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Paul Coen, PhD



    • Cancer Biology and Evolution Program

Education & Training


  • Rubenstein AB, Hinkley JM, Nair VD, Nudelman G, Standley RA, Yi F, Yu G, Trappe TA, Bamman MM, Trappe SW, Sparks L, Goodpaster B, Vega RB, Sealfon SC, Zaslavsky E, Coen PM. Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults. Am J Physiol Endocrinol Metab. 2022 Jan. Pubmedid: 35068187.
  • Pinckard KM, Shettigar VK, Wright KR, Abay E, Baer LA, Vidal P, Dewal RS, Das D, Duarte-Sanmiguel S, Hernández-Saavedra D, Arts PJ, Lehnig AC, Bussberg V, Narain NR, Kiebish MA, Yi F, Sparks LM, Goodpaster BH, Smith SR, Pratley RE, Lewandowski ED, Raman SV, Wold LE, Gallego-Perez D, Coen PM, Ziolo MT, Stanford KI. A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. Circulation. 2021 Jan.143(2):145-159. Pubmedid: 33106031. Pmcid: PMC7856257.
  • Brennan AM, Standley RA, Anthony SJ, Grench KE, Helbling NL, DeLany JP, Cornnell HH, Yi F, Stefanovic-Racic M, Toledo FGS, Coen PM, Carnero EA, Goodpaster BH. Weight loss and exercise differentially affect insulin sensitivity, body composition, cardiorespiratory fitness and muscle strength in older adults with obesity; a randomized controlled trial. J Gerontol A-Biol. 2021 Aug. Pubmedid: 34406407.
  • Standley RA, Distefano G, Trevino MB, Chen E, Narain NR, Greenwood B, Kondakci G, Tolstikov VV, Kiebish MA, Yu G, Qi F, Kelly DP, Vega RB, Coen PM, Goodpaster BH. Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults. J Gerontol A-Biol. 2020 Sep.75(9):1744-1753. Pubmedid: 31907525. Pmcid: PMC7494044.
  • Nair VD, Ge Y, Li S, Pincas H, Jain N, Seenarine N, Amper MAS, Goodpaster BH, Walsh MJ, Coen PM, Sealfon SC. Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise. Front Physiol. 2020 Jun.11:605. Pubmedid: 32587527. Pmcid: PMC7298138.
  • Hinkley JM, Cornnell HH, Standley RA, Chen EY, Narain NR, Greenwood BP, Bussberg V, Tolstikov VV, Kiebish MA, Yi F, Vega RB, Goodpaster BH, Coen PM. Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles. Aging Cell. 2020 Jun.19(6):e13135. Pubmedid: 32468656. Pmcid: PMC7294783.
  • Hinkley JM, Coen PM. Muscle phosphorus metabolites in sarcopenia. Aging (Albany NY). 2020 Aug.12(16):15880-15881. Pubmedid: 32860671. Pmcid: PMC7485693.
  • Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S. Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight. 2019 May.5. Pubmedid: 31120438. Pmcid: PMC6629251.
  • Coen PM, Musci RV, Hinkley JM, Miller BF. Mitochondria as a Target for Mitigating Sarcopenia. Front Physiol. 2019 Jan.9:1883. Pubmedid: 30687111. Pmcid: PMC6335344.
  • Gardell SJ, Zhang X, Kapoor N, Petucci C, Coen PM. Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading. Methods Mol Biol. 2019 Dec.1996:297-309. Pubmedid: 31127563.
  • Patsalos A, Simandi Z, Hays TT, Peloquin M, Hajian M, Restrepo I, Coen PM, Russell AJ, Nagy L. In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury. Aging Cell. 2018 Oct.17(5):e12815. Pubmedid: 30003692. Pmcid: PMC6156497.
  • Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM. Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle. 2018 Apr.9(2):279-294. Pubmedid: 29368427. Pmcid: PMC5879963.
  • Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L. Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging. Aging Cell. 2018 Apr.17(2). Pubmedid: 29356348. Pmcid: PMC5847858.
