Mark Kindy, PhD

Associations

• Molecular Medicine Program

Education & Training

Graduate:

• Boston University School of Medicine, PhD - Biochemistry

Fellowship:

• Salk Institute - Molecular Biology

• Hook G, Kindy M, Hook V. Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer's Disease Condition. J Alzheimers Dis. 2023 Mar. Pubmedid: 36970896.
• Yu J, Zhu H, Kindy MS, Taheri S. The impact of a high-sodium diet regimen on cerebrovascular morphology and cerebral perfusion in Alzheimer's disease. Cereb Circ Cogn Behav. 2023 Jan.4:100161. Pubmedid: 36741272. Pmcid: PMC9895990.
• Gopalakrishna R, Lin CY, Oh A, Le C, Yang S, Hicks A, Kindy MS, Mack WJ, Bhat NR. cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-β uptake and amyloid-β-induced neuronal cell death. FEBS Lett. 2022 Nov.596(22):2914-2927. Pubmedid: 35971617. Pmcid: PMC9712173.
• Hook G, Reinheckel T, Ni J, Wu Z, Kindy M, Peters C, Hook V. Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders. Pharmacol Rev. 2022 Jul.74(3):600-629. Pubmedid: 35710131. Pmcid: PMC9553114.
• Gopalakrishna R, Lin C, Kindy MS, Mack WJ. Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke. Neural Regen Res. 2022 Jan.17(1):91-92. Pubmedid: 34100435. Pmcid: PMC8451563.
• Sajan MP, Hansen BC, Acevedo-Duncan M, Kindy MS, Cooper DR, Farese RV. Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus. MedComm (Beijing). 2021 Mar.2(1):3-16. Pubmedid: 34766133. Pmcid: PMC8491214.
• Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kindy MS. Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activation. Int J Mol Sci. 2021 Jan.22(2). Pubmedid: 33430045. Pmcid: PMC7826722.
• Yu J, Zhu H, Kindy MS, Taheri S. Cytochrome P450 CYP2E1 Suppression Ameliorates Cerebral Ischemia Reperfusion Injury. Antioxidants (Basel). 2021 Jan.10(1). Pubmedid: 33466250. Pmcid: PMC7824747.
• Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B. Curr Alzheimer Res. 2021 Dec.18(12):941-955. Pubmedid: 34951366.
• Yazdani N, Kindy MS, Taheri S. CBF regulation in hypertension and Alzheimer's disease. Clin Exp Hypertens. 2020 Oct.42(7):622-639. Pubmedid: 32420765.
• D'Mello SR, Kindy MC. Overdosing on iron: Elevated iron and degenerative brain disorders. Exp Biol Med (Maywood). 2020 Oct.245(16):1444-1473. Pubmedid: 32878460. Pmcid: PMC7553095.
• Hoffman J, Yu J, Kirstein C, Kindy MS. Combined Effects of Repetitive Mild Traumatic Brain Injury and Alcohol Drinking on the Neuroinflammatory Cytokine Response and Cognitive Behavioral Outcomes. Brain Sci. 2020 Nov.10(11). Pubmedid: 33228251. Pmcid: PMC7699568.
• Gopalakrishna R, Mades A, Oh A, Zhu A, Nguyen J, Lin C, Kindy MS, Mack WJ. Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Bioph Res Co. 2020 Mar.523(3):678-684. Pubmedid: 31948754.
• Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D. Correction: GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. Transl Neurodegener. 2020 Jun.9:24. Pubmedid: 32537139. Pmcid: PMC7291644.
• Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kirstein C, Kindy MS. Effects of GrandFusion Diet on Cognitive Impairment in Transgenic Mouse Model of Alzheimer's Disease. Nutrients. 2020 Dec.13(1). Pubmedid: 33396967. Pmcid: PMC7824640.
• Ari C, Murdun C, Goldhagen C, Koutnik AP, Bharwani SR, Diamond DM, Kindy M, D'Agostino DP, Kovacs Z. Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models. Nutrients. 2020 Aug.12(8). Pubmedid: 32824223. Pmcid: PMC7468837.
• Ari C, Murdun C, Koutnik AP, Goldhagen CR, Rogers C, Park C, Bharwani S, Diamond DM, Kindy MS, D'Agostino DP, Kovács Z. Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models. Nutrients. 2019 Oct.11(10). Pubmedid: 31581549. Pmcid: PMC6835632.
• Newton DA, Baatz JE, Kindy MS, Gattoni-Celli S, Shary JR, Hollis BW, Wagner CL. Vitamin D binding protein polymorphisms significantly impact vitamin D status in children. Pediatr Res. 2019 Nov.86(5):662-669. Pubmedid: 30712059. Pmcid: PMC6677641.
