnetic resonance images. Artif Intell Med. 2001;21(1-3):43-63. Pubmedid: 11154873.
  • Shin M, Goldgof D, Bowyer K, Nikiforou S. Comparison of edge detection algorithms using a structure from motion task. Ieee Trans Syst Man Cybern B Cybern. 2001;31(4):589-601. Pubmedid: 18244823.
  • Tsap L, Goldgof D, Sarkar S. Nonrigid motion analysis based on dynamic refinement of finite element models. Ieee: Trans Patt Anal Mach Intel. 2000;22(5):526-543. Pubmedid: noPMID.
  • Powers P, Sarkar S, Goldgof D, Cruse C, Tsap L. Scar assessment: current problems and future solutions. J Burn Care Rehabil. 1999 Jan;20(1 Pt 1):54-60. Pubmedid: 9934638.
  • Tsap L, Goldgof D, Sarkar S, Powers P. A vision-based technique for objective assessment of burn scars. Ieee T Med Imaging. 1998 Aug;17(4):620-633. Pubmedid: 9845317.
  • Clark M, Hall L, Goldgof D, Velthuizen R, Silbiger M, Murtagh F. Automatic tumor segmentation using knowledge-based techniques. Ieee T Med Imaging. 1998 Apr;17(2):187-201. Pubmedid: 9688151.
  • Clarke L, Velthuizen R, Clark M, Gaviria G, Hall L, Goldgof D, Murtagh R, Phuphanich S, Brem S. MRI measurement of brain tumor response: comparison of visual metric and automatic segmentation. Magn Reson Imaging. 1998;16(3):271-279. Pubmedid: 9621968.
  • Hoover A, Goldgof D, Bowyer K. Dynamic-scale model construction from range imagery. Ieee: Trans Patt Anal Mach Intel. 1998;29(12):1352-1357. Pubmedid: noPMID.
  • Tsap L, Goldgof D, Sarkar S. Efficient nonlinear finite element modeling of nonrigid objects via optimization of mesh models. Computer Vision And Image Understanding. 1998;69(3):330-350. Pubmedid: noPMID.
  • Hoover A, Goldgof D, Bowyer K. The space envelope representation for 3D scenes. Comput Vis Im Understanding. 1998;69(3):310-329. Pubmedid: noPMID.
  • Tsap L, Goldgof D, Sarkar S. Efficient nonlinear finite element modeling of nonrigid objects via optimization of mesh models. Comput Vis Im Understanding. 1998;69(3):330-350. Pubmedid: noPMID.
  • Cheng T, Goldgof D, Hall L. Fast fuzzy clustering. Int J Fuzzy Sets Systems. 1998;93(1):49-56. Pubmedid: noPMID.
  • Bezdek J, Hall L, Clark M, Goldgof D, Clarke L. Medical image analysis with fuzzy models. Stat Methods Med Res. 1997 Sep;6(3):191-214. Pubmedid: 9339497.
  • Stark L, Bowyer K, Hoover A, Goldgof D. Recognizing object function through reasoning about partial shape descriptions and dynamic physical properties. Proceedings Ieee. 1996;84(11):1640-1656.
  • Hoover A, Jean-Baptiste J, Jiang X, Flynn P, Bunke H, Goldgof D, Bowyer K, Eggert D, Fitzgibbon A, Fisher R. An experimental comparison of range image segmentation algorithms. Ieee: Trans Patt Anal Mach Intel. 1996;18(7):673-689.
  • Tu HK, Matheny A, Goldgof DB, Bunke H. Left ventricular boundary detection from spatio-temporal volumetric computed tomography images. Comput Med Imag Grap. 1995 Jan;19(1):27-46. Pubmedid: 7736416.
  • Kumar S, Han S, Goldgof D, Bowyer K. On recovering hyperquadrics from range data. Ieee: Trans Patt Anal Mach Intel. 1995;17(11):1079-1083. Pubmedid: noPMID.
  • Hoover A, Goldgof D, Bowyer K. Extracting a valid boundary representation from a segmented range image. Ieee: Trans Patt Anal Mach Intel. 1995;17(9):920-924. Pubmedid: noPMID.
  • Bezdek J, Hall L, Clark M, Goldgof D, Clarke L. Segmenting medica images with fuzzy models: an update. In: Dubois D, Prade H, Yager R, et al, eds. Fuzzy information engineering. New York, NY: Wiley; 1997;69-92.
  • Clark M, Hall L, Goldgof D, Silbiger M. Using fuzzy information in knowledge guided segmentation of brain tumors. In: Cabonell J, Siekman J, eds. Fuzzy logic in AI: towards intelligent systems. Springer Verlag; 1997;167-181.
  • Hoover A, Goldgof D, Stark L, Bowyer K. Function-based analysis using partial shape, Chapter VIII. In: Stark L, Bowyer K, eds. Generic recognition using form and function. World Scientific; 1996;67-79.
  • Shin M, Goldgof D, Bowyer K. An objective comparison methodology of edge detection algorithms using a structure from motion task. In: Bowyer K, Phillips P, eds. Empirical Evaluation Techniques in Computer Vision. Los Alamitos, CA: IEEE Computer Society Press; 1998;235-254.
  • Clark M, Hall L, Goldgof D, Velthuizen R, Murtagh F, Silbiger M. Unsupervised brain tumor segmentation using knowledge based and fuzzy techniques. In: Theodorescu H, Kandel A, Jain L, et al, eds. Fuzzy and Neuro-Fuzzy Systems in Medicine. Boca Raton, FL: CRC Press; 1999;137-169.