Bill <span>J.</span> Baker
Researcher

Bill J. Baker

Overview

Discipline

    • Chemical Biology and Molecular Medicine Program

Education & Training

    • University of Hawaii at Manoa, PhD - Chemistry
    • Rice University, Fellow - Chemistry, Biosynthesis
    • Stanford University, Fellow - Chemistry, Biosynthesis
Research

Analysis of secondary metobolites from marine invertebrates, macroalgae and microorganisms, including chomatographic and spectroscopic characterization; drug discovery, including anti-infective and anti-cancer disease areas and multi-drug resistance; marine biotechnology; chemical ecology of marine organisms; generation of chemical diversity; biosynthesis of marine natural products; synthesis of marine natural products; agrochemical applications of marine natural products.

Publications

  • Soldatou S, Baker BJ. Cold-water marine natural products, 2006 to 2016. Nat Prod Rep. 2017 Jun;34(6):585-626. Pubmedid: 28322384.
  • Vankayala SL, Kearns FL, Baker BJ, Larkin JD, Lee Woodcock H. Elucidating a chemical defense mechanism of Antarctic sponges: A computational study. J Mol Graph Model. 2017 Jan;71:104-115. Pubmedid: 27894019.
  • Waterman C, Calcul L, Beau J, Ma WS, Lebar MD, von Salm JL, Harter C, Mutka T, Morton LC, Maignan P, Barisic B, von Olphen A, Kyle DE, Vrijmoed L, Pang KL, Pearce CJ, Baker BJ. Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Med Res Rev. 2016 Jan;36(1):144-168. Pubmedid: 25545963.
  • Shilling AJ, Salm JL, Young RM, Amsler MO, Amsler CD, McClintock JB, Baker BJ. Isolation and characterization of halogenated monoterpenes in the investigation of the ecological relationship between Antarctic Plocamium cartilagineum and Paradexamine fissicauda. Planta Med. 2016 Dec;81(S 01):S1-S381. Pubmedid: 27975874.
  • Soldatou S, Fleeman R, Shaw LN, Baker BJ. Anti-MRSA natural products from an epigenetic modified Floridian mangrove-associated fungus. Planta Med. 2016 Dec;81(S 01):S1-S381. Pubmedid: 27975942.
  • Thomas S, Fleming R, Shaw LN, Baker BJ. Isolation of bioactive secondary metabolites from mangrove fungal endophytes using epigenetic regulation. Planta Med. 2016 Dec;81(S 01):S1-S381. Pubmedid: 27975936.
  • Limon A, Fleeman R, Shaw LN, Baker BJ. Isolation of metabolites from epigenetically modified mangrove fungi for anti-infective drug discovery. Planta Med. 2016 Dec;81(S 01):S1-S381. Pubmedid: 27975876.
  • Young RM, Burkett-Cadena ND, McGaha TW, Rodriguez-Perez MA, Toé LD, Adeleke MA, Sanfo M, Soungalo T, Katholi CR, Noblet R, Fadamiro H, Torres-Estrada JL, Salinas-Carmona MC, Baker B, Unnasch TR, Cupp EW. Identification of human semiochemicals attractive to the major vectors of onchocerciasis. PLoS Negl Trop Dis. 2015 Jan;9(1):e3450. Pubmedid: 25569240. Pmcid: PMC4287528.
  • McGaha TW, Young RM, Burkett-Cadena ND, Iburg JP, Beau JM, Hassan S, Katholi CR, Cupp EW, Baker BJ, Unnasch TR, Noblet R. Identification of communal oviposition pheromones from the black fly Simulium vittatum. PLoS One. 2015;10(3):e0118904. Pubmedid: 25786206. Pmcid: PMC4364695.
  • von Salm JL, Wilson NG, Vesely BA, Kyle DE, Cuce J, Baker BJ. Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral. Org Lett. 2014 May;16(10):2630-2633. Pubmedid: 24779517. Pmcid: PMC4127331.
  • Young RM, von Salm JL, Amsler MO, Lopez-Bautista J, Amsler CD, McClintock JB, Baker BJ. Site-specific variability in the chemical diversity of the Antarctic red alga Plocamium cartilagineum. Mar Drugs. 2013 Jun;11(6):2126-2139. Pubmedid: 23771046. Pmcid: PMC3721224.
  • Wilson NG, Maschek JA, Baker BJ. A species flock driven by predation? Secondary metabolites support diversification of slugs in antarctica. PLoS One. 2013;8(11):e80277. Pubmedid: 24303002. Pmcid: PMC3841181.
  • Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future Med Chem. 2012 Sep;4(13):1751-1761. Pubmedid: 22924511. Pmcid: PMC3575183.