• Newton DA, Baatz JE, Kindy MS, Gattoni-Celli S, Shary JR, Hollis BW, Wagner CL. Insights image for vitamin D binding protein polymorphisms significantly impact vitamin D status in children. Pediatr Res. 2019 Nov.86(5):674. Pubmedid: 31234192.
• Yu J, Zhu H, Taheri S, Mondy W, Bonilha L, Magwood GS, Lackland D, Adams RJ, Kindy MS. Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia. J Neurosci. 2019 Nov.39(47):9465-9476. Pubmedid: 31611307. Pmcid: PMC6867810.
• Kovács Z, D'Agostino DP, Diamond D, Kindy MS, Rogers C, Ari C. Therapeutic Potential of Exogenous Ketone Supplement Induced Ketosis in the Treatment of Psychiatric Disorders: Review of Current Literature. Front Psychiatry. 2019 May.10:363. Pubmedid: 31178772. Pmcid: PMC6543248.
• Yu J, Zhu H, Taheri S, Mondy W, Kirstein C, Swindell WR, Ko D, Kindy MS. Correction to: GM6 Attenuates Alzheimer's Disease Pathology in APP Mice. Mol Neurobiol. 2019 Mar.56(9):6397. Pubmedid: 30905003.
• Mehta M, Allen-Gipson D, Mohapatra S, Kindy M, Limayem A. Study on the therapeutic index and synergistic effect of Chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition. Int J Pharm. 2019 Jun.565:472-480. Pubmedid: 31071421.
• Ari C, Koutnik AP, DeBlasi J, Landon C, Rogers CQ, Vallas J, Bharwani S, Puchowicz M, Bederman I, Diamond DM, Kindy MS, Dean JB, D Agostino DP. Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements. Physiol Rep. 2019 Jan.7(1):e13961. Pubmedid: 30604923. Pmcid: PMC6317287.
• Yu J, Zhu H, Taheri S, Monday W, Perry S, Kindy MS. Reduced Neuroinflammation and Improved Functional Recovery after Traumatic Brain Injury by Prophylactic Diet Supplementation in Mice. Nutrients. 2019 Jan.11(2). Pubmedid: 30708954. Pmcid: PMC6412510.
• Ari C, D'Agostino DP, Diamond DM, Kindy M, Park C, Kovács Z. Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements. J Vis Exp. 2019 Jan.(143). Pubmedid: 30663672.
• Nokkari A, Abou-El-Hassan H, Mechref Y, Mondello S, Kindy MS, Jaffa AA, Kobeissy F. Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms. Prog Neurobiol. 2019 Feb.165-167:26-50. Pubmedid: 29355711. Pmcid: PMC6026079.
• Yu J, Zhu H, Taheri S, Mondy W, Kirstein C, Swindell W, Ko D, Kindy MS. GM6 Attenuates Alzheimer's Disease Pathology in APP Mice. Mol Neurobiol. 2019 Feb.56(9):6386-6396. Pubmedid: 30798443.
• Marebwa BK, Adams RJ, Magwood GS, Kindy M, Wilmskoetter J, Wolf M, Bonilha L. Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes. PLoS One. 2018 Sep.13(9):e0203460. Pubmedid: 30192823. Pmcid: PMC6128563.
• Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kindy MS. Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy. J Neuroinflamm. 2018 Sep.15(1):277. Pubmedid: 30249250. Pmcid: PMC6154891.
• Lang B, Kindy MS, Kozel FA, Schultz SK, Taheri S. Multi-Parametric Classification of Vascular Cognitive Impairment and Dementia: The Impact of Diverse Cerebrovascular Injury Biomarkers. J Alzheimers Dis. 2018 Feb.62(1):39-60. Pubmedid: 29439338.
• Adams RJ, Ellis C, Magwood G, Kindy MS, Bonilha L, Lackland DT. Commentary: Addressing Racial Disparities in Stroke: The Wide Spectrum Investigation of Stroke Outcome Disparities on Multiple Levels (WISSDOM). Ethnic Dis. 2018 Feb.28(1):61-68. Pubmedid: 29467568. Pmcid: PMC5794450.
• Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D. GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. Transl Neurodegener. 2018 Dec.7:30. Pubmedid: 30524706. Pmcid: PMC6276193.
• Swindell WR, Bojanowski K, Kindy MS, Chau RMW, Ko D. GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis. Transl Neurodegener. 2018 Dec.7(1):30. Pubmedid: 32532315.