  • Wefers JF, Woodlief TL, Carnero EA, Helbling NL, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Goodpaster BH, Coen PM. Relationship among physical activity, sedentary behaviors, and cardiometabolic risk factors during gastric bypass surgery-induced weight loss. Surg Obes Relat Dis. 2017 Feb.13(2):210-219. Pubmedid: 27789136. Pmcid: PMC8607518.
  • Gordon BS, Steiner JL, Rossetti ML, Qiao S, Ellisen LW, Govindarajan SS, Eroshkin AM, Williamson DL, Coen PM. REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise. Am J Physiol Endocrinol Metab. 2017 Dec.313(6):E737-E747. Pubmedid: 28899858. Pmcid: PMC5814598.
  • DeLany JP, Dubé JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG. Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity. J Clin Endocrinol Metab. 2014 Nov.99(11):4307-4314. Pubmedid: 25105736. Pmcid: PMC4223429.
  • Avin KG, Coen PM, Huang W, Stolz DB, Sowa GA, Dubé JJ, Goodpaster BH, O'Doherty RM, Ambrosio F. Skeletal muscle as a regulator of the longevity protein, Klotho. Front Physiol. 2014 Jun.5:189. Pubmedid: 24987372. Pmcid: PMC4060456.
  • Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, DeLany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE. Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes. 2013 Oct.62(10):3350-3361. Pubmedid: 23835334. Pmcid: PMC3781480.
  • Layec G, Trinity JD, Hart CR, Hopker J, Passfield L, Coen PM, Conley KE, Hunter GR, Fisher G, Ferguson RA, Sasaki K, Malatesta D, Maffiuletti NA, Borrani F, Minetti AE, Rice CL, Dalton BH, McNeil CJ, Power GA, Manini TM. Comments on point:counterpoint: skeletal muscle mechanical efficiency does/does not increase with age. J Appl Physiol Respir Environ Exerc Physiol. 2013 Apr.114(8):1114-1118. Pubmedid: 23588541. Pmcid: PMC6208486.
  • Coen PM, Jubrias SA, Distefano G, Amati F, Mackey DC, Glynn NW, Manini TM, Wohlgemuth SE, Leeuwenburgh C, Cummings SR, Newman AB, Ferrucci L, Toledo FG, Shankland E, Conley KE, Goodpaster BH. Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A-Biol. 2013 Apr.68(4):447-455. Pubmedid: 23051977. Pmcid: PMC3593613.
  • Goodpaster BH, Coen PM. Do acute exercise and diet reveal the molecular basis for metabolic flexibility in skeletal muscle?. Diabetes. 2012 May.61(5):983. Pubmedid: 22517651. Pmcid: PMC3331737.
  • Coen PM, Goodpaster BH. Role of intramyocelluar lipids in human health. Trends Endocrinol Metab. 2012 Aug.23(8):391-398. Pubmedid: 22721584. Pmcid: PMC4908975.
  • Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomentowski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?. Diabetes. 2011 Oct.60(10):2588-2597. Pubmedid: 21873552. Pmcid: PMC3178290.
  • Chomentowski P, Coen PM, Radiková Z, Goodpaster BH, Toledo FG. Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. J Clin Endocrinol Metab. 2011 Feb.96(2):494-503. Pubmedid: 21106709. Pmcid: PMC3048328.
  • Skilling H, Coen PM, Fairfull L, Ferrell RE, Goodpaster BH, Vockley J, Goetzman ES. Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice. Biochem Bioph Res Co. 2010 Sep.400(3):318-322. Pubmedid: 20727852. Pmcid: PMC2946480.
  • Amati F, Dubé JJ, Coen PM, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Physical inactivity and obesity underlie the insulin resistance of aging. Diabetes Care. 2009 Aug.32(8):1547-1549. Pubmedid: 19401446. Pmcid: PMC2713647.