  • Bucolo P, Amsler CD, McClintock JB, Baker BJ. Effects of Macroalgal Chemical Extracts on Spore Behavior of the Antarctic Epiphyte Elachista antarctica Phaeophyceae. J Phycol. 2012 Dec;48(6):1403-1410. Pubmedid: 27009991.
  • Noguez JH, Diyabalanage TK, Miyata Y, Xie XS, Valeriote FA, Amsler CD, McClintock JB, Baker BJ. Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. Bioorg Med Chem. 2011 Nov;19(22):6608-6614. Pubmedid: 21737286.
  • Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. J Nat Prod. 2011 Jan;74(1):38-44. Pubmedid: 21141876. Pmcid: PMC3070757.
  • Diyabalanage T, Iken KB, McClintock JB, Amsler CD, Baker BJ. Palmadorins A--C, diterpene glycerides from the antarctic nudibranch Austrodoris kerguelenensis. J Nat Prod. 2010 Mar;73(3):416-421. Pubmedid: 20121160.
  • McClintock JB, Amsler CD, Baker BJ. Overview of the Chemical Ecology of Benthic Marine Invertebrates along the Western Antarctic Peninsula. Integr Comp Biol. 2010 Dec;50(6):967-980. Pubmedid: 21558253.
  • McClintock JB, Amsler CD, Moran AL, Woods HA, Baker BJ. Introduction to the symposium: advances in antarctic marine biology. Integr Comp Biol. 2010 Dec;50(6):948-949. Pubmedid: 21558251.
  • Ma WS, Mutka T, Vesley B, Amsler MO, McClintock JB, Amsler CD, Perman JA, Singh MP, Maiese WM, Zaworotko MJ, Kyle DE, Baker BJ. Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic Sponge Crella sp. J Nat Prod. 2009 Oct;72(10):1842-1846. Pubmedid: 19848433.
  • Baker B. Instant insight: in from the cold. Dalton Trans. 2007 Jun;(23):C47-C47. Pubmedid: 17844655.
  • Baker B. In from the cold. Chem Commun (Camb). 2007 Jun;(23):C47-C47. Pubmedid: 17844734.
  • Miyata Y, Diyabalanage T, Amsler C, McClintock J, Valeriote F, Baker B. Ecdysteroids from the Antarctic Tunicate Synoicum adareanum. J Nat Prod. 2007 Dec;70(12):1859-1864. Pubmedid: 18039009.
  • Lebar MF, Heimbegner JL, Baker BJ. Cold-water marine natural products. Nat Prod Rep. 2007 Aug;24(4):774-797. Pubmedid: 17653359.
  • Diyabalanage T, Amsler C, McClintock J, Baker B. Palmerolide a, a cytotoxic macrolide from the antarctic tunicate synoicumadareanum. 2006 May;128(17):5630-5631. Pubmedid: 16637618.
  • Ankisetty S, Nandiraju S, Win H, Park YC, Amsler CD, McClintock JB, Baker JA, Diyabalanage TK, Pasaribu A, Singh MP, Maiese WM, Walsh RD, Zaworotko MJ, Baker BJ. Chemical investigation of predator-deterred macroalgae from the Antarctic peninsula. J Nat Prod. 2004 Aug;67(8):1295-1302. Pubmedid: 15332845.
  • Ankisetty S, Amsler C, McClintock J, Baker B. Further membranolide diterpenes from the antarctic sponge dendrilla membranosa. J Nat Prod. 2004;67(7):1172-1174. Pubmedid: 15270575.
  • Iken K, Baker B. Ainigmaptilones, sesquiterpenes from the Antarctic gorgonian coral Ainigmaptilon antarcticus. J Nat Prod. 2003;66(6):888-890. Pubmedid: 12828486.
  • MacGregor BJ, Moser DP, Baker BJ, Alm EW, Maurer M, Nealson KH, Stahl DA. Seasonal and spatial variability in Lake Michigan sediment small-subunit rRNA concentrations. Appl Environ Microbiol. 2001 Sep;67(9):3908-3922. Pubmedid: 11525985. Pmcid: PMC93109.
  • Dinesh-Kumar SP, Baker BJ. Alternatively spliced N resistance gene transcripts: their possible role in tobacco mosaic virus resistance. Proc Natl Acad Sci U S A. 2000 Feb;97(4):1908-1913. Pubmedid: 10660679. Pmcid: PMC26535.
  • Dinesh-Kumar SP, Tham WH, Baker BJ. Structure-function analysis of the tobacco mosaic virus resistance gene N. Proc Natl Acad Sci U S A. 2000 Dec;97(26):14789-14794. Pubmedid: 11121079. Pmcid: PMC18997.
  • Erickson FL, Dinesh-Kumar SP, Holzberg S, Ustach CV, Dutton M, Handley V, Corr C, Baker BJ. Interactions between tobacco mosaic virus and the tobacco N gene. Philos Trans R Soc Lond B Biol Sci. 1999 Mar;354(1383):653-658. Pubmedid: 10212945. Pmcid: PMC1692539.
  • Czernilofsky AP, Hain R, Herrera-Estrella L, Lörz H, Goyvaerts E, Baker BJ, Schell J. Fate of selectable marker DNA integrated into the genome of Nicotiana tabacum. DNA. 1986 Apr;5(2):101-113. Pubmedid: 3519133.