• Yu J, Zhu H, Taheri S, Perry S, Kindy MS. The Effect of Diet on Improved Endurance in Male C57BL/6 Mice. Nutrients. 2018 Aug.10(8). Pubmedid: 30115854. Pmcid: PMC6115890.
• Yu J, Zhu H, Perry S, Taheri S, Kindy MS. Daily supplementation with GrandFusion improves memory and learning in aged rats. Aging (Albany NY). 2017 03.9(3):1041-1054. Pubmedid: 28351996. Pmcid: PMC5391217.
• Gwak SJ, Macks C, Jeong DU, Kindy M, Lynn M, Webb K, Lee JS. RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. Biomaterials. 2017 03.121:155-166. Pubmedid: 28088077. Pmcid: PMC5315572.
• Lou N, Lennard Richard ML, Yu J, Kindy M, Zhang XK. The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2). Mol Immunol. 2017 01.81:59-66. Pubmedid: 27889620.
• Kindy M, Lupinacci P, Chau R, Shum T, Ko D. A Phase 2A randomized, double-blind, placebo-controlled pilot trial of GM604 in patients with Amyotrophic Lateral Sclerosis (ALS Protocol GALS-001) and a single compassionate patient treatment (Protocol GALS-C). F1000Res. 2017.6:230. Pubmedid: 30057745. Pmcid: PMC6051227.
• Kuang SY, Yang X, Wang Z, Huang T, Kindy M, Xi T, Gao BZ. How Microelectrode Array-Based Chick Forebrain Neuron Biosensors Respond to Glutamate NMDA Receptor Antagonist AP5 and GABAA Receptor Antagonist Musimol. Sens Biosensing Res. 2016 Sep.10:9-14. Pubmedid: 27551670. Pmcid: PMC4991211.
• Kindy MS, Yu J, Zhu H, Smith MT, Gattoni-Celli S. A therapeutic cancer vaccine against GL261 murine glioma. J Transl Med. 2016 Jan.14:1. Pubmedid: 26727970. Pmcid: PMC4700644.
• Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan.291(4):1957-1973. Pubmedid: 26620563. Pmcid: PMC4722471.
• Taheri S, Yu J, Zhu H, Kindy MS. High-Sodium Diet Has Opposing Effects on Mean Arterial Blood Pressure and Cerebral Perfusion in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 10.54(3):1061-1072. Pubmedid: 27567835.
• Hook G, Jacobsen JS, Grabstein K, Kindy M, Hook V. Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Front Neurol. 2015 Sep.6:178. Pubmedid: 26388830. Pmcid: PMC4557097.
• Kuang SY, Wang Z, Huang T, Wei L, Xi T, Kindy M, Gao BZ. Prolonging life in chick forebrain-neuron culture and acquiring spontaneous spiking activity on a microelectrode array. Biotechnol Lett. 2015 Mar.37(3):499-509. Pubmedid: 25344105.
• Kuang SY, Huang T, Wang Z, Lin Y, Kindy M, Xi T, Gao BZ. Establishment of a Long-Term Chick Forebrain Neuronal Culture on a Microelectrode Array Platform. RSC Adv. 2015 Jan.5(69):56244-56254. Pubmedid: 26989485. Pmcid: PMC4792308.
• Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec.15(23-24):4051-4063. Pubmedid: 26364553.
• Alawieh A, Elvington A, Zhu H, Yu J, Kindy MS, Atkinson C, Tomlinson S. Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement. J Neuroinflamm. 2015 Dec.12:247. Pubmedid: 26714866. Pmcid: PMC4696299.
• Alshareef M, Krishna V, Ferdous J, Alshareef A, Kindy M, Kolachalama VB, Shazly T. Effect of spinal cord compression on local vascular blood flow and perfusion capacity. PLoS One. 2014 Sep.9(9):e108820. Pubmedid: 25268384. Pmcid: PMC4182502.
• Novgorodov SA, Riley CL, Yu J, Borg KT, Hannun YA, Proia RL, Kindy MS, Gudz TI. Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014 May.289(19):13142-13154. Pubmedid: 24659784. Pmcid: PMC4036326.
• Hook GR, Yu J, Sipes N, Pierschbacher MD, Hook V, Kindy MS. The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury. J Neurotrauma. 2014 Mar.31(5):515-529. Pubmedid: 24083575. Pmcid: PMC3934599.
• Hook G, Yu J, Toneff T, Kindy M, Hook V. Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. J Alzheimers Dis. 2014 Jun.41(1):129-149. Pubmedid: 24595198. Pmcid: PMC4059604.
• Krishna V, Andrews H, Varma A, Mintzer J, Kindy MS, Guest J. Spinal cord injury: how can we improve the classification and quantification of its severity and prognosis?. J Neurotrauma. 2014 Feb.31(3):215-227. Pubmedid: 23895105. Pmcid: PMC3904531.
• Krishna V, Konakondla S, Nicholas J, Varma A, Kindy M, Wen X. Biomaterial-based interventions for neuronal regeneration and functional recovery in rodent model of spinal cord injury: a systematic review. J Spinal Cord Med. 2013 May.36(3):174-190. Pubmedid: 23809587. Pmcid: PMC3654443.
• Hollis BW, Marshall DT, Savage SJ, Garrett-Mayer E, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation, low-risk prostate cancer, and health disparities. J Steroid Biochem -. 2013 Jul.136:233-237. Pubmedid: 23220550.
• Krishna V, Andrews H, Jin X, Yu J, Varma A, Wen X, Kindy M. A contusion model of severe spinal cord injury in rats. J Vis Exp. 2013 Aug.(78). Pubmedid: 23979022. Pmcid: PMC3855925.
• Yun X, Maximov VD, Yu J, Zhu H, Vertegel AA, Kindy MS. Nanoparticles for targeted delivery of antioxidant enzymes to the brain after cerebral ischemia and reperfusion injury. J Cereb Blood Flow Metab. 2013 Apr.33(4):583-592. Pubmedid: 23385198. Pmcid: PMC3618396.
• Krishna V, Lazaridis C, Ellegala D, Glazier S, Kindy M, Spampinato M, Chalela JA. Spinal cord infarction associated with subarachnoid hemorrhage. Clin Neurol Neurosurg. 2012 Sep.114(7):1030-1032. Pubmedid: 22386902. Pmcid: PMC3703243.
• Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl GL, Kindy MS, Tomlinson S. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov.189(9):4640-4647. Pubmedid: 23028050. Pmcid: PMC3478485.
• Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS. Protective effects of incensole acetate on cerebral ischemic injury. Brain Res. 2012 Mar.1443:89-97. Pubmedid: 22284622. Pmcid: PMC3294134.
• Marshall DT, Savage SJ, Garrett-Mayer E, Keane TE, Hollis BW, Horst RL, Ambrose LH, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab. 2012 Jul.97(7):2315-2324. Pubmedid: 22508710. Pmcid: PMC3387395.
• Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012 Jan.1824(1):89-104. Pubmedid: 21925292. Pmcid: PMC3232284.
• Elvington A, Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, Tomlinson S. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J Immunol. 2012 Feb.188(3):1460-1468. Pubmedid: 22198950. Pmcid: PMC3262954.
• Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook GR. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence. J Alzheimers Dis. 2012 Aug.29(4):827-840. Pubmedid: 22337825. Pmcid: PMC4309289.
• Garrett-Mayer E, Wagner CL, Hollis BW, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men. Am J Clin Nutr. 2012 Aug.96(2):332-336. Pubmedid: 22760568. Pmcid: PMC6443291.
• Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. J Alzheimers Dis. 2011 Sep.26(2):387-408. Pubmedid: 21613740. Pmcid: PMC4317342.
• Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem. 2011 May.117(3):359-374. Pubmedid: 21320126. Pmcid: PMC3076515.
• Novgorodov SA, Chudakova DA, Wheeler BW, Bielawski J, Kindy MS, Obeid LM, Gudz TI. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. J Biol Chem. 2011 Feb.286(6):4644-4658. Pubmedid: 21148554. Pmcid: PMC3039377.
• Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. J Alzheimers Dis. 2011.25(2):295-307. Pubmedid: 21422528. Pmcid: PMC5886011.
• Vest RS, O'Leary H, Coultrap SJ, Kindy MS, Bayer KU. Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor. J Biol Chem. 2010 Jul.285(27):20675-20682. Pubmedid: 20424167. Pmcid: PMC2898334.
• Varghese K, Molnar P, Das M, Bhargava N, Lambert S, Kindy MS, Hickman JJ. A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS One. 2010 Jan.5(1):e8643. Pubmedid: 20062810. Pmcid: PMC2799531.
• Ellis BC, Gattoni-Celli S, Kindy MS. The impact of methylmercury on 1,25-dihydroxyvitamin D3-induced transcriptomic responses in dolphin skin cells. Biol Chem. 2010 Feb.391(2-3):245-258. Pubmedid: 20030593.
• Qiao F, Atkinson C, Kindy MS, Shunmugavel A, Morgan BP, Song H, Tomlinson S. The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury. Am J Pathol. 2010 Dec.177(6):3061-3070. Pubmedid: 20952585. Pmcid: PMC2993269.
• Hook V, Hook G, Kindy M. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biol Chem. 2010 Aug.391(8):861-872. Pubmedid: 20536395. Pmcid: PMC4309269.
• Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A. 2009 Jan.106(4):1285-1290. Pubmedid: 19164583. Pmcid: PMC2633544.
• Yu J, Kindy MS, Gattoni-Celli S. Semi-allogeneic vaccines and tumor-induced immune tolerance. J Transl Med. 2009 Jan.7:3. Pubmedid: 19133135. Pmcid: PMC2631475.
• Ellis BC, Gattoni-Celli S, Mancia A, Kindy MS. The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin. Dev Comp Immunol. 2009 Aug.33(8):901-912. Pubmedid: 19454332. Pmcid: PMC3476053.
• Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Bioph Res Co. 2009 Aug.386(2):284-288. Pubmedid: 19501042. Pmcid: PMC2753505.
• Yu J, Zhu H, Ko D, Kindy MS. Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse. Brain Res. 2008 Oct.1238:143-153. Pubmedid: 18789909. Pmcid: PMC3275905.
• Chudakova DA, Zeidan YH, Wheeler BW, Yu J, Novgorodov SA, Kindy MS, Hannun YA, Gudz TI. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008 Oct.283(43):28806-28816. Pubmedid: 18682390. Pmcid: PMC2570874.
• Pettigrew LC, Kindy MS, Scheff S, Springer JE, Kryscio RJ, Li Y, Grass DS. Focal cerebral ischemia in the TNFalpha-transgenic rat. J Neuroinflamm. 2008 Oct.5:47. Pubmedid: 18947406. Pmcid: PMC2583993.
• El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol. 2008 May.172(5):1342-1354. Pubmedid: 18403590. Pmcid: PMC2329843.
• Govindaswami M, Brown SA, Yu J, Zhu H, Bishop PD, Kindy MS, Oeltgen PR. Delta 2-specific opioid receptor agonist and hibernating woodchuck plasma fraction provide ischemic neuroprotection. Acad Emerg Med. 2008 Mar.15(3):250-257. Pubmedid: 18304055.
• Hook VY, Kindy M, Hook G. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. J Biol Chem. 2008 Mar.283(12):7745-7753. Pubmedid: 18184658.
• Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul.106(1):475-485. Pubmedid: 18410513. Pmcid: PMC3897170.
• Hook G, Hook VY, Kindy M. Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics. Biol Chem. 2007 Sep.388(9):979-983. Pubmedid: 17696783.
• El-Amouri SS, Zhu H, Yu J, Gage FH, Verma IM, Kindy MS. Neprilysin protects neurons against Abeta peptide toxicity. Brain Res. 2007 Jun.1152:191-200. Pubmedid: 17459354. Pmcid: PMC2020816.
• Yu J, Kindy MS, Gattoni-Celli S. Semi-allogeneic vaccine for T-cell lymphoma. J Transl Med. 2007 Aug.5:39. Pubmedid: 17686178. Pmcid: PMC1971246.
• Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI. JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction. J Biol Chem. 2007 Aug.282(35):25940-25949. Pubmedid: 17609208.
• Atkinson C, Zhu H, Qiao F, Varela JC, Yu J, Song H, Kindy MS, Tomlinson S. Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol. 2006 Nov.177(10):7266-7274. Pubmedid: 17082645.
• Yu J, Kindy MS, Ellis BC, Baatz JE, Peden-Adams M, Ellingham TJ, Wolff DJ, Fair PA, Gattoni-Celli S. Establishment of epidermal cell lines derived from the skin of the Atlantic bottlenose dolphin (Tursiops truncatus). Anat Rec A Discov Mol Cell Evol Biol. 2005 Dec.287(2):1246-1255. Pubmedid: 16281302.
• Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. Embo J. 2004 Oct.23(20):4096-4105. Pubmedid: 15457210. Pmcid: PMC524347.
• Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004 Aug.5(6):517-528. Pubmedid: 15270198.
• Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci. 2004.22(1-2):5-11. Pubmedid: 14742905.
• Wu J, Zhu BB, Yu J, Zhu H, Qiu L, Kindy MS, Gu L, Seidel A, Li GM. In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system. Nucleic Acids Res. 2003 Nov.31(22):6428-6434. Pubmedid: 14602900. Pmcid: PMC275569.
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• Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul.9(7):907-913. Pubmedid: 12808450.
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• Webb NR, de Beer MC, Yu J, Kindy MS, Daugherty A, van der Westhuyzen DR, de Beer FC. Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice. J Lipid Res. 2002 Sep.43(9):1421-1428. Pubmedid: 12235173.
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